Abstract：
:Eighteen healthy volunteers participated in a histamine challenge, dose response study of cimetidine (H2 antagonist)/pyrilamine (H1 antagonist) eyedrops. This was a randomized, double-masked, multiple-crossover trial, consisting of six visits spaced 48 hours apart. At each visit, subjects were pretreated with one of six different doses of test medication in one randomly selected eye and with vehicle in the fellow eye. Five minutes later, one drop of 0.0075% histamine was instilled in both eyes. Conjunctival hyperemia and edema were graded at various time points during a 20-minute interval after the instillation of histamine. Results indicated that the cimetidine/pyrilamine combination was effective in preventing histamine-induced conjunctival hyperemia in normal volunteers; neither cimetidine nor pyrilamine was effective when administered alone.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Leon J,Charap A,Duzman E,Shen CDdoi
10.1016/s0161-6420(86)33789-8subject
Has Abstractpub_date
1986-01-01 00:00:00pages
120-3issue
1eissn
0161-6420issn
1549-4713pii
S0161-6420(86)33789-8journal_volume
93pub_type
临床试验,杂志文章,随机对照试验相关文献
OPHTHALMOLOGY文献大全abstract：:Two hundred fifteen diabetic patients (430 eyes) with early proliferative retinopathy, moderate-to-severe nonproliferative retinopathy, and/or diabetic macular edema in each eye were examined for the presence of white centered retinal hemorrhages (WCRHs). Of the eyes examined, 15.6% demonstrated at least one WCRH and ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(87)33435-9
更新日期：1987-04-01 00:00:00
abstract：PURPOSE:To describe associations between reticular pseudodrusen, individual characteristics, and retinal function. DESIGN:Cohort study. PARTICIPANTS:We recruited 105 patients (age range, 52-93 years) who had advanced neovascular age-related macular degeneration (AMD) in only 1 eye from 3 clinical centers in Europe. ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2014.03.015
更新日期：2014-09-01 00:00:00
abstract：PURPOSE:Quantification of diplopia is important for describing severity of strabismus, measuring change over time, and reporting surgical outcomes. The cervical range of motion (CROM) method has been proposed as a simple, inexpensive alternative to the Goldmann perimeter for quantifying diplopia. The purpose of this st...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2007.01.033
更新日期：2007-12-01 00:00:00
abstract：PURPOSE:The spaceflight-associated neuro-ocular syndrome (SANS) affects astronauts on missions to the International Space Station (ISS). The SANS has blurred vision and ocular changes as typical features. The objective of this study was to investigate if microgravity can create deformations or movements of the eye or o...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2020.07.007
更新日期：2021-02-01 00:00:00
abstract：OBJECTIVE:The study compares the use of Jones' retractor plication and the Wies procedure as a primary procedure for the repair of involutional lower lid entropion in the absence of horizontal lid shortening. DESIGN:Retrospective case series comparison. PARTICIPANTS:One hundred two cases with at least 6 months follow...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(00)00027-0
更新日期：2000-05-01 00:00:00
abstract：OBJECTIVE:To test whether alternate day vitamin E affects the incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women. DESIGN:Randomized, double-masked, placebo-controlled trial. PARTICIPANTS:Thirty-nine thousand eight hundred seventy-six apparently healthy female health profess...
journal_title：Ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ophtha.2009.10.043
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:To calculate the relationship between Medicare payment and service volume for the 3 highest-volume retina procedures: intravitreal injection (Current Procedural Terminology [CPT] code 67028), laser treatment for retinal edema (CPT code 67210), and laser treatment for proliferative retinopathy (CPT code 67228). ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2015.04.040
更新日期：2015-08-01 00:00:00
abstract：:A computer program designed according to the needs of clinical investigators has recently been implemented. This ambitious undertaking allows the ophthalmologist direct interfacing and control over all his data, presently 3,252 diabetic patient records, and thus harnesses his hypothesis-testing intuitions with the mem...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(81)34974-4
更新日期：1981-07-01 00:00:00
abstract：PURPOSE:To determine the trends in prevalence of myopia in Israeli young adults over approximately a generation, as well as associated factors and variation in the impact of these factors on myopia prevalence in this region over time. DESIGN:Retrospective, cross-sectional study. PARTICIPANTS:One hundred four thousand...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2019.06.025
更新日期：2019-12-01 00:00:00
abstract：:In a controlled, nonrandomized, longitudinal cohort study, we studied the efficacy of systemic immunosuppression in treatment of progressive cicatricial pemphigoid affecting the eyes. Twenty-six patients were studied; 18 received systemic immunosuppressive drugs, and eight received conventional therapy. Three patients...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(82)34791-0
更新日期：1982-04-01 00:00:00
abstract：PURPOSE:We sought to determine whether genotype is associated with rate of growth of geographic atrophy (GA) in eyes with age-related macular degeneration (AMD). DESIGN:Prospective analysis of participants in a randomized controlled clinical trial. PARTICIPANTS:We included 114 eyes of 114 participants in the Age-Rela...
journal_title：Ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ophtha.2009.12.012
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:To quantify the relationship between myopia and open-angle glaucoma, ocular hypertension (OH), and intraocular pressure (IOP) in a representative older population. DESIGN:Cross-sectional population-based study of 3654 Australians 49 to 97 years of age. METHODS:Subjects with any myopia (> or =-1.0 diopter [D...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(99)90416-5
更新日期：1999-10-01 00:00:00
abstract：OBJECTIVE:To determine agreement between spectral-domain (SD) and time-domain (TD) optical coherence tomography (OCT) image assessments by certified readers in eyes treated for neovascular age-related macular degeneration (AMD). DESIGN:Cross-sectional study within the Comparison of AMD Treatments Trials (CATT). PARTI...
journal_title：Ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ophtha.2014.04.020
更新日期：2014-10-01 00:00:00
abstract：:The authors studied intraobserver and interobserver agreement, under monoscopic and stereoscopic conditions, in estimating vertical cup-to-disc ratios and in assessing whether a disc had glaucomatous damage. Six glaucoma experts evaluated 75 optic disc photographs under both viewing conditions. The experts also re-eva...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(92)31990-6
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVE:To compare the visual outcomes and complication profiles of primary scleral-fixated intraocular lens (SFIOL) versus primary anterior chamber intraocular lens (ACIOL) implantation in cataract surgeries complicated by inadequate capsular support. DESIGN:Retrospective, interventional, comparative cases series. ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2005.11.024
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:Droperidol and the new serotonin-3 antagonists are effective drugs for the prophylaxis of postoperative nausea and vomiting (PONV). The aim of this trial was to evaluate whether dolasetron could be a substitute for droperidol, because the Food and Drug Administration has required a Black Box warning on the drop...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.ophtha.2004.01.031
更新日期：2004-08-01 00:00:00
abstract：:A 34-year-old white man with skin manifestations of the epidermal nevus syndrome was found to have anesthetic corneas, dry eyes, and localized opaque nodular elevations of both corneas. Similar corneal lesions, unassociated with corneal anesthesia, were found in four family members. Histology of corneal biopsies from ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(84)34320-2
更新日期：1984-02-01 00:00:00
abstract：PURPOSE:To assess the current burden of ocular toxocariasis (OT) and to gain knowledge regarding the diagnostic and treatment practices used in the ophthalmologic community in the United States. DESIGN:Web-based, cross-sectional survey. PARTICIPANTS:Subspecialty ophthalmologists who are currently practicing in the Un...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2011.12.013
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:The purpose of this study was to determine the prevalence of open-angle glaucoma and ocular hypertension in an Australian community whose residents are 49 years of age or older. SUBJECTS:There were 3654 persons, representing 82.4% of permanent residents from an area west of Sydney, Australia, who were examined...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(96)30449-1
更新日期：1996-10-01 00:00:00
abstract：PURPOSE:The purpose of the study was to determine long-term results of involutional entropion repair by a modified corncrib (inverted T) procedure with a Quickert suture. METHODS:A retrospective review of consecutive patients with involutional entropion who underwent repair by a modified corncrib procedure from Januar...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(97)30284-x
更新日期：1997-03-01 00:00:00
abstract：PURPOSE:To compare rates of peripheral retinal changes in Age-Related Eye Disease Study 2 (AREDS2) participants with at least intermediate age-related macular degeneration (AMD) with control subjects without intermediate age-related changes (large drusen). DESIGN:Cross-sectional evaluation of clinic-based patients enr...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2016.12.004
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:Static threshold automated perimetry is a demanding test which can be tiring for some patients. The authors investigate how to optimize early stages of the test which can shorten examination time and improve performance. The effectiveness of measuring every point twice to improve diagnostic precision (proportio...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(93)31612-x
更新日期：1993-04-01 00:00:00
abstract：:The interactions between rabbit corneal epithelium and endothelium were investigated in an organ culture model using scanning electron microscopy and correlative light microscopy. Following mechanical removal of corneal endothelium, corneal epithelium was observed to migrate across the cut surface of the corneal strom...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(84)34250-6
更新日期：1984-06-01 00:00:00
abstract：PURPOSE:To identify susceptibility genes associated with hereditary predisposition to uveal melanoma (UM) in patients with no detectable germline BAP1 alterations. DESIGN:Retrospective case series from academic referral centers. PARTICIPANTS:Cohort of 154 UM patients with high risk of hereditary cancer defined as pat...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2019.11.009
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:To investigate the hypothesis that the excessive growth of the eye in myopia is associated with general growth and thus influenced by early life biological and social factors, and that these associations underlie recent secular trends of increasing prevalence and severity of myopia. DESIGN:Cohort study. PARTI...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2010.09.025
更新日期：2011-05-01 00:00:00
abstract：PURPOSE:The purpose of this study was to evaluate 24-hour intraocular pressure (IOP) control in patients with moderate to severe open-angle glaucoma treated by trabeculectomy and mitomycin C versus maximum tolerated medical therapy. DESIGN:Prospective observational study. PARTICIPANTS:Thirty surgical patients and 30 ...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ophtha.2006.01.029
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVE:To describe the clinical presentation, outcome, and possible underlying mechanism of aqueous misdirection after glaucoma drainage device implantation. DESIGN:Retrospective, noncomparative, interventional case series. PARTICIPANTS:Ten eyes (five primary open-angle glaucoma, four chronic angle-closure glaucom...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(99)00530-8
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVE:To report endothelial cell densities (ECDs) and their correlation to anterior chamber depth (ACD) after implantation of the Artisan intraocular phakic lens. DESIGN:Prospective observational case series. PARTICIPANTS:Three hundred eighteen eyes of 173 myopic patients treated with the Artisan iris-fixated pha...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2007.05.036
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Earlier studies of subperiosteal abscess secondary to sinusitis showed considerable variation in the clinical course and bacteriology. At one extreme, patients recovered with intravenous antibiotics alone; at the other extreme, complex pathogens persisted despite early surgical drainage and appropriate antib...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(94)31297-8
更新日期：1994-03-01 00:00:00
abstract：:Many techniques for repositioning dislocated posterior chamber implants described in the recent literature involve intricate intraocular manipulation of a needle or other sharp instrument. The author describes an improved sulcus fixation technique, which combines the best features of external and internal approaches. ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(92)32012-3
更新日期：1992-01-01 00:00:00
