Abstract:
PURPOSE:To investigate the associations of serum amyloid A (SAA) protein and soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and sTNF-R2) with diabetic retinopathy (DR) in Hispanics. DESIGN:Prospective, nonrandomized, cross-sectional, family-based observational cohort study. PARTICIPANTS:A total of 473 Hispanic type II diabetic subjects in families ascertained via proband with DR. METHODS:Levels of SAA, sTNF-R1, and sTNF-R2 were measured with enzyme-linked immunosorbent assay. Diabetic retinopathy was assessed by fundus photography and graded using modified Airlie House classification. MAIN OUTCOME MEASURES:Levels of SAA, sTNF-R1, and sTNF-R2 to severity of DR with and without covariates. RESULTS:A direct association of sTNF-R1 (2.37±0.13, 2.15±0.09, 3.09±0.24, 3.25±0.46, 5.02±0.61 ng/ml; P < 0.0001) and sTNF-R2 (6.04±0.20, 6.25±0.52, 7.96±0.70, 8.14±1.13, 14.83±1.68 ng/ml; P < 0.0001) was found for no DR, mild nonproliferative DR (NPDR), moderate NPDR, severe NPDR, and proliferative DR, respectively. These associations remained significant after adjusting for age, gender, body mass index, glycosylated hemoglobin, diabetes duration, systolic blood pressure, and serum creatinine (P < 0.0001 for sTNF-R1 and P=0.0004 for sTNF-R2). A similar pattern was observed when we adjusted for urinary albumin:creatinine ratio in place of serum creatinine (P=0.005 for sTNF-R1 and P=0.02 for sTNF-R2). CONCLUSIONS:Levels of sTNF-R1 and sTNF-R2 are highly correlated with the severity of DR, suggesting that inflammation and insulin resistance may play a critical role in the development of DR. These may be useful biomarkers for DR, aiding in etiologic studies and possibly identifying at-risk patients for active intervention.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Kuo JZ,Guo X,Klein R,Klein BE,Cui J,Rotter JI,Ipp E,Chen YDdoi
10.1016/j.ophtha.2011.10.040subject
Has Abstractpub_date
2012-05-01 00:00:00pages
1041-6issue
5eissn
0161-6420issn
1549-4713pii
S0161-6420(11)01046-3journal_volume
119pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:OBJECTIVE:To determine the frequency distribution of bacteria on the external surface of eyes of patients with atopic dermatitis (AD) and to investigate the relationship between the frequency of bacterial colonization and the grade of atopy or ocular diseases associated with AD. DESIGN:Comparative cross-sectional stud...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00406-1
更新日期:2000-12-01 00:00:00
abstract:PURPOSE:To examine the effects of ametropia (spherocylindrical), corneal curvature, target anterior chamber depth (ACD), misplacement, and some design features on the performance of positional pseudoaccommodative intraocular lenses (PPAIOLs). DESIGN:Theoretical investigation based on computer models to determine the p...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.04.033
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:The authors compared two methods, the Marcus Gunn test and the alternating light test, for detecting a relative afferent pupillary defect. DESIGN:A randomized, prospective clinical trial. PARTICIPANTS:Fourteen patients with unilateral optic neuropathy. INTERVENTION:The Marcus Gunn and alternating light tes...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0161-6420(98)95029-1
更新日期:1998-05-01 00:00:00
abstract::Reductions in flicker sensitivity in ocular hypertension are thought to precede manifest glaucomatous damage, but the proportion of patients with ocular hypertension reported to have losses in flicker sensitivity (50-90%) is far out of step with the proportion of ocular hypertensive patients in whom clinically defined...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(90)32630-1
更新日期:1990-01-01 00:00:00
abstract::The authors examined 11 young adult, moderately myopic female patients who presented with visual loss secondary to a newly described disorder consisting of multiple small discrete lesions at the level of the retinal pigment epithelium and choriocapillaris. The condition appears to be inflammatory and occurs primarily ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33611-x
更新日期:1986-09-01 00:00:00
abstract:PURPOSE:To review the clinical characteristics, prevalence, and severity of retinopathy in diabetics with cranial nerve (CN) 3, 4, and/or 6 palsies, and to determine the relationship between type and duration of diabetes mellitus (DM), presence of retinopathy, and occurrence of CN palsy. DESIGN:Retrospective, comparat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00542-6
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:The purpose of the study is to evaluate whether a posterior capsulectomy combined with anterior vitrectomy is a necessity in pediatric cataract. DESIGN:The incidence of posterior capsule opacification, the need for additional surgical interventions, and the influence of a primary posterior capsulectomy after...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30045-1
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Malignant glaucoma (ciliary block glaucoma; aqueous misdirection glaucoma) is an incompletely understood, rare and serious complication of intraocular surgery. METHODS:A woman with pseudophakic malignant glaucoma underwent successful neodymium: YAG (Nd:YAG) laser photodisruption of the anterior hyaloid face...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31479-x
更新日期:1993-09-01 00:00:00
abstract:AIM:To report a rare presentation of colloid milium occurring only on the upper eyelid margins. DESIGN:Interventional case report. METHODS:(1) Slit-lamp examination of eyelids and eyes and clinical examination including the face and a general physical examination; (2) photography of the lesions on the lids; and (3) e...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)01180-6
更新日期:2002-10-01 00:00:00
abstract:PURPOSE:This study was undertaken to better characterize patients with multifocal choroiditis and panuveitis (MCP), punctate inner choroidopathy (PIC), multiple evanescent white dot syndrome (MEWDS), and diffuse subretinal fibrosis syndrome. The specific aim was to determine whether these disorders were different entit...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(96)30645-3
更新日期:1996-04-01 00:00:00
abstract:PURPOSE:To evaluate the effect of a hinged lamellar keratotomy on refraction, vision, and corneal topography of postkeratoplasty eyes with high-degree astigmatism. DESIGN:Noncomparative, interventional case series. PARTICIPANTS:A hinged lamellar keratotomy was performed on nine eyes of nine patients at least 9 months...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00702-3
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:To characterize retinal pigment epithelial (RPE) cell loss as evidenced by autofluorescence imaging in patients with neovascular age-related macular degeneration (AMD). DESIGN:Retrospective cohort study. PARTICIPANTS:There were 162 eyes of 116 consecutive patients with neovascular AMD examined in a retinal pr...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.07.076
更新日期:2013-02-01 00:00:00
abstract::Although the majority of aphakic patients will have intraocular lens implants (IOLs), there are several groups of patients for whom IOLs are not indicated. Synthetic keratophakia for the correction of aphakia has several inherent advantages over alternative forms of refractive surgery which use lathed corneal tissue. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33342-1
更新日期:1987-08-01 00:00:00
abstract:PURPOSE:To assess perifoveal capillary blood flow velocity (BFV), capillary occlusion, and retinal thickness at the central fovea in diabetic patients with or without clinically significant macular edema; to examine the relationships of these variables with visual acuity (VA); and to identify their contributions to vis...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.01.003
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate whether previously failed glaucoma filtration surgery is a risk factor for filtration failure of subsequent trabeculectomy combined with cataract surgery and to determine the role of adjunctive mitomycin C (MMC) in the secondary glaucoma triple procedure (SGTP) as compared to p...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0161-6420(98)94032-5
更新日期:1998-04-01 00:00:00
abstract:PURPOSE:To describe the ocular effects associated with the administration of the systemic epidermal growth factor receptor (EGFR) inhibitors panitumumab and erlotinib. DESIGN:Retrospective, noncomparative interventional case series. PARTICIPANTS:Ten eyes of 5 patients in treatment with systemic EGFR inhibitors, 4 pat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.03.002
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To assess the development of vision-threatening lesions at least 3.5 years after initiating anti-vascular endothelial growth factor (VEGF) for choroidal neovascularization (CNV) in eyes with age-related macular degeneration (AMD). DESIGN:Retrospective cohort study. PARTICIPANTS:A total of 75 patients (81 eyes...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2014.07.046
更新日期:2015-01-01 00:00:00
abstract::Iris (eye) color was examined for its effect on eye disease in a population-based study of diabetic retinopathy in Wisconsin. Eye color was determined by comparing the iris in a red reflex photograph with standard photographs. In younger-onset diabetic persons (N = 996), macular edema was more prevalent in persons wit...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)80004-0
更新日期:1987-10-01 00:00:00
abstract:PURPOSE:To evaluate the short-term safety and efficacy of intravitreal bevacizumab for the treatment of cystoid macular edema (CME) secondary to uveitis. DESIGN:Retrospective, noncomparative, interventional case series. PARTICIPANTS:Thirteen patients undergoing treatment for recalcitrant uveitic macular edema at one ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.11.028
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Opportunistic infections frequently involve the anterior and posterior segments of the eye but rarely occur in the orbit in patients with human immunodeficiency virus (HIV) infection. The authors managed eight patients with HIV and unilateral orbital infections who presented between July 1988 and March 1995....
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0161-6420(96)30479-x
更新日期:1996-09-01 00:00:00
abstract:PURPOSE:To develop a universal gene therapy to overcome the genetic heterogeneity in retinitis pigmentosa (RP) resulting from mutations in rhodopsin (RHO). DESIGN:Experimental study for a combination gene therapy that uses both gene ablation and gene replacement. PARTICIPANTS:This study included 2 kinds of human RHO ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2018.04.001
更新日期:2018-09-01 00:00:00
abstract::Carbonic anhydrase inhibitors used in the treatment of glaucoma are rarely associated with blood dyscrasias. Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature. This report documents two cases of aplastic anemia, at least one of w...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35229-9
更新日期:1980-04-01 00:00:00
abstract:PURPOSE:To identify effective methods to increase the number of cataract surgeries in a rural setting in Pucheng County of Shaanxi Province, northwestern China. DESIGN:Community-based randomized interventional study. PARTICIPANTS:Four hundred thirty-two patients 50 years of age or older with operable cataract who had...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2012.07.087
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:To investigate relationships between a wide range of macro- and micronutrients, including antioxidant vitamins, and the three main types of cataract in older people. DESIGN:Population-based cross-sectional study. PARTICIPANTS:Two thousand nine hundred people aged 49 to 97 years living in an urban community ne...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(99)00024-x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the surgical management and visual acuity outcomes in a large series of patients with dislocated intraocular lenses (IOLs). DESIGN:Retrospective consecutive noncomparative case series. PARTICIPANTS:All patients who underwent surgical management of dislocated IOLs by two vitreoretinal surgeons at...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(99)00017-2
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To report the outcomes of ipsilateral rotational autokeratoplasty (RAK) for nonprogressive paracentral corneal opacities in children <16 years of age. DESIGN:Retrospective, consecutive, interventional case series. PARTICIPANTS:Thirty-three eyes of 33 children aged <16 years undergoing RAK for nonprogressive...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.06.045
更新日期:2012-12-01 00:00:00
abstract::The 193-nm ultraviolet beam from an argon fluoride excimer laser was focused on the corneas of rabbits to produce incisions of the type necessary for radial keratotomy. The energy densities used were in two ranges, 1.0 to 2.1 J/cm2 per pulse and 200 to 700 mJ/cm2 per pulse. The eyes were enucleated and fixed for histo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(88)32996-9
更新日期:1988-10-01 00:00:00
abstract:PURPOSE:To report the 4-year outcomes of corneal cross-linking (CXL) for progressive keratoconus in a population of different age groups. DESIGN:Retrospective, single-center, nonrandomized clinical study. PARTICIPANTS:Four hundred consecutive eyes treated with corneal CXL for progressive keratoconus from April 2006 t...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.10.023
更新日期:2013-05-01 00:00:00
abstract::Data from the United States Consumer Product Safety Commission indicate that air-powered guns were responsible for 22,800 injuries treated in emergency rooms during 1981, of which 1255 were eye injuries. From 1970 to 1981, 32 patients have undergone surgical intervention at the Wilmer Eye Institute for airgun-related ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34159-8
更新日期:1984-10-01 00:00:00
abstract:PURPOSE:To evaluate the clinical results of epi-LASIK for the treatment of low to moderate myopia and myopic astigmatism. DESIGN:Retrospective, noncomparative, interventional case series. PARTICIPANTS:Two hundred thirty-four eyes of 138 patients underwent epi-LASIK for the correction of low to moderate myopia. Mean p...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.08.052
更新日期:2007-06-01 00:00:00