Abstract:
PURPOSE:To describe the incidence of and risk factors for visual acuity (VA) loss and ocular complications in patients with juvenile idiopathic arthritis (JIA)-associated uveitis. DESIGN:Multicenter retrospective cohort study. PARTICIPANTS:A total of 327 patients (596 affected eyes) with JIA-associated uveitis managed at 5 tertiary uveitis clinics in the United States. METHODS:Participants were identified from the Systemic Immunosuppressive Therapy for Eye Diseases (SITE) cohort study. Demographic and clinical characteristics were obtained for every eye of every patient at every visit via medical record review by trained expert reviewers. MAIN OUTCOME MEASURES:Loss of VA to 20/50 or to 20/200 or worse thresholds and the development of ocular complications. RESULTS:At presentation, 240 eyes (40.3%) had a VA of ≤20/50, 144 eyes (24.2%) had a VA of ≤20/200, and 359 eyes (60.2%) had at least 1 ocular complication. The incidences of VA loss to the ≤20/50 and ≤20/200 thresholds were 0.18 and 0.09 per eye-year (EY), respectively; the incidence of developing at least 1 new ocular complication over follow-up was 0.15/EY (95% confidence interval [CI], 0.13-0.17). However, among eyes with uveitis that had no complications at presentation, the rate of developing at least 1 ocular complication during follow-up was lower (0.04/EY; 95% CI, 0.02-0.06). Posterior synechiae, active uveitis, and prior intraocular surgery were statistically significantly associated with VA to the ≤20/50 and ≤20/200 thresholds both at presentation and during follow-up. Increasing (time-updated) anterior chamber cell grade was associated with increased rates of visual loss in a dose-dependent fashion. Use of immunosuppressive drugs was associated with a reduced risk of visual loss, particularly for the ≤20/50 outcome (hazard ratio, 0.40; 95% CI, 0.21-0.75; P<0.01). CONCLUSIONS:Ocular complications and vision loss were common in our cohort. Increasing uveitis activity was associated with increased risk of vision loss, and use of immunosuppressive drugs was associated with reduced risk of vision loss, suggesting that control of inflammation and use of immunosuppression may be critical aspects in improving the outcomes of patients with JIA-related uveitis. FINANCIAL DISCLOSURE(S):The author(s) have no proprietary or commercial interest in any materials discussed in this article.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Gregory AC 2nd,Kempen JH,Daniel E,Kaçmaz RO,Foster CS,Jabs DA,Levy-Clarke GA,Nussenblatt RB,Rosenbaum JT,Suhler EB,Thorne JE,Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study Research Group.doi
10.1016/j.ophtha.2012.07.052subject
Has Abstractpub_date
2013-01-01 00:00:00pages
186-92issue
1eissn
0161-6420issn
1549-4713pii
S0161-6420(12)00687-2journal_volume
120pub_type
杂志文章,多中心研究相关文献
OPHTHALMOLOGY文献大全abstract:PURPOSE:The aim of this study was to describe a new technique for transscleral suturing of posterior chamber intraocular lenses (PCIOLs) without intraocular knots. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:Twenty-four eyes underwent implantation of PCIOLs with this new technique. METHODS:Suture f...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00467-6
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:This article presents three patients with endophthalmitis associated with infection with Capnocytophaga species. METHODS:The medical records of three patients with culture-positive Capnocytophaga endophthalmitis were reviewed. A panel of isolates of Capnocytophaga were then tested for sensitivity to third-gene...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31622-2
更新日期:1993-04-01 00:00:00
abstract:PURPOSE:Multiple independent laboratories have confirmed the histologic observation that some tumor microcirculation patterns (MCPs) in uveal melanomas are associated strongly with death resulting from metastatic disease. Because these patterns are imageable with confocal indocyanine green angiography (ICG), we designe...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/s0161-6420(02)01266-6
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Sterile corneal ulceration is a rare complication of rheumatoid arthritis and may lead to corneal perforation. Surgical management for visual restoration frequently is unsuccessful. The authors analyze the factors that may determine the failure of corneal surgery in perforations associated with rheumatoid ar...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30867-6
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:To determine whether lamina cribrosa (LC) depth (LCD) and LC thickness (LCT) are associated with a faster rate of progressive retinal nerve fiber layer (RNFL) thinning in primary open-angle glaucoma (POAG). DESIGN:Prospective, observational study. PARTICIPANTS:One hundred ten eyes diagnosed with POAG (n = 1...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2014.10.007
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To investigate the penetration of linezolid, a synthetic oxazolidinone antibiotic, into the aqueous and vitreous humor after oral administration. DESIGN:Noncomparative interventional, prospective case series study, randomized into group 1 (dose, one 600-mg tablet) or group 2 (2 doses of 600 mg given 12 hours...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ophtha.2003.09.042
更新日期:2004-06-01 00:00:00
abstract:PURPOSE:To investigate the characteristics and prognosis of immune rejection after allogeneic cultivated limbal epithelial transplantation (CLET). DESIGN:Retrospective, noncomparative case series. PARTICIPANTS:Forty-two eyes of 41 patients undergoing allogeneic CLET for total limbal stem cell deficiency who completed...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.11.001
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To examine the hypotheses that in glaucomatous eyes with single-hemifield damage, retinal blood flow (RBF) is significantly reduced in the retinal hemisphere corresponding with the abnormal visual hemifield and that there are significant associations among reduced retinal sensitivity (RS) in the abnormal hemifi...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2013.10.022
更新日期:2014-03-01 00:00:00
abstract::Krabbe's disease is an autosomal recessive leukodystrophy characterized by a lack of galactocerebroside beta-galactosidase activity. In contrast to the classic early infantile-onset form of Krabbe's disease, less recognized, late-onset variants exist. The authors present a case of late juvenile-onset Krabbe's disease,...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(90)32439-9
更新日期:1990-09-01 00:00:00
abstract:PURPOSE:To evaluate and correlate findings obtained by optical coherence tomography (OCT) imaging with visual acuity (VA) and macular lesions in patients with X-linked retinoschisis (XLRS). DESIGN:Prospective comparative case series. PARTICIPANTS:Thirty-one patients with confirmed XLRS. METHODS:Best-corrected VA was...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2004.08.027
更新日期:2005-03-01 00:00:00
abstract::A 4-year-old white female presented with leukocoria of the right eye. White punctate lesions were observed posterior to the retrolental membrane, which suggested retinoblastoma of some examiners. A full history, physical examination, ultrasonography, and CT scan failed to rule the diagnosis of retinoblastoma in or out...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)34860-x
更新日期:1981-12-01 00:00:00
abstract::Four cases of acute angle closure glaucoma with different types of ocular vascular accidents are presented: one case of optic nerve head ischemia; two cases of central retinal vein occlusion, and one case of vitreous hemorrhage. One of the patients had vitreous hemorrhage following the lowering of intraocular pressure...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)35046-5
更新日期:1981-03-01 00:00:00
abstract:PURPOSE:To evaluate bone spicule pigmentation, a fundus feature in retinitis pigmentosa (RP) formed by migration of pigment-containing cells to perivascular sites in the inner retina. METHODS:The authors performed light and electron microscopy, including immunocytochemistry, on the retinas from ten patients with RP an...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30953-0
更新日期:1995-05-01 00:00:00
abstract::The authors present a series of seven patients with acute visual loss associated with mild anterior uveitis, multifocal retinal vasculitis, retinal capillary nonperfusion, retinal hemorrhage, disc swelling, and vitreitis. Oral prednisone was of some benefit in these patients and oral acyclovir was generally ineffectiv...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(88)32951-9
更新日期:1988-12-01 00:00:00
abstract:PURPOSE:To investigate postoperative macular ganglion cell-inner plexiform layer (GCIPL) thickness, determine the factors related to GCIPL thickness, and evaluate the association of GCIPL thickness with postoperative visual outcomes in patients with idiopathic epiretinal membrane (ERM). DESIGN:Retrospective, cohort st...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2014.02.010
更新日期:2014-08-01 00:00:00
abstract::Anterior clear spaces were observed prospectively at slit-lamp examination in 26 of 69 consecutive eyes (38%) with keratoconus. Two corneal buttons with this finding were examined by light and electron microscopy and revealed breaks in Bowman's layer. Anterior clear spaces should be considered in the spectrum of clini...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33571-1
更新日期:1986-10-01 00:00:00
abstract:PURPOSE:Intravitreal anti-vascular endothelial growth factor (VEGF) pharmacotherapy plays a central role in the management of neovascular age-related macular degeneration (nAMD), diabetic retinal disease (DRD), and retinal venous occlusive disease (RVO). Within clinical trials, rates of systemic serious adverse events ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2020.07.062
更新日期:2020-08-08 00:00:00
abstract:OBJECTIVE:To assess associations between health-related quality of life (HRQOL) and the decision to perform strabismus surgery for children with intermittent exotropia. DESIGN:Retrospective chart review. PARTICIPANTS:Children with intermittent exotropia. METHODS:Included subjects, identified in a clinical practice, ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.10.029
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:To evaluate the costs and cost-utility of examination for posterior vitreous detachment (PVD) and treatment of associated pathology, and of managing various other peripheral retinal disorders to prevent retinal detachment (RD). DESIGN:A decision analysis model of cost-utility. PARTICIPANTS:There were no parti...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2017.06.019
更新日期:2018-01-01 00:00:00
abstract::The authors studied 11 eyes of 10 patients who complained of a recent decrease in vision and whose eyes had the clinical appearance of stage 5 retinopathy of prematurity (ROP) as diagnosed by the presence of a dense, opaque retrolenticular membrane. Patients ranged in age from 4 to 33 years, and birth weights ranged f...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32170-5
更新日期:1991-07-01 00:00:00
abstract:PURPOSE:To identity anatomic risk factors involved in the onset of retinal complications causing decrease of visual acuity (VA) in the fellow eyes of highly myopic patients operated for retinal detachment with macular hole (RDMH). DESIGN:Cohort study. PARTICIPANTS:Ninety-eight patients (mean age, 51.5+/-8.0 years) wi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.02.016
更新日期:2008-09-01 00:00:00
abstract::Triamcinolone acetonide (TA) was injected subconjunctivally in nine human eyes one week before trabeculectomy. A biopsy specimen of conjunctiva and subconjunctiva was obtained from the site of drug injection, as well as a site 6 mm from the injection at the time of trabeculectomy. The tissue was evaluated by electron ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:
更新日期:1987-02-01 00:00:00
abstract:PURPOSE:To investigate side effects seen with this formulation and to search for evidence of effectiveness after a single intravitreal injection of IBI-20089 in eyes with cystoid macular edema (CME) secondary to retinal vein occlusion. DESIGN:Prospective, phase 1 clinical trial. PARTICIPANTS:Ten patients with chronic...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.12.029
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the ability of stereoscopic nonmydriatic digital retinal imaging to detect ocular pathologic features other than diabetic retinopathy (DR) in patients with diabetes mellitus (DM) compared with dilated retinal examination by retinal specialist ophthalmologists. DESIGN:Clinic-based comparative inst...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.12.025
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of oversized corneal grafts in the pediatric age group. DESIGN:Prospective, nonrandomized clinical trial. PARTICIPANTS AND INTERVENTION:Forty pediatric patients with unilateral or bilateral corneal opacification of congenital or acquired origin underwent corneal grafting surgery ove...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/S0161-6420(99)90174-4
更新日期:1999-04-01 00:00:00
abstract:PURPOSE:Patients undergoing enucleation for uveal melanoma need to be informed of the possibility of phantom eye syndrome (PES). The number with uveal melanoma in PES studies has been small. Aims were to: (1) determine the prevalence, symptoms, and characteristics of PES and to test associations of PES symptoms with so...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2015.04.005
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVES:To determine the anatomic and functional outcomes of photorefractive surgery in patients with underlying systemic diseases that are traditionally listed as relative or absolute contraindications. DESIGN:Observational retrospective case-control study. PARTICIPANTS:The case groups were composed of 275 eyes o...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.02.023
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:To study the adherence of rheumatologists to the hydroxychloroquine (HCQ) dosing guidelines established by the American Academy of Ophthalmology in 2011 and 2016. DESIGN:Retrospective review of electronic medical records (EMRs) in an integrated health care system. PARTICIPANTS:All rheumatology patients starte...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.12.021
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:To investigate the ability of sectorial analysis using the Heidelberg Retinal Tomograph 3 (HRT3) to discriminate between healthy and glaucomatous eyes and to determine whether this is affected by disc size and glaucoma severity. DESIGN:Multicenter, cross-sectional evaluation of diagnostic tests. PARTICIPANTS:...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2009.01.020
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:The ability to detect reticular pseudodrusen (RPD)/subretinal drusenoid deposits (SDDs) using 12×12-mm widefield en face swept-source optical coherence tomography (SS-OCT) imaging was compared with conventional multimodal imaging (color, fundus autofluorescence (FAF), and infrared reflectance [IR] imaging) in e...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.10.009
更新日期:2017-02-01 00:00:00