Acute promyelocytic infiltration of the optic nerve treated by oral trans-retinoic acid.

Abstract:

BACKGROUND:Oral trans-retinoic acid has recently been shown to be an effective treatment modality for acute promyelocytic leukemia. This type of drug differs from traditional tumoricidal agents by promoting differentiation of the malignant, immature cells. METHODS:The authors describe a patient with optic nerve infiltration by acute promyelocytic leukemia documented ophthalmoscopically and confirmed by standardized echography and magnetic resonance imaging. High-resolution chromosome banding revealed the patient had a 15;17 chromosomal translocation known to be associated with acute promyelocytic leukemia. Treatment was instituted with oral all trans-retinoic acid without adjuvant radiotherapy or intrathecal chemotherapy. RESULTS:Results of serial bone marrow examination showed progressive differentiation of malignant cells with complete bone marrow remission. Results of serial ophthalmic examinations showed complete resolution of the leukemic optic nerve head infiltration. CONCLUSION:All trans-retinoic acid alone can be an effective treatment for optic nerve head infiltration in acute promyelocytic leukemia. This case suggests that radiation therapy may not be necessary in acute promyelocytic leukemia with optic nerve infiltration.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Brown DM,Kimura AE,Ossoinig KC,Weiner GJ

doi

10.1016/s0161-6420(92)31783-x

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

1463-7

issue

9

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(92)31783-X

journal_volume

99

pub_type

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