Abstract:
PURPOSE:To characterize the types and frequencies of image artifacts associated with macular scanning using 2 common spectral-domain optical coherence tomography (SD OCT) instruments and to evaluate the impact of artifacts on foveal thickness measurements. DESIGN:Retrospective, observational chart review. PARTICIPANTS:For the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA), scans of 98 eyes from 58 patients were included in the study. For the Spectralis HRA+OCT (Heidelberg Engineering, Heidelberg, Germany), scans of 88 eyes from 54 patients were included. METHODS:Macular volume scans of healthy and diseased eyes were evaluated systematically for image artifacts within each scan overall and within the center 1-mm area. The frequency of each artifact type was compared for scans stratified by diagnosis category. Artifacts in the center 1-mm area were graded for severity and were corrected manually using each instrument's software. Artifacts that resulted in errors of more than 50 microm or more than 10% of retinal thickness or that caused a misdiagnosis of macular edema or retinal thinning were defined as clinically significant and were analyzed further. MAIN OUTCOME MEASURES:Overall frequency of image artifacts by artifact type, relative frequency of artifacts in scans stratified by posterior segment disease diagnosis, and retinal thickness measurements of the center 1-mm subfield before and after artifact corrections. RESULTS:For Cirrus, 84.7% of scans had artifacts and 32.7% had at least 1 artifact in the center 1-mm area of the scan. For Spectralis, 90.9% of scans had at least 1 artifact, and 37.5% had at least 1 artifact in the center 1-mm area. Certain artifact types were observed more frequently with specific disease states. Clinically significant artifacts involving the center 1-mm area were seen in 5.1% of Cirrus and 8.0% of Spectralis scans. CONCLUSIONS:Image artifacts in SD OCT volume scanning are common and frequently involve segmentation errors. Artifacts are relatively less common in the center 1-mm area of scans, but may affect retinal thickness measurements in a clinically significant manner. Careful review of scans for artifacts is important when using SD OCT images and retinal thickness measurements in patient care or clinical trials.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Han IC,Jaffe GJdoi
10.1016/j.ophtha.2009.10.029subject
Has Abstractpub_date
2010-06-01 00:00:00pages
1177-1189.e4issue
6eissn
0161-6420issn
1549-4713pii
S0161-6420(09)01224-Xjournal_volume
117pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:PURPOSE:To evaluate the short-term safety and efficacy of intravitreal bevacizumab for the treatment of cystoid macular edema (CME) secondary to uveitis. DESIGN:Retrospective, noncomparative, interventional case series. PARTICIPANTS:Thirteen patients undergoing treatment for recalcitrant uveitic macular edema at one ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.11.028
更新日期:2007-08-01 00:00:00
abstract:PURPOSE:To show that chiasmal hypoplasia or aplasia need not be an isolated developmental anomaly and to examine the spectrum of associated clinical findings to explore the possibility that these patients may represent a phenotypic manifestation of a developmental gene anomaly. DESIGN:An observational case series. PA...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(99)90539-0
更新日期:1999-12-01 00:00:00
abstract::A prospective, randomized, double-masked, placebo-controlled clinical trial was conducted to study the effects of oral acyclovir on 55 patients with acute herpes zoster ophthalmicus. Treatment with oral acyclovir resulted in more prompt resolution of signs and symptoms, particularly in patients treated within 72 hours...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(85)33842-3
更新日期:1985-11-01 00:00:00
abstract::An 80-year-old man was evaluated for an epibulbar tumor on a phthisical eye. The initial biopsy diagnosis of the epibulbar tumor was poorly differentiated neoplasm. Exenteration of the phthisical eye and orbital contents showed an extensive pleomorphic adenocarcinoma of the nonpigmented epithelium of the ciliary body ...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0161-6420(90)32522-8
更新日期:1990-06-01 00:00:00
abstract::A computer program designed according to the needs of clinical investigators has recently been implemented. This ambitious undertaking allows the ophthalmologist direct interfacing and control over all his data, presently 3,252 diabetic patient records, and thus harnesses his hypothesis-testing intuitions with the mem...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)34974-4
更新日期:1981-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of superior and temporal scleral incisions on regular and irregular astigmatism in small incision cataract surgery. DESIGN:Prospective, randomized, comparative clinical trial. PARTICIPANTS:One hundred seventy-four eyes of 87 patients with bilateral cataracts scheduled to undergo routi...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(00)00379-1
更新日期:2000-11-01 00:00:00
abstract::Nabilone is a synthesized crystalline benzopyran that resembles the cannabinols but is not a tetrahydrocannabinol. Oral administration of 0.5 to 2 mg to patients with open-angle glaucoma reduced the intraocular pressure from 10% to 54% with an average of 28%. Administration of a topical ophthalmic nabilone solution (0...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(79)35539-7
更新日期:1979-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of eculizumab, a systemic inhibitor of complement component (C5), on the growth of geographic atrophy (GA) in patients with age-related macular degeneration (AMD). DESIGN:Prospective, double-masked, randomized clinical trial. PARTICIPANTS:Patients with GA measuring from 1.25 to 18 mm(2)...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2013.09.044
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:Central retinal vein occlusion (CRVO) is a vision-threatening disease, primarily occurring among patients aged more than 60 years. Several risk factors, including arterial hypertension and diabetes mellitus, have been identified. Compression of the central retinal vein by an atherosclerotic retinal artery at ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.10.014
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To determine the safety and efficacy of low-dose methotrexate (MTX) for sarcoid-associated panuveitis. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:Twenty eyes from 11 patients were analyzed. Eight patients had sarcoidosis. Three patients were clinically suspected of sarcoidosis despite neg...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/S0161-6420(99)90011-8
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To describe the association of demographic, behavioral, medical, and nonretinal ocular factors with the incidence of neovascular age-related macular degeneration (AMD) and central geographic atrophy (CGA) in the Age-Related Eye Disease Study (AREDS), a randomized trial of antioxidants and zinc supplementation p...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2004.10.047
更新日期:2005-04-01 00:00:00
abstract::Thirty-one corneal transplant cases underwent a visual-evoked potential and electroretinogram examination prior to keratoplasty. There were 12 cases that had a good visual prognosis and 19 cases with a poor visual prognosis based on the preoperative diagnosis and clinical examination. The addition of electrophysiologi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(82)34752-1
更新日期:1982-06-01 00:00:00
abstract:PURPOSE:To test a linear model relating the regional loss in retinal nerve fiber (RNFL) thickness to the corresponding regional loss in sensitivity with data from patients with previous anterior ischemic optic neuropathy (AION). DESIGN:Case-control study. PARTICIPANTS:Twenty-four individuals with AION and 20 with nor...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.06.001
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:The purpose of the study is to evaluate whether a posterior capsulectomy combined with anterior vitrectomy is a necessity in pediatric cataract. DESIGN:The incidence of posterior capsule opacification, the need for additional surgical interventions, and the influence of a primary posterior capsulectomy after...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30045-1
更新日期:1997-12-01 00:00:00
abstract:PURPOSE:To evaluate the association between cystoid macular edema (CME) observed in very preterm infants and developmental outcomes at 18 to 24 months corrected age. DESIGN:Cohort study. PARTICIPANTS:Infants born at or less than 1500 g or at or less than 30 weeks postmenstrual age who underwent screening for retinopa...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2014.09.022
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To study early direct effects of transpupillary thermotherapy (TTT) on choroidal neovascularization (CNV) and choroid. DESIGN:Retrospective, noncomparative interventional case series. PARTICIPANTS:Sixty-four eyes with subfoveal CNV. INTERVENTION:TTT was delivered using a diode laser at 810 nm through a con...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)01034-5
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVE:To determine the most appropriate method for measuring the effect on contrast sensitivity of neodymium:YAG (Nd:YAG) posterior capsulotomy for early posterior capsular opacification (PCO). DESIGN:Prospective comparison of five different methods for luminous contrast sensitivity testing in patients undergoing ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(99)90154-9
更新日期:1999-04-01 00:00:00
abstract::Although systemic immunosuppressive chemotherapy is effective in halting progressive necrotizing scleritis, the onset of its action may be too slow to prevent profound scleral thinning and/or traumatic or spontaneous perforation. Scleral homografts may be used to maintain the integrity of the globe until immunosuppres...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32892-2
更新日期:1989-03-01 00:00:00
abstract::Fine needle aspiration biopsy (FNAB) of orbital tumors has been recently advocated as a reliable diagnostic modality. An accuracy rate of 92% has been claimed by some authors. This figure remains unproven as most patients have not undergone simultaneous pathologic examination. We recently performed FNAB on 34 patients...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)33984-2
更新日期:1985-05-01 00:00:00
abstract:PURPOSE:To determine the incidence and types of posterior staphylomas in eyes with pathologic myopia by analyzing the entire eye shape by 3-dimensional (3D) magnetic resonance imaging (MRI). DESIGN:Observational, case series. PARTICIPANTS:A total of 105 patients with pathologic myopia (spherical equivalent <-8.0 diop...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2014.03.035
更新日期:2014-09-01 00:00:00
abstract::We encountered two clinically similar but genetically unrelated cases of a disorder characterized by an unusual white pupillary-iris-lens membrane with extension to a prominent Schwalbe's line, the membranes were vascularized and their appearance changed over time. In both cases the abnormality was unilateral. Anomalo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33659-5
更新日期:1986-06-01 00:00:00
abstract:OBJECTIVE:To describe multifocal electroretinogram (mfERG) responses in 2 patients with nonorganic visual loss and in 11 eyes of 6 healthy persons who suppressed their mfERG responses. DESIGN:Observational case series. METHODS:The mfERG results were recorded in all individuals using the Veris Science 4.2 instrument. ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2003.04.011
更新日期:2004-01-01 00:00:00
abstract::Between April 1986 and April 1989, the authors conducted a prospective study of the use of open-loop anterior chamber intraocular lenses (AC IOLs) in patients undergoing penetrating keratoplasty for pseudophakic bullous keratopathy or monocular aphakic bullous keratopathy. All patients underwent the same operation--a ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(90)32513-7
更新日期:1990-06-01 00:00:00
abstract::Five hundred forty-seven reports of adverse reactions to timolol maleate received by the National Registry for Drug-induced Ocular Side Effects during an eleven-month period were reviewed. Approximately half the reports concerned systemic reactions affecting the cardiac, pulmonary, central nervous, gastrointestinal, a...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35215-9
更新日期:1980-05-01 00:00:00
abstract:PURPOSE:To evaluate the effect of glaucoma on functional vision and on vision-related (VR) and health-related (HR) quality of life (QoL) in children up to 16 years of age. DESIGN:Cross-sectional observational study. PARTICIPANTS:One hundred nineteen children 2 to 16 years of age (mean age, 9.4 years; standard deviati...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2017.02.024
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To evaluate prospectively the corneal refractive status before and after pterygium surgery and its relationship with preoperative pterygium size. DESIGN:Prospective, nonrandomized, comparative (self-controlled) trial. PARTICIPANTS:One hundred thirty-six eyes undergoing primary pterygium removal surgery. MA...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00219-0
更新日期:2000-08-01 00:00:00
abstract:PURPOSE:To report the long-term results of corneal collagen cross-linking (CXL) in ectasia after LASIK and photorefractive keratectomy (PRK). DESIGN:Retrospective, interventional cases series. PARTICIPANTS:Twenty-six eyes of 26 patients (18 male, 8 female) with postoperative ectasia after LASIK (23 eyes) and PRK (3 e...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.12.027
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:To update the findings from the Choroidal Neovascularization Prevention Trial (CNVPT) with respect to resolution of drusen, incidence of choroidal neovascularization, and visual function. DESIGN:A multicenter, randomized, controlled, pilot clinical trial. PARTICIPANTS:The 120 patients enrolled in the CNVPT. P...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/S0161-6420(03)00098-8
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:To determine the outcome of pediatric dacryocystorhinostomy (DCR) for large mucoceles or for primary nasolacrimal duct obstruction unresponsive to multiple probings. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:One hundred thirty-four external dacryocystorhinostomies were performed in 121 c...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00699-6
更新日期:2001-09-01 00:00:00
abstract:PURPOSE:The purpose of this study was to characterize the contemporary clinical presentation and treatment results of patients with dislocated intraocular lenses (IOLs). DESIGN:Retrospective, noncomparative, single-surgeon interventional case series. PARTICIPANTS:Two hundred eighty-four eyes of 277 patients operated ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.04.016
更新日期:2008-10-01 00:00:00