Abstract:
:The Diabetic Retinopathy Study (DRS) demonstrated that prompt argon laser photocoagulation, in comparison to indefinite delay in treatment, could reduce by more than 50% the risk of severe visual loss from proliferative diabetic retinopathy. The DRS also enlightened two generations of ophthalmologists about the value of the randomized controlled clinical trial as a way of assessing new and existing treatments for unsolved therapeutic problems. After the example of the DRS, laser treatment was shown to be effective in reducing vision loss in selected patients with branch retinal vein occlusion, age-related macular degeneration, ocular histoplasmosis, and diabetic macular edema. Existing trials, supported by the National Eye Institute, are seeking to determine the appropriate treatment for selected patients with newly diagnosed glaucoma, vascularized corneas, retinopathy of prematurity, proliferative vitreoretinopathy and complicated retinal detachment, and choroidal melanoma. Clinical practice has benefited enormously from these studies all of which owe their existence, at least in part, to the prototypical clinical trial, the DRS. This symposium discusses the DRS and places it in today's perspective, with a look to the past as well.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Fine SL,Patz Adoi
10.1016/s0161-6420(87)33523-7subject
Has Abstractpub_date
1987-07-01 00:00:00pages
739-40issue
7eissn
0161-6420issn
1549-4713pii
S0161-6420(87)33523-7journal_volume
94pub_type
临床试验,杂志文章相关文献
OPHTHALMOLOGY文献大全abstract::One hundred and sixty-two patients with presumed ocular histoplasmosis syndrome were evaluated. New macular scars not present on initial angiogram developed in 9% of eyes. The risk of developing a symptomatic macular lesion in eyes with asymptomatic macular scars was 23%. In eyes with peripapillary scarring, 3.8% deve...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35226-3
更新日期:1980-05-01 00:00:00
abstract::A high resolution photokeratoscope using digital video image acquisition and computer graphics was used to describe anterior corneal topography before and after radial keratotomy. After radial keratotomy, the entire cornea is flattened, but this effect is more pronounced centrally. The flat central "optical zone" vari...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32927-7
更新日期:1989-01-01 00:00:00
abstract::A new procedure for neovascular glaucoma that has reduced intraocular pressure (IOP) significantly and has caused relatively few postoperative complications is introduced. Aqueous is shunted to the reservoir of an encircling no. 20 silicone band from which fluid is postulated to diffuse into the orbit. The anterior ch...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(82)34671-0
更新日期:1982-10-01 00:00:00
abstract:OBJECTIVE:To assess the incidence or progression of macular edema (ME) after cataract surgery in diabetic patients using optical coherence tomography (OCT) and correlating this with degree of diabetic retinopathy or other risk factors. DESIGN:Prospective cohort study. PARTICIPANTS:Fifty diabetic eyes undergoing catar...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.08.053
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To examine the impact of glaucoma and visual acuity (VA) and visual field (VF) losses on psychosocial functioning (PF). DESIGN:Cross-sectional study. PARTICIPANTS:We compared PF between 192 participants with bilateral glaucoma with VA or VF losses and 40 controls from a tertiary eye hospital clinic in Singa...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2014.09.030
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Diffuse iris melanoma is a rare variant of iris melanoma that has a flat growth pattern and often presents as unilateral hyperchromic heterochromia and glaucoma. There have been no large clinical reports of diffuse iris melanoma. DESIGN:Single-center retrospective case series. PARTICIPANTS:Twenty-five cons...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0161-6420(02)01104-1
更新日期:2002-08-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and toxicity of subconjunctival carboplatin for intraocular retinoblastoma. DESIGN:A phase I/II clinical trial (noncomparative case series). PARTICIPANTS:Eleven children with bilateral retinoblastoma who had 13 eyes containing active tumor. METHODS:Subconjunctival carboplatin (1.4-2....
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/S0161-6420(99)90406-2
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:This study aimed to examine the characteristics of intraretinal changes associated with macular holes and epiretinal membranes by scanning retinal thickness analysis. STUDY DESIGN:The study design was a nonconsecutive case series. PATIENTS:Fifty-six eyes of patients who had either a suspected or clinically ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(98)91274-x
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To determine whether multiple B-scan averaging improves the quality of spectral-domain optical coherence tomography (SD OCT) images of the retina. DESIGN:Prospective cross-sectional study. PARTICIPANTS:One hundred one eyes of 84 patients with various retinal diseases. METHODS:A prototype SD OCT system was ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.09.001
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:This study sought to determine the validity of self-report of prior panretinal photocoagulation (PRP) and focal photocoagulation (FP) compared with fundus photography. DESIGN:Prospective cohort study. PARTICIPANTS:One thousand three hundred sixty-three type 1 diabetic subjects from the Epidemiology of Diabete...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.ophtha.2013.06.002
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:We sought to determine the most cost-effective treatment for patients with newly diagnosed neovascular macular degeneration: monthly or as-needed bevacizumab injections, or monthly or as-needed ranibizumab injections. DESIGN:Cost-effectiveness analysis. PARTICIPANTS:Hypothetical cohort of 80-year-old patients...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.10.037
更新日期:2014-04-01 00:00:00
abstract::A CW YAG laser was used to coagulate retina and to produce an optical iridotomy in a human eye that was to be enucleated for malignant melanoma at the optic nerve head. Moderate coagulation with the CW YAG laser produced a deep choroidal reaction involving the outer portion of the retina. The inner structure of the fo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34185-9
更新日期:1984-09-01 00:00:00
abstract:PURPOSE:Choroidal detachment and anterior chamber (AC) shallowing develop in some cases after scleral buckling surgery for rhegmatogenous retinal detachment (RD). Postoperative angle-closure glaucoma has been reported to occur in 4% of cases. It is supposed that compression by the local scleral buckling induces ciliary...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.09.023
更新日期:2006-01-01 00:00:00
abstract::In a long-term study of 252 eyes that had initial glaucoma filtration surgery, there was an overall success rate of 85%. Rigid criteria for success included an intraocular pressure equal to or less than 19 mmHg, no further visual field loss or disc damage, and no glaucomatous etiology for a decrease in visual acuity. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33771-0
更新日期:1986-01-01 00:00:00
abstract:PURPOSE:Neovascular glaucoma is a frequent complication of vitrectomy performed to treat proliferative diabetic retinopathy (PDR). We assessed the level of vascular endothelial growth factor (VEGF) in the vitreous fluid obtained during vitrectomy and at postoperative fluid-air exchange. METHODS:We measured VEGF levels...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2004.03.035
更新日期:2004-10-01 00:00:00
abstract:PURPOSE:Nonspecific orbital inflammation, also called "orbital pseudotumor," has many of the features of thyroid-associated ophthalmopathy, especially when localized to the eye muscle. The purpose of this study is to test for circulating autoantibodies against eye muscle antigens and features of possible thyroid autoim...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)31066-4
更新日期:1995-01-01 00:00:00
abstract:TOPIC:The incidence and morbidity of herpes zoster (HZ) and HZ ophthalmicus (HZO), and the potential impact of varicella vaccine on their epidemiology. CLINICAL RELEVANCE:Herpes zoster affects 20% to 30% of the population at some point in their lifetime; approximately 10% to 20% of these individuals will have HZO. ME...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/j.ophtha.2007.10.009
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:To describe presenting and corrected visual acuities after cataract surgery in a nationally representative sample of adults. Another objective was to describe refractive errors in operated eyes and to determine the optimal range of intraocular lens (IOL) powers for this population. DESIGN:Cross-sectional, po...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.08.025
更新日期:2011-04-01 00:00:00
abstract::The effectiveness of trabeculectomy with adjunctive low-dose 5-fluorouracil (5-FU) as the initial surgical procedure in uncomplicated glaucoma was evaluated retrospectively in a consecutive series of 52 patients (mean follow-up, 18.6 +/- 11.7 mos) and 74 control subjects. The cumulative 2-year success (intraocular pre...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32180-8
更新日期:1991-07-01 00:00:00
abstract::A 38-year-old male homosexual with the new Acquired Immunodeficiency Syndrome (AIDS) had biopsy proven Kaposi's sarcoma of the right palpebral conjunctiva, extraocular mucocutaneous areas, and lymph nodes. Histologically, the palpebral tumor was characterized by atypical spindle cell proliferation and multiple slit-li...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(83)80011-6
更新日期:1983-08-01 00:00:00
abstract:OBJECTIVE:To compare effective phacoemulsification time after femtosecond laser pretreatment with conventional phacoemulsification and the associated effect on visual outcomes and endothelial cell loss. DESIGN:Prospective, consecutive, single-surgeon case-control study. CONTROLS:Controls underwent phacoemulsification...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.11.045
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To determine the incidence of retinopathy of prematurity (ROP) over a 2-year period before and after a change in the practice of oxygen supplementation. DESIGN:Nonrandomized, retrospective study. PARTICIPANTS:All infants in a single Level III neonatal intensive care unit between the years of 2005 and 2007. M...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.09.051
更新日期:2009-03-01 00:00:00
abstract::A 35-year-old white man, on immunosuppressive medications for 3 1/2 years following a renal transplant, presented with a whitish-yellow mass at the medial end of the left lower eyelid. An initial incisional biopsy was performed that was misinterpreted as granular cell myoblastoma. The mass was subsequently excised and...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33633-9
更新日期:1986-08-01 00:00:00
abstract:OBJECTIVE:To investigate the safety and efficacy of a new laser procedure using a q-switched 532-nm neodymium (Nd):YAG laser, also called "selective laser trabeculoplasty," to lower intraocular pressure (IOP) in patients with open-angle glaucoma (OAG). The laser parameters were set to selectively target pigmented trabe...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/S0161-6420(98)91129-0
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:The purpose of this study is to determine if an endoscope would improve visualization of the anterior chamber angle and facilitate goniotomy in a surgical cloudy corneal model of primary infantile glaucoma. METHODS:A 23-gauge needle coupled to a 0.8-mm diameter flexible endoscope entered the anterior chamber o...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:To describe three cases of squamous cell carcinoma of the conjunctiva presenting with corneal and scleral inflammation, thinning, and perforation without any tumor formation. DESIGN:Three case reports. PARTICIPANTS:Three male subjects aged 76, 66, and 61 years. INTERVENTION:The subjects had symptoms of ext...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00585-6
更新日期:2001-03-01 00:00:00
abstract::Triamcinolone acetonide (TA) was injected subconjunctivally in nine human eyes one week before trabeculectomy. A biopsy specimen of conjunctiva and subconjunctiva was obtained from the site of drug injection, as well as a site 6 mm from the injection at the time of trabeculectomy. The tissue was evaluated by electron ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:
更新日期:1987-02-01 00:00:00
abstract::Rotational ipsilateral penetrating autokeratoplasty is useful in the treatment of certain nonprogressive corneal scars. The procedure alleviates difficulties with the availability of donor tissue and with graft rejection. A method is presented for determining the maximum clear central corneal area that can be obtained...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(78)35561-5
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND:To undertake a clinical and molecular analysis of a previously unpublished kindred with a phenotypically distinct vitreoretinopathy characterized by associated ocular developmental abnormalities. DESIGN:Family genetic study. PARTICIPANTS:A total of 23 members, both affected and unaffected, of 1 kindred wit...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(99)90486-4
更新日期:1999-11-01 00:00:00
abstract:PURPOSE:To identify effective methods to increase the number of cataract surgeries in a rural setting in Pucheng County of Shaanxi Province, northwestern China. DESIGN:Community-based randomized interventional study. PARTICIPANTS:Four hundred thirty-two patients 50 years of age or older with operable cataract who had...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2012.07.087
更新日期:2013-02-01 00:00:00