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Imaging of macular diseases with optical coherence tomography.

Abstract：

BACKGROUND/PURPOSE:To assess the potential of a new diagnostic technique called optical coherence tomography for imaging macular disease. Optical coherence tomography is a novel noninvasive, noncontact imaging modality which produces high depth resolution (10 microns) cross-sectional tomographs of ocular tissue. It is analogous to ultrasound, except that optical rather than acoustic reflectivity is measured. METHODS:Optical coherence tomography images of the macula were obtained in 51 eyes of 44 patients with selected macular diseases. Imaging is performed in a manner compatible with slit-lamp indirect biomicroscopy so that high-resolution optical tomography may be accomplished simultaneously with normal ophthalmic examination. The time-of-flight delay of light backscattered from different layers in the retina is determined using low-coherence interferometry. Cross-sectional tomographs of the retina profiling optical reflectivity versus distance into the tissue are obtained in 2.5 seconds and with a longitudinal resolution of 10 microns. RESULTS:Correlation of fundus examination and fluorescein angiography with optical coherence tomography tomographs was demonstrated in 12 eyes with the following pathologies: full- and partial-thickness macular hole, epiretinal membrane, macular edema, intraretinal exudate, idiopathic central serous chorioretinopathy, and detachments of the pigment epithelium and neurosensory retina. CONCLUSION:Optical coherence tomography is potentially a powerful tool for detecting and monitoring a variety of macular diseases, including macular edema, macular holes, and detachments of the neurosensory retina and pigment epithelium.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Puliafito CA,Hee MR,Lin CP,Reichel E,Schuman JS,Duker JS,Izatt JA,Swanson EA,Fujimoto JG

doi

10.1016/s0161-6420(95)31032-9

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

217-29

issue

2

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(95)31032-9

journal_volume

102

pub_type

杂志文章

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