Abstract：
BACKGROUND:Intraocular lymphoma is associated with significant morbidity and mortality, but early diagnosis and treatment may improve prognosis. METHODS:The diagnostic features of 12 cases of intraocular lymphoma diagnosed at the National Eye Institute between 1984 and 1992 were retrospectively reviewed. RESULTS:A pathologic diagnosis of large B-cell lymphoma was made on vitrectomy specimens in ten patients, cerebral spinal fluid in one, and on an enucleation specimen in one. The mean time from onset of symptoms to diagnosis was 21.4 months (range, 1-66 months). All 12 patients were given a final diagnosis of non-Hodgkin's lymphoma of the central nervous system (NHL-CNS), based on the epidemiology, pathology, and clinical course of their tumors. Although an initial vitrectomy was negative for malignant cells in three of ten patients, a repeat vitrectomy specimen subsequently showed intraocular lymphoma. Results of examination of the cerebrospinal fluid (CSF) showed malignant cells in 5 of 11 patients, although malignant cells were only identified after repeat examination of additional samples of CSF in three of these patients. Malignant cells often are difficult to identify, and an experienced cytopathologist was critical in making the correct diagnosis. In addition, corticosteroids are lympholytic to the lymphoma cells, and they appeared to decrease the viability of tumor cells obtained in samples of vitreous and CSF. CONCLUSION:The prompt, appropriate handling of specimens and review by an experienced cytopathologist are critical to the diagnosis of intraocular lymphoma. Malignant cells often are present in the cerebral spinal fluid at the time that ocular lymphoma is diagnosed. Nevertheless, multiple vitrectomies and lumbar punctures may be necessary before the correct diagnosis is made.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Whitcup SM,de Smet MD,Rubin BI,Palestine AG,Martin DF,Burnier M Jr,Chan CC,Nussenblatt RBdoi
10.1016/s0161-6420(93)31469-7subject
Has Abstractpub_date
1993-09-01 00:00:00pages
1399-406issue
9eissn
0161-6420issn
1549-4713pii
S0161-6420(93)31469-7journal_volume
100pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract：PURPOSES:To evaluate submacular surgery for the management of subfoveal choroidal neovascularization in punctate inner choroidopathy, to describe the histopathology and ultrastructure of the excised subretinal tissue, and to propose a staging system that characterizes the development of choroidal neovascularization wit...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(96)30387-4
更新日期：1996-12-01 00:00:00
abstract：PURPOSE:To test if improving optical coherence tomography (OCT) resolution and scanning speed improves the visualization of glaucomatous structural changes as compared with conventional OCT. DESIGN:Prospective observational case series. PARTICIPANTS:Healthy and glaucomatous subjects in various stages of disease. MET...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2007.06.038
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of superior and temporal scleral incisions on regular and irregular astigmatism in small incision cataract surgery. DESIGN:Prospective, randomized, comparative clinical trial. PARTICIPANTS:One hundred seventy-four eyes of 87 patients with bilateral cataracts scheduled to undergo routi...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0161-6420(00)00379-1
更新日期：2000-11-01 00:00:00
abstract：:Nine patients with advanced epithelial ingrowth underwent Molteno implantation for medically uncontrollable secondary glaucomas. Substantial reductions in intraocular pressures (IOPs) were observed in most patients (preoperative IOPs ranged from 5 to 48 mmHg [mean +/- standard deviation, 33.6 +/- 14.6 mmHg]; postopera...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(90)32541-1
更新日期：1990-05-01 00:00:00
abstract：PURPOSE:To report the histopathologic findings of a series of patients from an outbreak of Streptococcal endophthalmitis after intravitreal injection of bevacizumab prepared by a single compounding pharmacy. DESIGN:Case series. PARTICIPANTS:Seven surgical specimens (5 enucleated globes and 2 evisceration specimens) f...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2013.10.015
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:To assess the posterior corneal power and asphericity changes after myopic laser in situ keratomileusis (LASIK) and to correlate these changes with the amount of correction and the residual stromal bed thickness. DESIGN:Prospective nonrandomized (self-controlled) comparative study. PARTICIPANTS:Fifty-seven ...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/s0161-6420(00)00581-9
更新日期：2001-04-01 00:00:00
abstract：PURPOSE:To calculate the relationship between Medicare payment and service volume for the 3 highest-volume retina procedures: intravitreal injection (Current Procedural Terminology [CPT] code 67028), laser treatment for retinal edema (CPT code 67210), and laser treatment for proliferative retinopathy (CPT code 67228). ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2015.04.040
更新日期：2015-08-01 00:00:00
abstract：:An elderly, Spanish-speaking patient, who was a poor historian, presented with a hemorrhagic corneal condition that was mistakenly diagnosed as a spontaneous expulsive choroidal hemorrhage leading to enucleation of the globe. The enucleation specimen revealed pathologically a diffuse hemorrhagic pannus without corneal...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(81)34964-1
更新日期：1981-07-01 00:00:00
abstract：PURPOSE:To study the associations between long-term and short-term use of topical beta-blockers and mortality. DESIGN:Prospective population-based cohort study. PARTICIPANTS:To examine long-term effects, 3842 participants aged 55 years and older were recruited. To examine short-term effects, 484 incident beta-blocker...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2008.07.004
更新日期：2008-11-01 00:00:00
abstract：:Granulomatous uveitis has infrequently been described as a manifestation of the autoimmune phenomena of multiple sclerosis (MS). The authors describe six cases of anterior granulomatous uveitis in patients with MS. All six patients had features of iridocyclitis and three patients had features of periphlebitis, which w...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(91)32324-8
更新日期：1991-02-01 00:00:00
abstract：OBJECTIVE:To compare pathologic changes in photoreceptors in eyes with resolved central serous chorioretinopathy (CSC) seen on high-resolution images obtained by adaptive optics scanning laser ophthalmoscopy (AO SLO) with visual acuity (VA) and findings on spectral-domain optical coherence tomography (SD OCT). DESIGN:...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2010.01.042
更新日期：2010-09-01 00:00:00
abstract：PURPOSE:To demonstrate dynamic, reversible abnormalities in ophthalmic artery blood flow velocity identified with color Doppler imaging (CDI) in patients with clinical findings of ocular ischemia with and without carotid artery stenosis. METHODS:One patient with ocular ischemia and normal carotid arteries had abnormal...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(95)30821-4
更新日期：1995-11-01 00:00:00
abstract：PURPOSE:Ketorolac is a new, parenteral, nonsteroidal, anti-inflammatory agent. The authors compare the effectiveness of a single intravenous dose of ketorolac with a single oral dose of either acetaminophen or ibuprofen in controlling postoperative pain in patients with strabismus. METHODS:A prospective, randomized, d...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0161-6420(94)31238-3
更新日期：1994-05-01 00:00:00
abstract：:Bimedial rectus recession with measurement from the limbus was combined with conjuctival recession 85 children undergoing surgery for esotropia. Using this augmented recession technique, the prism diopters of correction per millimeter of surgery done were 4.8 compared with 3.2 found in 56 control patients. Postoperati...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(78)35647-5
更新日期：1978-05-01 00:00:00
abstract：OBJECTIVE:To determine the usefulness of "routine" lacrimal sac biopsy to evaluate unsuspected neoplasm or systemic disease in patients with acquired nasolacrimal duct obstruction. DESIGN:Noncomparative, interventional case series with histopathologic correlation. PARTICIPANTS:Review of charts revealed histopathologi...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(02)01082-5
更新日期：2002-07-01 00:00:00
abstract：:The treatment of severe congenital ptosis may include frontalis suspension or maximal levator resection. A previous study of 145 consecutive frontalis suspensions for congenital ptosis showed a fairly high recurrence rate, frequent granuloma formation, and significant brow scars. In 28 patients undergoing 32 maximal l...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(86)33714-x
更新日期：1986-04-01 00:00:00
abstract：OBJECTIVE:To determine the efficacy of a combination of 5-fluorouracil (5FU) and low-molecular-weight heparin (LMWH) in the treatment of unselected rhegmatogenous retinal detachment (RRD) undergoing primary vitrectomy. DESIGN:Double-masked, prospective, randomized, placebo-controlled clinical trial. PARTICIPANTS:Six ...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2006.08.042
更新日期：2007-04-01 00:00:00
abstract：:Patients suffering a central retinal vein occlusion should be evaluated for conditions that promote and/or contribute to the formation of a thrombosis in the central retinal vein. These conditions include alterations of blood flow, altered viscosity of the blood, abnormalities of coagulation, and abnormalities of vess...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(83)34528-0
更新日期：1983-05-01 00:00:00
abstract：PURPOSE:To compare preoperative and postoperative spherical aberration, coma, and other higher order aberrations from wavefront LASIK at varying pupil analysis diameters and different myopic corrections, and to determine acceptable parameters for wavefront measurements. DESIGN:Nonrandomized retrospective chart review....
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2005.01.013
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Orbital decompression has been used to describe surgical procedures that remove some portion of the orbital walls to reduce pressure on the orbital contents. Substantial morbidity associated with these procedures includes infraorbital anesthesia, worsened extraocular motility, globe displacement, and blindne...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(93)31589-7
更新日期：1993-05-01 00:00:00
abstract：:The authors studied 80 eyes of patients with choroidal neovascular membranes (CNVMs) associated with age-related macular degeneration between 1982 and 1988. In each case, fluorescein angiography was done on two occasions separated by an interval of 2 days to 11 weeks (average, 13 days) without intervening photocoagula...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(89)32741-2
更新日期：1989-09-01 00:00:00
abstract：:The authors report seven patients in whom the acute retinal necrosis (ARN) syndrome developed shortly after cutaneous varicella zoster infection. The length of time between the skin infection and ARN varied from 5 days to 3 months. Both eyes were affected in one of seven cases. The ophthalmic branch of cranial nerve V...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(87)33405-0
更新日期：1987-06-01 00:00:00
abstract：PURPOSE:To estimate payments for glaucoma care among Medicare beneficiaries from 2002 to 2009. DESIGN:Database study. PARTICIPANTS:Data from a 5% random sample of Medicare billing information from 2002 to 2009. METHODS:Medicare beneficiaries, aged 65 years or older, with both Parts A and B fee-for-service (FFS) enro...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2013.04.027
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:To describe the histopathology of Molteno implant capsules in cases of primary and secondary glaucoma and to correlate them with surgical technique and clinical outcomes in quiet eyes. DESIGN:Human tissue study with clinicopathological correlation. MATERIALS:Seventy-five autopsy eyes or surgical pathology s...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(03)00803-0
更新日期：2003-11-01 00:00:00
abstract：PURPOSE:We sought to determine whether genotype is associated with rate of growth of geographic atrophy (GA) in eyes with age-related macular degeneration (AMD). DESIGN:Prospective analysis of participants in a randomized controlled clinical trial. PARTICIPANTS:We included 114 eyes of 114 participants in the Age-Rela...
journal_title：Ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ophtha.2009.12.012
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:To evaluate prospectively the corneal refractive status before and after pterygium surgery and its relationship with preoperative pterygium size. DESIGN:Prospective, nonrandomized, comparative (self-controlled) trial. PARTICIPANTS:One hundred thirty-six eyes undergoing primary pterygium removal surgery. MA...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(00)00219-0
更新日期：2000-08-01 00:00:00
abstract：:Up to now, the attention of ophthalmic surgeons has been focused mainly on the clinical results of epikeratophakia, demonstrating its safety, relative predictability, and capability of correcting a wide range of refractive errors. However, no prospective study has ever been undertaken to evaluate the influence of epik...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(90)32585-x
更新日期：1990-03-01 00:00:00
abstract：:Comparisons between automated suprathreshold static perimetry and manual kinetic perimetry were performed for 226 eyes with glaucoma or ocular hypertension, and 147 eyes with other optic nerve disease. Both techniques produced similar high detection rates for glaucomatous visual field defects, whereas suprathreshold s...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(79)35399-4
更新日期：1979-07-01 00:00:00
abstract：PURPOSE:To develop a new foveal hypoplasia grading system using optical coherence tomography (OCT) and to determine the correlations of visual acuity to the iris transillumination, macular transparency, and foveal hypoplasia grades, respectively, in young albinism patients. DESIGN:Observational case series. PARTICIPA...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2006.10.054
更新日期：2007-08-01 00:00:00
abstract：PURPOSE:To evaluate Orbscan II (Bausch & Lomb, Orbtek Inc., Salt Lake City, UT) corneal topography in individuals with myopia. DESIGN:Retrospective, observational, consecutive, clinical case series. PARTICIPANTS:One hundred forty eyes of 70 persons with myopia. METHODS:Manifest refraction results and the Orbscan II ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2005.11.004
更新日期：2006-02-01 00:00:00
