Abstract:
PURPOSE:To measure the thickness of the precorneal lipid layer and the stability of the precorneal tear film in neonates and infants in the first 6 postnatal months. DESIGN:Prospective, observational case series. PARTICIPANTS:One hundred ninety-eight neonates and infants in the newborn nursery. METHODS:The Keeler Tearscope Plus (Keeler Instruments Inc., Broomall, PA) was used to evaluate lipid layer thickness by interference fringe biomicroscopy and directly to measure noninvasive tear breakup time (NIBUT). The thickness was classified from level 1 (open meshwork-very thin) to level 9 (colored fringe pattern-very thick). MAIN OUTCOME MEASURES:Noninvasive tear breakup time in seconds and classification level of lipid layer thickness. RESULTS:The mean lipid layer classification for all newborns was 8.3 +/- 0.9, with no significant difference between genders. The thickest classifications (levels 8 and 9) were found in 83.3% of all infants. At 3 and 6 postnatal months, all infants studied had a lipid layer classification of 9. Mean NIBUT was 32.5 +/- 5.2 seconds (range, 17.6-48.5 seconds) and was not significantly different whether stratified by race, postconceptional age, or birthweight. However, although NIBUT was longer in males at birth (35.1 +/- 4.2 seconds versus 29.4 +/- 4.5 seconds; P < 0.001), it was equal in both genders at 3 and 6 postnatal months. CONCLUSIONS:In the first 6 postnatal months, the lipid layer of the tear film is much thicker than in adults. The NIBUT in newborns is prolonged compared with adult values. This thick lipid layer in infants provides stability that may help prevent the thin aqueous layer from evaporating.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Isenberg SJ,Del Signore M,Chen A,Wei J,Guillon JPdoi
10.1016/S0161-6420(03)00451-2subject
Has Abstractpub_date
2003-07-01 00:00:00pages
1408-11issue
7eissn
0161-6420issn
1549-4713pii
S0161-6420(03)00451-2journal_volume
110pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract::Preliminary investigations of optimal target distribution patterns of automated perimetry were conducted. In the first study, frequency distributions of visual field defects were determined in glaucoma (260 scotomata) and optic nerve disease (110 scotomata) for approximately 30,000 visual field locations. The frequenc...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)80037-1
更新日期:1981-10-01 00:00:00
abstract:PURPOSE:We compared smartphone fundus photography, nonmydriatic fundus photography, and 7-field mydriatic fundus photography for their abilities to detect and grade diabetic retinopathy (DR). DESIGN:This was a prospective, comparative study of 3 photography modalities. PARTICIPANTS:Diabetic patients (n = 300) were re...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2015.06.011
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To determine the use of indocyanine green (ICG) angiography in detecting choroidal neovascularization obscured by hemorrhage. STUDY/DESIGN: Indocyanine green angiography was performed on 20 consecutive patients who were suspected to have choroidal neovascular membranes (CNVs) that were obscured...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30781-6
更新日期:1995-12-01 00:00:00
abstract:PURPOSE:To evaluate the progression rate of macular and circumpapillary retinal nerve fiber layer (RNFL) thickness in advanced glaucomatous eyes using spectral domain optical coherence tomography (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA). DESIGN:Longitudinal, observational study. PARTICIPANTS:A total of 98 eyes...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2011.08.022
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:To use longitudinal quantitative morphologic and visual acuity (VA) data to investigate the risk of choroidal neovascularization (CNV) event occurrence in eyes with dry age-related macular degeneration (AMD). DESIGN:Prospective observational study. PARTICIPANTS:A total of 513 participants (844 eyes) followed ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.02.048
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:Visual acuity (VA) is the primary outcome measure in many studies involving eye diseases. A standard statistical approach for comparing a continuous measurement such as a VA letter score between 2 treatment groups is to perform a t test comparing the means. However, frequently a binary variable is created from ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.06.047
更新日期:2007-10-01 00:00:00
abstract:PURPOSE:To compare the relation between vertical eyelid fissure height and downgaze in healthy subjects and in patients with Graves upper eyelid retraction and congenital blepharoptosis. METHODS:With a caliper rule, the authors measured the vertical eyelid fissure height of 25 patients with no previous history of eye ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30887-1
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVE:To compare adverse medical events by different anesthesia strategies for cataract surgery. DESIGN:Prospective cohort study. PARTICIPANTS:Patients 50 years of age and older undergoing 19,250 cataract surgeries at nine centers in the United States and Canada between June 1995 and June 1997. INTERVENTION:Loca...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0161-6420(01)00704-7
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:To identify effective methods to increase the number of cataract surgeries in a rural setting in Pucheng County of Shaanxi Province, northwestern China. DESIGN:Community-based randomized interventional study. PARTICIPANTS:Four hundred thirty-two patients 50 years of age or older with operable cataract who had...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2012.07.087
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:To provide an initial assessment of the safety of a recombinant adeno-associated virus vector expressing RPE65 (rAAV2-CB-hRPE65) in adults and children with retinal degeneration caused by RPE65 mutations. DESIGN:Nonrandomized, multicenter clinical trial. PARTICIPANTS:Eight adults and 4 children, 6 to 39 years...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.ophtha.2016.03.003
更新日期:2016-07-01 00:00:00
abstract::Chorioretinitis developed in the right eye of a patient with contact lens-associated Acanthamoeba keratitis in the left eye during an acute exacerbation of the keratitis. This chorioretinitis may have resulted from hematogenous dissemination from his corneal infection. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(88)33143-x
更新日期:1988-05-01 00:00:00
abstract::Sixty-four consecutive patients with aphakic penetrating keratoplasty and penetrating keratoplasty combined with intracapsular cataract extraction were reviewed in a prospective fashion with a minimum of a one-year follow-up. Five were lost to follow-up. There were seven graft failures at the end of one year. Five of ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35187-7
更新日期:1980-07-01 00:00:00
abstract:PURPOSE:This study was undertaken to evaluate the risk of eye injury in motor vehicle accidents in which airbags deploy. An attempt was made to assess the possible associations between eye injuries and eyewear in these accidents. DESIGN:Retrospective observational case series and literature review with analysis. PART...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00244-6
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:To estimate the psychometric properties of a vision-targeted measure of health-related quality of life, the National Eye Institute-Refractive Error Quality of Life survey (NEI-RQL), which includes 13 scales designed to assess the impact of refractive error and its correction on day-to-day life. DESIGN:Cross-...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2002.07.001
更新日期:2003-12-01 00:00:00
abstract::Taping the superior aspect of patient masks qualitatively decreases air flow and bacterial dispersion towards the ocular surface while inappropriately worn masks both qualitatively and quantitatively increase bacterial dispersion towards the ocular surface. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2021.01.007
更新日期:2021-01-11 00:00:00
abstract:OBJECTIVE:To report the effects of intravenous immunoglobulin treatment of ten patients with progressive ocular cicatricial pemphigoid who did not respond to conventional immunomodulatory regimens. DESIGN:Noncomparative, interventional case series. PARTICIPANTS:Ten patients with biopsy-proven progressive cicatricial ...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/S0161-6420(99)90496-7
更新日期:1999-11-01 00:00:00
abstract:PURPOSE:To prospectively examine the change in upper eyelid position on downgaze in patients with blepharoptosis. METHODS:Upper eyelid margin to corneal light reflex distance (uMRD) was measured in primary gaze and in 30 degrees to 40 degrees downgaze in 50 consecutive patients with acquired ptosis and 10 consecutive ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30837-8
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Anterior chamber and iris-plane intraocular lenses (IOLs) have been implicated in causing corneal endothelial damage and progression to pseudophakic bullous keratopathy. METHODS:The authors performed IOL exchanges on 102 eyes with signs of early corneal decompensation or progressive endothelial cell loss as...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31637-4
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Oral trans-retinoic acid has recently been shown to be an effective treatment modality for acute promyelocytic leukemia. This type of drug differs from traditional tumoricidal agents by promoting differentiation of the malignant, immature cells. METHODS:The authors describe a patient with optic nerve infilt...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31783-x
更新日期:1992-09-01 00:00:00
abstract:PURPOSE:Ophthalmologic telemedicine has the ability to provide eye care for patients remotely, and many countries have used screening tele-ophthalmology programs for several years. One such initiative at the Veterans Affairs (VA) Healthcare System is Technology-based Eye Care Services (TECS). The TECS services are loca...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2019.07.026
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:The Specular Microscopy Ancillary Study was designed to examine donor corneal endothelial specular image quality, compare the central endothelial cell density determined by eye banks with the endothelial cell density determined by a central specular microscopy reading center, and evaluate donor factors that may...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2004.10.045
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:En bloc perfluorodissection (EBPD) is a surgical dissection technique that facilitates removal of epiretinal membranes and the posterior hyaloid. It is carried out by injecting perfluorocarbon liquid between the retina and the posterior hyaloid to separate the epiretinal tissues from the subjacent retina. The...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.02.008
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To report 3 patients with type I osteogenesis imperfecta (OI) who developed retinal hemorrhages and subdural hematomas after minor trauma. DESIGN:Observational case series. METHOD:Children with OI who developed retinal hemorrhages after minor trauma were identified through an international e-mail-based mail...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2003.10.028
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:To evaluate photodynamic therapy (PDT) for symptomatic circumscribed choroidal hemangioma (CCH). DESIGN:Prospective, multicenter, nonrandomized clinical trial. PARTICIPANTS:Thirty-one eyes of 31 patients with posterior pole CCH and symptoms caused by exudation into the macular area. INTERVENTION:Photodynamic...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2008.08.029
更新日期:2009-01-01 00:00:00
abstract::The authors examined 11 young adult, moderately myopic female patients who presented with visual loss secondary to a newly described disorder consisting of multiple small discrete lesions at the level of the retinal pigment epithelium and choriocapillaris. The condition appears to be inflammatory and occurs primarily ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33611-x
更新日期:1986-09-01 00:00:00
abstract:PURPOSE:To determine the risks for altered cytogenetic profile based on melanoma features and size. DESIGN:Retrospective case series. PARTICIPANTS:A total of 1059 patients with uveal melanoma. METHODS:Fine-needle aspiration biopsy (FNAB) of tumor for DNA amplification and whole genome array-based assay. MAIN OUTCOM...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.12.026
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:The purpose of the study is to delineate the visual prognosticators in sarcoid-associated uveitis given the current standards of care. METHODS:The records of 60 patients with sarcoid-associated uveitis who were observed for at least 6 months were studied retrospectively. Multivariate regression models using th...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(96)30417-x
更新日期:1996-11-01 00:00:00
abstract::Fifty-eight patients with keratitis sicca were enrolled in a long-term study to test the effectiveness of slow-release artificial tears (SRAT). The average follow up period of 39 weeks, with a range of 9 to 136 weeks. Forty-six (79%) are still being followed. Almost all of these patients have had marked relief from th...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)35074-x
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship of HLA status and autoantibodies to glutamic acid decarboxylase (GAD) in proliferative diabetic retinopathy (PDR) to assess the role of autoimmunity and genetic markers in retinopathy. DESIGN:Retrospective, nonrandomized, comparative study. PARTICIPANTS:Patients who had suffe...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.05.016
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:The purpose of the study was to determine the nature and course of ophthalmic abnormalities in long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency, a recently discovered disorder of mitochondrial fatty acid beta-oxidation. STUDY DESIGN:The study design was a cohort (case series). PARTICIPANTS:A re...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(98)95019-9
更新日期:1998-05-01 00:00:00