Discoid lupus erythematosus masquerading as chronic blepharoconjunctivitis.

Abstract:

PURPOSE:To recognize discoid lupus erythematosus (DLE) as a treatable cause of chronic blepharoconjunctivitis. DESIGN:Retrospective observational case series. PARTICIPANTS:Records of 5 patients with biopsy-proven DLE were reviewed. METHODS:Clinical and pathology records were examined. MAIN OUTCOME MEASURES:Patients' clinical and histopathological characteristics and response to treatment were assessed. RESULTS:Clinical features included meibomian gland dysfunction, blepharitis, chalazia, trichiasis, madarosis, conjunctivitis, chronic eyelid edema, and eyelid plaques. Histopathology showed hyperkeratotic epithelium, degeneration of the basal cell layer, and a perivascular lymphocytic infiltrate. There was delayed diagnosis in all cases, ranging from 4 months to 25 years. All of the patients responded to systemic hydroxychloroquine therapy. CONCLUSIONS:Heightened awareness of eyelid DLE may lead to earlier detection and specific therapy for this chronic disorder.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Acharya N,Pineda R 2nd,Uy HS,Foster CS

doi

10.1016/j.ophtha.2005.01.035

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

e19-23

issue

5

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(05)00278-2

journal_volume

112

pub_type

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