Abstract：
PURPOSE:To describe the ocular effects associated with the administration of the systemic epidermal growth factor receptor (EGFR) inhibitors panitumumab and erlotinib. DESIGN:Retrospective, noncomparative interventional case series. PARTICIPANTS:Ten eyes of 5 patients in treatment with systemic EGFR inhibitors, 4 patients with erlotinib for end-stage lung carcinoma, and 1 patient with panitumumab for end-stage colorectal cancer. METHODS:Data collected from charts included gender, age at presentation, systemic disease, and clinical presentation in each eye. MAIN OUTCOME MEASURES:Demographics on presentation and clinical findings. RESULTS:Multiple epithelial defects were observed in all 10 eyes, corneal melting and thinning were observed in 3 eyes of 2 patients, 2 eyes of 1 patient presented with lower lid ectropion, and 2 eyes of 2 patients presented with corneal perforation, both requiring a penetrating keratoplasty. CONCLUSIONS:Severe ocular side effects, including corneal perforation, may be associated with the use of the EGFR inhibitors panitumumab and erlotinib.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Saint-Jean A,Sainz de la Maza M,Morral M,Torras J,Quintana R,Molina JJ,Molina-Prat Ndoi
10.1016/j.ophtha.2012.03.002subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1798-802issue
9eissn
0161-6420issn
1549-4713pii
S0161-6420(12)00227-8journal_volume
119pub_type
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