Abstract：
PURPOSE:This is a pilot study to assess the use of autologous plasmin enzyme (APE) as an adjunct to vitreous surgery in eyes with advanced diabetic retinopathy. DESIGN:Prospective noncomparative interventional case series. PARTICIPANTS:Seven patients with advanced diabetic retinopathy selected at random from our practice population. METHODS:Seven eyes were treated with APE as an adjunct to standard vitreous surgery. Six eyes had macular tractional retinal detachments, and one eye had refractory macular edema. Three fellow eyes had standard vitreous surgery performed for macular tractional retinal detachments without APE. All 10 eyes had macular edema and background diabetic retinopathy. MAIN OUTCOME MEASURES:The main outcome measures included induction of a posterior vitreous detachment, retinal reattachment, improvement in visual acuity, and resolution of macular edema. RESULTS:All seven APE-treated eyes achieved spontaneous or easy removal of the posterior hyaloid including one eye that had vitreoschisis over areas of detached retina. All eyes treated with APE had resolution of intraretinal edema. Retinas of all eyes treated with APE were reattached. The three fellow eyes were treated by vitreous surgery without APE. Two of the three fellow eyes had reattached retinas, but none had resolution of intraretinal edema without further focal photocoagulation treatment. Mean visual acuity improvement was 0.7 logarithm of the minimum angle of resolution (LogMAR) units in APE-treated eyes and 0.1 LogMAR units in eyes without APE. The average follow-up period was 14 months. CONCLUSIONS:This pilot study suggests that APE may be beneficial in the surgical management of diabetic retinopathy.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Williams JG,Trese MT,Williams GA,Hartzer MKdoi
10.1016/s0161-6420(01)00720-5subject
Has Abstractpub_date
2001-10-01 00:00:00pages
1902-5; discussion 1905-6issue
10eissn
0161-6420issn
1549-4713pii
S0161-6420(01)00720-5journal_volume
108pub_type
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