Visual function in prolactinoma patients treated with bromocriptine.

Abstract:

:Ten patients with prolactin-secreting pituitary adenomas (prolactinoma) and visual dysfunction were treated primarily with bromocriptine. Nine patients had improvement of visual field or acuity associated with computed tomography (CT) evidence of a decrease in tumor size and reduction of serum prolactin level (SPL). Visual improvement usually began within days of commencing bromocriptine therapy. One patient with initial improvement had a worsening of visual fields at 11 months despite a normal SPL and a stable CT appearance of tumor size. This patient and the single patient without visual improvement underwent trans-sphenoidal hypophysectomy (TSH), but neither patient had postoperative visual improvement. Two other patients underwent TSH for nonvisual reasons. The remaining six patients have maintained excellent visual function at last follow-up (average of 18 months on bromocriptine therapy). This study shows that bromocriptine is an effective short- and long-term therapy for most patients with visual dysfunction due to prolactinoma.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Moster ML,Savino PJ,Schatz NJ,Snyder PJ,Sergott RC,Bosley TM

doi

10.1016/s0161-6420(85)33853-8

subject

Has Abstract

pub_date

1985-10-01 00:00:00

pages

1332-41

issue

10

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(85)33853-8

journal_volume

92

pub_type

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