Glaucoma and associated visual acuity and field loss significantly affect glaucoma-specific psychosocial functioning.


OBJECTIVE:To examine the impact of glaucoma and visual acuity (VA) and visual field (VF) losses on psychosocial functioning (PF). DESIGN:Cross-sectional study. PARTICIPANTS:We compared PF between 192 participants with bilateral glaucoma with VA or VF losses and 40 controls from a tertiary eye hospital clinic in Singapore. METHODS:Glaucoma was defined using the Hodapp-Anderson-Parish criteria. Four psychosocial outcomes of the Glaucoma Quality of Life 36 questionnaire were psychometrically assessed using Rasch analysis. Multivariate regression was performed to determine the independent impact of glaucoma and VA and VF losses on PF. The impact of VA and VF on PF were evaluated by restricted cubic spline analysis. MAIN OUTCOME MEASURES:Anxiety, self-image, psychological well-being, and confidence in health care. RESULTS:The mean age of participants was 66.2±11.0 years, and 63% were male. In the better eye, VA and mean deviation were Snellen 20/25 and -8.89±6.52 dB, respectively. In multivariate models, glaucoma patients had 63.0% greater anxiety (95% confidence interval [CI], -66.0% to -61.2%; P<0.001), 71.0% lower self-image (95% CI, -74.1% to -68.5%; P<0.001), 38.3% less psychological well-being (95% CI, -37.4% to -39.0%; P<0.001), and 32.4% reduced confidence in health care than patients without glaucoma. The worst VA and VF categories had the most reduced PF (range, 26.0% to 81.5%; P<0.001 for all associations) compared with controls. With worsening VA, there was a linear increase in anxiety (P=0.009) and decrease in self-image (P=0.005). With worsening VF from 0 to -12.1 dB (P=0.003), anxiety increased before plateauing. Self-image decreased as VF worsened from 0 to -10 dB (P<0.001), and confidence in health care decreased when VF worsened from 0 to -9.3 dB (P=0.008). However, self-image and confidence in health care actually improved at greater levels of VF loss beyond these thresholds. CONCLUSION:Glaucoma negatively affects PF. Early stage glaucoma with mild VF loss adversely affects anxiety, self-image, and confidence in health care. As VA worsens in advanced glaucoma, anxiety further increases and self-image deteriorates. Ophthalmologists and glaucoma patients need to be aware that both VA and VF losses at different stages of glaucoma negatively impact PF.






Chan EW,Chiang PP,Liao J,Rees G,Wong TY,Lam JS,Aung T,Lamoureux E




Has Abstract


2015-03-01 00:00:00














  • Long-term trends in glaucoma-related blindness in Olmsted County, Minnesota.

    abstract:OBJECTIVE:To determine the longitudinal trends in the probability of blindness due to open-angle glaucoma (OAG) in Olmsted County, Minnesota, from 1965 to 2009. DESIGN:Retrospective, population-based cohort study. PARTICIPANTS:All residents of Olmsted County, Minnesota (aged ≥ 40 years) who were diagnosed with OAG be...


    pub_type: 杂志文章


    authors: Malihi M,Moura Filho ER,Hodge DO,Sit AJ

    更新日期:2014-01-01 00:00:00

  • Needling revision of trabeculectomies bleb morphology and long-term survival.

    abstract:PURPOSE:To assess the long-term success rate and to determine factors that predict survival after 5-fluorouracil-augmented needling revision of poorly functioning trabeculectomy blebs. DESIGN:Prospective observational cohort study. PARTICIPANTS:Eighty-one consecutive patients undergoing bleb needling. METHODS:Surviv...


    pub_type: 杂志文章


    authors: Rotchford AP,King AJ

    更新日期:2008-07-01 00:00:00

  • The Red Badge.

    abstract::This article discusses the experience of progressing from a young ophthalmic resident to a full-time professional and, ultimately, to service on the American Board of Ophthalmology. ...


    pub_type: 杂志文章


    authors: Alward WL

    更新日期:2016-09-01 00:00:00

  • Immunocytologic localization of herpes simplex type 1 viral antigens in herpetic retinitis and encephalitis in an adult.

    abstract::An immunoperoxidase technique was utilized to identify herpes simplex type I viral antigens in the retina, optic nerve and brain of an adult with herpetic retinitis and encephalitis. Viral antigens were demonstrated in all layers of retina, retinal pigment epithelium and to a lesser extent, in choroid. Oligodendroglia...


    pub_type: 杂志文章


    authors: Pepose JS,Kreiger AE,Tomiyasu U,Cancilla PA,Foos RY

    更新日期:1985-01-01 00:00:00

  • Risk factors associated with age-related nuclear and cortical cataract : a case-control study in the Age-Related Eye Disease Study, AREDS Report No. 5.

    abstract:OBJECTIVE:To investigate possible risk factors for age-related nuclear and cortical cataracts in participants in the Age-Related Eye Disease Study (AREDS). DESIGN:Case-control study. PARTICIPANTS:Of the 4757 persons enrolled in AREDS, 4477 age 60 to 80 years are included in the study. MAIN OUTCOME MEASURES:Slit-lamp...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Age-Related Eye Disease Study Research Group.

    更新日期:2001-08-01 00:00:00

  • Clinicopathologic study of the effect of radial tears and loop fixation on intraocular lens decentration.

    abstract:PURPOSE:The purpose of this study is to determine the effect of loop fixation and anterior capsular tears on intraocular lens (IOL) decentration. METHODS:A retrospective measurement of IOL decentration was performed on 144 human eyes with posterior chamber (PC) IOLs obtained after death. RESULTS:Decentration in eyes ...


    pub_type: 杂志文章


    authors: Assia EI,Legler UF,Merrill C,Hicklin JC,Castaneda VE,Hoggatt JP,Wasserman D,Apple DJ

    更新日期:1993-02-01 00:00:00

  • Patients with Sjögren-Larsson syndrome lack macular pigment.

    abstract:PURPOSE:Sjögren-Larsson syndrome (SLS), an autosomal recessive hereditary disorder with congenital ichthyosis, spastic diplegia or tetraplegia, and mental retardation, reveals a characteristic macular dystrophy with intraretinal crystals and foveal pseudocysts. Ophthalmic symptoms in SLS are reduced visual acuity and p...


    pub_type: 杂志文章


    authors: van der Veen RL,Fuijkschot J,Willemsen MA,Cruysberg JR,Berendschot TT,Theelen T

    更新日期:2010-05-01 00:00:00

  • Whole Exome Sequencing Identifies Candidate Genes Associated with Hereditary Predisposition to Uveal Melanoma.

    abstract:PURPOSE:To identify susceptibility genes associated with hereditary predisposition to uveal melanoma (UM) in patients with no detectable germline BAP1 alterations. DESIGN:Retrospective case series from academic referral centers. PARTICIPANTS:Cohort of 154 UM patients with high risk of hereditary cancer defined as pat...


    pub_type: 杂志文章


    authors: Abdel-Rahman MH,Sample KM,Pilarski R,Walsh T,Grosel T,Kinnamon D,Boru G,Massengill JB,Schoenfield L,Kelly B,Gordon D,Johansson P,DeBenedictis MJ,Singh A,Casadei S,Davidorf FH,White P,Stacey AW,Scarth J,Fewings E,T

    更新日期:2020-05-01 00:00:00

  • Impact of a 1-day ophthalmology experience on medical students.

    abstract:OBJECTIVE:To improve the ophthalmic knowledge and eye examination skills of third-year medical students through the development and implementation of a 1-day ophthalmology experience. DESIGN:Noncomparative interventional case series. PARTICIPANTS:One hundred twenty-one third-year medical students at the Penn State Co...


    pub_type: 杂志文章


    authors: Quillen DA,Cantore WA

    更新日期:2006-12-01 00:00:00

  • Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity.

    abstract:PURPOSE:Geographic atrophy (GA) may cause significant compromise of visual function, even when there still is good visual acuity (VA), because of parafoveal scotomas and foveal function abnormalities antedating visible atrophy. This study evaluates the visual function abnormalities at baseline and the 2-year worsening ...


    pub_type: 杂志文章


    authors: Sunness JS,Rubin GS,Applegate CA,Bressler NM,Marsh MJ,Hawkins BS,Haselwood D

    更新日期:1997-10-01 00:00:00

  • Risk of advanced age-related macular degeneration after cataract surgery in the Age-Related Eye Disease Study: AREDS report 25.

    abstract:PURPOSE:To assess the risk of advanced age-related macular degeneration (AMD) developing after cataract surgery. DESIGN:Cohort study. PARTICIPANTS:Four thousand five hundred seventy-seven participants (8050 eyes) from a multicenter, controlled, randomized clinical trial, the Age-Related Eye Disease Study (AREDS). ME...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Chew EY,Sperduto RD,Milton RC,Clemons TE,Gensler GR,Bressler SB,Klein R,Klein BE,Ferris FL 3rd

    更新日期:2009-02-01 00:00:00

  • Retinal folds in Terson syndrome.

    abstract:BACKGROUND:Perimacular retinal folds have been reported in the shaken baby syndrome, but have not been described in adults with Terson syndrome. METHODS:The authors present two patients with perimacular retinal folds in adults with Terson syndrome. In one patient, electron microscopy was used to examine the membrane s...


    pub_type: 杂志文章


    authors: Keithahn MA,Bennett SR,Cameron D,Mieler WF

    更新日期:1993-08-01 00:00:00

  • The Evolution of Outer Retinal Tubulation, a Neurodegeneration and Gliosis Prominent in Macular Diseases.

    abstract:PURPOSE:To document outer retinal tubulation (ORT) formation in advanced retinal disorders. DESIGN:Retrospective, observational study. PARTICIPANTS:Consecutive cases with retinal diseases showing outer retinal disruption and atrophy of the retinal pigment epithelium (RPE) associated with ORT on spectral-domain (SD) o...


    pub_type: 杂志文章


    authors: Dolz-Marco R,Litts KM,Tan ACS,Freund KB,Curcio CA

    更新日期:2017-09-01 00:00:00

  • Potential impact of seatbelt use on the spectrum of ocular injuries and visual acuity outcomes after motor vehicle accidents with airbag deployment.

    abstract:PURPOSE:To investigate the association between seatbelt use and (1) the spectrum of ocular injuries and (2) visual acuity outcomes after motor vehicle accidents (MVAs) with airbag deployment. DESIGN:Single-center retrospective observational case series. PARTICIPANTS:Forty-seven patients involved in MVAs with airbag d...


    pub_type: 杂志文章


    authors: Rao SK,Greenberg PB,Filippopoulos T,Scott IU,Katsoulakis NP,Enzer YR

    更新日期:2008-03-01 00:00:00

  • The effect of therapeutic soft contact lenses on antibiotic delivery to the cornea.

    abstract::The effects of high (71%) and low (38.6%) water content lenses on antibiotic delivery to the cornea were studied in rabbits by measuring corneal tobramycin concentrations 1, 2, 4 and 6 hours after topical application at intervals of 15 minutes. In the presence of the low water content lens corneal drug levels were hig...


    pub_type: 杂志文章


    authors: Matoba AY,McCulley JP

    更新日期:1985-01-01 00:00:00

  • The barrier function in extracapsular cataract surgery.

    abstract::The distribution of fluorescein between the anterior chamber and the anterior vitreous was measured in two groups of patients after oral administration: group I, extracapsular cataract extraction (ECCE) patients with intact capsule and posterior chamber intraocular lens (PC IOL) (n = 12); group II, intracapsular catar...


    pub_type: 杂志文章


    authors: Smith RT,Campbell CJ,Koester CJ,Trokel S,Anderson A

    更新日期:1990-01-01 00:00:00

  • Epibulbar granular cell tumor. Report of a case and review of the literature.

    abstract:BACKGROUND:The granular cell tumor (GCT) is a common, usually benign, neoplasm of uncertain histogenesis that may affect any organ in the body. It occurs rarely in ophthalmic sites, where orbital location is most frequent. The purpose of this report is to describe a unique case of an epibulbar, subconjunctival GCT in a...


    pub_type: 杂志文章,评审


    authors: Charles NC,Fox DM,Glasberg SS,Sawicki J

    更新日期:1997-09-01 00:00:00

  • Internal and transconjunctival neodymium:YAG laser revision of late failing filters.

    abstract::Seven cases of hypofunctioning trabeculectomies or full-thickness filters were treated using the Q-switched neodymium:YAG (Nd:YAG) laser delivered either transconjunctivally, gonioscopically, or by a combination approach. In four eyes, internal laser revision was attempted initially. Internal revision was successful i...


    pub_type: 杂志文章


    authors: Latina MA,Rankin GA

    更新日期:1991-02-01 00:00:00

  • The Impact of Systemic Factors on Clinical Response to Ranibizumab for Diabetic Macular Edema.

    abstract:PURPOSE:To evaluate the effect of systemic factors on best-corrected visual acuity (BCVA) achieved with ranibizumab (Lucentis; Genentech, Inc, South San Francisco, CA) for treatment of diabetic macular edema (DME) in the RIDE and RISE phase 3 studies. DESIGN:Exploratory, post hoc analysis of 2 randomized, double-maske...


    pub_type: 杂志文章,随机对照试验


    authors: Singh RP,Habbu K,Ehlers JP,Lansang MC,Hill L,Stoilov I

    更新日期:2016-07-01 00:00:00

  • Retinal detachment in eyes undergoing pars plana vitrectomy for removal of retained lens fragments.

    abstract:PURPOSE:To investigate the incidence and outcomes of retinal detachment (RD) associated with retained lens fragments removed by pars plana vitrectomy (PPV). DESIGN:Retrospective, noncomparative, interventional consecutive case series. PARTICIPANTS:All patients who underwent PPV for retained lens material after catara...


    pub_type: 杂志文章


    authors: Moore JK,Scott IU,Flynn HW Jr,Smiddy WE,Murray TG,Kim JE,Vilar NF,Pereira MB,Jorge R

    更新日期:2003-04-01 00:00:00

  • Vascular endothelial growth factor in patients with exudative age-related macular degeneration treated with ranibizumab.

    abstract:OBJECTIVES:To analyze the temporal correlations of vascular endothelial growth factor (VEGF) suppression, morphologic recurrence of choroidal neovascularization (CNV), and visual acuity loss in eyes with exudative age-related macular degeneration (AMD) treated with ranibizumab. DESIGN:Nonrandomized, prospective, clini...


    pub_type: 杂志文章


    authors: Muether PS,Hermann MM,Viebahn U,Kirchhof B,Fauser S

    更新日期:2012-10-01 00:00:00

  • Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration.

    abstract:OBJECTIVE:To evaluate the efficacy of a second year of pegaptanib sodium therapy in patients with neovascular age-related macular degeneration (AMD). DESIGN:Two concurrent, multicenter, randomized, double-masked, sham-controlled studies (V.I.S.I.O.N. [Vascular Endothelial Growth Factor Inhibition Study in Ocular Neova...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group.,Chakravarthy U,Adamis AP,Cunningham ET Jr,Goldbaum M,Guyer DR,Katz B,Patel M

    更新日期:2006-09-01 00:00:00

  • Eyelid, conjunctival, and corneal findings in sleep apnea syndrome.

    abstract:OBJECTIVE:To determine the prevalence of eyelid, conjunctival, and corneal findings in patients with sleep apnea syndrome (SAS). DESIGN:Case series. PARTICIPANTS:Seventy-two white patients referred for evaluation of suspected SAS. INTERVENTION:Complete examination of eyelids, conjunctiva, and cornea, including video...


    pub_type: 杂志文章


    authors: Mojon DS,Goldblum D,Fleischhauer J,Chiou AG,Frueh BE,Hess CW,Gugger M,Bassetti C,Boehnke M,Mathis J

    更新日期:1999-06-01 00:00:00

  • Complications of motility peg placement for the hydroxyapatite orbital implant.

    abstract:PURPOSE:The hydroxyapatite implant is an ocular motility implant designed to provide natural movement of the artificial eye. The movement of the prosthesis is maximized when the implant is coupled to the prosthesis via a peg. The purpose of this study is to determine the complications of the hydroxyapatite motility peg...


    pub_type: 杂志文章


    authors: Edelstein C,Shields CL,De Potter P,Shields JA

    更新日期:1997-10-01 00:00:00

  • Evaluation of diagnostic capabilities of interactive test strategies in automated perimetry.

    abstract::Simple strategies for visual field screening with automated perimeters can detect abnormalities at acceptable rates. However, the information available from a screening field chart is often insufficient to assign the field into a diagnostic category, and further field testing is necessary. Automated perimeters can be ...


    pub_type: 杂志文章


    authors: Mills RP

    更新日期:1985-09-01 00:00:00

  • Perfluorocarbon liquid in the management of retinal detachment with proliferative vitreoretinopathy.

    abstract:PURPOSE:To describe the techniques and results of perfluoro-N-octane used during vitrectomy for managing retinal detachment with severe proliferative vitreoretinopathy (PVR). METHODS:The authors retrospectively studied 223 consecutive patients who underwent vitreoretinal surgery for severe PVR (93% D1-D3). Patients un...


    pub_type: 杂志文章


    authors: Coll GE,Chang S,Sun J,Wieland MR,Berrocal MH

    更新日期:1995-04-01 00:00:00

  • Prognostic factors in vitrectomy for epiretinal membranes of the macula.

    abstract::A retrospective multivariate analysis of 264 consecutive cases of vitrectomy for removal of epiretinal membranes of the macula was performed. Two main preoperative prognostic factors were identified that were associated with the visual outcome of surgery: (1) the preoperative visual acuity, and (2) the duration of blu...


    pub_type: 杂志文章


    authors: Rice TA,De Bustros S,Michels RG,Thompson JT,Debanne SM,Rowland DY

    更新日期:1986-05-01 00:00:00

  • Surgical anatomy of the lacrimal fossa a prospective computed tomodensitometry scan analysis.

    abstract:PURPOSE:To establish the accurate surgical anatomy of endonasal dacryocystorhinostomy (DCR) based on the radiological analysis of underlying bony structures. DESIGN:Prospective noncomparative observational case series study. PARTICIPANTS:Fifty-nine patients with complete nasolacrimal stenosis underwent a computed tom...


    pub_type: 杂志文章


    authors: Fayet B,Racy E,Assouline M,Zerbib M

    更新日期:2005-06-01 00:00:00

  • Poorer neurodevelopmental outcomes associated with cystoid macular edema identified in preterm infants in the intensive care nursery.

    abstract:PURPOSE:To evaluate the association between cystoid macular edema (CME) observed in very preterm infants and developmental outcomes at 18 to 24 months corrected age. DESIGN:Cohort study. PARTICIPANTS:Infants born at or less than 1500 g or at or less than 30 weeks postmenstrual age who underwent screening for retinopa...


    pub_type: 杂志文章


    authors: Rothman AL,Tran-Viet D,Gustafson KE,Goldstein RF,Maguire MG,Tai V,Sarin N,Tong AY,Huang J,Kupper L,Cotten CM,Freedman SF,Toth CA

    更新日期:2015-03-01 00:00:00

  • Clinical and Genetic Characteristics of Japanese Patients with Age-Related Macular Degeneration and Pseudodrusen.

    abstract:PURPOSE:To investigate differences in clinical characteristics and genotype distribution in Japanese patients with age-related macular degeneration (AMD) and pseudodrusen using multimodal imaging. DESIGN:Retrospective, observational case series. PARTICIPANTS:A total of 101 patients (101 eyes) with AMD and pseudodruse...


    pub_type: 杂志文章


    authors: Elfandi S,Ooto S,Ueda-Arakawa N,Takahashi A,Yoshikawa M,Nakanishi H,Tamura H,Oishi A,Yamashiro K,Yoshimura N

    更新日期:2016-10-01 00:00:00