Abstract：
:The effectiveness of trabeculectomy with adjunctive low-dose 5-fluorouracil (5-FU) as the initial surgical procedure in uncomplicated glaucoma was evaluated retrospectively in a consecutive series of 52 patients (mean follow-up, 18.6 +/- 11.7 mos) and 74 control subjects. The cumulative 2-year success (intraocular pressure [IOP] less than 21 mmHg) was 100% in the 5-FU group and 78.9% in the control group (P = 0.01, Wilcoxon test). The 5-FU group had a mean postoperative IOP of 12.5 +/- 4.6 mmHg versus 17.4 +/- 5.7 mmHg in the control group at 2-year follow-up (P = 0.015, t test). Antiglaucoma medications were required in 5.8% of patients in the 5-FU group and in 41.9% of controls within 2 years (P less than 0.0001, Fisher's exact test). These results suggest that low-dose 5-FU at the time of initial trabeculectomy leads to a higher success rate, lower IOP, and less need for antiglaucoma medications postoperatively.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Liebmann JM,Ritch R,Marmor M,Nunez J,Wolner Bdoi
10.1016/s0161-6420(91)32180-8subject
Has Abstractpub_date
1991-07-01 00:00:00pages
1036-41issue
7eissn
0161-6420issn
1549-4713pii
S0161-6420(91)32180-8journal_volume
98pub_type
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