Abstract:
OBJECTIVE:To describe the observed frequency of oculo-auriculo-vertebral spectrum (OAVS) in patients with dermolipoma. DESIGN:Retrospective case series. PARTICIPANTS:Patients with primary presentation of ocular dermolipoma. METHODS:All patients with ocular dermolipoma or lipodermoid were identified from the authors' clinical databases from 1990 to 2011 inclusive. Case notes were reviewed retrospectively for the gender and age of presentation, the laterality of dermolipoma, and features of OAVS. MAIN OUTCOME MEASURES:The frequency of OAVS in patients with dermolipoma, the severity of the OAVS phenotype, and other concurrent ophthalmic features observed. RESULTS:Thirty-four patients (24 females) presented with dermolipoma at ages ranging from 6 months to 57 years (mean, 20 years; median, 16 years). Twelve patients (35.5%) had features of OAVS (10 patients with dermolipoma had ipsilateral OAVS and 2 patients had contralateral features of OAVS). Ten patients with dermolipoma had hemifacial microsomia, and 2 patients had features of Goldenhar's syndrome. None of the patients had bilateral dermolipoma and OAVS. Other associated ophthalmic features were limbal dermoids (2 cases), lateral canthal coloboma (3 cases), and facial nerve palsy (1 case). CONCLUSIONS:Dermolipoma is an independent ocular association of OAVS that is more commonly observed than previously reported. It is an ocular feature in both the milder and more complex forms of the spectrum. FINANCIAL DISCLOSURE(S):The authors have no proprietary or commercial interest in any materials discussed in this article.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Khong JJ,Hardy TG,McNab AAdoi
10.1016/j.ophtha.2013.01.015subject
Has Abstractpub_date
2013-08-01 00:00:00pages
1529-32issue
8eissn
0161-6420issn
1549-4713pii
S0161-6420(13)00017-1journal_volume
120pub_type
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