Abstract：
:We compared the ocular-hypotensive efficacy and systemic and ocular safety of an ophthalmic solution of levobunolol (0.5% and 1%) twice daily, with timolol (0.5%) twice daily in a long-term double-masked study of 391 patients with open-angle glaucoma or ocular hypertension. Patients received the test medication in both eyes for up to two years. Over the two-year period, both concentrations of levobunolol reduced mean IOP by 27% (range, -6 to -8 mmHg). This ocular-hypotensive effect was sustained throughout the study and was similar to that produced by timolol. Slight decreases in mean heart rate and blood pressure were observed. No unexpected adverse ocular or systemic reactions were reported. The results of these studies indicate that levobunolol is an effective therapy for the long-term treatment of glaucoma.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
subject
Has Abstractpub_date
1985-09-01 00:00:00pages
1271-6issue
9eissn
0161-6420issn
1549-4713pii
S0161-6420(85)33887-3journal_volume
92pub_type
临床试验,杂志文章,随机对照试验相关文献
OPHTHALMOLOGY文献大全abstract：OBJECTIVE:The authors prospectively studied visual outcome, relapse, complications, and survival of patients with acquired immune deficiency syndrome (AIDS)-related cytomegalovirus (CMV) treated with high-dose intravitreous ganciclovir (2 mg/0.1 ml) injections. The outcomes were compared with those of patients treated ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(98)98020-4
更新日期：1998-08-01 00:00:00
abstract：PURPOSE:To describe and classify patterns of abnormal fundus autofluorescence (FAF) of patients with β-thalassemia receiving long-term treatment with deferoxamine (DFO). DESIGN:Prospective, cross-sectional, case-control study. PARTICIPANTS:A total of 197 consecutive patients with β-thalassemia major or intermedia wit...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.01.039
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:To investigate the relationship between the degree of posterior bowing of the lamina cribrosa (LC) at baseline and the rate of subsequent visual field (VF) progression in eyes with primary open-angle glaucoma (POAG). DESIGN:Prospective, observational study. PARTICIPANTS:One hundred one early-stage (VF mean de...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2018.05.017
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Orbital extraocular extension of choroidal melanoma is well known and is usually detected in eyes with medium and large tumors, but it is very rare with small melanomas. It is particularly unusual for choroidal melanomas of any size to invade the optic nerve or its meninges. DESIGN:Two case reports. PARTIC...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(99)00723-X
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND/PURPOSE:To assess the potential of a new diagnostic technique called optical coherence tomography for imaging macular disease. Optical coherence tomography is a novel noninvasive, noncontact imaging modality which produces high depth resolution (10 microns) cross-sectional tomographs of ocular tissue. It is ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(95)31032-9
更新日期：1995-02-01 00:00:00
abstract：OBJECTIVE:Nonmydriatic fundus photography by non-ophthalmic-trained personnel has recently been shown to be a potential alternative to direct ophthalmoscopy in the emergency department (ED). We evaluated the reliability of a novel quality rating scale and applied this scale to nonmydriatic fundus photographs taken duri...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2011.09.013
更新日期：2012-03-01 00:00:00
abstract：:The case of a young woman with giant cell polymyositis is described. She had bilateral, severe, midly painful proptosis and ophthalmoplegia. Extensive pharyngeal, laryngeal, and cardiac muscle involvement occurred 18 months later coincident with fatal cardiac arrhythmia. At autopsy, extensive muscle necrosis and giant...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(90)32554-x
更新日期：1990-04-01 00:00:00
abstract：PURPOSE:To determine the incidence of retinopathy of prematurity (ROP) over a 2-year period before and after a change in the practice of oxygen supplementation. DESIGN:Nonrandomized, retrospective study. PARTICIPANTS:All infants in a single Level III neonatal intensive care unit between the years of 2005 and 2007. M...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2008.09.051
更新日期：2009-03-01 00:00:00
abstract：:A prospective randomized trial was carried out during the years 1974 to 1981 to determine whether preoperative antibiotic soaking of silicone sponges used in retinal detachment surgery would reduce the incidence of postoperative infection and extrusion. During this period 2972 consecutive primary scleral buckles were ...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0161-6420(84)34105-7
更新日期：1984-12-01 00:00:00
abstract：PURPOSE:To describe a systematic approach for managing the structural adnexal anomalies encountered in Fraser syndrome, a multisystem, autosomal recessive condition associated with cryptophthalmos. DESIGN:Retrospective, noncomparative, interventional case series. PARTICIPANTS:All patients with Fraser syndrome-related...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2009.05.018
更新日期：2009-09-01 00:00:00
abstract：PURPOSE:To evaluate whether nonrecovery from acute traumatic sixth nerve palsy could be predicted from demographic factors or palsy characteristics. DESIGN:Prospective, observational case series SETTING:Multicenter (academic and private practices). OUTCOME MEASURE:Nonrecovery, defined as the presence of diplopia in ...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/s0161-6420(01)00633-9
更新日期：2001-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the visual and refractive outcome of corneal transplant surgery, cataract extraction, and intraocular lens (IOL) implantation in children with traumatic corneal laceration and cataract. DESIGN:Retrospective, noncomparative case series. PARTICIPANTS:Five patients, 7 years of age or younger, who u...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(00)00524-8
更新日期：2001-02-01 00:00:00
abstract：PURPOSE:To describe the safety and effectiveness of using autologous serum-based eye drops for the treatment of severe dry eye and persistent corneal epithelial defect. METHODS:Literature searches of the PubMed and Cochrane Library databases were conducted most recently in March 2019. The searches identified 281 citat...
journal_title：Ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/j.ophtha.2019.08.018
更新日期：2020-01-01 00:00:00
abstract：:The exposure of the levator aponeurosis during blepharoplasty allows the creation of a fixed, distinct lid crease and the opportunity for repair of any defect in the aponeurosis. The conventional blepharoplasty without deep fixation may show the scar separate from the crease and a tendency for early redundancy of skin...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(78)35623-2
更新日期：1978-07-01 00:00:00
abstract：PURPOSE:To describe a newly recognized clinical syndrome consisting of ptosis, diplopia, vertical gaze limitation, and abduction weakness that can occur after orbital roof removal during orbito-zygomatic-pterional craniotomy. DESIGN:Case series. PARTICIPANTS:Eight study patients (7 women), 44 to 80 years of age, with...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2014.09.011
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:The differentiating characteristics in blebitis and early and late endophthalmitis after glaucoma filtration surgery are reviewed. METHODS:All admission records and operative reports, as well as available office notes, on patients with blebitis or bleb-associated endophthalmitis admitted to a large referral ey...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(97)30196-1
更新日期：1997-06-01 00:00:00
abstract：PURPOSE:As of December 31, 2000, the neodymium:yttrium-aluminum-garnet (Nd:YAG) laser posterior capsulotomy rate for the Alcon AcrySof intraocular lens (IOL) as measured in our database was 3.3%. This was the lowest of any IOL model used in the United States. Only 12 of 361 cases required treatment. We analyzed possibl...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(02)01116-8
更新日期：2002-08-01 00:00:00
abstract：OBJECTIVE:To compare the intraocular pressure (IOP)-reducing effect and side effects of 0.005% latanoprost once daily to 0.5% timolol twice daily in patients with primary chronic angle closure glaucoma (CACG). DESIGN:Randomized, double-masked two-center clinical trial. PARTICIPANTS:Thirty-two Asian patients with CACG...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0161-6420(00)00073-7
更新日期：2000-06-01 00:00:00
abstract：PURPOSE:To determine the risks for altered cytogenetic profile based on melanoma features and size. DESIGN:Retrospective case series. PARTICIPANTS:A total of 1059 patients with uveal melanoma. METHODS:Fine-needle aspiration biopsy (FNAB) of tumor for DNA amplification and whole genome array-based assay. MAIN OUTCOM...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2016.12.026
更新日期：2017-05-01 00:00:00
abstract：:Because of their size and mass, weight is a major concern in the fitting of soft gel lenses. Lenticular design is necessary, and there are essentially two lens designs for aphakia: the spin-cast lens of Bausch & Lomb and the lathe-cut lenses of the other manufacturers. A solution to the problem of weight in a single c...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(79)35500-2
更新日期：1979-03-01 00:00:00
abstract：OBJECTIVE:To assess the posterior corneal power and asphericity changes after myopic laser in situ keratomileusis (LASIK) and to correlate these changes with the amount of correction and the residual stromal bed thickness. DESIGN:Prospective nonrandomized (self-controlled) comparative study. PARTICIPANTS:Fifty-seven ...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0161-6420(00)00581-9
更新日期：2001-04-01 00:00:00
abstract：BACKGROUND:Malignant glaucoma (ciliary block glaucoma; aqueous misdirection glaucoma) is an incompletely understood, rare and serious complication of intraocular surgery. METHODS:A woman with pseudophakic malignant glaucoma underwent successful neodymium: YAG (Nd:YAG) laser photodisruption of the anterior hyaloid face...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(93)31479-x
更新日期：1993-09-01 00:00:00
abstract：OBJECTIVES:To determine the anatomic and functional outcomes of photorefractive surgery in patients with underlying systemic diseases that are traditionally listed as relative or absolute contraindications. DESIGN:Observational retrospective case-control study. PARTICIPANTS:The case groups were composed of 275 eyes o...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2006.02.023
更新日期：2006-07-01 00:00:00
abstract：PURPOSE:To establish the accurate surgical anatomy of endonasal dacryocystorhinostomy (DCR) based on the radiological analysis of underlying bony structures. DESIGN:Prospective noncomparative observational case series study. PARTICIPANTS:Fifty-nine patients with complete nasolacrimal stenosis underwent a computed tom...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2005.01.012
更新日期：2005-06-01 00:00:00
abstract：PURPOSE:To develop a standardized clinical grading system for the management of patients with vernal keratoconjunctivitis (VKC) and to identify the risk factors associated with a worsened outcome of the disease, including decrease of visual acuity and ocular complications development. DESIGN:Retrospective cohort study...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2009.11.043
更新日期：2010-07-01 00:00:00
abstract：PURPOSE:To describe the clinical and cytopathologic characteristics in patients with vitreous opacity of unknown cause or preceding inflammation, diagnosed cytopathologically as inflammation. DESIGN:Retrospective case series. PARTICIPANTS:Forty-three consecutive patients (61 eyes) who underwent vitrectomy for vitreou...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2011.10.020
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:To compare 3-year outcomes and complications of the Ahmed FP7 Glaucoma Valve (AGV) (New World Medical, Cucamonga, CA) and the Baerveldt Glaucoma Implant (BGI) 101-350 (Abbott Medical Optics, Abbott Park, IL) for the treatment of refractory glaucoma. DESIGN:Multicenter, randomized, controlled clinical trial. P...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2014.01.036
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the spectrum and antibiotic susceptibility panel of infectious keratitis at a major tertiary care referral eye center and a major county hospital in Southern California. DESIGN:Retrospective case series. PARTICIPANTS:All cultured infectious keratitis cases from July 1, 2008, through December 31,...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2014.11.027
更新日期：2015-05-01 00:00:00
abstract：:Asymptomatic hyperdeviation (HD) in peripheral gaze may be caused by muscle paresis, restrictive orbital diseases, cranial neuropathy, or skew deviation. The authors suspected that this finding was often physiologic and therefore examined 61 normal subjects with the Maddox rod. Forty-seven of 61 patients (77%) showed ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(88)33108-8
更新日期：1988-06-01 00:00:00
abstract：OBJECTIVE:To determine the longitudinal trends in the probability of blindness due to open-angle glaucoma (OAG) in Olmsted County, Minnesota, from 1965 to 2009. DESIGN:Retrospective, population-based cohort study. PARTICIPANTS:All residents of Olmsted County, Minnesota (aged ≥ 40 years) who were diagnosed with OAG be...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2013.09.003
更新日期：2014-01-01 00:00:00
