Capnocytophaga keratitis. A clinicopathologic study of three patients, including electron microscopic observations.


BACKGROUND:Histopathologic studies of this unusual keratitis caused by Capnocytophaga species have not been reported previously. METHODS:The authors report the light microscopic and ultrastructural findings of three patients with a distinctive necrotizing keratitis caused by an anaerobic gram-negative bacillus. In three patients, ages 19, 81, and 91 years, a necrotizing stromal keratitis developed; two of these patients had a previous penetrating keratoplasty for pseudophakic bullous keratopathy. The first patient did not have ocular surgery previously and was treated initially for presumed Acanthamoeba keratitis. RESULTS:By light microscopy, all three keratectomy specimens were strikingly similar and showed a necrotizing and/or suppurative stromal keratitis displaying myriad slender, fusiform, gram-negative bacilli located anterior to Descemet's membrane and extending into the deep corneal stroma, assuming a "picket fence" appearance. Cultures of the cornea in case 1 grew Capnocytophaga ochracea. For the remaining two patients, a diagnosis presumptively was made based on characteristic histopathologic features. Results of electron microscopic examination showed numerous bacilli that were mostly extracellular; occasional organisms were phagocytosed by macrophages. CONCLUSION:The histopathologic features of Capnocytophaga keratitis are unique; therefore, a presumptive diagnosis can be made based on the morphology and location of the bacilli in the keratectomy specimens. To the authors' knowledge, this is the first study describing the typical histopathologic and electron microscopic findings of Capnocytophaga keratitis.






Font RL,Jay V,Misra RP,Jones DB,Wilhelmus KR




Has Abstract


1994-12-01 00:00:00














  • Management of dislocated lens fragments during phacoemulsification.

    abstract:BACKGROUND:Dislocation of nuclear lens fragments during phacoemulsification can lead to a high incidence of glaucoma, uveitis, and poor visual acuity. The correct approach to these patients is uncertain. The authors report on eight patients who underwent pars plana vitrectomy with removal of lens fragments. METHODS:Ch...


    pub_type: 杂志文章


    authors: Lambrou FH Jr,Stewart MW

    更新日期:1992-08-01 00:00:00

  • Effect of hinged lamellar keratotomy on postkeratoplasty eyes.

    abstract:PURPOSE:To evaluate the effect of a hinged lamellar keratotomy on refraction, vision, and corneal topography of postkeratoplasty eyes with high-degree astigmatism. DESIGN:Noncomparative, interventional case series. PARTICIPANTS:A hinged lamellar keratotomy was performed on nine eyes of nine patients at least 9 months...


    pub_type: 杂志文章


    authors: Busin M,Arffa RC,Zambianchi L,Lamberti G,Sebastiani A

    更新日期:2001-10-01 00:00:00

  • Anterior shift of zonular insertion onto the anterior surface of human crystalline lens with age.

    abstract:OBJECTIVE:This study aimed to investigate the age-related changes in the position of zonular insertion onto the anterior lens capsule. DESIGN:The study design was an experimental cadaveric eye study. PARTICIPANTS:Two hundred twenty-three cadaveric eyes (range, 16-100 years old) from eye banks in the United States wer...


    pub_type: 杂志文章


    authors: Sakabe I,Oshika T,Lim SJ,Apple DJ

    更新日期:1998-02-01 00:00:00

  • Long-term follow-up of idiopathic central serous chorioretinopathy by fluorescein angiography.

    abstract::Idiopathic central serous chorioretinopathy (ICSC) is typically described as a self-limited, unilateral disease that affects healthy, young adult males. The authors studied 13 patients (14 eyes) who had documented spontaneous resolution of symptomatic macular detachments. These patients were evaluated in a longitudina...


    pub_type: 杂志文章


    authors: Levine R,Brucker AJ,Robinson F

    更新日期:1989-06-01 00:00:00

  • Retinal crystals in type 2 idiopathic macular telangiectasia.

    abstract:PURPOSE:To characterize the phenotype and investigate the associations of intraretinal crystalline deposits in a large cohort with type 2 idiopathic macular telangiectasia (MacTel). DESIGN:Case-control study. PARTICIPANTS:Patients with and without retinal crystals from the Macular Telangiectasia Project, an internati...


    pub_type: 杂志文章,多中心研究


    authors: Sallo FB,Leung I,Chung M,Wolf-Schnurrbusch UE,Dubra A,Williams DR,Clemons T,Pauleikhoff D,Bird AC,Peto T,MacTel Study Group.

    更新日期:2011-12-01 00:00:00

  • The Endophthalmitis Vitrectomy Study. Relationship between clinical presentation and microbiologic spectrum.

    abstract:PURPOSE:The authors determine if specific features of the clinical presentation of acute postoperative endophthalmitis correlated with the microbiologic culture results. METHODS:A total of 420 patients who had clinical evidence of endophthalmitis within 6 weeks after cataract surgery or secondary intraocular lens impl...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Johnson MW,Doft BH,Kelsey SF,Barza M,Wilson LA,Barr CC,Wisniewski SR

    更新日期:1997-02-01 00:00:00

  • Genetic and Dietary Factors Influencing the Progression of Nuclear Cataract.

    abstract:PURPOSE:To determine the heritability of nuclear cataract progression and to explore prospectively the effect of dietary micronutrients on the progression of nuclear cataract. DESIGN:Prospective cohort study. PARTICIPANTS:Cross-sectional nuclear cataract and dietary measurements were available for 2054 white female t...


    pub_type: 杂志文章


    authors: Yonova-Doing E,Forkin ZA,Hysi PG,Williams KM,Spector TD,Gilbert CE,Hammond CJ

    更新日期:2016-06-01 00:00:00

  • Profiles of Ganglion Cell-Inner Plexiform Layer Thickness in a Multi-Ethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study.

    abstract:PURPOSE:To examine the normative profile and determinants of macular ganglion cell-inner plexiform layer (GCIPL) thickness based on spectral-domain OCT (SD-OCT) in a nonglaucoma, multi-ethnic Asian population. DESIGN:Population-based, cross-sectional study. PARTICIPANTS:Ethnic Chinese, Malay, and Indian adults aged ≥...


    pub_type: 杂志文章,多中心研究


    authors: Tham YC,Chee ML,Dai W,Lim ZW,Majithia S,Siantar R,Thakur S,Rim T,Cheung CY,Sabanayagam C,Aung T,Wong TY,Cheng CY

    更新日期:2020-08-01 00:00:00

  • Microscope-induced retinal phototoxicity in cataract surgery of short duration.

    abstract:OBJECTIVE:Microscope-induced retinal phototoxicity has been described after prolonged cataract surgery, usually in operations lasting longer than 100 minutes. The purpose of this study was to compare the features of microscope-induced retinal phototoxicity occurring in patients who underwent cataract surgery of short d...


    pub_type: 临床试验,杂志文章


    authors: Kleinmann G,Hoffman P,Schechtman E,Pollack A

    更新日期:2002-02-01 00:00:00

  • Computer-assisted, interactive fundus image processing for macular drusen quantitation.

    abstract:PURPOSE:To design and validate a software package to quantitate the area subtended by drusen in color fundus photographs for the conduct of efficient, accurate clinical trials in age-related macular degeneration. DESIGN:Algorithm and software development. Comparisons with manual methodologies. PARTICIPANTS:Evaluation...


    pub_type: 临床试验,杂志文章


    authors: Shin DS,Javornik NB,Berger JW

    更新日期:1999-06-01 00:00:00

  • Comparison of intraocular lens power calculation formulae in pediatric eyes.

    abstract:PURPOSE:To evaluate accuracy of intraocular lens (IOL) power calculation formulae (SRK II, SRK/T, Holladay 1, Hoffer Q) in pediatric eyes. DESIGN:Retrospective case series. PARTICIPANTS:One hundred thirty-five eyes of 96 children with congenital, developmental, or acquired cataracts who underwent uncomplicated catara...


    pub_type: 杂志文章


    authors: Nihalani BR,VanderVeen DK

    更新日期:2010-08-01 00:00:00

  • Autologous Serum-Based Eye Drops for Treatment of Ocular Surface Disease: A Report by the American Academy of Ophthalmology.

    abstract:PURPOSE:To describe the safety and effectiveness of using autologous serum-based eye drops for the treatment of severe dry eye and persistent corneal epithelial defect. METHODS:Literature searches of the PubMed and Cochrane Library databases were conducted most recently in March 2019. The searches identified 281 citat...


    pub_type: 杂志文章,评审


    authors: Shtein RM,Shen JF,Kuo AN,Hammersmith KM,Li JY,Weikert MP

    更新日期:2020-01-01 00:00:00

  • Clinical results of keratophakia and keratomileusis.

    abstract::Thirteen keratophakia patients were followed for 13 to 35 months. Eighteen cases of hyperopic keratomileusis or hyperopic keratomileusis using preserved corneal tissue were followed for 2 to 30 months. All 13 patients who underwent keratophakia achieved 20/50 or better acuity. All seven patients having hyperopic kerat...


    pub_type: 杂志文章


    authors: Friedlander MH,Werblin TP,Kaufman HE,Granet NS

    更新日期:1981-08-01 00:00:00

  • Impact of First Eye versus Second Eye Cataract Surgery on Visual Function and Quality of Life.

    abstract:PURPOSE:To compare the impact of first eye versus second eye cataract surgery on visual function and quality of life. DESIGN:Cohort study. PARTICIPANTS:A total of 328 patients undergoing separate first eye and second eye phacoemulsification cataract surgeries at 5 veterans affairs centers in the United States. Patien...


    pub_type: 杂志文章,多中心研究


    authors: Shekhawat NS,Stock MV,Baze EF,Daly MK,Vollman DE,Lawrence MG,Chomsky AS

    更新日期:2017-10-01 00:00:00

  • Effects of the CW YAG laser on the human iris and retina.

    abstract::A CW YAG laser was used to coagulate retina and to produce an optical iridotomy in a human eye that was to be enucleated for malignant melanoma at the optic nerve head. Moderate coagulation with the CW YAG laser produced a deep choroidal reaction involving the outer portion of the retina. The inner structure of the fo...


    pub_type: 杂志文章


    authors: Peyman GA,Larson B

    更新日期:1984-09-01 00:00:00

  • Intraretinal leakage of indocyanine green dye.

    abstract:PURPOSE:Indocyanine green (ICG) dye is known to remain selectively in and around choroidal neovascularization (CNV) associated with age-related macular degeneration, and is thought to be cleared from the overlying retinal circulation without leakage. This is the basis of ICG dye-enhanced laser photocoagulation. The aut...


    pub_type: 杂志文章


    authors: Ho AC,Yannuzzi LA,Guyer DR,Slakter JS,Sorenson JA,Orlock DA

    更新日期:1994-03-01 00:00:00

  • Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome.

    abstract:PURPOSE:To characterize the visual prognosis of patients with multifocal choroiditis and panuveitis (MCP), punctate inner choroidopathy (PIC), and the diffuse subretinal fibrosis (DSF) syndrome. METHODS:Forty-one patients with MCP, 16 with PIC, and 5 with DSF syndrome were evaluated. The mean follow-up was approximate...


    pub_type: 杂志文章


    authors: Brown J Jr,Folk JC,Reddy CV,Kimura AE

    更新日期:1996-07-01 00:00:00

  • Krupin disk implantation for complicated glaucomas.

    abstract:BACKGROUND:The Krupin Eye Valve with Disk (Krupin disk) is a glaucoma shunt that incorporates a slit valve intended to minimize early postoperative hypotony. METHODS:The medical records of all patients who have undergone Krupin disk implantation at the Doheny Eye Institute between July 1990 and December 1992 (25 eyes ...


    pub_type: 杂志文章


    authors: Fellenbaum PS,Almeida AR,Minckler DS,Sidoti PA,Baerveldt G,Heuer DK

    更新日期:1994-07-01 00:00:00

  • Relaxing retinotomies. Analysis of anatomic and visual results.

    abstract::The authors analyzed 100 consecutive eyes undergoing relaxing retinotomies to determine the anatomic and visual results associated with the use of this procedure. With a minimum follow-up of 6 months, 58 eyes were completely attached, 8 were partially attached (macula on), and 34 were detached. Thirty-four percent of ...


    pub_type: 杂志文章


    authors: Morse LS,McCuen BW 2nd,Machemer R

    更新日期:1990-05-01 00:00:00

  • Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface.

    abstract:PURPOSE:To evaluate components of the integrated ocular surface/lacrimal gland unit in a series of patients before and after undergoing bilateral laser in situ keratomileusis (LASIK). DESIGN:Prospective, noncomparative case series. PARTICIPANTS:Forty-eight eyes of 14 men and 34 women (age range, 26-54; mean, 39.2 yea...


    pub_type: 杂志文章


    authors: Battat L,Macri A,Dursun D,Pflugfelder SC

    更新日期:2001-07-01 00:00:00

  • Retinal and choroidal biopsies are helpful in unclear uveitis of suspected infectious or malignant origin.

    abstract:OBJECTIVES:To assess the clinical value of retinal or choroidal biopsy in establishing a definitive diagnosis directing subsequent management and to assess the risk involved in such surgery. DESIGN:Retrospective noncomparative interventional case series. PARTICIPANTS:Thirteen patients with uveitis of suspected malign...


    pub_type: 杂志文章


    authors: Johnston RL,Tufail A,Lightman S,Luthert PJ,Pavesio CE,Cooling RJ,Charteris D

    更新日期:2004-03-01 00:00:00

  • Is there a racial difference in physiologic cup size?

    abstract::Although many clinicians believe that there is a racial difference in the size of the physiologic cup, this premise has not been studied. To evaluate this, we prospectively examined 100 black and 100 white volunteers. Stereoscopic optic disc photographs taken of each subject were masked to block out the fundus pigment...


    pub_type: 杂志文章


    authors: Beck RW,Messner DK,Musch DC,Martonyi CL,Lichter PR

    更新日期:1985-07-01 00:00:00

  • Retinal detachment after branch retinal vein occlusion: influence of the type of break on the outcome of vitreous surgery.

    abstract:BACKGROUND:Branch retinal vein occlusion (BRVO) is occasionally complicated by two types of retinal breaks (retinal holes without vitreous traction or retinal traction tears) that may lead to a rhegmatogenous retinal detachment (RRD). The authors describe surgical results of vitrectomy for RRD after BRVO and investigat...


    pub_type: 杂志文章


    authors: Ikuno Y,Tano Y,Lewis JM,Ikeda T,Sato Y

    更新日期:1997-01-01 00:00:00

  • Chorioretinal juncture. Multiple extramacular drusen.

    abstract::A clinicopathologic study of multiple extramacular drusen (MED) was performed on 784 eyes of 412 consecutive autopsies and on 100 eyes of 50 consecutive patients with MED. The clinical and histopathologic characteristics of MED and its correlation with reticular degeneration of the pigment epithelium (RDPE) and with m...


    pub_type: 杂志文章


    authors: Lewis H,Straatsma BR,Foos RY

    更新日期:1986-08-01 00:00:00

  • Rabbit ocular reactivity to bacterial endotoxin contained in aqueous solution and ophthalmic viscosurgical devices.

    abstract:OBJECTIVE:To describe the ocular reactivity of the rabbit to bacterial endotoxin contained in an aqueous medium and in a cohesive and a dispersive ophthalmic viscosurgical device (OVD). DESIGN:Experimental, randomized animal study. PARTICIPANTS:Seventy-five New Zealand white rabbits. METHODS:This study was performed...


    pub_type: 杂志文章


    authors: Buchen SY,Calogero D,Hilmantel G,Eydelman MB

    更新日期:2012-07-01 00:00:00

  • Toxocara canis infestation. Clinical and epidemiological associations with seropositivity in kindergarten children.

    abstract::We studied a cohort of 333 children in kindergarten to determine the prevalence of seropositivity to Toxocara canis, and to detect and measure chronic health effects that might be attributable to past infection. We found that 23.1% of the children had serologic evidence of infection (antibody titer greater than or equ...


    pub_type: 杂志文章


    authors: Ellis GS Jr,Pakalnis VA,Worley G,Green JA,Frothingham TE,Sturner RA,Walls KW

    更新日期:1986-08-01 00:00:00

  • Internal orbital fractures in the pediatric age group: characterization and management.

    abstract:OBJECTIVE:To evaluate the specific characteristics and management of internal orbital fractures in the pediatric population. DESIGN:Retrospective observational case series. PARTICIPANTS:Thirty-four pediatric patients between the ages of 1 and 18 years with internal orbital ("blowout") fractures. METHODS:Records of p...


    pub_type: 杂志文章


    authors: Bansagi ZC,Meyer DR

    更新日期:2000-05-01 00:00:00

  • Multicentric Kaposi's sarcoma of the conjunctiva in a male homosexual with the acquired immunodeficiency syndrome.

    abstract::A 38-year-old male homosexual with the new Acquired Immunodeficiency Syndrome (AIDS) had biopsy proven Kaposi's sarcoma of the right palpebral conjunctiva, extraocular mucocutaneous areas, and lymph nodes. Histologically, the palpebral tumor was characterized by atypical spindle cell proliferation and multiple slit-li...


    pub_type: 杂志文章


    authors: Macher AM,Palestine A,Masur H,Bryant G,Chan CC,Nussenblatt RB,Rodrigues MM

    更新日期:1983-08-01 00:00:00

  • Automated lamellar keratoplasty. American Academy of Ophthalmology.

    abstract::The Academy finds in its preliminary review of keratomileusis in situ and ALK reason for more rigorous evaluation of the safety, refractive accuracy, stability, and optical quality of these microkeratome-based procedures. To understand these issues more thoroughly, the ophthalmic community needs continued access to pe...


    pub_type: 杂志文章,评审



    更新日期:1996-05-01 00:00:00

  • Intraocular pressure variations after diode laser photocoagulation for threshold retinopathy of prematurity.

    abstract:PURPOSE:To investigate the intraocular pressure (IOP) variations occurring after indirect diode laser photocoagulation for threshold retinopathy of prematurity. DESIGN:Prospective, nonrandomized, comparative study. PARTICIPANTS:A study group-21 consecutive premature babies (42 eyes) undergoing diode laser photocoagul...


    pub_type: 杂志文章


    authors: Axer-Siegel R,Bourla D,Friling R,Shalev B,Sirota L,Benjamini Y,Weinberger D,Snir M

    更新日期:2004-09-01 00:00:00