Prevalence and risks factors of age-related macular degeneration in Oklahoma Indians: the Vision Keepers Study.


OBJECTIVE:To determine the prevalence of age-related macular degeneration (AMD) and to identify its risk factors in an Oklahoma Indian population. DESIGN:Cross-sectional study design. PARTICIPANTS:Included 1019 Oklahoma Indians who participated in baseline and second examinations of the Strong Heart Study. METHODS:Retinal photographs of at least 1 eye were obtained and graded for AMD by the University of Wisconsin Ocular Epidemiology Reading Center. Retinal photographs of 986 participants were considered gradable and were included in the study. MAIN OUTCOME MEASURES:Age-related macular degeneration (early and late). RESULTS:The overall prevalence of AMD in the study was 35.2%, including a prevalence of 0.81% for late AMD. The prevalence of early AMD increased from 30.6% in those aged 48 to 59 years to 46.1% in those 70 to 82 years of age. When potential risk factors were analyzed individually (univariate analyses), men with hypertension had a significantly higher prevalence of AMD (P = 0.02) than those without hypertension. In women, high-density lipoprotein cholesterol and sun exposure were associated positively with the prevalence of AMD (P = 0.01), whereas a history of using multivitamins was associated with lower AMD prevalence (P = 0.005). When multiple risk factors were analyzed simultaneously using logistic regression, only age showed significant association with AMD in both men (P = 0.02) and women (P<0.0001) and was the only significant risk factor in men. In women, multivitamin use and total cholesterol had a significant inverse association with AMD, whereas sun exposure and high-density lipoprotein cholesterol had a positive association. When men and women were combined, age and high-density lipoprotein cholesterol had significant positive associations, whereas total cholesterol, multivitamin use, and current alcohol use showed a significant inverse association with AMD. CONCLUSIONS:This study was the first to report a detailed prevalence of AMD in Oklahoma Indians and its risk factors. The prevalence seemed to be relatively high compared with that in other ethnic groups. Some of the modifiable risk factors identified confirmed previous findings and can be used to design preventive programs to reduce the burden of AMD, although longitudinal data are still needed.






Butt AL,Lee ET,Klein R,Russell D,Ogola G,Warn A,Kingsley RM,Yeh J




Has Abstract


2011-07-01 00:00:00














  • Adverse reactions from timolol administration.

    abstract::Five hundred forty-seven reports of adverse reactions to timolol maleate received by the National Registry for Drug-induced Ocular Side Effects during an eleven-month period were reviewed. Approximately half the reports concerned systemic reactions affecting the cardiac, pulmonary, central nervous, gastrointestinal, a...


    pub_type: 杂志文章


    authors: Van Buskirk EM

    更新日期:1980-05-01 00:00:00

  • Acute promyelocytic infiltration of the optic nerve treated by oral trans-retinoic acid.

    abstract:BACKGROUND:Oral trans-retinoic acid has recently been shown to be an effective treatment modality for acute promyelocytic leukemia. This type of drug differs from traditional tumoricidal agents by promoting differentiation of the malignant, immature cells. METHODS:The authors describe a patient with optic nerve infilt...


    pub_type: 杂志文章


    authors: Brown DM,Kimura AE,Ossoinig KC,Weiner GJ

    更新日期:1992-09-01 00:00:00

  • Effect of hinged lamellar keratotomy on postkeratoplasty eyes.

    abstract:PURPOSE:To evaluate the effect of a hinged lamellar keratotomy on refraction, vision, and corneal topography of postkeratoplasty eyes with high-degree astigmatism. DESIGN:Noncomparative, interventional case series. PARTICIPANTS:A hinged lamellar keratotomy was performed on nine eyes of nine patients at least 9 months...


    pub_type: 杂志文章


    authors: Busin M,Arffa RC,Zambianchi L,Lamberti G,Sebastiani A

    更新日期:2001-10-01 00:00:00

  • The Relationship between Medicare Payment and Service Volume for Retina Procedures from 2005 through 2009.

    abstract:PURPOSE:To calculate the relationship between Medicare payment and service volume for the 3 highest-volume retina procedures: intravitreal injection (Current Procedural Terminology [CPT] code 67028), laser treatment for retinal edema (CPT code 67210), and laser treatment for proliferative retinopathy (CPT code 67228). ...


    pub_type: 杂志文章


    authors: Gong D,Jun L,Tsai JC

    更新日期:2015-08-01 00:00:00

  • Enucleation versus plaque irradiation for choroidal melanoma.

    abstract::The Collaborative Ocular Melanoma Study (COMS) is an international, multicenter-controlled study. The organization includes an Executive Committee, Steering Committee, 6 Central Units, 32 Clinical Centers, and a Data and Safety Monitoring Committee. Scientifically, the COMS consists of (1) a randomized trial of patien...


    pub_type: 杂志文章


    authors: Straatsma BR,Fine SL,Earle JD,Hawkins BS,Diener-West M,McLaughlin JA

    更新日期:1988-07-01 00:00:00

  • Treatment of vitreoretinal disorders in the developing world: indications and outcomes of vitreoretinal surgery in Nepal.

    abstract:PURPOSE:To examine the outcomes of vitreoretinal surgery for retinal disorders at Tilganga Eye Centre in Kathmandu, Nepal. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:Records of 255 patients undergoing vitreoretinal surgery from December 2000 to January 2003 were reviewed. METHODS:Demographics, dia...


    pub_type: 杂志文章


    authors: Paudyal G,Doshi V,Shrestha MK,Kalayoglu MV,Tabin G,Gurung R,Shrestha B,Ruit S

    更新日期:2005-02-01 00:00:00

  • Congenital Horner's syndrome resulting from agenesis of the internal carotid artery.

    abstract:OBJECTIVE:To report a patient with agenesis of the right internal carotid artery associated with ipsilateral, congenital Homer's syndrome. DESIGN:Case report. METHODS:A 30-year-old woman, with a past history of migraine headaches, underwent neuro-ophthalmologic and neuroradiologic evaluation for transient visual obsc...


    pub_type: 杂志文章


    authors: Ryan FH,Kline LB,Gomez C

    更新日期:2000-01-01 00:00:00

  • Malignant rhabdoid tumor of the orbit.

    abstract::Malignant rhabdoid tumor (MRT), originally described as a sarcomatous variant of Wilms' tumor, is now recognized as a distinct, highly malignant entity. The authors describe, for the first time, a primary tumor of the orbit with histologic, immunohistochemical, and ultrastructural features of MRT. Their findings sugge...


    pub_type: 杂志文章


    authors: Rootman J,Damji KF,Dimmick JE

    更新日期:1989-11-01 00:00:00

  • Excimer laser smoothing of a reproducible model of anterior corneal surface irregularity.

    abstract::A reproducible model of an irregular corneal surface was developed to test the ability of the excimer laser to treat such surfaces. Using a 193-nm argon fluoride excimer laser set at a fluence of 160 mJ/cm2, repetition rate of 10 Hz, and 185 pulses, fresh de-epithelialized pig eyes underwent phototherapeutic ablations...


    pub_type: 杂志文章


    authors: Fasano AP,Moreira H,McDonnell PJ,Sinbawy A

    更新日期:1991-12-01 00:00:00

  • Ophthalmic manifestations of Danon disease.

    abstract:PURPOSE:To describe the ophthalmic findings in patients with Danon disease, an X-linked condition causing cardiomyopathy in males and females. DESIGN:Retrospective case series. PARTICIPANTS:Patients with genetically proven Danon disease. METHODS:Retrospective chart review of complete eye examinations including elect...


    pub_type: 杂志文章


    authors: Prall FR,Drack A,Taylor M,Ku L,Olson JL,Gregory D,Mestroni L,Mandava N

    更新日期:2006-06-01 00:00:00

  • Congenital pupillary-iris-lens membrane with goniodysgenesis (a new entity).

    abstract::We encountered two clinically similar but genetically unrelated cases of a disorder characterized by an unusual white pupillary-iris-lens membrane with extension to a prominent Schwalbe's line, the membranes were vascularized and their appearance changed over time. In both cases the abnormality was unilateral. Anomalo...


    pub_type: 杂志文章


    authors: Cibis GW,Waeltermann JM,Hurst E,Tripathi RC,Richardson W

    更新日期:1986-06-01 00:00:00

  • Chorioretinitis in the contralateral eye of a patient with Acanthamoeba keratitis.

    abstract::Chorioretinitis developed in the right eye of a patient with contact lens-associated Acanthamoeba keratitis in the left eye during an acute exacerbation of the keratitis. This chorioretinitis may have resulted from hematogenous dissemination from his corneal infection. ...


    pub_type: 杂志文章


    authors: Johns KJ,O'Day DM,Feman SS

    更新日期:1988-05-01 00:00:00

  • Mantle cell lymphoma in the ocular adnexal region.

    abstract:PURPOSE:To study the clinicopathologic features of mantle cell lymphoma (MCL) in the ocular adnexal region. DESIGN:Retrospective review. METHODS:The slides of 23 suspect patients were reevaluated with a panel of monoclonal antibodies, including anti-CD20, cyclin-D1, CD5, CD3, and p53 immunostains. Patients confirmed ...


    pub_type: 杂志文章


    authors: Looi A,Gascoyne RD,Chhanabhai M,Connors JM,Rootman J,White VA

    更新日期:2005-01-01 00:00:00

  • An analysis and interpretation of refractive errors after penetrating keratoplasty.

    abstract::Despite advances in microsurgical techniques, astigmatism after penetrating keratoplasty is still a perplexing problem. In this paper, using retrospective studies, experiments, and observations, the factors that seem most significant in creating excessive postoperative astigmatism are delineated. The difficulty of cre...


    pub_type: 杂志文章


    authors: Perlman EM

    更新日期:1981-01-01 00:00:00

  • Iontophoresis of fluorescein into the posterior segment of the rabbit eye.

    abstract::Iontophoresis of appreciable quantities of fluorescein into the vitreous body of the rabbit results from the use of a high electrical current density over a limited area of the globe. This is achieved by passing current through the fluorescein when it is held against the region of the ora serrata in a tube less than 1...


    pub_type: 杂志文章


    authors: Maurice DM

    更新日期:1986-01-01 00:00:00

  • Congenital periodic alternating nystagmus. Diagnosis and Management.

    abstract:PURPOSE:The purpose of the study is to investigate diagnostic criteria and treatment methods for patients with congenital periodic alternating nystagmus (PAN). METHODS:A retrospective analysis was performed of clinical findings and serial eye movement recordings of patients with congenital PAN. Eighteen patients obser...


    pub_type: 杂志文章


    authors: Gradstein L,Reinecke RD,Wizov SS,Goldstein HP

    更新日期:1997-06-01 00:00:00

  • Outpatient cataract surgery: incident and procedural risk analysis do not support current clinical ophthalmology guidelines.

    abstract:OBJECTIVE:To evaluate whether an ophthalmologist-led, non-anesthesia-supported, limited monitoring pathway for phacoemulsification/intraocular lens cataract surgery, can be performed safely with only a medical emergency team providing support. DESIGN:Retrospective, observational, cohort study. PARTICIPANTS:All patien...


    pub_type: 杂志文章


    authors: Koolwijk J,Fick M,Selles C,Turgut G,Noordergraaf JI,Tukkers FS,Noordergraaf GJ

    更新日期:2015-02-01 00:00:00

  • Incidence and rates of visual field progression after longitudinally measured optic disc change in glaucoma.

    abstract:OBJECTIVE:To determine whether glaucoma patients with progressive optic disc change have subsequent visual field progression earlier and at a faster rate compared with those without disc change. DESIGN:Prospective, longitudinal, cohort study. PARTICIPANTS AND CONTROLS:Eighty-one patients with open-angle glaucoma. ME...


    pub_type: 杂志文章


    authors: Chauhan BC,Nicolela MT,Artes PH

    更新日期:2009-11-01 00:00:00

  • Twenty-four-Month Outcomes of the Ranibizumab for Edema of the Macula in Diabetes - Protocol 3 with High Dose (READ-3) Study.

    abstract:PURPOSE:To compare 2.0 mg ranibizumab (RBZ) injections with 0.5 mg RBZ for eyes with center-involved diabetic macular edema (DME). DESIGN:Randomized, controlled, double-masked (to the dose), interventional, multicenter clinical trial. PARTICIPANTS:A total of 152 patients (152 eyes) with DME. METHODS:Eligible eyes we...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Sepah YJ,Sadiq MA,Boyer D,Callanan D,Gallemore R,Bennett M,Marcus D,Halperin L,Hassan M,Campochiaro PA,Nguyen QD,Do DV,READ-3 Study Group.

    更新日期:2016-12-01 00:00:00

  • Merkel cell carcinoma of the eyelid review of the literature and report of patients with Merkel cell carcinoma showing spontaneous regression.

    abstract:PURPOSE:To evaluate the clinical and histopathologic characteristics of Merkel cell carcinoma (MCC) of the eyelid. DESIGN:Retrospective case series and literature review. PARTICIPANTS:Three consecutive patients with MCC of the eyelid who were referred to the Ocular Oncology Unit of Leiden University Medical Center, N...


    pub_type: 杂志文章


    authors: Missotten GS,de Wolff-Rouendaal D,de Keizer RJ

    更新日期:2008-01-01 00:00:00

  • Validated prediction model for the development of primary open-angle glaucoma in individuals with ocular hypertension.

    abstract:OBJECTIVE:To test the validity and generalizability of the Ocular Hypertension Treatment Study (OHTS) prediction model for the development of primary open-angle glaucoma (POAG) in a large independent sample of untreated ocular hypertensive individuals and to develop a quantitative calculator to estimate the 5-year risk...


    pub_type: 杂志文章


    authors: Ocular Hypertension Treatment Study Group.,European Glaucoma Prevention Study Group.,Gordon MO,Torri V,Miglior S,Beiser JA,Floriani I,Miller JP,Gao F,Adamsons I,Poli D,D'Agostino RB,Kass MA

    更新日期:2007-01-01 00:00:00

  • Comparison of Visual Outcomes of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients with and without Diabetes Mellitus.

    abstract:PURPOSE:Diabetic patients have a greater risk of nonarteritic anterior ischemic optic neuropathy (NAION) than nondiabetic patients. We compare visual outcomes, prevalence of bilateral/sequential ION, and predictors of visual outcomes in NAION between diabetic and nondiabetic patients. DESIGN:Case-control study. PARTI...


    pub_type: 杂志文章


    authors: Sharma S,Kwan S,Fallano KA,Wang J,Miller NR,Subramanian PS

    更新日期:2017-04-01 00:00:00

  • Experiments on the absorption of argon and krypton laser by blood.

    abstract::Experiments were performed to determine the absorption by and transmission through blood of argon blue-green (ABG) and green (AG) and krypton red (KR) laser light. Krypton was transmitted better through intact erythrocytes than argon. The difference between krypton and argon was greater if the erythrocytes contained o...


    pub_type: 杂志文章


    authors: Folk JC,Shortt SG,Kleiber PD

    更新日期:1985-01-01 00:00:00

  • Extended-wear contact lenses for the treatment of pediatric aphakia.

    abstract::The practicality of extended-wear contact lenses in the refractive correction of pediatric aphakia was assessed with 240 eyes in 184 patients. Patient ages at the time of contact lens fitting ranged from 18 days to 9.8 years. One hundred forty-one eyes were fit from 1 day to 55 months postoperatively and then followed...


    pub_type: 杂志文章


    authors: Levin AV,Edmonds SA,Nelson LB,Calhoun JH,Harley RD

    更新日期:1988-08-01 00:00:00

  • Surgical approaches to the orbit.

    abstract::After the appropriate workup, the size, location, and consistency of an orbital mass will dictate the surgical approach chosen. Masses in the muscle cone area or in the temporal portion of the orbit are most easily approached by the lateral orbitotomy. For lacrimal gland tumors a superior extension of the lateral orbi...


    pub_type: 杂志文章


    authors: Leone CR Jr

    更新日期:1979-05-01 00:00:00

  • Retinal vascular autoregulation in diabetes mellitus.

    abstract::The blue field entoptic technique was used to study autoregulation of the macular retinal circulation in response to acute alterations of intraocular pressure in 71 diabetic eyes and 30 normals matched for age, systemic blood pressure, and ophthalmic artery diastolic pressure. IOPmax, the maximal intraocular pressure ...


    pub_type: 杂志文章


    authors: Sinclair SH,Grunwald JE,Riva CE,Braunstein SN,Nichols CW,Schwartz SS

    更新日期:1982-07-01 00:00:00

  • Cytomegalovirus retinitis and optic neuritis in acquired immune deficiency syndrome. Report of a case.

    abstract::A 33-year-old man with acquired immune deficiency syndrome (AIDS) was found to have bilateral cytomegalovirus (CMV) retinitis with concomitant unilateral optic neuritis. The patient died and postmortem examination of both eyes disclosed CMV inclusions in all layers of the involved retinas including the retinal pigment...


    pub_type: 杂志文章


    authors: Grossniklaus HE,Frank KE,Tomsak RL

    更新日期:1987-12-01 00:00:00

  • Orbital involvement in allergic fungal sinusitis.

    abstract:BACKGROUND:Although allergic fungal sinusitis is a relatively common, noninvasive form of paranasal sinus mycosis, and despite frequent orbital involvement, there have been few reports of this condition in the ophthalmic literature. METHODS:Two cases of allergic fungal sinusitis having orbital symptoms are described. ...


    pub_type: 杂志文章


    authors: Klapper SR,Lee AG,Patrinely JR,Stewart M,Alford EL

    更新日期:1997-12-01 00:00:00

  • Results of bilateral cataract extraction with posterior chamber intraocular lens implantation in children.

    abstract:OBJECTIVE:A retrospective study was undertaken to evaluate long-term anatomic and visual outcomes in eyes of children who underwent bilateral intraocular lens implantation. DESIGN:The study design was a review of medical records of 24 children operated on for bilateral cataracts and posterior chamber-intraocular lense...


    pub_type: 杂志文章


    authors: Gimbel HV,Basti S,Ferensowicz M,DeBroff BM

    更新日期:1997-11-01 00:00:00

  • Teller acuity cards versus clinical judgment in the diagnosis of amblyopia with strabismus.

    abstract::Teller acuity card testing, which is a form of the preferential-looking procedure, is a popular way of assessing visual acuity in preverbal patients. The authors suspected that the clinical judgment of a pediatric ophthalmologist is superior to the Teller acuity cards in diagnosing amblyopia when strabismus is present...


    pub_type: 杂志文章


    authors: Ellis GS Jr,Hartmann EE,Love A,May JG,Morgan KS

    更新日期:1988-06-01 00:00:00