Conjunctival metastasis as initial sign of disseminated cutaneous melanoma.


PURPOSE:To describe a patient with conjunctival metastasis as the initial manifestation of metastasis from a cutaneous melanoma. DESIGN:Single interventional case report. METHODS:A 48-year-old woman with a history of cutaneous axillary melanoma developed a rapidly growing conjunctival mass. Subsequent systemic evaluation disclosed asymptomatic liver metastasis. The conjunctival lesion was resected. RESULTS:Histopathologic evaluation of the conjunctival tumor disclosed an epithelioid cell melanoma located in the conjunctival stroma, without appreciable junctional activity, compatible with metastatic melanoma. CONCLUSIONS:Conjunctival metastasis from cutaneous melanoma can rarely be the initial manifestation of disseminated melanoma.






Shields JA,Shields CL,Eagle RC Jr,Raber IM




Has Abstract


2004-10-01 00:00:00














  • Malignant nonteratoid medulloepithelioma of the ciliary body in an adult.

    abstract:BACKGROUND:The authors describe a 62-year-old man with a malignant nonteratoid malignant medulloepithelioma of the ciliary body with extension into the anterior choroid and posterior chamber. He developed gradual loss of vision in his right eye, and a clinical diagnosis of malignant melanoma of the ciliary body and cho...


    pub_type: 杂志文章,评审


    authors: Husain SE,Husain N,Boniuk M,Font RL

    更新日期:1998-04-01 00:00:00

  • The management of corneal perforations associated with rheumatoid arthritis. An analysis of 32 eyes.

    abstract:BACKGROUND:Sterile corneal ulceration is a rare complication of rheumatoid arthritis and may lead to corneal perforation. Surgical management for visual restoration frequently is unsuccessful. The authors analyze the factors that may determine the failure of corneal surgery in perforations associated with rheumatoid ar...


    pub_type: 杂志文章


    authors: Bernauer W,Ficker LA,Watson PG,Dart JK

    更新日期:1995-09-01 00:00:00

  • Cytomegalovirus retinitis and optic neuritis in acquired immune deficiency syndrome. Report of a case.

    abstract::A 33-year-old man with acquired immune deficiency syndrome (AIDS) was found to have bilateral cytomegalovirus (CMV) retinitis with concomitant unilateral optic neuritis. The patient died and postmortem examination of both eyes disclosed CMV inclusions in all layers of the involved retinas including the retinal pigment...


    pub_type: 杂志文章


    authors: Grossniklaus HE,Frank KE,Tomsak RL

    更新日期:1987-12-01 00:00:00

  • Acute promyelocytic infiltration of the optic nerve treated by oral trans-retinoic acid.

    abstract:BACKGROUND:Oral trans-retinoic acid has recently been shown to be an effective treatment modality for acute promyelocytic leukemia. This type of drug differs from traditional tumoricidal agents by promoting differentiation of the malignant, immature cells. METHODS:The authors describe a patient with optic nerve infilt...


    pub_type: 杂志文章


    authors: Brown DM,Kimura AE,Ossoinig KC,Weiner GJ

    更新日期:1992-09-01 00:00:00

  • Experimental endoscopic goniotomy. A potential treatment for primary infantile glaucoma.

    abstract:PURPOSE:The purpose of this study is to determine if an endoscope would improve visualization of the anterior chamber angle and facilitate goniotomy in a surgical cloudy corneal model of primary infantile glaucoma. METHODS:A 23-gauge needle coupled to a 0.8-mm diameter flexible endoscope entered the anterior chamber o...


    pub_type: 杂志文章


    authors: Joos KM,Alward WL,Folberg R

    更新日期:1993-07-01 00:00:00

  • Surgical complications of pars plana vitreous surgery.

    abstract::Evaluation of 200 consecutive pars plana vitrectomies shows delayed corneal epithelial healing after intentional scraping and formation of a posterior subcapsular cataract, presumably due to exposure to inadequate infusion fluids. Posterior retinal holes occur frequently, whereas entrance site complications have been ...


    pub_type: 杂志文章


    authors: Faulborn J,Conway BP,Machemer R

    更新日期:1978-02-01 00:00:00

  • Pre-keratoplasty potential acuity evaluation. Laser interferometer and potential acuity meter.

    abstract::Twenty-three patients who underwent penetrating keratoplasty were evaluated preoperatively for potential retinal acuity utilizing the Randwal Laser Interferometer and the Mentor Potential Acuity Meter. When compared with Snellen visual acuity during the early postoperative period (1-6 months), both instruments were us...


    pub_type: 杂志文章


    authors: Steinert RF,Minkowski JS,Boruchoff SA

    更新日期:1984-10-01 00:00:00

  • Photopsias: A Key to Diagnosis.

    abstract:PURPOSE:To assess the character and cause of photopsias in vitreoretinal patients. DESIGN:Cross-sectional study. PARTICIPANTS:A total of 169 consecutive patients (217 eyes) with vitreoretinal disease presenting with a history of photopsias. METHODS:A total of 217 eyes with photopsias in 169 patients were evaluated. ...


    pub_type: 杂志文章


    authors: Brown GC,Brown MM,Fischer DH

    更新日期:2015-10-01 00:00:00

  • Why do phacoemulsification? Manual small-incision cataract surgery is almost as effective, but less expensive.

    abstract:PURPOSE:To compare the cost of phacoemulsification with foldable lenses with that of manual small-incision cataract surgery (SICS) in a hospital setting. DESIGN:Average cost comparision between 2 surgical techniques. PARTICIPANTS:Four hundred patients and 4 surgeons. METHODS:A single masked randomized controlled cli...


    pub_type: 杂志文章,随机对照试验


    authors: Gogate P,Deshpande M,Nirmalan PK

    更新日期:2007-05-01 00:00:00

  • Interim FDA report on intraocular lenses.

    abstract::Intraocular lenses have been regulated by the Food and Drug Administration since February 9, 1978. Data reported through August 9, 1979 reveal 177,503 lenses of four different classes have been implanted. The anterior chamber intraocular lens appears to have a higher incidence of certain postoperative complications co...


    pub_type: 杂志文章


    authors: Worthen DM,Boucher JA,Buxton JN,Hayreh SS,Lowther G,Reinecke RD,Spencer WH,Talbott M,Weeks DF

    更新日期:1980-04-01 00:00:00

  • Experience with the Baerveldt glaucoma implant in treating neovascular glaucoma.

    abstract:PURPOSE:The authors present a retrospective study designed to assess the effectiveness of the Baerveldt glaucoma implant in controlling intraocular pressure (IOP) and maintaining visual function in eyes with neovascular glaucoma. METHODS:The medical records of all 36 patients (36 eyes) who underwent Baerveldt glaucoma...


    pub_type: 杂志文章


    authors: Sidoti PA,Dunphy TR,Baerveldt G,LaBree L,Minckler DS,Lee PP,Heuer DK

    更新日期:1995-07-01 00:00:00

  • Intraocular pressure control and complications with two-stage insertion of the Baerveldt implant.

    abstract:PURPOSE:To evaluate intraocular pressure (IOP) control and the prevalence of complications associated with the two-stage insertion of the Baerveldt implant. DESIGN:Retrospective, noncomparative, interventional case series. METHODS:We reviewed the medical records of all patients who underwent the two-stage Baerveldt i...


    pub_type: 杂志文章


    authors: Tong L,Frazao K,LaBree L,Varma R

    更新日期:2003-02-01 00:00:00

  • Adverse reactions from timolol administration.

    abstract::Five hundred forty-seven reports of adverse reactions to timolol maleate received by the National Registry for Drug-induced Ocular Side Effects during an eleven-month period were reviewed. Approximately half the reports concerned systemic reactions affecting the cardiac, pulmonary, central nervous, gastrointestinal, a...


    pub_type: 杂志文章


    authors: Van Buskirk EM

    更新日期:1980-05-01 00:00:00

  • Iontophoresis of fluorescein into the posterior segment of the rabbit eye.

    abstract::Iontophoresis of appreciable quantities of fluorescein into the vitreous body of the rabbit results from the use of a high electrical current density over a limited area of the globe. This is achieved by passing current through the fluorescein when it is held against the region of the ora serrata in a tube less than 1...


    pub_type: 杂志文章


    authors: Maurice DM

    更新日期:1986-01-01 00:00:00

  • Comparison of Two Questionnaires for Dry Eye Symptom Assessment: The Ocular Surface Disease Index and the Symptom Assessment in Dry Eye.

    abstract:PURPOSE:The aim of this study was to compare patient-reported symptoms of dry eye disease (DED) as assessed by the Ocular Surface Disease Index (OSDI), a 12-item symptom frequency-based questionnaire, and the Symptom Assessment iN Dry Eye (SANDE), a 2-item frequency- and severity-based visual analog scale. DESIGN:Clin...


    pub_type: 杂志文章


    authors: Amparo F,Schaumberg DA,Dana R

    更新日期:2015-07-01 00:00:00

  • The Impact of Systemic Factors on Clinical Response to Ranibizumab for Diabetic Macular Edema.

    abstract:PURPOSE:To evaluate the effect of systemic factors on best-corrected visual acuity (BCVA) achieved with ranibizumab (Lucentis; Genentech, Inc, South San Francisco, CA) for treatment of diabetic macular edema (DME) in the RIDE and RISE phase 3 studies. DESIGN:Exploratory, post hoc analysis of 2 randomized, double-maske...


    pub_type: 杂志文章,随机对照试验


    authors: Singh RP,Habbu K,Ehlers JP,Lansang MC,Hill L,Stoilov I

    更新日期:2016-07-01 00:00:00

  • Long-term efficacy of argon laser trabeculoplasty.

    abstract::Long-term efficacy of 360 degrees argon laser trabeculoplasty was studied in 118 eyes of 93 patients with uncontrolled chronic open-angle glaucoma. The mean intraocular pressure (IOP) decrease was 8.9 +/- 5.4 mmHg (mean +/- standard deviation [SD] in 71 eyes at 1 year, 9.3 +/- 4.3 mmHg (mean +/- SD) in 51 eyes at 3 ye...


    pub_type: 杂志文章


    authors: Shingleton BJ,Richter CU,Bellows AR,Hutchinson BT,Glynn RJ

    更新日期:1987-12-01 00:00:00

  • Orbital Angiogenesis and Lymphangiogenesis in Thyroid Eye Disease: An Analysis of Vascular Growth Factors with Clinical Correlation.

    abstract:PURPOSE:The human orbit is an environment that is vulnerable to inflammation and edema in the setting of autoimmune thyroid disease. Our study investigated the tenet that orbital adipose tissue lacks lymphatic vessels and analyzed the clinicopathologic differences between patients with acute and chronic thyroid eye dis...


    pub_type: 杂志文章


    authors: Wong LL,Lee NG,Amarnani D,Choi CJ,Bielenberg DR,Freitag SK,D'Amore PA,Kim LA

    更新日期:2016-09-01 00:00:00

  • Structure and clinical significance of central optic disc pits.

    abstract:OBJECTIVE:To assess the structure of central optic disc pits (ODPs) using enhanced-depth imaging optical coherence tomography (EDI OCT) and to ascertain their clinical significance. DESIGN:Prospective, cross-sectional study. PARTICIPANTS:Patients with an ophthalmoscopically visible central ODP in either eye, irrespec...


    pub_type: 杂志文章


    authors: Qayum S,Sullivan T,Park SC,Merchant K,Banik R,Liebmann JM,Ritch R

    更新日期:2013-07-01 00:00:00

  • Diurnal variation in corneal endothelial morphology.

    abstract::Transient changes in the corneal endothelium were the earliest detectable response to low atmospheric oxygen in experimental animals. Similar changes have been reported after hard and soft contact lens wear. We describe widespread transient cell changes by wide-field specular microscopy in the normal corneal endotheli...


    pub_type: 杂志文章


    authors: Khodadoust AA,Hirst LW

    更新日期:1984-10-01 00:00:00

  • Electron microscopic study of corneal epithelial-endothelial interactions in organ culture.

    abstract::The interactions between rabbit corneal epithelium and endothelium were investigated in an organ culture model using scanning electron microscopy and correlative light microscopy. Following mechanical removal of corneal endothelium, corneal epithelium was observed to migrate across the cut surface of the corneal strom...


    pub_type: 杂志文章


    authors: Sassani JW,John T,Cameron JD,Yanoff M,Eagle RC Jr

    更新日期:1984-06-01 00:00:00

  • Ocular complications of pediatric uveitis.

    abstract:PURPOSE:To determine the cumulative proportion and the visual significance of ocular complications of pediatric uveitis. DESIGN:Cohort study. PARTICIPANTS:Patients with onset of endogenous or infectious uveitis before or at age 16 years. METHODS:Retrospective review of existing records at a university-based uveitis ...


    pub_type: 杂志文章


    authors: Rosenberg KD,Feuer WJ,Davis JL

    更新日期:2004-12-01 00:00:00

  • Extraocular muscle repositioning and diplopia: associated with ophthalmic plaque radiation therapy for choroidal melanoma.

    abstract:OBJECTIVE:To evaluate extraocular muscle surgery associated with plaque brachytherapy for choroidal melanoma. DESIGN:Single-center retrospective cohort study. PARTICIPANTS:Three hundred twenty-nine eyes of 329 consecutive patients with clinically diagnosed choroidal melanoma. INTERVENTION:Palladium 103 plaque brachy...


    pub_type: 杂志文章


    authors: Nagendran ST,Finger PT,Campolattaro BN

    更新日期:2014-11-01 00:00:00

  • Long-term Natural History of Dry Eye Disease from the Patient's Perspective.

    abstract:PURPOSE:To describe the natural history of dry eye disease (DED), which chronically affects millions of people in the United States. DESIGN:This study is based on the Women's Health Study and Physicians' Health Studies, and uses questionnaires and medical records. PARTICIPANTS:A total of 398 men and 386 women who rep...


    pub_type: 杂志文章


    authors: Lienert JP,Tarko L,Uchino M,Christen WG,Schaumberg DA

    更新日期:2016-02-01 00:00:00

  • Tractional retinal detachment after branch retinal vein occlusion. Influence of disc neovascularization on the outcome of vitreous surgery.

    abstract:OBJECTIVE:This study aimed to investigate the influence of disc neovascularization on the outcome of vitreous surgery for tractional retinal detachment (TRD) after branch retinal vein occlusion (BRVO). DESIGN:The study design was a retrospective case series. PARTICIPANTS:Twenty-two eyes of 22 patients who had undergo...


    pub_type: 杂志文章


    authors: Ikuno Y,Ikeda T,Sato Y,Tano Y

    更新日期:1998-03-01 00:00:00

  • Indocyanine green videoangiographic findings in detachment of the retinal pigment epithelium.

    abstract:BACKGROUND:Several forms of retinal pigment epithelial detachment have been reported. The authors used indocyanine green (ICG) videoangiography, which is useful to study the choroidal vasculature and Bruch membrane, to study pigment epithelial detachments. METHODS:Ninety-eight pigment epithelial detachments in 75 eyes...


    pub_type: 杂志文章


    authors: Yuzawa M,Kawamura A,Yamaguchi C,Shouda M,Shimoji M,Matsui M

    更新日期:1995-04-01 00:00:00

  • Comparison of the intraocular pressure-lowering effect of latanoprost and timolol in patients with chronic angle closure glaucoma: a preliminary study.

    abstract:OBJECTIVE:To compare the intraocular pressure (IOP)-reducing effect and side effects of 0.005% latanoprost once daily to 0.5% timolol twice daily in patients with primary chronic angle closure glaucoma (CACG). DESIGN:Randomized, double-masked two-center clinical trial. PARTICIPANTS:Thirty-two Asian patients with CACG...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Aung T,Wong HT,Yip CC,Leong JY,Chan YH,Chew PT

    更新日期:2000-06-01 00:00:00

  • Operator learning effect and interoperator reproducibility of the scanning laser polarimeter with variable corneal compensation.

    abstract:PURPOSE:To ascertain operator learning effect, and to quantify the interoperator reproducibility, using the newly introduced GDx VCC (variable corneal compensator) scanning laser polarimeter. DESIGN:Prospective instrument validation study. PARTICIPANTS:Three operators with no prior experience in operating the GDx VCC...


    pub_type: 杂志文章


    authors: Frenkel S,Slonim E,Horani A,Molcho M,Barzel I,Blumenthal EZ

    更新日期:2005-02-01 00:00:00

  • Computer-assisted, interactive fundus image processing for macular drusen quantitation.

    abstract:PURPOSE:To design and validate a software package to quantitate the area subtended by drusen in color fundus photographs for the conduct of efficient, accurate clinical trials in age-related macular degeneration. DESIGN:Algorithm and software development. Comparisons with manual methodologies. PARTICIPANTS:Evaluation...


    pub_type: 临床试验,杂志文章


    authors: Shin DS,Javornik NB,Berger JW

    更新日期:1999-06-01 00:00:00

  • Nonarteritic anterior ischemic optic neuropathy: natural history of visual outcome.

    abstract:OBJECTIVE:To investigate systematically the natural history of visual outcome in nonarteritic anterior ischemic optic neuropathy (NAION). DESIGN:Cohort study. PARTICIPANTS:Three hundred forty consecutive untreated patients (386 eyes) with NAION, first seen in our clinic from 1973 to 2000. METHODS:At first visit, all...


    pub_type: 杂志文章


    authors: Hayreh SS,Zimmerman MB

    更新日期:2008-02-01 00:00:00