Abstract:
:Nabilone is a synthesized crystalline benzopyran that resembles the cannabinols but is not a tetrahydrocannabinol. Oral administration of 0.5 to 2 mg to patients with open-angle glaucoma reduced the intraocular pressure from 10% to 54% with an average of 28%. Administration of a topical ophthalmic nabilone solution (0.1 mg/drop) to both eyes of adult albino rabbits (1.5 to 3.5 kg) lowered the IOP an average of 25%. The peak action of the nabilone administered in this manner was 60 minutes, with a return to normal IOP by 180 minutes. Tolerance developed in rabbits after one week of topical administration.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Newell FW,Stark P,Jay WM,Schanzlin DJdoi
10.1016/s0161-6420(79)35539-7subject
Has Abstractpub_date
1979-01-01 00:00:00pages
156-60issue
1eissn
0161-6420issn
1549-4713pii
S0161-6420(79)35539-7journal_volume
86pub_type
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