Abstract：
PURPOSE:The aim of this study was to compare patient-reported symptoms of dry eye disease (DED) as assessed by the Ocular Surface Disease Index (OSDI), a 12-item symptom frequency-based questionnaire, and the Symptom Assessment iN Dry Eye (SANDE), a 2-item frequency- and severity-based visual analog scale. DESIGN:Clinic-based evaluation of a diagnostic test. PARTICIPANTS:A total of 114 patients with DED. METHODS:Patients were administered the OSDI and SANDE questionnaires at baseline and follow-up visits to evaluate DED-related symptoms. The correlations between both questionnaires' scores were evaluated using the Spearman coefficient, and their clinical differences were assessed using Bland-Altman analysis. MAIN OUTCOME MEASURES:Baseline and follow-up visit OSDI and SANDE dry eye symptom scores. RESULTS:At the baseline visit, the OSDI and SANDE questionnaire scores were significantly correlated (R = 0.64; P < 0.001). Moreover, a significant correlation was found between changes in the OSDI and SANDE scores from baseline to follow-up visits (R = 0.47; P < 0.001). A Bland-Altman analysis, after score normalization, revealed a difference (bias) of less than 2 centesimal units between the scores of the 2 questionnaires. CONCLUSIONS:Data collected from the SANDE questionnaire showed a significant correlation and negligible score differences with those from the OSDI, suggesting that the SANDE visual analog scale-based questionnaire has the potential to provide clinicians with a short, quick, and reliable measure for DED symptoms.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Amparo F,Schaumberg DA,Dana Rdoi
10.1016/j.ophtha.2015.02.037subject
Has Abstractpub_date
2015-07-01 00:00:00pages
1498-503issue
7eissn
0161-6420issn
1549-4713pii
S0161-6420(15)00181-5journal_volume
122pub_type
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