Abstract：
OBJECTIVE:To report the prevalence of ocular complications of AIDS in the era of highly active antiretroviral therapy (HAART). DESIGN:Cohort study. PARTICIPANTS:Patients with AIDS, 13 years or older. METHODS:History, eye examination, and laboratory testing at enrollment. MAIN OUTCOME MEASURE:Frequency of ocular complications at enrollment. RESULTS:As of March 31, 2003, 1632 participants with AIDS were enrolled. The cohort had a history of severe immune deficiency, as evidenced by a median nadir CD4+ T-cell count of 30 cells per microliter. At enrollment, the median CD4+ T-cell count was 164 cells per microliter. CD4+ T-cell counts were <50 in 24.1% but > or =100 in 63.6% and > or =200 in 43.0%. Cytomegalovirus (CMV) retinitis was present in 22.1%, whereas other ocular opportunistic infections each were present in < or =0.6%. The incidence of CMV retinitis estimated from retrospective data was 5.60/100 person-years. Of the 360 patients with CMV retinitis, 22.5% were newly diagnosed at enrollment, and the remainder had more long-standing CMV retinitis (median, 2.8 years). CONCLUSIONS:Although there is the possibility of oversampling patients with AIDS and ocular complications (as compared with a random sample), which would lead to increased estimates of prevalent and incident ocular morbidities, these data still suggest a substantial decline in the incidence of CMV retinitis from the pre-HAART era. Nevertheless, new cases of CMV retinitis continue to occur, and there is a population of patients with long-standing retinitis who will require management.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Jabs DA,Van Natta ML,Holbrook JT,Kempen JH,Meinert CL,Davis MD,Studies of the Ocular Complications of AIDS Research Group.doi
10.1016/j.ophtha.2006.11.008subject
Has Abstractpub_date
2007-04-01 00:00:00pages
780-6issue
4eissn
0161-6420issn
1549-4713pii
S0161-6420(06)01548-Xjournal_volume
114pub_type
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