Prospective clinical trial evaluating the efficacy of photodynamic therapy for symptomatic circumscribed choroidal hemangioma.


PURPOSE:To evaluate photodynamic therapy (PDT) for symptomatic circumscribed choroidal hemangioma (CCH). DESIGN:Prospective, multicenter, nonrandomized clinical trial. PARTICIPANTS:Thirty-one eyes of 31 patients with posterior pole CCH and symptoms caused by exudation into the macular area. INTERVENTION:Photodynamic therapy was applied by Zeiss laser. Intravenous verteporfin at 6 mg/m(2) body surface was administered before treatment, and light emitted at 689 nm for photosensitization. The treatment spot diameter was calculated on early-phase frames of pretreatment indocyanine green angiography. Fifteen minutes after starting the verteporfin infusion, the laser beam was applied to the retina at radiant exposure 50 J/cm(2) and exposure time 83 seconds. One to 4 treatments were applied at 12-week intervals over 1 year. Standardized evaluation was performed before and at 4-week intervals after each treatment, and at 3, 6, 9, and 12 months. All patients were followed for >or=12 months. MAIN OUTCOME MEASURES:The primary outcome measure was the absence of exudative retinal detachment at the 12-month follow-up visit on ophthalmoscopy, fluorescein angiography, and optical coherence tomography. Secondary measures were the visual acuity outcome, with best-corrected visual acuity determined by the Early Treatment for Diabetic Retinopathy Study chart, tumor thickness decrease on B-scan ultrasonography, and adverse events. RESULTS:Among the total, 82.8% of patients required 1, 13.8% 2, and 3.4% 3 PDTs to eliminate exudative retinal detachment. Visual acuity increased from a mean of 20/60 to 20/35 (P<0.001). Sixty-nine percent of patients demonstrated visual recovery (P<0.001). Cystoid macular edema regressed in all cases and exudative macular detachment disappeared in all but 2 cases. The CCH thickness decreased in all cases from a mean of 3.0 to 1.7 mm, with the most intense effect seen after 4 weeks of treatment (P<0.001). Visual fields showed resolution of central scotomas. There were no severe adverse events. CONCLUSIONS:Combining PDT with the standard age-related macular degeneration protocol is an effective treatment for CCH in terms of resolution of exudative subretinal fluid and recovery of VA. FINANCIAL DISCLOSURE(S):The authors have no proprietary or commercial interest in any materials discussed in this article.






Boixadera A,García-Arumí J,Martínez-Castillo V,Encinas JL,Elizalde J,Blanco-Mateos G,Caminal J,Capeans C,Armada F,Navea A,Olea JL




Has Abstract


2009-01-01 00:00:00














  • Intraocular lymphoma. Clinical and histopathologic diagnosis.

    abstract:BACKGROUND:Intraocular lymphoma is associated with significant morbidity and mortality, but early diagnosis and treatment may improve prognosis. METHODS:The diagnostic features of 12 cases of intraocular lymphoma diagnosed at the National Eye Institute between 1984 and 1992 were retrospectively reviewed. RESULTS:A pa...


    pub_type: 杂志文章


    authors: Whitcup SM,de Smet MD,Rubin BI,Palestine AG,Martin DF,Burnier M Jr,Chan CC,Nussenblatt RB

    更新日期:1993-09-01 00:00:00

  • Adjuvant Sunitinib in High-Risk Patients with Uveal Melanoma: Comparison with Institutional Controls.

    abstract:PURPOSE:To compare overall survival in high-risk patients with primary uveal melanoma who received adjuvant sunitinib with institutional controls. DESIGN:Retrospective cohort. PARTICIPANTS:Selection criteria were (1) monosomy 3 and 8q amplification by cytogenetic or DecisionDx-UM Class 2 and (2) monosomy 3 and large ...


    pub_type: 杂志文章


    authors: Valsecchi ME,Orloff M,Sato R,Chervoneva I,Shields CL,Shields JA,Mastrangelo MJ,Sato T

    更新日期:2018-02-01 00:00:00

  • Increased level of vascular endothelial growth factor in aqueous humor of patients with neovascular glaucoma.

    abstract:PURPOSE:This study aimed to quantitate and compare the concentration of vascular endothelial growth factor (VEGF) in aqueous humor samples from patients with neovascular glaucoma (NVG), primary open-angle glaucoma (POAG), and cataract, as well as in serum samples of healthy human subjects. METHODS:The authors collecte...


    pub_type: 杂志文章


    authors: Tripathi RC,Li J,Tripathi BJ,Chalam KV,Adamis AP

    更新日期:1998-02-01 00:00:00

  • Surgical outcomes in patients with bilateral ptosis and Hering's dependence.

    abstract:PURPOSE:To assess whether sequential or simultaneous ptosis repair yields a better postoperative outcome in patients with documented preoperative Hering's dependency. DESIGN:Retrospective, case-control study. PARTICIPANTS AND CONTROLS:Of the 216 patients who underwent bilateral ptosis surgery, 109 patients with docum...


    pub_type: 杂志文章


    authors: Cetinkaya A,Kersten RC

    更新日期:2012-02-01 00:00:00

  • Ocular Whipple's disease: therapeutic strategy and long-term follow-up.

    abstract:OBJECTIVE:To characterize the clinical features of ocular Whipple's disease (WD) and determine the long-term prognosis after antibiotic treatment. DESIGN:Retrospective case series. PARTICIPANTS:Medical records of patients referred between January 1993 and December 2010 were reviewed for chronic corticosteroid-resista...


    pub_type: 杂志文章


    authors: Touitou V,Fenollar F,Cassoux N,Merle-Beral H,LeHoang P,Amoura Z,Drancourt M,Bodaghi B

    更新日期:2012-07-01 00:00:00

  • Prevalence of open-angle glaucoma in Australia. The Blue Mountains Eye Study.

    abstract:PURPOSE:The purpose of this study was to determine the prevalence of open-angle glaucoma and ocular hypertension in an Australian community whose residents are 49 years of age or older. SUBJECTS:There were 3654 persons, representing 82.4% of permanent residents from an area west of Sydney, Australia, who were examined...


    pub_type: 杂志文章


    authors: Mitchell P,Smith W,Attebo K,Healey PR

    更新日期:1996-10-01 00:00:00

  • Contact lens induced keratopathy: a severe complication extending the spectrum of keratoconjunctivitis in contact lens wearers.

    abstract::A 21-year-old woman developed bilateral keratoconjunctivitis from contact lens wear, which progressed to diffuse corneal scarring and vascularization after the patient refused to discontinue wearing contact lenses. The visual disturbance became so severe that a penetrating keratoplasty had to be performed in one eye f...


    pub_type: 杂志文章


    authors: Bloomfield SE,Jakobiec FA,Theodore FH

    更新日期:1984-03-01 00:00:00

  • Relationship between ganglion cell layer thickness and estimated retinal ganglion cell counts in the glaucomatous macula.

    abstract:PURPOSE:To investigate the relationship between macular ganglion cell-inner plexiform layer (mGCIPL) thickness and estimated macular retinal ganglion cell (RGC) counts in glaucoma. DESIGN:Observational cohort study. PARTICIPANTS:Cross-sectional study of 77 healthy, 154 glaucoma suspect, and 159 glaucomatous eyes from...


    pub_type: 杂志文章


    authors: Zhang C,Tatham AJ,Weinreb RN,Zangwill LM,Yang Z,Zhang JZ,Medeiros FA

    更新日期:2014-12-01 00:00:00

  • 24-hour intraocular pressure control with maximum medical therapy compared with surgery in patients with advanced open-angle glaucoma.

    abstract:PURPOSE:The purpose of this study was to evaluate 24-hour intraocular pressure (IOP) control in patients with moderate to severe open-angle glaucoma treated by trabeculectomy and mitomycin C versus maximum tolerated medical therapy. DESIGN:Prospective observational study. PARTICIPANTS:Thirty surgical patients and 30 ...


    pub_type: 临床试验,杂志文章


    authors: Konstas AG,Topouzis F,Leliopoulou O,Pappas T,Georgiadis N,Jenkins JN,Stewart WC

    更新日期:2006-05-01 00:00:00

  • Phakic anterior chamber lenses for the correction of myopia: a 7-year cumulative analysis of complications in 263 cases.

    abstract:OBJECTIVE:To perform a prospective, clinical trial to determine the potential cumulative complications of patients implanted with angle-supported phakic intraocular lenses (PIOLs) for the correction of myopia. DESIGN:Nonrandomized, prospective, comparative trial. PARTICIPANTS:Two hundred sixty-three eyes of 160 conse...


    pub_type: 临床试验,杂志文章


    authors: Alió JL,de la Hoz F,Pérez-Santonja JJ,Ruiz-Moreno JM,Quesada JA

    更新日期:1999-03-01 00:00:00

  • Hydrogel intracorneal inlays for the correction of hyperopia: outcomes and complications after 5 years of follow-up.

    abstract:PURPOSE:To evaluate safety and efficacy of an intracorneal inlay for the correction of hyperopia. DESIGN:A prospective, nonrandomized, noncomparative, 2-center study. PARTICIPANTS:Thirty-four hyperopic eyes were implanted with a hydrogel intracorneal inlay (Permavision, Anamed, Lake Forest, CA). Preoperative hyperopi...


    pub_type: 杂志文章,多中心研究


    authors: Mulet ME,Alio JL,Knorz MC

    更新日期:2009-08-01 00:00:00

  • Influence of the vitreomacular interface on outcomes of ranibizumab therapy in neovascular age-related macular degeneration.

    abstract:PURPOSE:To investigate the influence of the vitreomacular interface (VMI) on the functional and anatomic efficacy of ranibizumab therapy in patients with neovascular age-related macular degeneration (AMD). DESIGN:Subanalysis of a prospective, 12-month, multicenter, phase IIIb trial. PARTICIPANTS:A total of 353 treatm...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Mayr-Sponer U,Waldstein SM,Kundi M,Ritter M,Golbaz I,Heiling U,Papp A,Simader C,Schmidt-Erfurth U

    更新日期:2013-12-01 00:00:00

  • Enophthalmos: a clinical review.

    abstract::Twenty-six cases of enophthalmos were reviewed. The causes in order of frequency were: orbital asymmetry (8); trauma (5); orbital metastasis (4); microphthalmos (2); orbital varix (2); maxillary mucocele (2); localized scleroderma (1); absence of sphenoid wing (neurofibromatosis) (1); post irradiation atrophy (1). Onl...


    pub_type: 杂志文章


    authors: Cline RA,Rootman J

    更新日期:1984-03-01 00:00:00

  • Leber's hereditary optic neuropathy. Clinical manifestations of the 15257 mutation.

    abstract:BACKGROUND:Leber's hereditary optic neuropathy is associated with four known pathogenetic mutations of mitochondrial DNA (mtDNA) at nucleotide positions (np) 11778, 3460, 15257, and 14484. METHODS:The authors collected clinical data from 12 visually symptomatic patients from seven different pedigrees with the 15257 mu...


    pub_type: 杂志文章


    authors: Johns DR,Smith KH,Savino PJ,Miller NR

    更新日期:1993-07-01 00:00:00

  • Corneal topographic changes after radial keratotomy.

    abstract::A high resolution photokeratoscope using digital video image acquisition and computer graphics was used to describe anterior corneal topography before and after radial keratotomy. After radial keratotomy, the entire cornea is flattened, but this effect is more pronounced centrally. The flat central "optical zone" vari...


    pub_type: 杂志文章


    authors: McDonnell PJ,Garbus J

    更新日期:1989-01-01 00:00:00

  • Long-term effects of tocilizumab therapy for refractory uveitis-related macular edema.

    abstract:OBJECTIVE:To report the long-term efficacy and safety of the interleukin-6 receptor antagonist tocilizumab for refractory uveitis-related macular edema (ME). DESIGN:Retrospective cohort study. PARTICIPANTS:Eyes with uveitis seen at a single tertiary referral center for which ME was the principal cause of reduced visu...


    pub_type: 杂志文章


    authors: Mesquida M,Molins B,Llorenç V,Sainz de la Maza M,Adán A

    更新日期:2014-12-01 00:00:00

  • In vivo laser confocal microscopy findings for Bowman's layer dystrophies (Thiel-Behnke and Reis-Bücklers corneal dystrophies).

    abstract:OBJECTIVE:To investigate microstructures in patients with genetically confirmed Bowman's layer dystrophies (Thiel-Behnke or Reis-Bücklers corneal dystrophy) using an in vivo laser scanning confocal microscope. DESIGN:Single-center, prospective, comparative small case series. PARTICIPANTS:Two patients from one pedigre...


    pub_type: 杂志文章


    authors: Kobayashi A,Sugiyama K

    更新日期:2007-01-01 00:00:00

  • An ultrastructural study of corneal incisions induced by an excimer laser at 193 nm.

    abstract::Far ultraviolet light (193 nm) produced by an excimer laser has been used to produce a variety of incisions in the corneas of anaesthetised rabbits. Tissue was lost from the site of irradiation but the nature of the underlying molecular interactions responsible for such tissue erosion remain obscure. Ultrastructural a...


    pub_type: 杂志文章


    authors: Marshall J,Trokel S,Rothery S,Schubert H

    更新日期:1985-06-01 00:00:00

  • Structure and clinical significance of central optic disc pits.

    abstract:OBJECTIVE:To assess the structure of central optic disc pits (ODPs) using enhanced-depth imaging optical coherence tomography (EDI OCT) and to ascertain their clinical significance. DESIGN:Prospective, cross-sectional study. PARTICIPANTS:Patients with an ophthalmoscopically visible central ODP in either eye, irrespec...


    pub_type: 杂志文章


    authors: Qayum S,Sullivan T,Park SC,Merchant K,Banik R,Liebmann JM,Ritch R

    更新日期:2013-07-01 00:00:00

  • Cost-Utility of Evaluation for Posterior Vitreous Detachment and Prophylaxis of Retinal Detachment.

    abstract:PURPOSE:To evaluate the costs and cost-utility of examination for posterior vitreous detachment (PVD) and treatment of associated pathology, and of managing various other peripheral retinal disorders to prevent retinal detachment (RD). DESIGN:A decision analysis model of cost-utility. PARTICIPANTS:There were no parti...


    pub_type: 杂志文章,多中心研究


    authors: Yannuzzi NA,Chang JS,Brown GC,Smiddy WE

    更新日期:2018-01-01 00:00:00

  • Vertical diplopia and ptosis from removal of the orbital roof in pterional craniotomy.

    abstract:PURPOSE:To describe a newly recognized clinical syndrome consisting of ptosis, diplopia, vertical gaze limitation, and abduction weakness that can occur after orbital roof removal during orbito-zygomatic-pterional craniotomy. DESIGN:Case series. PARTICIPANTS:Eight study patients (7 women), 44 to 80 years of age, with...


    pub_type: 杂志文章


    authors: Desai SJ,Lawton MT,McDermott MW,Horton JC

    更新日期:2015-03-01 00:00:00

  • Mechanisms of maculopathy.

    abstract::This article will review the cellular constituents of the macula and speculate on their contribution to the pathogenesis of macular disease. The retinal pigment epithelium (RPE) has been implicated in senile macular degeneration (SMD). Over time, RPE dysfunction and death may result from the cumulative effect of light...


    pub_type: 杂志文章


    authors: Eagle RC Jr

    更新日期:1984-06-01 00:00:00

  • Costs of refractive correction of distance vision impairment in the United States, 1999-2002.

    abstract:OBJECTIVE:Correctable vision impairment caused by refractive error is common in the United States population. We estimated the direct costs of providing eyeglasses to all Americans (age> or =12) who need refractive correction to achieve good distance vision. DESIGN:Cross-sectional study of a nationally representative ...


    pub_type: 杂志文章


    authors: Vitale S,Cotch MF,Sperduto R,Ellwein L

    更新日期:2006-12-01 00:00:00

  • Negative predictive value of a population-based preschool vision screening program.

    abstract:BACKGROUND:The Enhanced Vision Screening Program is a population-based vision screening program that has, at present, examined 59,782 children. Its main goal is to detect amblyopia, strabismus, and high refractive errors. An average of 11,910 4 1/2- to 5 1/2-year-old children are screened yearly. The current study dete...


    pub_type: 杂志文章


    authors: De Becker I,MacPherson HJ,LaRoche GR,Braunstein J,Cottle R,McIntyre LL,Kozousek V

    更新日期:1992-06-01 00:00:00

  • The axial length/disc area ratio in anisometropic hyperopic amblyopia: a hypothesis for decreased unilateral vision associated with hyperopic anisometropia.

    abstract:OBJECTIVE:Hyperopic anisometropia is a risk factor for amblyopia. Disc areas and axial lengths are reduced in amblyopic eyes. This study's aim was to investigate the differences in the relative size of the optic disc in 5 groups of eyes: (1) normal right eyes; (2) smaller eyes of nonamblyopic, anisometropic, bilateral ...


    pub_type: 杂志文章


    authors: Lempert P

    更新日期:2004-02-01 00:00:00

  • Retinal detachments and topical ocular miotics.

    abstract::There is increasing suspicion that topical ocular miotic therapy in selected persons may precipitate retinal detachments. This is a rare event and probably does not occur in patients free of retinal pathology. Data supporting a possible cause and effect relationship, obtained from the National Registry of Drug-Induced...


    pub_type: 杂志文章


    authors: Beasley H,Fraunfelder FT

    更新日期:1979-01-01 00:00:00

  • Differences in clinical findings between Caucasians and African Americans with biopsy-proven sarcoidosis.

    abstract:OBJECTIVE:To study the prevalence of ocular manifestations in African American and Caucasian patients with biopsy-proven sarcoidosis at the initial ophthalmic examination and to determine the relationship between angiotensin-converting enzyme (ACE) levels, chest x-ray findings, and ocular signs of sarcoidosis. DESIGN:...


    pub_type: 杂志文章


    authors: Evans M,Sharma O,LaBree L,Smith RE,Rao NA

    更新日期:2007-02-01 00:00:00

  • Results of buccal mucosal grafting for patients with medically controlled ocular cicatricial pemphigoid.

    abstract::Eyelid surgery for patients with ocular cicatricial pemphigoid is risky when there is unchecked perioperative inflammation. The authors performed buccal mucosal grafts on 42 eyelids (23 eyes) of 17 patients with ocular cicatricial pemphigoid whose disease was controlled by systemic immunosuppression. Results were grad...


    pub_type: 杂志文章


    authors: Shore JW,Foster CS,Westfall CT,Rubin PA

    更新日期:1992-03-01 00:00:00

  • The Ocular Surface Frailty Index as a Predictor of Ocular Surface Symptom Onset after Cataract Surgery.

    abstract:PURPOSE:The identification of healthy persons more susceptible to dry eye (DED) symptoms developing after surgery remains an unmet need. We performed this study to build a new Ocular Surface Frailty Index (OSFI) and assess its predictive value for DED symptom onset after cataract surgery. DESIGN:Single-center, observa...


    pub_type: 杂志文章


    authors: Villani E,Marelli L,Bonsignore F,Lucentini S,Luccarelli S,Sacchi M,Serafino M,Nucci P

    更新日期:2020-07-01 00:00:00

  • High-dose (2000-microgram) intravitreous ganciclovir in the treatment of cytomegalovirus retinitis.

    abstract:OBJECTIVE:The authors prospectively studied visual outcome, relapse, complications, and survival of patients with acquired immune deficiency syndrome (AIDS)-related cytomegalovirus (CMV) treated with high-dose intravitreous ganciclovir (2 mg/0.1 ml) injections. The outcomes were compared with those of patients treated ...


    pub_type: 杂志文章


    authors: Young S,Morlet N,Besen G,Wiley CA,Jones P,Gold J,Li Y,Freeman WR,Coroneo MT

    更新日期:1998-08-01 00:00:00