Abstract:
PURPOSE:To examine the hypotheses that in glaucomatous eyes with single-hemifield damage, retinal blood flow (RBF) is significantly reduced in the retinal hemisphere corresponding with the abnormal visual hemifield and that there are significant associations among reduced retinal sensitivity (RS) in the abnormal hemifield, RBF, and structural measurements in the corresponding hemisphere. DESIGN:Prospective, nonrandomized, case-control study. PARTICIPANTS:Thirty eyes of 30 patients with glaucoma with visual field loss confined to a single hemifield and 27 eyes of 27 controls. METHODS:Normal and glaucomatous eyes underwent spectral-domain optical coherence tomography (SD-OCT) and standard automated perimetry. Doppler SD-OCT with a double-circle scanning pattern was used to measure RBF. The RBF was derived from the recorded Doppler frequency shift and the measured angle between the beam and the vessel. Total and hemispheric RBF, retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) values were calculated. The RS values were converted to 1/Lambert. Analysis of variance and regression analyses were performed. MAIN OUTCOME MEASURES:Total and hemispheric RS, RBF, RNFL, and GCC values. RESULTS:The total RBF (34.6±12.2 μl/minute) and venous cross-sectional area (0.039 ± 0.009 mm(2)) were reduced (P<0.001) in those with glaucoma compared with controls (46.5 ± 10.6 μl/minute; 0.052 ± 0.012 mm(2)). Mean RBF was reduced in the abnormal hemisphere compared with the opposite hemisphere (15.3 ± 5.4 vs. 19.3 ± 8.4 μl/minute; P = 0.004). The RNFL and GCC were thinner in the corresponding abnormal hemisphere compared with the opposite hemisphere (87.0 ± 20.2 vs. 103.7 ± 20.6 μm, P = 0.002; 77.6 ± 12.1 vs. 83.6 ± 10.1 μm, P = 0.04). The RBF was correlated with RNFL (r = 0.41; P = 0.02) and GCC (r = 0.43; P = 0.02) but not the RS (r = 0.31; P = 0.09) in the abnormal hemisphere. The RBF (19.3 ± 8.4 μl/minute), RNFL (103.7 ± 20.6 μm), and GCC (83.6 ± 10.1 μm) were reduced (P<0.05) in the hemisphere with apparently normal visual field in glaucomatous eyes compared with the mean hemispheric values of the normal eyes (23.2 ± 5.3 μl/minute, 124.8 ± 9.6 μm, and 96.1 ± 5.7 μm, respectively). CONCLUSIONS:In glaucomatous eyes with single-hemifield damage, the RBF is significantly reduced in the hemisphere associated with the abnormal hemifield. Reduced RBF is associated with thinner RNFL and GCC in the corresponding abnormal hemisphere. Reduced RBF and RNFL and GCC loss also are observed in the perimetrically normal hemisphere of glaucomatous eyes.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Sehi M,Goharian I,Konduru R,Tan O,Srinivas S,Sadda SR,Francis BA,Huang D,Greenfield DSdoi
10.1016/j.ophtha.2013.10.022subject
Has Abstractpub_date
2014-03-01 00:00:00pages
750-8issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(13)00947-0journal_volume
121pub_type
杂志文章,多中心研究相关文献
OPHTHALMOLOGY文献大全abstract::Extended-wear contact lenses (EWCL) were fitted successfully on 61 aphakic eyes with penetrating corneal grafts. In two- to 32-months follow-up there were 26 eyes that had varying amounts of superficial neovascularization of the grafts and one Staphylococcus epidermidis corneal graft ulcer. There were five homograft r...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(82)34756-9
更新日期:1982-06-01 00:00:00
abstract:PURPOSE:Patients undergoing enucleation for uveal melanoma need to be informed of the possibility of phantom eye syndrome (PES). The number with uveal melanoma in PES studies has been small. Aims were to: (1) determine the prevalence, symptoms, and characteristics of PES and to test associations of PES symptoms with so...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2015.04.005
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:To describe and classify patterns of abnormal fundus autofluorescence (FAF) of patients with β-thalassemia receiving long-term treatment with deferoxamine (DFO). DESIGN:Prospective, cross-sectional, case-control study. PARTICIPANTS:A total of 197 consecutive patients with β-thalassemia major or intermedia wit...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.01.039
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To assess the distribution of the macular pigments (MPs) lutein (L) and zeaxanthin (Z) in a healthy sample more representative of the general population than past studies and to determine which dietary factors and personal characteristics might explain the large interindividual differences in the density of t...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00655-2
更新日期:2001-04-01 00:00:00
abstract::Proton irradiation was used in the treatment of uveal melanomas in 36 eyes. The average follow-up period was 16 months. One patient developed metastatic disease and died. No eye has been enucleated and tumor regression has been observed in all 22 eyes with a follow-up of more than 12 months. This type of treatment off...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35212-3
更新日期:1980-06-01 00:00:00
abstract::A reproducible model of an irregular corneal surface was developed to test the ability of the excimer laser to treat such surfaces. Using a 193-nm argon fluoride excimer laser set at a fluence of 160 mJ/cm2, repetition rate of 10 Hz, and 185 pulses, fresh de-epithelialized pig eyes underwent phototherapeutic ablations...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32050-5
更新日期:1991-12-01 00:00:00
abstract::The degree of retinal involvement of 20 patients (ages 3-21) with mucopolysaccharidosis (MPS) types I, II, and III was assessed using electroretinography (ERG) under standardized conditions. ERG evidence of retinal dysfunction ranged from none to severe in MPS I and II, and from moderate to severe in MPS III. The ERG ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33537-1
更新日期:1986-12-01 00:00:00
abstract:OBJECTIVE:To study the prevalence of undercorrected refractive error and associated sociodemographic factors among Singaporean Chinese adults. DESIGN:Cross-sectional, population-based survey. PARTICIPANTS:Singaporean Chinese adults aged 40 to 79 years (n = 1152). METHODS:The Singapore electoral register of Tanjong P...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2004.05.032
更新日期:2004-12-01 00:00:00
abstract:PURPOSE:To report the therapeutic effects of ethanol (ETOH) irrigation into epithelial iris cysts (EIC). STUDY DESIGN:Retrospective noncomparative interventional case series. PARTICIPANTS:102 eyes of 102 patients aged between 4 and 71 years with EIC, with 4 months to 15 years follow-up. INTERVENTION:Under local or g...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(03)00543-8
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:To develop a simulator for training in phacoemulsification to be used as a learning device for both beginners and experienced surgeons to shorten the learning curve. DESIGN:Experimental study. METHODS:The system consists of a personal computer, a 3-dimensional visual interface, a phacoemulsification handpie...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2003.06.023
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:To document the long-term effect of argon laser peripheral iridoplasty (ALPI) in eyes with plateau iris syndrome. DESIGN:Retrospective, noncomparative, interventional case series. SETTING:New York Eye and Ear Infirmary. METHODS:The charts of all patients with plateau iris syndrome treated with ALPI from 19...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2003.05.001
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To investigate the penetration of linezolid, a synthetic oxazolidinone antibiotic, into the aqueous and vitreous humor after oral administration. DESIGN:Noncomparative interventional, prospective case series study, randomized into group 1 (dose, one 600-mg tablet) or group 2 (2 doses of 600 mg given 12 hours...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ophtha.2003.09.042
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:To evaluate prospectively a diffractive (811E, Pharmacia; power add +4.0 D) versus a refractive (PA154N, Allergan; power add +3.5 D) designed multifocal lens. PARTICIPANTS:Eighty patients planned for cataract surgery without additional ocular pathologies were randomized into the diffractive or refractive gro...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(97)30127-4
更新日期:1997-09-01 00:00:00
abstract:PURPOSE:To describe a patient with conjunctival metastasis as the initial manifestation of metastasis from a cutaneous melanoma. DESIGN:Single interventional case report. METHODS:A 48-year-old woman with a history of cutaneous axillary melanoma developed a rapidly growing conjunctival mass. Subsequent systemic evalua...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2004.04.020
更新日期:2004-10-01 00:00:00
abstract:PURPOSE:To evaluate the life and professional work of the English ophthalmologist Herbert Herbert (1865-1942). DESIGN:Historical study. METHODS:The main sources for this investigation are Herbert's approximately 65 published papers and 3 monographs. Other sources are contemporary publications by other ophthalmologist...
journal_title:Ophthalmology
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.ophtha.2013.11.018
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:We have used an artificial neural network in an attempt to classify and predict the progression of thyroid-associated ophthalmopathy (TAO) at the first clinical examination. DESIGN:This retrospective comparative case series included a group of patients examined by the ophthalmologist only once because of the...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)01127-2
更新日期:2002-09-01 00:00:00
abstract::Three patients with idiopathic central serous chorioretinopathy (ICSC) and bullous retinal detachment (RD) were examined at least 2 years after the onset of the disease in one patient and over 10 years in the other two patients. There were large areas of retinal pigment epithelium (RPE) degeneration in each patient. I...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33243-9
更新日期:1987-12-01 00:00:00
abstract:PURPOSE:The differentiating characteristics in blebitis and early and late endophthalmitis after glaucoma filtration surgery are reviewed. METHODS:All admission records and operative reports, as well as available office notes, on patients with blebitis or bleb-associated endophthalmitis admitted to a large referral ey...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30196-1
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:The current understanding of the anatomy of Whitnall ligament does not explain its functional role in eyelid movement. This anatomic study was designed to determine the exact relation of Whitnall ligament to the levator muscle and aponeurosis. METHODS:The anatomy of the eyelid was examined by surgical disse...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30761-0
更新日期:1995-12-01 00:00:00
abstract::A cross-sectional study was undertaken to determine the prevalence of ocular and oculodermal melanocytosis. Thirteen thousand one hundred fifty patients were examined for ocular and oculodermal melanocytosis. Fifty-three percent of these patients were black, 40% were white, and 7% were of other racial groups. In the w...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:
更新日期:1982-08-01 00:00:00
abstract:PURPOSE:To test if improving optical coherence tomography (OCT) resolution and scanning speed improves the visualization of glaucomatous structural changes as compared with conventional OCT. DESIGN:Prospective observational case series. PARTICIPANTS:Healthy and glaucomatous subjects in various stages of disease. MET...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.06.038
更新日期:2008-05-01 00:00:00
abstract:PURPOSE:To evaluate the clinical results of epi-LASIK for the treatment of low to moderate myopia and myopic astigmatism. DESIGN:Retrospective, noncomparative, interventional case series. PARTICIPANTS:Two hundred thirty-four eyes of 138 patients underwent epi-LASIK for the correction of low to moderate myopia. Mean p...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.08.052
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Opportunistic infections frequently involve the anterior and posterior segments of the eye but rarely occur in the orbit in patients with human immunodeficiency virus (HIV) infection. The authors managed eight patients with HIV and unilateral orbital infections who presented between July 1988 and March 1995....
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0161-6420(96)30479-x
更新日期:1996-09-01 00:00:00
abstract::Autosomal dominant vitreoretinochoroidopathy (ADVIRC), a recently described disease, is clinically characterized by a slowly progressive or stationary circumferential peripheral pigmentary retinopathy with fibrillar condensation of the vitreous. Histopathologic study of an 88-year-old patient with this disease showed ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32663-7
更新日期:1989-12-01 00:00:00
abstract::Vitreous surgery techniques are useful in the management of selected retinal detachments with an otherwise poor prognosis. Vitrectomy methods can be used to remove intraocular opacities; cut vitreous sheets causing vitreo-retinal traction and separate epiretinal membranes covering or distorting the retina; provide a f...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(79)35485-9
更新日期:1979-04-01 00:00:00
abstract:PURPOSE:The ability to detect reticular pseudodrusen (RPD)/subretinal drusenoid deposits (SDDs) using 12×12-mm widefield en face swept-source optical coherence tomography (SS-OCT) imaging was compared with conventional multimodal imaging (color, fundus autofluorescence (FAF), and infrared reflectance [IR] imaging) in e...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.10.009
更新日期:2017-02-01 00:00:00
abstract::Diagnostic anterior chamber and vitreous aspiration confirmed an infectious etiology in 78 of 140 eyes (56%) with suspected endophthalmitis. In 27 eyes the vitreous aspirate was positive, while the anterior chamber aspirate was negative. Intraocular antibiotics were used in 88 eyes including 50 which underwent therape...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35241-x
更新日期:1980-04-01 00:00:00
abstract:OBJECTIVE:To investigate refractive error in eyes with nonarteritic anterior ischemic optic neuropathy (NA-AION) and its relationship to cup/disc (C/D) ratio. DESIGN:Cohort study. PARTICIPANTS:A total of 608 consecutive patients with NA-AION. METHODS:At first visit, all patients had a comprehensive ophthalmic evalua...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.08.007
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To compare the visual outcomes and complication profiles of primary scleral-fixated intraocular lens (SFIOL) versus primary anterior chamber intraocular lens (ACIOL) implantation in cataract surgeries complicated by inadequate capsular support. DESIGN:Retrospective, interventional, comparative cases series. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.11.024
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to examine the characteristics of intraretinal changes associated with macular holes and epiretinal membranes by scanning retinal thickness analysis. STUDY DESIGN:The study design was a nonconsecutive case series. PATIENTS:Fifty-six eyes of patients who had either a suspected or clinically ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(98)91274-x
更新日期:1998-01-01 00:00:00