Abstract:
PURPOSE:Droperidol and the new serotonin-3 antagonists are effective drugs for the prophylaxis of postoperative nausea and vomiting (PONV). The aim of this trial was to evaluate whether dolasetron could be a substitute for droperidol, because the Food and Drug Administration has required a Black Box warning on the droperidol package insert. DESIGN:Randomized, placebo-controlled, double-blinded trial. PARTICIPANTS:Inpatients undergoing vitreoretinal surgery (standard 3-port pars plana vitrectomy for proliferative diabetic vitreoretinopathy, complicated retinal detachment, or macular disease, such as macular pucker, macular hole, or choroidal neovascularization). INTERVENTION:Two hundred forty patients (3x80) receiving droperidol (10 microg. kg(-1)), dolasetron (12.5 mg), or the combination of both drugs administered 5 to 10 minutes before the end of surgery. CONTROL:Eighty patients received saline placebos as controls. METHODS:Standardized general anesthesia was performed, including benzodiazepine premedication, propofol, atracurium or vecuronium, desflurane in N(2)O/O(2), and a continuous infusion of remifentanil. Postoperative analgesia and antiemetic rescue medication were standardized. Episodes of vomiting, retching, nausea, and the need for additional antiemetics were recorded for 24 hours. MAIN OUTCOME MEASURES:Severity of PONV (rated by a standardized scoring algorithm) was analyzed as the main end point of the study using the Kruskal-Wallis test. RESULTS:Data of 304 patients could be analyzed. Mean severity scores in the placebo, dolasetron, droperidol, and combination groups were 1.21, 0.76, 0.47, and 0.30. Incidences of PONV of any severity were 56%, 40%, 28%, and 18%, respectively. The reduction of the incidence of PONV and its severity was statistically significant in the droperidol group and in the combination group relative to the placebo. Dolasetron alone failed to reduce the incidence of PONV. The combination of dolasetron and droperidol showed an additive antiemetic efficacy. CONCLUSION:Low-dose droperidol (10 microg. kg(-1)) but not dolasetron (12.5 mg) reduced postoperative nausea and vomiting after vitreoretinal surgery. Dolasetron (12.5 mg) is not an equivalent substitute for droperidol.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Eberhart LH,Morin AM,Hoerle S,Wulf H,Geldner Gdoi
10.1016/j.ophtha.2004.01.031subject
Has Abstractpub_date
2004-08-01 00:00:00pages
1569-75issue
8eissn
0161-6420issn
1549-4713pii
S0161-6420(04)00520-2journal_volume
111pub_type
临床试验,杂志文章,随机对照试验相关文献
OPHTHALMOLOGY文献大全abstract:PURPOSE:To assess blindness prevalence and that caused specifically by cataract in rural southern China. DESIGN:Population-based, cross-sectional study. PARTICIPANTS:A total of 5342 persons older than 50 years of age. METHODS:Visual acuity and eye examinations were performed in the summer of 1997 in a random sample ...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0161-6420(99)90459-1
更新日期:1999-08-01 00:00:00
abstract::An experience utilizing the carbon dioxide laser for blepharoplasty in a series of 40 patients with an average follow-up of 16 months is reported. The advantages of this method include improved control of intraoperative hemorrhage which occurs because the laser cauterizes small vessels as it cuts tissues. Postoperativ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34305-6
更新日期:1984-03-01 00:00:00
abstract:PURPOSE:To describe the clinical characteristics of spontaneous reattachment of rhegmatogenous retinal detachment (SRRRD). DESIGN:Retrospective observational case series. PARTICIPANTS:Fifteen patients who were diagnosed with SRRRD. METHODS:The medical records of 15 patients were reviewed. Spontaneous reattachment of...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.05.080
更新日期:2007-03-01 00:00:00
abstract::Sixty consecutive eyes that met the standard criteria for cataract surgery underwent phacoemulsification with insertion of a posterior chamber lens implant. The filtration angle of each eye was examined with routine postoperative gonioscopy in a prospective manner. Peripheral anterior synechia (PAS) overlying the posi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(90)32564-2
更新日期:1990-04-01 00:00:00
abstract:PURPOSE:To ascertain operator learning effect, and to quantify the interoperator reproducibility, using the newly introduced GDx VCC (variable corneal compensator) scanning laser polarimeter. DESIGN:Prospective instrument validation study. PARTICIPANTS:Three operators with no prior experience in operating the GDx VCC...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2004.08.013
更新日期:2005-02-01 00:00:00
abstract:PURPOSE:To evaluate treatment of juxtapapillary choroidal melanoma with plaque radiotherapy and to investigate the role of supplemental transpupillary thermotherapy (TTT). DESIGN:Retrospective, comparative case series. PARTICIPANTS:We included 650 consecutive eyes with juxtapapillary choroidal melanoma within 1 mm of...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.06.007
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:To compare the rotational stability of the 2 most commonly used toric intraocular lenses (TIOLs). DESIGN:Retrospective cohort study in a single private practice. SUBJECTS:The study included all patients receiving an Acrysof (n = 626) or Tecnis TIOL (n = 647) over an 18-month period from April 2015 to Septembe...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2018.02.012
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:To identify the prevalence and determinants of self-reported eye care use in Latinos. DESIGN:Population-based ocular epidemiologic study in Latinos aged 40+ years living in La Puente, California. PARTICIPANTS:A total of 5455 participants. METHODS:Univariate, multivariable, and stepwise logistic regression an...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2009.07.015
更新日期:2010-02-01 00:00:00
abstract:PURPOSE:The purpose of the study is to investigate diagnostic criteria and treatment methods for patients with congenital periodic alternating nystagmus (PAN). METHODS:A retrospective analysis was performed of clinical findings and serial eye movement recordings of patients with congenital PAN. Eighteen patients obser...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30206-1
更新日期:1997-06-01 00:00:00
abstract::Radial keratotomy was performed in 33 rabbits using an eight-incision technique. At various postoperative intervals up to 90 days, these eyes were enucleated and subjected to increasing quantitated trauma until ocular rupture occurred. Control animals (13 eyes) were subjected to similar trauma. The eyes that had surge...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(83)34502-4
更新日期:1983-06-01 00:00:00
abstract:OBJECTIVE:To report the first case of gaze-evoked amaurosis secondary to an intraocular foreign body and to highlight the characteristic clinical findings of patients with this symptom. DESIGN:Case report and review of the literature. METHODS:Case review, clinical history, electrophysiologic testing, and follow-up. ...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0161-6420(00)00433-4
更新日期:2001-01-01 00:00:00
abstract::Krabbe's disease is an autosomal recessive leukodystrophy characterized by a lack of galactocerebroside beta-galactosidase activity. In contrast to the classic early infantile-onset form of Krabbe's disease, less recognized, late-onset variants exist. The authors present a case of late juvenile-onset Krabbe's disease,...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(90)32439-9
更新日期:1990-09-01 00:00:00
abstract:PURPOSE:To evaluate the long-term success rate of vitreoretinal surgery for severe cases of retinal capillary hemangiomas (RCHs) caused by von Hippel-Lindau (VHL) disease. DESIGN:Retrospective case series. PARTICIPANTS:Twenty-three eyes of 21 patients with severe exudative or tractional retinal detachment caused by R...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.04.031
更新日期:2011-01-01 00:00:00
abstract::Argon laser intraocular photocoagulation is now available during vitreous surgery, to treat retinal breaks and to give panretinal photocoagulation. Twenty patients, including phakic patients with gas-filled eyes, were treated using a new operative contact lens without complication. This intraoperative technique allows...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(82)34723-5
更新日期:1982-07-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate whether previously failed glaucoma filtration surgery is a risk factor for filtration failure of subsequent trabeculectomy combined with cataract surgery and to determine the role of adjunctive mitomycin C (MMC) in the secondary glaucoma triple procedure (SGTP) as compared to p...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0161-6420(98)94032-5
更新日期:1998-04-01 00:00:00
abstract::Since its description in 1950, numerous surgical techniques have been advocated to treat Brown's superior oblique tendon sheath syndrome. Of these, a tenectomy of the homolateral superior oblique has emerged as the most effective method. However, an iatrogenically produced superior oblique paralysis has been found to ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(82)34787-9
更新日期:1982-04-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of a combination of 5-fluorouracil and low-molecular-weight heparin (LMWH) to improve the outcome of surgery for established proliferative vitreoretinopathy (PVR). DESIGN:Double-masked, prospective, randomized, placebo-controlled clinical trial. SETTING:Three tertiary-referral teac...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2004.05.036
更新日期:2004-12-01 00:00:00
abstract:PURPOSE:To develop a new foveal hypoplasia grading system using optical coherence tomography (OCT) and to determine the correlations of visual acuity to the iris transillumination, macular transparency, and foveal hypoplasia grades, respectively, in young albinism patients. DESIGN:Observational case series. PARTICIPA...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.10.054
更新日期:2007-08-01 00:00:00
abstract:PURPOSE:The Argus I implant is the first-generation epiretinal prosthesis approved for an investigational clinical trial by the United States Food and Drug Administration. Herein we report testing results obtained from a 10-year follow-up to study the physiologic effects of the bioelectronic visual implant after prolon...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2015.08.008
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:To describe the natural history of dry eye disease (DED), which chronically affects millions of people in the United States. DESIGN:This study is based on the Women's Health Study and Physicians' Health Studies, and uses questionnaires and medical records. PARTICIPANTS:A total of 398 men and 386 women who rep...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2015.10.011
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:To investigate the clinical manifestations and ocular findings in children with ocular myasthenia gravis (MG) that rarely have been reported in the literature. DESIGN:Retrospective, noncomparative case series. PARTICIPANTS:Twenty-four consecutive patients less than 15 years of age with ocular MG treated betwe...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00460-3
更新日期:2003-07-01 00:00:00
abstract::The records of 84 patients with functional visual loss (59 adults and 25 children) were reviewed over a six-year period. The patients were between 7 and 69 years of age. In the young patients, psychosocial problems relating to parental divorce, poor school performance and attention-getting behavior were common, while ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and tolerability of a single subconjunctival (SCJ) or intravitreal (IVT) injection of an ophthalmic sirolimus formulation in eyes with diabetic macular edema (DME). DESIGN:Randomized, open-label, dose-escalating phase I study. PARTICIPANTS:Fifty eyes among 50 patients with DME, retina...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2011.07.034
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:This study was undertaken to evaluate the risk of eye injury in motor vehicle accidents in which airbags deploy. An attempt was made to assess the possible associations between eye injuries and eyewear in these accidents. DESIGN:Retrospective observational case series and literature review with analysis. PART...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00244-6
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:To measure accuracy and reliability of the computer-based Retinal Image Multiscale Analysis (RISA) system compared with those of recognized retinopathy of prematurity (ROP) experts, for plus disease diagnosis. DESIGN:Evaluation of diagnostic test or technology. PARTICIPANTS:Eleven recognized ROP experts and...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.10.006
更新日期:2007-12-01 00:00:00
abstract:PURPOSE:This study aimed to quantitate and compare the concentration of vascular endothelial growth factor (VEGF) in aqueous humor samples from patients with neovascular glaucoma (NVG), primary open-angle glaucoma (POAG), and cataract, as well as in serum samples of healthy human subjects. METHODS:The authors collecte...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(98)92782-8
更新日期:1998-02-01 00:00:00
abstract:CASE REPORT:An 85-year-old woman had a bluish tumor medially on the margin of the left upper eyelid. Malignant melanoma of the conjunctiva was presumed; the lesion was excised and submitted for routine histopathologic examination. There are no signs of recurrence or metastatic disease after follow-up for 1 year. METHO...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31412-0
更新日期:1993-11-01 00:00:00
abstract:PURPOSE:A trabeculectomy is frequently combined with extracapsular cataract surgery to minimize the risks of further optic nerve damage associated with intraocular pressure (IOP) elevations after cataract surgery in eyes with glaucoma. Acute IOP elevations still occur after this combined surgery. The author evaluated t...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(93)31603-9
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVES:To determine whether the incidence and severity of retinopathy of prematurity (ROP) differs between infants conceived naturally and those born after assisted conception, and to analyze the impact of singleton versus multiple gestation on ROP. DESIGN:Comparative case series. PARTICIPANTS:The study group con...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.11.010
更新日期:2007-02-01 00:00:00
abstract:PURPOSE:To investigate the adherence of one clinically relevant ocular isolate of Staphylococcus epidermidis to polymethyl methacrylate (PMMA) and Acrysof (Alcon Surgical, Fort Worth, TX) intraocular lenses (IOLs). DESIGN:Experimental study. PARTICIPANTS:The authors examined the in vitro adherence of one clinically r...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00080-4
更新日期:2000-06-01 00:00:00