Nabilone: a pressure-reducing synthetic benzopyran in open-angle glaucoma.

Abstract:

:Nabilone is a synthesized crystalline benzopyran that resembles the cannabinols but is not a tetrahydrocannabinol. Oral administration of 0.5 to 2 mg to patients with open-angle glaucoma reduced the intraocular pressure from 10% to 54% with an average of 28%. Administration of a topical ophthalmic nabilone solution (0.1 mg/drop) to both eyes of adult albino rabbits (1.5 to 3.5 kg) lowered the IOP an average of 25%. The peak action of the nabilone administered in this manner was 60 minutes, with a return to normal IOP by 180 minutes. Tolerance developed in rabbits after one week of topical administration.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Newell FW,Stark P,Jay WM,Schanzlin DJ

doi

10.1016/s0161-6420(79)35539-7

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

156-60

issue

1

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(79)35539-7

journal_volume

86

pub_type

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