Abstract:
:Ten patients with prolactin-secreting pituitary adenomas (prolactinoma) and visual dysfunction were treated primarily with bromocriptine. Nine patients had improvement of visual field or acuity associated with computed tomography (CT) evidence of a decrease in tumor size and reduction of serum prolactin level (SPL). Visual improvement usually began within days of commencing bromocriptine therapy. One patient with initial improvement had a worsening of visual fields at 11 months despite a normal SPL and a stable CT appearance of tumor size. This patient and the single patient without visual improvement underwent trans-sphenoidal hypophysectomy (TSH), but neither patient had postoperative visual improvement. Two other patients underwent TSH for nonvisual reasons. The remaining six patients have maintained excellent visual function at last follow-up (average of 18 months on bromocriptine therapy). This study shows that bromocriptine is an effective short- and long-term therapy for most patients with visual dysfunction due to prolactinoma.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Moster ML,Savino PJ,Schatz NJ,Snyder PJ,Sergott RC,Bosley TMdoi
10.1016/s0161-6420(85)33853-8subject
Has Abstractpub_date
1985-10-01 00:00:00pages
1332-41issue
10eissn
0161-6420issn
1549-4713pii
S0161-6420(85)33853-8journal_volume
92pub_type
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