当前位置： SCI文献检索 > OPHTHALMOLOGY期刊下所有文献 > Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy.

Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy.

Abstract：

PURPOSE:To investigate the frequency of variants in 3 major age-related macular degeneration (AMD)-associated loci in patients of European-American descent with polypoidal choroidal vasculopathy (PCV). DESIGN:Cross-sectional, case-control association study. PARTICIPANTS:Fifty-five patients with PCV, 368 patients with advanced AMD, and 368 age-matched and ethnically matched unaffected controls of European-American descent. METHODS:Association analysis of allele and genotype frequencies, determined by TaqMan assays, was performed for the following haplotype-tagging single nucleotide polymorphisms (htSNPs): risk alleles in the complement factor H (CFH) gene (Y402H and IVS14) in the ARMS2/HTRA1 locus on 10q26 (A69S) and protective alleles in CFH (IVS1 and IVS6) and in the complement factor B/complement component C2 (CFB/C2) locus (IVS10 and H9L). MAIN OUTCOME MEASURES:Allele and genotype frequencies of the htSNPs in the CFH, CFB/C2, and ARMS2/HTRA1 loci. RESULTS:Four AMD-associated haplotype-tagging alleles (rs547154, rs1061170, rs1410996, rs10490924) in the 3 major loci, CFH, CFB/C2, and ARMS2/HTRA1, also were statistically significantly associated with the PCV phenotype (P<0.05). Three other alleles from the same loci (rs4151667, rs529825, rs3766404) showed a trend toward association (P<0.2) but did not reach statistical significance, possibly because of the combined effects of a relatively small sample size and low minor allele frequency in the screened populations. CONCLUSIONS:The PCV phenotype in Caucasian patients is associated with the major alleles/genotypes in the AMD-associated loci, suggesting that PCV and AMD are genetically similar in the tested loci.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Lima LH,Schubert C,Ferrara DC,Merriam JE,Imamura Y,Freund KB,Spaide RF,Yannuzzi LA,Allikmets R

doi

10.1016/j.ophtha.2009.12.018

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

1567-70

issue

8

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(09)01443-2

journal_volume

117

pub_type

杂志文章,多中心研究

相关文献

OPHTHALMOLOGY文献大全
  • Topical retinoid therapy for squamous metaplasia of various ocular surface disorders. A multicenter, placebo-controlled double-masked study.

    abstract：:In a prospective, double-masked clinical study, the authors evaluated the efficacy and safety of topically applied tretinoin ophthalmic ointment (0.01%) versus placebo in the treatment of squamous metaplasia associated with various ocular surface disorders involving dry eyes. Study parameters consisted of graded sympt...

    journal_title：Ophthalmology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0161-6420(88)33009-5

    authors： Soong HK,Martin NF,Wagoner MD,Alfonso E,Mandelbaum SH,Laibson PR,Smith RE,Udell I

    更新日期：1988-10-01 00:00:00

  • Polymerase chain reaction detection of Neisseria meningitidis in the intraocular fluid of a patient with endogenous endophthalmitis but without associated meningitis.

    abstract：PURPOSE:To report a patient with Neisseria meningitidis endophthalmitis without associated meningitis with full visual recovery, with early detection of the microorganism using polymerase chain reaction (PCR) analysis. DESIGN:Retrospective, observational case report. PARTICIPANTS:One patient with endogenous endophtha...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/S0161-6420(03)00834-0

    authors： Kerkhoff FT,van der Zee A,Bergmans AM,Rothova A

    更新日期：2003-11-01 00:00:00

  • Microbial keratitis predisposing factors and morbidity.

    abstract：PURPOSE:To examine predisposing factors, treatment costs, and visual outcome of microbial keratitis in an ophthalmic casualty and inpatient population. DESIGN:Retrospective medical records review. PARTICIPANTS:Fifteen- to 64-year-olds with microbial keratitis treated at the Royal Victorian Eye and Ear Hospital betwee...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2005.08.013

    authors： Keay L,Edwards K,Naduvilath T,Taylor HR,Snibson GR,Forde K,Stapleton F

    更新日期：2006-01-01 00:00:00

  • Baseline Lamina Cribrosa Curvature and Subsequent Visual Field Progression Rate in Primary Open-Angle Glaucoma.

    abstract：PURPOSE:To investigate the relationship between the degree of posterior bowing of the lamina cribrosa (LC) at baseline and the rate of subsequent visual field (VF) progression in eyes with primary open-angle glaucoma (POAG). DESIGN:Prospective, observational study. PARTICIPANTS:One hundred one early-stage (VF mean de...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2018.05.017

    authors： Ha A,Kim TJ,Girard MJA,Mari JM,Kim YK,Park KH,Jeoung JW

    更新日期：2018-12-01 00:00:00

  • Rand-Stein analgesia protocol for cataract surgery.

    abstract：OBJECTIVE:To describe the safety and efficacy of an analgesia protocol that enables the surgeon to maintain control over an alert patient experiencing seemingly painless ambulatory cataract surgery, while eliminating the risks and side effects associated with general, local, topical, and intracameral anesthesia. DESIG...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(00)00008-7

    authors： Rand WJ,Stein SC,Velazquez GE

    更新日期：2000-05-01 00:00:00

  • Atrophic macular degeneration. Rate of spread of geographic atrophy and visual loss.

    abstract：:The authors studied 50 eyes with atrophic (dry) macular degeneration (geographic atrophy of age-related macular degeneration [GAMD], in 50 consecutive patients for 2 to 6 years (average, 3.4 years). There were 35 women and 15 men ranging in age from 60 to 89 years (average, 73 years). The areas of atrophy tended to fo...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(89)32694-7

    authors： Schatz H,McDonald HR

    更新日期：1989-10-01 00:00:00

  • Histopathology of bone spicule pigmentation in retinitis pigmentosa.

    abstract：PURPOSE:To evaluate bone spicule pigmentation, a fundus feature in retinitis pigmentosa (RP) formed by migration of pigment-containing cells to perivascular sites in the inner retina. METHODS:The authors performed light and electron microscopy, including immunocytochemistry, on the retinas from ten patients with RP an...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(95)30953-0

    authors： Li ZY,Possin DE,Milam AH

    更新日期：1995-05-01 00:00:00

  • Intravitreal cidofovir (HPMPC) treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome.

    abstract：PURPOSE:The authors previously conducted a pilot, dose-escalating study which suggested that a 20-micrograms dose of intravitreal cidofovir (HPMPC) may be safe and effective in treating cytomegalovirus (CMV) retinitis in humans. The purpose of this series is to expand the authors' prior experience with the 20-microgram...

    journal_title：Ophthalmology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0161-6420(95)30985-2

    authors： Kirsch LS,Arevalo JF,Chavez de la Paz E,Munguia D,de Clercq E,Freeman WR

    更新日期：1995-04-01 00:00:00

  • Malakoplakia of the eyelid.

    abstract：:A 35-year-old white man, on immunosuppressive medications for 3 1/2 years following a renal transplant, presented with a whitish-yellow mass at the medial end of the left lower eyelid. An initial incisional biopsy was performed that was misinterpreted as granular cell myoblastoma. The mass was subsequently excised and...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(86)33633-9

    authors： Addison DJ

    更新日期：1986-08-01 00:00:00

  • Outcomes of cataract extraction with multifocal intraocular lens implantation: functional status and quality of life.

    abstract：OBJECTIVE:The authors measured functional status after bilateral implantation of a multifocal versus a monofocal intraocular lens (IOL). METHODS:A retrospective, case-control study was done on 100 subjects implanted bilaterally with a silicone-optic foldable zonal progressive IOL under United States Food and Drug Admi...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(97)30265-6

    authors： Javitt JC,Wang F,Trentacost DJ,Rowe M,Tarantino N

    更新日期：1997-04-01 00:00:00

  • Clinical ability of Heidelberg retinal tomograph examination to detect glaucomatous visual field changes.

    abstract：PURPOSE:To determine the agreement between Heidelberg Retinal Tomograph (HRT; Heidelberg Instruments, Heidelberg, Germany) and visual field examinations in differentiating normal from glaucomatous eyes and to evaluate the sensitivity and specificity of HRT optic disc examination in detecting eyes with glaucomatous dama...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(01)00676-5

    authors： Miglior S,Casula M,Guareschi M,Marchetti I,Iester M,Orzalesi N

    更新日期：2001-09-01 00:00:00

  • Longitudinal Changes of Optic Nerve Head and Peripapillary Structure during Childhood Myopia Progression on OCT: Boramae Myopia Cohort Study Report 1.

    abstract：PURPOSE:To delineate longitudinal changes in the optic nerve head (ONH) and peripapillary structure during myopia progression in childhood using spectral-domain (SD) OCT and to explore the factors associated with myopic ONH and peripapillary changes. DESIGN:Prospective cohort study. PARTICIPANTS:Twenty-three healthy ...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2018.01.026

    authors： Kim M,Choung HK,Lee KM,Oh S,Kim SH

    更新日期：2018-08-01 00:00:00

  • Penetrating ocular injuries. Types of injuries and visual results.

    abstract：:The authors studied the hospital records of 453 patients who underwent primary surgical repair of penetrating ocular injuries at the Wilmer Institute from January 1970 through December 1981. The injury was due to blunt force in 22%, a sharp laceration in 37%, and a missile in 41%. The following factors correlated with...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(83)34387-6

    authors： De Juan E Jr,Sternberg P Jr,Michels RG

    更新日期：1983-11-01 00:00:00

  • Fundus Tessellation: Prevalence and Associated Factors: The Beijing Eye Study 2011.

    abstract：PURPOSE:To examine the prevalence of fundus tessellation and its associated factors. DESIGN:Population-based study. PARTICIPANTS:The Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6±9.8 years (range, 50-93 years). METHODS:Participants underwent a comprehensive ophthalmic examination. By using...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2015.05.031

    authors： Yan YN,Wang YX,Xu L,Xu J,Wei WB,Jonas JB

    更新日期：2015-09-01 00:00:00

  • Meta-analysis of 1- versus 2-Site Phacotrabeculectomy.

    abstract：TOPIC:Comparison of efficacy of intraocular pressure (IOP) reduction between 1- versus 2-site phacotrabeculectomy. CLINICAL RELEVANCE:The last systematic review concluded that there was weak evidence to suggest that 2-site phacotrabeculectomy provides 1- to 2-mmHg lower IOP than 1-site surgery. Since this study, there...

    journal_title：Ophthalmology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ophtha.2010.04.008

    authors： Gdih GA,Yuen D,Yan P,Sheng L,Jin YP,Buys YM

    更新日期：2011-01-01 00:00:00

  • Retinal vascular loss in idiopathic central serous chorioretinopathy with bullous retinal detachment.

    abstract：:Three patients with idiopathic central serous chorioretinopathy (ICSC) and bullous retinal detachment (RD) were examined at least 2 years after the onset of the disease in one patient and over 10 years in the other two patients. There were large areas of retinal pigment epithelium (RPE) degeneration in each patient. I...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(87)33243-9

    authors： Akiyama K,Kawamura M,Ogata T,Tanaka E

    更新日期：1987-12-01 00:00:00

  • Bowman layer transplantation to reduce and stabilize progressive, advanced keratoconus.

    abstract：OBJECTIVE:To evaluate the clinical outcome of mid-stromal isolated Bowman layer transplantation, a new surgical technique to reduce and stabilize ectasia in eyes with advanced keratoconus, to postpone penetrating keratoplasty or deep anterior lamellar keratoplasty, and to enable continued daily contact lens wear. DESI...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2014.12.005

    authors： van Dijk K,Liarakos VS,Parker J,Ham L,Lie JT,Groeneveld-van Beek EA,Melles GR

    更新日期：2015-05-01 00:00:00

  • Retinal vascular autoregulation in diabetes mellitus.

    abstract：:The blue field entoptic technique was used to study autoregulation of the macular retinal circulation in response to acute alterations of intraocular pressure in 71 diabetic eyes and 30 normals matched for age, systemic blood pressure, and ophthalmic artery diastolic pressure. IOPmax, the maximal intraocular pressure ...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(82)34720-x

    authors： Sinclair SH,Grunwald JE,Riva CE,Braunstein SN,Nichols CW,Schwartz SS

    更新日期：1982-07-01 00:00:00

  • A retrospective study of disposable extended-wear lenses in 100 patients.

    abstract：:A retrospective evaluation of 100 patients who wore disposable extended-wear contact lenses is presented. The patients were selected at random and were fitted with one of three lens brands approved for extended wear. There were 37 males and 63 females in the study. The mean age was 40.1 years (range, 14 to 76 years). ...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(91)32068-2

    authors： Maguen E,Tsai JC,Martinez M,Rosner I,Cot PC,Macy JI,Nesburn AB

    更新日期：1991-11-01 00:00:00

  • Assessment of thyroid function.

    abstract：:The thyroid hormones Thyroxine (T4) and Triiodothyronine (T3) can be measured directly in serum by radioimmunoassay. Most serum T4 and T3 circulates bound to specific serum-binding proteins but the small unbound fraction, free T4, correlates best with hormonal activity. The free T4 concentration can be measured direct...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(81)35000-3

    authors： Surks MI

    更新日期：1981-06-01 00:00:00

  • Retinal crystals in type 2 idiopathic macular telangiectasia.

    abstract：PURPOSE:To characterize the phenotype and investigate the associations of intraretinal crystalline deposits in a large cohort with type 2 idiopathic macular telangiectasia (MacTel). DESIGN:Case-control study. PARTICIPANTS:Patients with and without retinal crystals from the Macular Telangiectasia Project, an internati...

    journal_title：Ophthalmology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ophtha.2011.05.022

    authors： Sallo FB,Leung I,Chung M,Wolf-Schnurrbusch UE,Dubra A,Williams DR,Clemons T,Pauleikhoff D,Bird AC,Peto T,MacTel Study Group.

    更新日期：2011-12-01 00:00:00

  • Isolated metastasis to optic nerve from medulloblastoma.

    abstract：:Isolated involvement of the optic nerve with metastatic tumor is uncommon. A 19-year-old man had a midline cerebellar medulloblastoma; a gross total removal was performed. He received postoperative radiation therapy to the whole brain, posterior fossa, and craniospinal axis. A progressive optic neuropathy developed 28...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(89)32912-5

    authors： Garrity JA,Herman DC,Dinapoli RP,Waller RR,Campbell RJ

    更新日期：1989-02-01 00:00:00

  • A double-blind, multicenter clinical trial of acyclovir vs idoxuridine for treatment of epithelial herpes simplex keratitis.

    abstract：:Thirty patients randomized to the Acyclovir (ACV) group (26 with dendritic lesions, 4 geographic lesions) and 34 patients randomized to the idoxuridine (IDU) treatment group (26 dendritic lesions, 8 geographic lesions) with epithelial herpetic keratitis were evaluated for efficacy and adverse reactions in a multi-cent...

    journal_title：Ophthalmology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0161-6420(82)34668-0

    authors： McCulley JP,Binder PS,Kaufman HE,O'Day DM,Poirier RH

    更新日期：1982-10-01 00:00:00

  • Potential impact of seatbelt use on the spectrum of ocular injuries and visual acuity outcomes after motor vehicle accidents with airbag deployment.

    abstract：PURPOSE:To investigate the association between seatbelt use and (1) the spectrum of ocular injuries and (2) visual acuity outcomes after motor vehicle accidents (MVAs) with airbag deployment. DESIGN:Single-center retrospective observational case series. PARTICIPANTS:Forty-seven patients involved in MVAs with airbag d...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2007.05.053

    authors： Rao SK,Greenberg PB,Filippopoulos T,Scott IU,Katsoulakis NP,Enzer YR

    更新日期：2008-03-01 00:00:00

  • Foscarnet in the treatment of cytomegalovirus retinitis in acquired immune deficiency syndrome.

    abstract：:Cytomegalovirus (CMV) retinitis is the major cause of visual loss in acquired immune deficiency syndrome (AIDS). Thirty-one patients with active CMV retinitis were treated with the new antiviral drug, Foscarnet (trisodium phosphonoformate). After a 3-week course of induction therapy, the retinitis improved in 29 of 31...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(89)32824-7

    authors： Lehoang P,Girard B,Robinet M,Marcel P,Zazoun L,Matheron S,Rozenbaum W,Katlama C,Morer I,Lernestedt JO

    更新日期：1989-06-01 00:00:00

  • Early surgical alignment for congenital esotropia.

    abstract：:To provide sufficient numbers of patients varying in age of initial adequate surgical alignment for congenital esotropia, 162 patients managed by seven ophthalmologists in three countries were personally examined by the author and the results compiled for a clinical study. From this population group, 106 patients were...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(83)34586-3

    authors： Ing MR

    更新日期：1983-02-01 00:00:00

  • Calf lung surfactant extract prophylaxis and retinopathy of prematurity.

    abstract：:Retinopathy of prematurity (ROP) is an important cause of blindness among extremely low birth weight infants (birth weight less than or equal to 1000 g). In the 1990s, greater numbers of extremely low birth weight infants will survive, in part due to routine surfactant replacement therapy for neonatal respiratory dist...

    journal_title：Ophthalmology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/s0161-6420(92)31937-2

    authors： Repka MX,Hudak ML,Parsa CF,Tielsch JM

    更新日期：1992-04-01 00:00:00

  • A comparative analysis of five methods of determining corneal refractive power in eyes that have undergone myopic laser in situ keratomileusis.

    abstract：OBJECTIVE:To evaluate the accuracy of computerized videokeratography, keratometry, and the Gaussian optics formula for measuring corneal refractive power in patients after myopic laser in situ keratomileusis (LASIK). DESIGN:Noncomparative case series. PARTICIPANTS:One hundred eyes of 63 patients (mean age, 45.0 +/- 1...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/s0161-6420(01)01001-6

    authors： Hamed AM,Wang L,Misra M,Koch DD

    更新日期：2002-04-01 00:00:00

  • Comparison of intraocular lens power calculation formulae in pediatric eyes.

    abstract：PURPOSE:To evaluate accuracy of intraocular lens (IOL) power calculation formulae (SRK II, SRK/T, Holladay 1, Hoffer Q) in pediatric eyes. DESIGN:Retrospective case series. PARTICIPANTS:One hundred thirty-five eyes of 96 children with congenital, developmental, or acquired cataracts who underwent uncomplicated catara...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2009.12.031

    authors： Nihalani BR,VanderVeen DK

    更新日期：2010-08-01 00:00:00

  • Population-based incidence of macular holes.

    abstract：PURPOSE:To determine the incidence of full-thickness macular holes in Olmsted County, Minnesota. DESIGN:Population-based retrospective chart review (cross-sectional study). PARTICIPANTS:Ninety-four eyes of 85 patients who were residents of Olmsted County, Minnesota. METHODS:A population-based retrospective chart rev...

    journal_title：Ophthalmology

    pub_type： 杂志文章

    doi：10.1016/j.ophtha.2009.01.052

    authors： McCannel CA,Ensminger JL,Diehl NN,Hodge DN

    更新日期：2009-07-01 00:00:00