Cataractous changes due to posterior chamber flattening with a posterior chamber phakic intraocular lens secondary to the administration of pilocarpine.


OBJECTIVE:To present the first reported case of cataract formation as a consequence of instillation of pilocarpine in an eye with a posterior chamber phakic intraocular lens (IOL). DESIGN:Interventional case report. INTERVENTION:A 46-year-old man received a hyperopic implantable collamer lens (ICL) bilaterally. MAIN OUTCOME MEASURES:Determination of best-corrected visual acuity (BCVA); contrast sensitivity testing with and without glare; and intraocular pressure (IOP), specular endothelial cell, and slit-lamp examinations were performed serially. In addition, the distance between the ICL and crystalline lens was measured with optical coherence tomography. RESULTS:Both eyes underwent uneventful ICL implantation for the correction of a manifest spherical equivalent of +7 diopters (D) in the right eye and +7.1 D in the left eye. The left eye was followed for 2 years without developing complications. The right eye, however, showed on the first postoperative day a fleckenlike opacification on the anterior pole of the crystalline lens after instillation on the operative day of 2% pilocarpine in an attempt to accelerate recovery from unwanted pupil dilation causing patient complaints of glare disability after surgery. Optical coherence tomography demonstrated complete contact of the ICL with the natural lens 24 hours postoperatively. Serial IOP measurements were always within the normal limits. The instillation of 1% cyclopentolate resulted in an increase in the ICL vault that measured 132 mum 24 hours later. Three days after the completion of a 3-day course of topical 1% cyclopentolate, the opacification was less dense and demarcated, and a 124-mum vault was measured. Three months postoperatively, the cataract was associated with a 3-line loss of BCVA and considerable degradation of the contrast sensitivity, especially at higher spatial frequencies and with a glare source, and corneal endothelial cell changes were within normal limits. One year after ICL implantation, the right eye had to undergo phacoemulsification and IOL implantation, which were uneventful. CONCLUSIONS:Posterior chamber flattening with resulting crystalline lens opacification can occur immediately after the instillation of pilocarpine in an eye with a hyperopic ICL. Therefore, caution should be taken with the administration of cholinergic agonists such as pilocarpine in patients with phakic IOLs, at least if they are hyperopic ICLs.






Maldonado MJ,García-Feijoó J,Benítez Del Castillo JM,Teutsch P




Has Abstract


2006-08-01 00:00:00














  • The Gardner syndrome. Significance of ocular features.

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    pub_type: 杂志文章


    authors: Lewis RA,Crowder WE,Eierman LA,Nussbaum RL,Ferrell RE

    更新日期:1984-08-01 00:00:00

  • Dietary antioxidant intake and incidence of early age-related maculopathy: the Blue Mountains Eye Study.

    abstract:OBJECTIVE:To investigate associations between dietary intake, including modest supplement intake, of antioxidant vitamins and zinc at baseline and the 5-year incidence of early age-related maculopathy (ARM). DESIGN:Population-based cohort study. PARTICIPANTS:From 1992 through 1994, 3654 persons aged 49 years or more ...


    pub_type: 杂志文章


    authors: Flood V,Smith W,Wang JJ,Manzi F,Webb K,Mitchell P

    更新日期:2002-12-01 00:00:00

  • Longitudinal Changes of Optic Nerve Head and Peripapillary Structure during Childhood Myopia Progression on OCT: Boramae Myopia Cohort Study Report 1.

    abstract:PURPOSE:To delineate longitudinal changes in the optic nerve head (ONH) and peripapillary structure during myopia progression in childhood using spectral-domain (SD) OCT and to explore the factors associated with myopic ONH and peripapillary changes. DESIGN:Prospective cohort study. PARTICIPANTS:Twenty-three healthy ...


    pub_type: 杂志文章


    authors: Kim M,Choung HK,Lee KM,Oh S,Kim SH

    更新日期:2018-08-01 00:00:00

  • Globe Axial Length Growth at Age 5 Years in the Infant Aphakia Treatment Study.

    abstract:PURPOSE:To report the longitudinal change in axial length (AL) from the time of unilateral cataract surgery at age 1 to 7 months to age 5 years, and to compare AL growth of operated eyes with that of fellow unoperated eyes. DESIGN:Comparative case series. PARTICIPANTS:Infants enrolled in the Infant Aphakia Treatment ...


    pub_type: 杂志文章


    authors: Wilson ME,Trivedi RH,Weakley DR Jr,Cotsonis GA,Lambert SR,Infant Aphakia Treatment Study Group.

    更新日期:2017-05-01 00:00:00

  • Vascular endothelial growth factor gene and the response to anti-vascular endothelial growth factor treatment for choroidal neovascularization in high myopia.

    abstract:PURPOSE:To investigate the association between the vascular endothelial growth factor (VEGF) gene polymorphism and the response to anti-VEGF treatment for choroidal neovascularization (CNV) in highly myopic eyes. DESIGN:Retrospective cohort study. PARTICIPANTS:A total of 357 unrelated highly myopic Japanese patients ...


    pub_type: 杂志文章


    authors: Miyake M,Yamashiro K,Akagi-Kurashige Y,Kumagai K,Nakata I,Nakanishi H,Oishi A,Tsujikawa A,Yamada R,Matsuda F,Yoshimura N

    更新日期:2014-01-01 00:00:00

  • Evaluation of functional and morphologic parameters of the cornea after epikeratophakia using prelathed, lyophilized tissue.

    abstract::Up to now, the attention of ophthalmic surgeons has been focused mainly on the clinical results of epikeratophakia, demonstrating its safety, relative predictability, and capability of correcting a wide range of refractive errors. However, no prospective study has ever been undertaken to evaluate the influence of epik...


    pub_type: 杂志文章


    authors: Busin M,Spitznas M,Hockwin O

    更新日期:1990-03-01 00:00:00

  • Iontophoresis of fluorescein into the posterior segment of the rabbit eye.

    abstract::Iontophoresis of appreciable quantities of fluorescein into the vitreous body of the rabbit results from the use of a high electrical current density over a limited area of the globe. This is achieved by passing current through the fluorescein when it is held against the region of the ora serrata in a tube less than 1...


    pub_type: 杂志文章


    authors: Maurice DM

    更新日期:1986-01-01 00:00:00

  • A prospective study on the implantation of anterior chamber intraocular lenses during keratoplasty for pseudophakic and aphakic bullous keratopathy.

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    pub_type: 杂志文章


    authors: Zaidman GW,Goldman S

    更新日期:1990-06-01 00:00:00

  • Traumatic hyphema in children. Treatment with epsilon-aminocaproic acid.

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kraft SP,Christianson MD,Crawford JS,Wagman RD,Antoszyk JH

    更新日期:1987-10-01 00:00:00

  • Effects of the CW YAG laser on the human iris and retina.

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    pub_type: 杂志文章


    authors: Peyman GA,Larson B

    更新日期:1984-09-01 00:00:00

  • Conjunctival autograft transplantation for advanced and recurrent pterygium.

    abstract::The technique and results of conjunctival autograft transplantation for advanced and recurrent pterygium are presented for 57 eyes of 54 patients. The pterygia were primary in 16 eyes and recurrent in 41; among the latter group, 14 patients had diplopia resulting from cicatricial involvement of the medial rectus muscl...


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    authors: Kenyon KR,Wagoner MD,Hettinger ME

    更新日期:1985-11-01 00:00:00

  • Five-year experience of the 2-incision push-pull technique for anterior and posterior capsulorrhexis in pediatric cataract surgery.

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    authors: Hamada S,Low S,Walters BC,Nischal KK

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  • Oral acyclovir in the management of herpes simplex ocular infections.

    abstract::Acyclovir, an oral antiviral agent that inhibits viral DNA replication, was used to treat 27 patients (16 males, 11 females) (mean age, 50 years) with vision-threatening herpes simplex virus (HSV) infections. Twenty patients had active stromal keratitis or keratouveitis, four had controlled nonnecrotizing stromal kera...


    pub_type: 杂志文章


    authors: Schwab IR

    更新日期:1988-04-01 00:00:00

  • Prospective intrapatient comparison of 6.0-millimeter optic single-piece and 3-piece hydrophobic acrylic foldable intraocular lenses.

    abstract:PURPOSE:To compare postoperative performance and stability of 6.0-mm optic single- and 3-piece acrylic foldable intraocular lenses (IOLs). DESIGN:Prospective, randomized, self-controlled trial. PARTICIPANTS:Eighty eyes of 40 patients with bilateral senile cataracts. INTERVENTION:Phacoemulsification and IOL implantat...


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    authors: Nejima R,Miyai T,Kataoka Y,Miyata K,Honbou M,Tokunaga T,Kawana K,Kiuchi T,Oshika T

    更新日期:2006-04-01 00:00:00

  • A prospective evaluation of a diffractive versus a refractive designed multifocal intraocular lens.

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Walkow T,Liekfeld A,Anders N,Pham DT,Hartmann C,Wollensak J

    更新日期:1997-09-01 00:00:00

  • Arteriolar occlusive diseases of the macula.

    abstract::Occlusion of retinal precapillary arterioles may be related to vascular endothelial damage, embolization, vasculitis, and other factors. Following acute retinal precapillary arteriolar occlusion in the macular area, inhibition of axoplasmic transport results in the formation of cotton-wool patches. A variable loss of ...


    pub_type: 杂志文章


    authors: Jampol LM

    更新日期:1983-05-01 00:00:00

  • Risk factors, clinical features, and outcomes of recurrent fungal keratitis after corneal transplantation.

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    pub_type: 杂志文章


    authors: Shi W,Wang T,Xie L,Li S,Gao H,Liu J,Li H

    更新日期:2010-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Praeger DL

    更新日期:1979-11-01 00:00:00

  • Follow-up of nonarteritic anterior ischemic optic neuropathy with optical coherence tomography.

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    pub_type: 杂志文章


    authors: Contreras I,Noval S,Rebolleda G,Muñoz-Negrete FJ

    更新日期:2007-12-01 00:00:00

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    pub_type: 杂志文章


    authors: González-Avila G,Lozano D,Manjarrez ME,Ruiz VM,Terán L,Vadillo-Ortega F,Selman M

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  • Long-term follow-up of endothelial cell change after Artisan phakic intraocular lens implantation.

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  • The role of adjunctive mitomycin C in secondary glaucoma triple procedure as compared to primary glaucoma triple procedure.

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    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:1998-04-01 00:00:00

  • Complications associated with aphakic contact lenses.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Shirakashi M,Nanba K,Iwata K

    更新日期:1992-07-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:1978-11-01 00:00:00

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    pub_type: 杂志文章,多中心研究


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    更新日期:1995-11-01 00:00:00

  • Molteno implantation for secondary glaucomas associated with advanced epithelial ingrowth.

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    pub_type: 杂志文章


    authors: Fish LA,Heuer DK,Baerveldt G,Minckler DS,McDonnell PJ

    更新日期:1990-05-01 00:00:00