Abstract：
OBJECTIVE:To test whether alternate day vitamin E affects the incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women. DESIGN:Randomized, double-masked, placebo-controlled trial. PARTICIPANTS:Thirty-nine thousand eight hundred seventy-six apparently healthy female health professionals aged 45 years or older. INTERVENTION:Participants were assigned randomly to receive either 600 IU of natural-source vitamin E on alternate days or placebo. MAIN OUTCOME MEASURES:Incident AMD responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-report confirmed by medical record review. RESULTS:After 10 years of treatment and follow-up, there were 117 cases of AMD in the vitamin E group and 128 cases in the placebo group (relative risk, 0.93; 95% confidence interval, 0.72-1.19). CONCLUSIONS:In a large-scale randomized trial of female health professionals, long-term alternate-day use of 600 IU of natural-source vitamin E had no large beneficial or harmful effect on risk of AMD.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Christen WG,Glynn RJ,Chew EY,Buring JEdoi
10.1016/j.ophtha.2009.10.043subject
Has Abstractpub_date
2010-06-01 00:00:00pages
1163-8issue
6eissn
0161-6420issn
1549-4713pii
S0161-6420(09)01283-4journal_volume
117pub_type
杂志文章,随机对照试验相关文献
OPHTHALMOLOGY文献大全abstract：:An entire family (father, mother, and three daughters) were given thiabendazole because one of the children had acquired pinworm infestation. The mother and one daughter (non-infected) developed a sicca complex (keratoconjunctivitis sicca and xerostomia) accompanied by cholangiostatic jaundice. Sjögren's syndrome is a...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(79)35334-9
更新日期：1979-10-01 00:00:00
abstract：PURPOSE:Neovascular glaucoma is a frequent complication of vitrectomy performed to treat proliferative diabetic retinopathy (PDR). We assessed the level of vascular endothelial growth factor (VEGF) in the vitreous fluid obtained during vitrectomy and at postoperative fluid-air exchange. METHODS:We measured VEGF levels...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2004.03.035
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVE:To report the fungal isolates, treatment strategies, and clinical outcomes for a large series of patients with exogenous fungal endophthalmitis. DESIGN:Retrospective, single institution, consecutive case series. PARTICIPANTS:All patients treated at Bascom Palmer Eye Institute between January 1, 1990, and Ju...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2008.02.027
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:To investigate the association of cardiovascular risk factors and inflammatory markers with neovascular age-related macular degeneration (AMD). DESIGN:Cross-sectional case-control study. PARTICIPANTS:Of the 410 of the >/=65-year-old community sample invited to attend, 205 participated (50% response rate). Of ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2007.07.031
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To study the effects of trabeculectomy and needling revision of poorly functioning blebs on the optic nerve head (ONH) circulation in patients with primary open-angle glaucoma (POAG). DESIGN:Prospective, nonrandomized, self-controlled trial. PARTICIPANTS:Nineteen POAG patients (age range, 52 +/- 12 years; m...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0161-6420(00)00541-8
更新日期：2001-03-01 00:00:00
abstract：:A review of all cases of aponeurotic repair done since 1980 by the author identified 140 patients and 174 eyelids. An acceptable result at 6 weeks was defined as a lid level within 1 mm of the desired level achieved in 74% of lids with acquired ptosis. The amount of ptosis present preoperatively was the major factor i...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：PURPOSE:To estimate payments for glaucoma care among Medicare beneficiaries from 2002 to 2009. DESIGN:Database study. PARTICIPANTS:Data from a 5% random sample of Medicare billing information from 2002 to 2009. METHODS:Medicare beneficiaries, aged 65 years or older, with both Parts A and B fee-for-service (FFS) enro...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2013.04.027
更新日期：2013-11-01 00:00:00
abstract：:The slow-releasing artificial tear (SR-AT) is a soluble polymer in solid form. Placed in the inferior cul-de-sac and allowed to dissolve, it is used to treat dry-eye patients. The SR-AT was studied in two phases. The short-term cross-over study of 40 patients was completed in October 1976. The long-term open study is ...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0161-6420(78)35610-4
更新日期：1978-08-01 00:00:00
abstract：BACKGROUND:Orbital extraocular extension of choroidal melanoma is well known and is usually detected in eyes with medium and large tumors, but it is very rare with small melanomas. It is particularly unusual for choroidal melanomas of any size to invade the optic nerve or its meninges. DESIGN:Two case reports. PARTIC...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(99)00723-X
更新日期：1999-07-01 00:00:00
abstract：PURPOSE:To study the adherence of rheumatologists to the hydroxychloroquine (HCQ) dosing guidelines established by the American Academy of Ophthalmology in 2011 and 2016. DESIGN:Retrospective review of electronic medical records (EMRs) in an integrated health care system. PARTICIPANTS:All rheumatology patients starte...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2016.12.021
更新日期：2017-05-01 00:00:00
abstract：PURPOSE:To evaluate the relationship between retinal sensitivity and the photoreceptor inner segment/outer segment (IS/OS) layer status in patients with diabetic macular edema (DME). DESIGN:Cross-sectional study. PARTICIPANTS:Twenty-five adult patients (37 eyes) diagnosed with DME and managed at the Wilmer Eye Instit...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.12.003
更新日期：2013-06-01 00:00:00
abstract：:*Subspecialty synopses are intended to present major clinical developments and innovations in diagnosis, treatment, surgical technique, and recent clinical research. Each synopsis, written by a recognized knowledgeable subspecialist, is co-sponsored by a major subspecialty society or organization. This subspecialty sy...
journal_title：Ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0161-6420(89)32789-8
更新日期：1989-07-01 00:00:00
abstract：:A fleshy, polypoidal and partially lobulated lesion that protruded between the eyelids from the medial caruncular region and that infiltrated the contiguous anterior orbital tissues developed over 1 month in a 9-month-old infant. The microscopic features of the tumor included a plump spindle cell population, more poly...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(88)33167-2
更新日期：1988-04-01 00:00:00
abstract：PURPOSE:To identify ophthalmologic manifestations of the blue rubber bleb nevus syndrome, a rare cutaneovisceral hemangiomatosis. METHODS:The authors report two patients with a diagnosis of blue rubber bleb nevus syndrome with orbital hemangiomas. RESULTS:In one patient, the orbital lesion presented with signs and sy...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(96)30584-8
更新日期：1996-06-01 00:00:00
abstract：PURPOSE:To present a rare case of microsporidial keratoconjunctivitis in an otherwise healthy contact lens wearer without human immunodeficiency virus infection who responded to treatment with systemic albendazole and topical fumagillin. DESIGN:Interventional case report. METHOD:A cornea epithelial scraping from a ma...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(01)00542-5
更新日期：2001-05-01 00:00:00
abstract：:Normal crystalline lenses and a variety of primary and secondary cataracts were photographed with a contact clinical specular microscope having a new W10X long working distance objective. In the normal lens, the anterior and posterior cell pattern and the lens fiber pattern could be seen. In patients with developing c...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(83)34548-6
更新日期：1983-04-01 00:00:00
abstract：OBJECTIVE:To describe the clinical presentation, outcome, and possible underlying mechanism of aqueous misdirection after glaucoma drainage device implantation. DESIGN:Retrospective, noncomparative, interventional case series. PARTICIPANTS:Ten eyes (five primary open-angle glaucoma, four chronic angle-closure glaucom...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(99)00530-8
更新日期：1999-05-01 00:00:00
abstract：:Intraocular lenses have been regulated by the Bureau of Devices of the Food and Drug Administration since February 9, 1978. One year ago, data were reported through August 9, 1979, at which time more than 177,000 lenses of four different classes had been implanted. In the meantime, appeals and legal action by the Publ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(81)35014-3
更新日期：1981-05-01 00:00:00
abstract：:A 23-year-old white woman presented with a pigmented ciliary body mass in the left eye. The tumor appeared to transilluminate when observed with indirect illumination. Clinically the tumor was considered to represent either a malignant melanoma or a cyst and was excised by iridocyclectomy. Electron microscopic examina...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(82)34657-6
更新日期：1982-10-01 00:00:00
abstract：PURPOSE:To describe the authors' 5-year experience of the 2-incision push-pull (TIPP) technique for pediatric anterior and posterior capsulorrhexis formation. DESIGN:Retrospective descriptive study over a 5-year period. PARTICIPANTS:A total of 84 eyes of 63 patients who had undergone cataract surgery in 1 center. ME...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2006.03.057
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:To determine whether glaucoma patients with progressive optic disc change have subsequent visual field progression earlier and at a faster rate compared with those without disc change. DESIGN:Prospective, longitudinal, cohort study. PARTICIPANTS AND CONTROLS:Eighty-one patients with open-angle glaucoma. ME...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2009.04.031
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:To describe the clinical features and to present results of new diagnostic methods to help define the cause of the clinical syndrome of intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage (IHAPSH). DESIGN:Retrospective review of patients with IHAPSH at presentation seen in 3 centers in ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2003.08.040
更新日期：2004-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the specific characteristics and management of internal orbital fractures in the pediatric population. DESIGN:Retrospective observational case series. PARTICIPANTS:Thirty-four pediatric patients between the ages of 1 and 18 years with internal orbital ("blowout") fractures. METHODS:Records of p...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(00)00015-4
更新日期：2000-05-01 00:00:00
abstract：PURPOSE:To evaluate relationships between the Disc Damage Likelihood Scale (DDLS), global and sectoral structural parameters provided by the Heidelberg Retina Tomograph (HRT), and global and regional functional loss in visual field (VF) testing. DESIGN:Consecutive observational case series. PARTICIPANTS:One hundred t...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2005.10.055
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:To report a patient with agenesis of the right internal carotid artery associated with ipsilateral, congenital Homer's syndrome. DESIGN:Case report. METHODS:A 30-year-old woman, with a past history of migraine headaches, underwent neuro-ophthalmologic and neuroradiologic evaluation for transient visual obsc...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(99)00006-8
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:To ascertain the clinical features, visual outcome, and recurrence rates of ocular toxoplasmosis (OT) in a large series of patients. To determine the efficacy of various treatment strategies and identify the patients at risk of visual loss. DESIGN:Retrospective noncomparative observational case series. PARTIC...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(02)00990-9
更新日期：2002-05-01 00:00:00
abstract：PURPOSE:To characterize retinal pigment epithelial (RPE) cell loss as evidenced by autofluorescence imaging in patients with neovascular age-related macular degeneration (AMD). DESIGN:Retrospective cohort study. PARTICIPANTS:There were 162 eyes of 116 consecutive patients with neovascular AMD examined in a retinal pr...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.07.076
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:To analyze the use of the Cutler-Beard transmarginal rotation entropion clamp (Karl Ilg & Co., St. Charles, IL) in patients undergoing the Cutler-Beard procedure for repair of eyelid defects after tumor excision or trauma. DESIGN:Prospective, noncomparative case series. PARTICIPANTS:Twenty-five patients under...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(02)01995-4
更新日期：2003-04-01 00:00:00
abstract：:Stromal keratitis and iritis developed in the left eye of a healthy 45-year-old man with no history of ocular disease, trauma, or contact lens wear. The clinical course over a 2-year period was characterized by progressive central disciform keratitis, recurrent anterior stromal patchy infiltration, and iritis which wa...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：PURPOSE:To generate wide-field automated seamless retinal montage images. DESIGN:Prospective, observational, case series study. PARTICIPANTS:Eighteen eyes of 14 patients were studied. INTERVENTION:A digital scanning laser ophthalmoscope (SLO), the Heidelberg Retina Angiograph (HRA), was used to obtain overlapping im...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(99)90529-8
更新日期：1999-12-01 00:00:00
