当前位置： SCI文献检索 > OPHTHALMOLOGY期刊下所有文献 > Sunken eyes, sagging brain syndrome: bilateral enophthalmos from chronic intracranial hypotension.

Sunken eyes, sagging brain syndrome: bilateral enophthalmos from chronic intracranial hypotension.

Abstract：

PURPOSE:To explain the mechanism for acquired enophthalmos after ventriculoperitoneal shunting (VPS). DESIGN:Case series and a case-control study. PARTICIPANTS AND CONTROLS:Four study patients with bilateral enophthalmos after VPS and 10 control subjects. METHODS:Case description of 4 study patients. Calculated orbital volumes for 2 study patients were compared with controls using the Wilcoxon rank-sum test. MAIN OUTCOME MEASURES:Exophthalmometry measurements and total orbital and fat volumes. RESULTS:Patient 1 is a 25-year-old man who presented with progressive enophthalmos 3 years after VPS for traumatic intracranial bleeding. Imaging demonstrated upward expansion of the orbital roof and evidence of intracranial hypotension. The intracranial pressure (ICP) was 20 mm H₂O. The enophthalmos improved after shunt revision. Patient 2 is a 19-year-old man who presented with progressive enophthalmos 18 months after VPS for traumatic intracranial hemorrhage. Patient 3 is a 38-year-old woman who presented with bilateral enophthalmos 15 years after VPS after a ruptured aneurysm. Imaging showed orbital expansion. Patient 4 is a 16-year-old man who presented with severe enophthalmos 5 years after a VPS for aneurysm-related hemorrhage. Imaging demonstrated orbital enlargement and findings of intracranial hypotension. Intracranial pressure ranged between -200 and 0 mm H₂O. Shunt revision improved the enophthalmos. Total orbital volumes were significantly greater in the study patients than in the controls. Control subjects (5 male, 5 female, ages 23-45 years) had an average right orbital volume of 24.6 ± 3.3 cm³ (n = 10). In comparison, the right orbital volumes of patients 1 and 3 were 32.6 and 32.1 cm³. Similar results were found for the left orbits (23.9 ± 2.7 cm³ [control average] vs. 35.9 and 32.6 cm³). In patient 1, the post-shunt volumes increased 14% (right) and 23% (left) from pre-shunt volumes. In contrast, orbital fat volume was not statistically significantly different between the control group and enophthalmic patients (right orbit control mean 7.94 ± 3.1 cm³ [n = 10] vs. 7.9 and 9.8 cm³; left orbit control mean 7.88+3.1 cm³ vs. 9.2 and 10.0 cm³). CONCLUSIONS:Enophthalmos after VPS results primarily from chronic intracranial hypotension. Low ICP causes expansion of orbital volume with no fat atrophy. In such patients, shunt revision with a pressure-regulating valve to correct intracranial hypotension should be considered. FINANCIAL DISCLOSURE(S):The author(s) have no proprietary or commercial interest in any materials discussed in this article.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Hwang TN,Rofagha S,McDermott MW,Hoyt WF,Horton JC,McCulley TJ

doi

10.1016/j.ophtha.2011.04.031

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

2286-95

issue

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(11)00418-0

journal_volume

118

pub_type

杂志文章

在线工具

Sunken eyes, sagging brain syndrome: bilateral enophthalmos from chronic intracranial hypotension.