Abstract:
PURPOSE:To recognize discoid lupus erythematosus (DLE) as a treatable cause of chronic blepharoconjunctivitis. DESIGN:Retrospective observational case series. PARTICIPANTS:Records of 5 patients with biopsy-proven DLE were reviewed. METHODS:Clinical and pathology records were examined. MAIN OUTCOME MEASURES:Patients' clinical and histopathological characteristics and response to treatment were assessed. RESULTS:Clinical features included meibomian gland dysfunction, blepharitis, chalazia, trichiasis, madarosis, conjunctivitis, chronic eyelid edema, and eyelid plaques. Histopathology showed hyperkeratotic epithelium, degeneration of the basal cell layer, and a perivascular lymphocytic infiltrate. There was delayed diagnosis in all cases, ranging from 4 months to 25 years. All of the patients responded to systemic hydroxychloroquine therapy. CONCLUSIONS:Heightened awareness of eyelid DLE may lead to earlier detection and specific therapy for this chronic disorder.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Acharya N,Pineda R 2nd,Uy HS,Foster CSdoi
10.1016/j.ophtha.2005.01.035subject
Has Abstractpub_date
2005-05-01 00:00:00pages
e19-23issue
5eissn
0161-6420issn
1549-4713pii
S0161-6420(05)00278-2journal_volume
112pub_type
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