Abstract：
PURPOSE:To investigate relationships between a wide range of macro- and micronutrients, including antioxidant vitamins, and the three main types of cataract in older people. DESIGN:Population-based cross-sectional study. PARTICIPANTS:Two thousand nine hundred people aged 49 to 97 years living in an urban community near Sydney, Australia. TESTING:Food frequency questionnaires and lens photography. MAIN OUTCOME MEASURE:Lens photographs were graded for presence and severity of cortical, nuclear, and posterior subcapsular cataracts. RESULTS:Higher intakes of protein, vitamin A, niacin, thiamin, and riboflavin were associated with reduced prevalence of nuclear cataract. After adjusting for multiple known cataract risk factors, the odds ratios for those in the highest intake quintile groups compared to those in the lowest intake quintiles were 0.5 (95% confidence interval [CI], 0.3-0.8) for protein, 0.5 (95% CI, 0.3-0.9) for vitamin A, 0.6 (95% CI, 0.4-0.9) for niacin, 0.6 (95% CI, 0.4-0.9) for thiamin, and 0.5 (95% CI, 0.3-0.9) for riboflavin. Intake of polyunsaturated fats was associated with reduced prevalence of cortical cataract. No nutrients were associated with posterior subcapsular cataract. CONCLUSIONS:The nucleus of the lens is particularly sensitive to nutrient deficiencies. Protein, vitamin A, niacin, thiamin, and riboflavin protected against nuclear cataract in this study.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Cumming RG,Mitchell P,Smith Wdoi
10.1016/s0161-6420(99)00024-xsubject
Has Abstractpub_date
2000-03-01 00:00:00pages
450-6issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(99)00024-Xjournal_volume
107pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract：OBJECTIVE:To determine the efficacy of a combination of 5-fluorouracil (5FU) and low-molecular-weight heparin (LMWH) in the treatment of unselected rhegmatogenous retinal detachment (RRD) undergoing primary vitrectomy. DESIGN:Double-masked, prospective, randomized, placebo-controlled clinical trial. PARTICIPANTS:Six ...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2006.08.042
更新日期：2007-04-01 00:00:00
abstract：:One hundred and sixty-two patients with presumed ocular histoplasmosis syndrome were evaluated. New macular scars not present on initial angiogram developed in 9% of eyes. The risk of developing a symptomatic macular lesion in eyes with asymptomatic macular scars was 23%. In eyes with peripapillary scarring, 3.8% deve...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(80)35226-3
更新日期：1980-05-01 00:00:00
abstract：PURPOSE:Cataract and glaucoma commonly coexist in elderly patients and present complex treatment options. This study investigates the results of simultaneous treatment of both conditions using phacoemulsification with posterior chamber lens implant and mitomycin-augmented trabeculectomy (combined surgery). METHODS:A r...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(96)30571-x
更新日期：1996-07-01 00:00:00
abstract：PURPOSE:To compare the efficacy and safety of fibrin glue and suturing for attaching conjunctival autografts among patients undergoing pterygium excision. DESIGN:Prospective, randomized, interventional case series. PARTICIPANTS:Twenty-two patients undergoing excision of primary pterygium. METHODS:A superior conjunct...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.ophtha.2004.08.028
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of a second year of pegaptanib sodium therapy in patients with neovascular age-related macular degeneration (AMD). DESIGN:Two concurrent, multicenter, randomized, double-masked, sham-controlled studies (V.I.S.I.O.N. [Vascular Endothelial Growth Factor Inhibition Study in Ocular Neova...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2006.02.064
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the responsiveness of 2 health-related quality-of-life (HRQOL) questionnaires, the Adult Strabismus-20 (AS-20) and National Eye Institute Visual Function Questionnaire-25 (VFQ-25), to changes in HRQOL after strabismus surgery. DESIGN:Cohort study. PARTICIPANTS:We included 106 adults (aged 18-84 ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2010.03.042
更新日期：2010-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the clinical outcome of mid-stromal isolated Bowman layer transplantation, a new surgical technique to reduce and stabilize ectasia in eyes with advanced keratoconus, to postpone penetrating keratoplasty or deep anterior lamellar keratoplasty, and to enable continued daily contact lens wear. DESI...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2014.12.005
更新日期：2015-05-01 00:00:00
abstract：PURPOSES:To evaluate submacular surgery for the management of subfoveal choroidal neovascularization in punctate inner choroidopathy, to describe the histopathology and ultrastructure of the excised subretinal tissue, and to propose a staging system that characterizes the development of choroidal neovascularization wit...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(96)30387-4
更新日期：1996-12-01 00:00:00
abstract：PURPOSE:To describe the clinical characteristics of and risk factors for the development of optic neuropathy after pars plana vitrectomy (PPV) for macula-sparing primary rhegmatogenous retinal detachment (RRD) repair. DESIGN:Retrospective case-control study. PARTICIPANTS:Seven patients who underwent PPV for macula-sp...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.06.002
更新日期：2012-11-01 00:00:00
abstract：PURPOSE:To describe the clinical presentation and outcomes of Acanthamoeba keratitis (AK) in rigid gas permeable (RGP) contact lens wearers and to identify modifiable risk factors. DESIGN:Case-control investigation. PARTICIPANTS:Patients were RGP contact lens-wearing United States residents with a diagnosis of AK fro...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2016.03.039
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:To characterize the types and frequencies of image artifacts associated with macular scanning using 2 common spectral-domain optical coherence tomography (SD OCT) instruments and to evaluate the impact of artifacts on foveal thickness measurements. DESIGN:Retrospective, observational chart review. PARTICIPANT...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2009.10.029
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:The authors report the case of an 83-year-old patient with a benign oncocytoma of the inferior eyelid. DESIGN:INTERVENTIONal case report. INTERVENTION:Treatment consisted of a large orbital exenteration followed by reconstruction with a pedicled temporalis muscle flap. MAIN OUTCOME MEASURES:Histologic eval...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(98)91219-2
更新日期：1998-12-01 00:00:00
abstract：OBJECTIVE:To investigate whether artificial tears and cold compress alone or in combination provide a treatment benefit and whether they were as effective as or could enhance topical antiallergic medication. DESIGN:Randomized, masked clinical trial. PARTICIPANTS:Eighteen subjects (mean age, 29.5±11.0 years) allergic ...
journal_title：Ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ophtha.2013.08.007
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:The differentiating characteristics in blebitis and early and late endophthalmitis after glaucoma filtration surgery are reviewed. METHODS:All admission records and operative reports, as well as available office notes, on patients with blebitis or bleb-associated endophthalmitis admitted to a large referral ey...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(97)30196-1
更新日期：1997-06-01 00:00:00
abstract：:The optic discs of eight normal subjects were photographed on three separate visits under widely varying conditions. Each photograph was scanned by a television camera, converted to digital form, and then analyzed using computer image analysis techniques. The computer was programmed to delineate the boundary around th...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(85)34057-5
更新日期：1985-02-01 00:00:00
abstract：:Recent studies have suggested that diffuse field loss and localized visual field loss in glaucomatous patients may have different pathophysiologic mechanisms. Testing that hypothesis requires that some patients present with purely localized field loss and other patients with purely diffuse loss. This article describes...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(91)32092-x
更新日期：1991-10-01 00:00:00
abstract：OBJECTIVE:To investigate the impact of resident participation in cataract surgery on operative time and cost. DESIGN:Retrospective chart review. PARTICIPANTS:All patients who underwent phacoemulsification cataract surgery by an attending or resident surgeon of the Penn State Hershey Eye Center between July 1, 2004, a...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2011.06.026
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:To describe the echographic characteristics of splitting the outer posterior cortical vitreous in patients with proliferative diabetic retinopathy and vitreous hemorrhage. METHODS:The authors retrospectively reviewed the echographic findings in 270 patients who were evaluated at the Doheny Eye Institute betwee...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(96)30698-2
更新日期：1996-02-01 00:00:00
abstract：OBJECTIVE:To test whether alternate day vitamin E affects the incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women. DESIGN:Randomized, double-masked, placebo-controlled trial. PARTICIPANTS:Thirty-nine thousand eight hundred seventy-six apparently healthy female health profess...
journal_title：Ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ophtha.2009.10.043
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:The ability to detect reticular pseudodrusen (RPD)/subretinal drusenoid deposits (SDDs) using 12×12-mm widefield en face swept-source optical coherence tomography (SS-OCT) imaging was compared with conventional multimodal imaging (color, fundus autofluorescence (FAF), and infrared reflectance [IR] imaging) in e...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2016.10.009
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:Syndromes with genetically determined retinal diseases and concurrent multiple neurologic abnormalities are rare. Kjellin described an autosomal recessive entity with spastic paraplegia, mental retardation, amyotrophia, and macular dystrophy. We sought to further characterize the retinal phenotype and to cont...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(02)01110-7
更新日期：2002-08-01 00:00:00
abstract：PURPOSE:Lifitegrast is an integrin antagonist that decreases T-cell-mediated inflammation associated with dry eye disease (DED). We report the results of OPUS-2, a phase III study evaluating the efficacy and safety of lifitegrast compared with placebo for the treatment of DED. DESIGN:A 12-week, multicenter, randomized...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2015.08.001
更新日期：2015-12-01 00:00:00
abstract：:The zonules of 27 postmortem eyes were studied grossly using a histologic staining technique that allowed easy visualization of the zonules. Large disinsertions of the zonules were present in 5 of the 20 eyes that had undergone extracapsular cataract extraction (ECCE). ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(87)33423-2
更新日期：1987-05-01 00:00:00
abstract：OBJECTIVE:To examine the effectiveness of scleral buckling surgery for active stage 4A retinopathy of prematurity. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:Eight eyes of seven infants were examined. All except one had previous peripheral ablation (cryotherapy-laser) but retinal detachment was act...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(98)91023-5
更新日期：1998-10-01 00:00:00
abstract：PURPOSE:To examine the hypotheses that in glaucomatous eyes with single-hemifield damage, retinal blood flow (RBF) is significantly reduced in the retinal hemisphere corresponding with the abnormal visual hemifield and that there are significant associations among reduced retinal sensitivity (RS) in the abnormal hemifi...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ophtha.2013.10.022
更新日期：2014-03-01 00:00:00
abstract：:Phenylephrine hydrochloride is a potent, effective, relatively safe drug with few ocular side effects. Side effects from topical instillation are uncommon but include severe systemic cardiovascular effects with elevated blood pressure and stroke. Ten percent phenylephrine should be used with caution in patients with k...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(80)35108-7
更新日期：1980-11-01 00:00:00
abstract：:Taping the superior aspect of patient masks qualitatively decreases air flow and bacterial dispersion towards the ocular surface while inappropriately worn masks both qualitatively and quantitatively increase bacterial dispersion towards the ocular surface. ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2021.01.007
更新日期：2021-01-11 00:00:00
abstract：:A study group of eight patients with diabetic retinopathy and marked accumulation of hard exudates in the fundi is described. There was a significant increase in serum triglyceride levels (P less than 0.05) in the study group as compared to a control group of 23 consecutive patients with diabetic retinopathy. This exu...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(84)34098-2
更新日期：1984-12-01 00:00:00
abstract：:The clinical features of 290 patients with scleral inflammation were reviewed to determine whether a classification based on the anatomical site and clinical appearance of the disease at presentation reflected its natural history. The authors' results confirm that the majority of patients remain in the same clinical c...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(91)32269-3
更新日期：1991-04-01 00:00:00
abstract：OBJECTIVE:To investigate the visual outcome, pattern of discontinuation, ocular complications, and mortality of patients treated with a variable ranibizumab dosing regimen for neovascular age-related macular degeneration (AMD) for 4 years. DESIGN:Retrospective chart review supplemented with clinical examination. PART...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2013.05.018
更新日期：2013-12-01 00:00:00
