Abstract:
PURPOSE:To develop a standardized clinical grading system for the management of patients with vernal keratoconjunctivitis (VKC) and to identify the risk factors associated with a worsened outcome of the disease, including decrease of visual acuity and ocular complications development. DESIGN:Retrospective cohort study. PARTICIPANTS:A total of 207 consecutive patients with VKC, referred to our Cornea and External Diseases Center from 1997 to 2007, were included in the study. A total of 110 of those patients were included in the follow-up study (range 1-10 years). METHODS:Classification and regression tree (CART) analysis was performed to separate the patients into 5 subgroups by therapeutic approach. Regression tree and multivariate logistic regression analyses were performed during follow-up to identify predictors of worse visual outcome. MAIN OUTCOME MEASURES:Age, gender, duration and course of disease, signs, symptoms, overall symptoms score, history of atopy, markers of allergy, best-corrected visual acuity, and therapy were collected at baseline and during follow-up. The number of relapses and number of patients with decreased visual acuity were also evaluated in the follow-up. RESULTS:A decision tree for VKC treatment was developed by CART analysis, and a new clinical grading system was proposed accordingly. Sixteen patients were classified as grade 0 (absence of symptoms and no therapy); 59 patients were classified as grade 1 (presence of symptoms without photophobia, occasional use of anti-allergic eye drop); 74 patients were classified as grade 2 (presence of symptoms including photophobia, daily anti-allergic treatment); 22 patients with superficial punctuate keratopathy (SPK) were classified as grade 3 (daily anti-allergic treatment associated with occasional topical steroid); and 36 patients were classified as grade 4 (diffuse SPK or corneal ulcer; pulsed high-dose topical steroid). A higher number of relapses and a higher baseline grade of VKC were the main predictor factors for worse visual outcome. CONCLUSIONS:This grading system allows for identifying the more severe forms of VKC that are at higher risk of recurrences, corneal ulceration, and worse final visual outcome. FINANCIAL DISCLOSURE(S):The author(s) have no proprietary or commercial interest in any materials discussed in this article.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Sacchetti M,Lambiase A,Mantelli F,Deligianni V,Leonardi A,Bonini Sdoi
10.1016/j.ophtha.2009.11.043subject
Has Abstractpub_date
2010-07-01 00:00:00pages
1294-9issue
7eissn
0161-6420issn
1549-4713pii
S0161-6420(09)01401-8journal_volume
117pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract::A cross-sectional study was undertaken to determine the prevalence of ocular and oculodermal melanocytosis. Thirteen thousand one hundred fifty patients were examined for ocular and oculodermal melanocytosis. Fifty-three percent of these patients were black, 40% were white, and 7% were of other racial groups. In the w...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:
更新日期:1982-08-01 00:00:00
abstract:OBJECTIVE:To identify risk factors associated with failure of anatomic reattachment in primary rhegmatogenous retinal detachment repair. DESIGN:Nonrandomized, multicenter, collaborative study. PARTICIPANTS:Primary procedures for 7678 rhegmatogenous retinal detachments reported by 176 surgeons from 48 countries. METH...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2014.03.012
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:To analyze hyperreflective foci typically seen in diabetic macular edema (DME) in optical coherence tomography (OCT). DESIGN:Prospective clinical trial. PARTICIPANTS:Twelve consecutive patients with treatment-naïve, clinically significant DME. METHODS:During a same-day examination, a standardized visual acui...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2008.12.039
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:Motor vehicle accidents (MVAs) are a pandemic associated with human suffering and a burden to national economies. Whiplash-associated disorders (WADs) after MVAs are associated commonly with disability claims, many of which are related to vision. Convergence insufficiency (CI) leads to visual disability associa...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2017.11.030
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To evaluate prospectively a diffractive (811E, Pharmacia; power add +4.0 D) versus a refractive (PA154N, Allergan; power add +3.5 D) designed multifocal lens. PARTICIPANTS:Eighty patients planned for cataract surgery without additional ocular pathologies were randomized into the diffractive or refractive gro...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(97)30127-4
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:The study compares the use of Jones' retractor plication and the Wies procedure as a primary procedure for the repair of involutional lower lid entropion in the absence of horizontal lid shortening. DESIGN:Retrospective case series comparison. PARTICIPANTS:One hundred two cases with at least 6 months follow...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00027-0
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:To assess visual acuity (VA) and 2 questionnaires of health-related quality of life--the Visual Function 14 (VF-14) index and the Medical Outcomes Study Short Form 36 Health Survey (SF-36)--as instruments for capturing clinically important changes after cataract surgery. DESIGN:Prospective, observational stu...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2008.11.020
更新日期:2009-03-01 00:00:00
abstract::The age distribution, frequency, and correlation among histologic macular changes, including formation of a basal laminar deposit, drusen, and thickening and calcification of Bruch's membrane, were studied by light microscopy. The authors studied 182 unpaired postmortem human maculae from patients between 8 and 100 ye...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31982-7
更新日期:1992-02-01 00:00:00
abstract:PURPOSE:To present the largest cohort of preschool children screened by the MTI PhotoScreener over a 9-year period from a single, statewide vision screening effort. DESIGN:Cross-sectional study. PARTICIPANTS:We included 147,809 children screened between May 1, 2000, and April 30, 2009 by a photoscreening program. ME...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.03.036
更新日期:2010-10-01 00:00:00
abstract::Gardner syndrome is a dominantly inherited familial cancer syndrome characterized by intestinal polyposis, bony hamartomata, and various soft tissue tumors. The risk of malignancy during adult life is essentially 100%, but as yet no phenotypic marker nor biochemical or serological linkage have been useful to identify ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34213-0
更新日期:1984-08-01 00:00:00
abstract:PURPOSE:Cataract and glaucoma commonly coexist in elderly patients and present complex treatment options. This study investigates the results of simultaneous treatment of both conditions using phacoemulsification with posterior chamber lens implant and mitomycin-augmented trabeculectomy (combined surgery). METHODS:A r...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(96)30571-x
更新日期:1996-07-01 00:00:00
abstract::A 4-year-old white female presented with leukocoria of the right eye. White punctate lesions were observed posterior to the retrolental membrane, which suggested retinoblastoma of some examiners. A full history, physical examination, ultrasonography, and CT scan failed to rule the diagnosis of retinoblastoma in or out...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)34860-x
更新日期:1981-12-01 00:00:00
abstract::It was the purpose of this study to determine whether age could be used to predict central endothelial cell count in preoperative cataract patients aged 40 to 90. Three separate series of cell counts on a total of almost 3,000 eyes were performed and analyzed regarding age relationship. Although statistically endothel...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35149-x
更新日期:1980-09-01 00:00:00
abstract::An entire family (father, mother, and three daughters) were given thiabendazole because one of the children had acquired pinworm infestation. The mother and one daughter (non-infected) developed a sicca complex (keratoconjunctivitis sicca and xerostomia) accompanied by cholangiostatic jaundice. Sjögren's syndrome is a...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(79)35334-9
更新日期:1979-10-01 00:00:00
abstract::Use of a fiberoptic endoscope to visualize the vault of the inferior turbinate during lacrimal duct probing and irrigation revealed a high incidence of false passages. This was confirmed on dacryocystofluoroscopy. The creation of false passages as documented by us can help explain clinical probing failure in apparentl...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(79)35373-8
更新日期:1979-08-01 00:00:00
abstract:PURPOSE:To evaluate the growth of geographic atrophy (GA) during anti-vascular endothelial growth factor (VEGF) therapy. DESIGN:Cohort within a clinical trial. PARTICIPANTS:Patients included in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). METHODS:Participants were randomly assigned to...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2014.11.007
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:To present a rare case of microsporidial keratoconjunctivitis in an otherwise healthy contact lens wearer without human immunodeficiency virus infection who responded to treatment with systemic albendazole and topical fumagillin. DESIGN:Interventional case report. METHOD:A cornea epithelial scraping from a ma...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00542-5
更新日期:2001-05-01 00:00:00
abstract:PURPOSE:To assess the current burden of ocular toxocariasis (OT) and to gain knowledge regarding the diagnostic and treatment practices used in the ophthalmologic community in the United States. DESIGN:Web-based, cross-sectional survey. PARTICIPANTS:Subspecialty ophthalmologists who are currently practicing in the Un...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2011.12.013
更新日期:2012-06-01 00:00:00
abstract::Fluorescein angiography is an application of the physical phenomenon of fluorescence, which is phosphorescence in which the quantum mechanical decay curve is so rapid that it appears instantaneous, and it consequently has no afterglow. Sodium fluorescein is excited by light energy between 465 and 490 nm, and it decays...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33521-8
更新日期:1986-12-01 00:00:00
abstract:PURPOSE:To compare the timing, radiologic, and clinical indications for surgical management of orbital floor fractures in the pediatric and adult populations. DESIGN:Retrospective observational case series. PARTICIPANTS:Twenty-four pediatric and 31 adult patients who underwent primary repair of an orbital floor fract...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.02.025
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:The authors measured functional status after bilateral implantation of a multifocal versus a monofocal intraocular lens (IOL). METHODS:A retrospective, case-control study was done on 100 subjects implanted bilaterally with a silicone-optic foldable zonal progressive IOL under United States Food and Drug Admi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30265-6
更新日期:1997-04-01 00:00:00
abstract:OBJECTIVE:To report the prevalence of ocular complications of AIDS in the era of highly active antiretroviral therapy (HAART). DESIGN:Cohort study. PARTICIPANTS:Patients with AIDS, 13 years or older. METHODS:History, eye examination, and laboratory testing at enrollment. MAIN OUTCOME MEASURE:Frequency of ocular com...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2006.11.008
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:To investigate associations between dietary intake, including modest supplement intake, of antioxidant vitamins and zinc at baseline and the 5-year incidence of early age-related maculopathy (ARM). DESIGN:Population-based cohort study. PARTICIPANTS:From 1992 through 1994, 3654 persons aged 49 years or more ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)01263-0
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To investigate whether interleukin (IL)-6 or vascular endothelial growth factor (VEGF) influences macular edema in patients with central retinal vein occlusion (CRVO). DESIGN:Retrospective case-control study. PARTICIPANTS:Twenty-seven patients who had macular edema with CRVO and 16 patients with nonischemic...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.09.034
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether artificial tears and cold compress alone or in combination provide a treatment benefit and whether they were as effective as or could enhance topical antiallergic medication. DESIGN:Randomized, masked clinical trial. PARTICIPANTS:Eighteen subjects (mean age, 29.5±11.0 years) allergic ...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2013.08.007
更新日期:2014-01-01 00:00:00
abstract::A retrospective evaluation of 100 patients who wore disposable extended-wear contact lenses is presented. The patients were selected at random and were fitted with one of three lens brands approved for extended wear. There were 37 males and 63 females in the study. The mean age was 40.1 years (range, 14 to 76 years). ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32068-2
更新日期:1991-11-01 00:00:00
abstract:OBJECTIVE:To study the anatomic and visual outcomes of a surgical procedure in which tissue plasminogen activator and air are injected subretinally to displace massive submacular hemorrhages secondary to age-related macular degeneration. DESIGN:Prospective, consecutive, interventional case series. PARTICIPANTS:Thirte...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2014.07.027
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to provide a comparative analysis of American population-based prevalence of uncorrected binocular distance visual acuity in Hispanics and non-Hispanics. DESIGN:The study design was a population-based survey. PARTICIPANTS:Data from the Hispanic Health and Nutrition Examination Survey betwee...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(98)93042-1
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To estimate the incremental cost-effectiveness of routine glaucoma assessment and treatment under current eye care visit and treatment patterns and different levels of treatment effectiveness (from randomized trials). DESIGN:We compared the costs and benefits of routine glaucoma assessment and treatment comp...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.12.056
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:One assumption of the uniocular drug trial in glaucoma management is that fellow-eye pairs exhibit symmetric intraocular pressure (IOP) responses when both eyes are treated with the same topical IOP-lowering medication. The purpose of this study was to determine if this assumption is true. DESIGN:Observational...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2004.11.028
更新日期:2005-04-01 00:00:00