Prevalence and risks factors of age-related macular degeneration in Oklahoma Indians: the Vision Keepers Study.


OBJECTIVE:To determine the prevalence of age-related macular degeneration (AMD) and to identify its risk factors in an Oklahoma Indian population. DESIGN:Cross-sectional study design. PARTICIPANTS:Included 1019 Oklahoma Indians who participated in baseline and second examinations of the Strong Heart Study. METHODS:Retinal photographs of at least 1 eye were obtained and graded for AMD by the University of Wisconsin Ocular Epidemiology Reading Center. Retinal photographs of 986 participants were considered gradable and were included in the study. MAIN OUTCOME MEASURES:Age-related macular degeneration (early and late). RESULTS:The overall prevalence of AMD in the study was 35.2%, including a prevalence of 0.81% for late AMD. The prevalence of early AMD increased from 30.6% in those aged 48 to 59 years to 46.1% in those 70 to 82 years of age. When potential risk factors were analyzed individually (univariate analyses), men with hypertension had a significantly higher prevalence of AMD (P = 0.02) than those without hypertension. In women, high-density lipoprotein cholesterol and sun exposure were associated positively with the prevalence of AMD (P = 0.01), whereas a history of using multivitamins was associated with lower AMD prevalence (P = 0.005). When multiple risk factors were analyzed simultaneously using logistic regression, only age showed significant association with AMD in both men (P = 0.02) and women (P<0.0001) and was the only significant risk factor in men. In women, multivitamin use and total cholesterol had a significant inverse association with AMD, whereas sun exposure and high-density lipoprotein cholesterol had a positive association. When men and women were combined, age and high-density lipoprotein cholesterol had significant positive associations, whereas total cholesterol, multivitamin use, and current alcohol use showed a significant inverse association with AMD. CONCLUSIONS:This study was the first to report a detailed prevalence of AMD in Oklahoma Indians and its risk factors. The prevalence seemed to be relatively high compared with that in other ethnic groups. Some of the modifiable risk factors identified confirmed previous findings and can be used to design preventive programs to reduce the burden of AMD, although longitudinal data are still needed.






Butt AL,Lee ET,Klein R,Russell D,Ogola G,Warn A,Kingsley RM,Yeh J




Has Abstract


2011-07-01 00:00:00














  • Posterior capsulectomy in pediatric cataract surgery: the necessity of a choice.

    abstract:OBJECTIVE:The purpose of the study is to evaluate whether a posterior capsulectomy combined with anterior vitrectomy is a necessity in pediatric cataract. DESIGN:The incidence of posterior capsule opacification, the need for additional surgical interventions, and the influence of a primary posterior capsulectomy after...


    pub_type: 杂志文章


    authors: BenEzra D,Cohen E

    更新日期:1997-12-01 00:00:00

  • Vision-Related Quality of Life Associated with Unilateral and Bilateral Ocular Conditions.

    abstract:PURPOSE:To present ophthalmic patient time-tradeoff vision utilities for quantifying vision-related quality-of-life when the fellow eye still has good vision. These utilities are important for performing reliable cost-utility analyses. DESIGN:Consecutive time-tradeoff vision utilities were obtained from ophthalmic pat...


    pub_type: 杂志文章


    authors: Brown GC,Brown MM,Stein JD,Smiddy WE,Ophthalmic Utility Research Study Group.

    更新日期:2018-07-01 00:00:00

  • Design and evaluation of a customized reading rehabilitation program for patients with age-related macular degeneration.

    abstract:PURPOSE:To evaluate the efficacy of a reading rehabilitation program (RRP) specifically designed for patients with impaired central vision from age-related macular degeneration (AMD) and the impact of the program on the quality of life (QoL) and to determine any predictable reading performance improvements between visi...


    pub_type: 杂志文章


    authors: Coco-Martín MB,Cuadrado-Asensio R,López-Miguel A,Mayo-Iscar A,Maldonado MJ,Pastor JC

    更新日期:2013-01-01 00:00:00

  • Glaucoma and survival: the National Health Interview Survey 1986-1994.

    abstract:OBJECTIVE:Associations between glaucoma and survival have not been studied extensively, in part, because of the relatively low prevalence of this condition. This study examines associations between self-reported glaucoma and mortality in a nationally representative sample of U.S. adults. DESIGN:Annual cross-sectional ...


    pub_type: 杂志文章


    authors: Lee DJ,Gómez-Marín O,Lam BL,Zheng DD

    更新日期:2003-08-01 00:00:00

  • Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity.

    abstract:PURPOSE:Geographic atrophy (GA) may cause significant compromise of visual function, even when there still is good visual acuity (VA), because of parafoveal scotomas and foveal function abnormalities antedating visible atrophy. This study evaluates the visual function abnormalities at baseline and the 2-year worsening ...


    pub_type: 杂志文章


    authors: Sunness JS,Rubin GS,Applegate CA,Bressler NM,Marsh MJ,Hawkins BS,Haselwood D

    更新日期:1997-10-01 00:00:00

  • Effects of pterygium on corneal spherical power and astigmatism.

    abstract:OBJECTIVE:To evaluate prospectively the corneal refractive status before and after pterygium surgery and its relationship with preoperative pterygium size. DESIGN:Prospective, nonrandomized, comparative (self-controlled) trial. PARTICIPANTS:One hundred thirty-six eyes undergoing primary pterygium removal surgery. MA...


    pub_type: 杂志文章


    authors: Tomidokoro A,Miyata K,Sakaguchi Y,Samejima T,Tokunaga T,Oshika T

    更新日期:2000-08-01 00:00:00

  • Chorioretinal lesions in nonfatal cases of West Nile virus infection.

    abstract:OBJECTIVE:West Nile virus (WNV) disease is a zoonotic infection with recent outbreaks in the United States. Recent reports have highlighted the intraocular findings associated with WNV disease. We describe the intraocular findings observed in two patients infected by the West Nile virus. DESIGN:Observational case repo...


    pub_type: 杂志文章


    authors: Hershberger VS,Augsburger JJ,Hutchins RK,Miller SA,Horwitz JA,Bergmann M

    更新日期:2003-09-01 00:00:00

  • Initial experience using the transconjunctival sutureless vitrectomy system for vitreoretinal surgery.

    abstract:OBJECTIVE:To describe the initial experience and to evaluate the safety and feasibility of using the 25-gauge Transconjunctival Sutureless Vitrectomy System (TSV) for a variety of vitreoretinal procedures. DESIGN:Retrospective review of a consecutive interventional case series. PARTICIPANTS:Thirty-five eyes of 33 pat...


    pub_type: 杂志文章


    authors: Fujii GY,De Juan E Jr,Humayun MS,Chang TS,Pieramici DJ,Barnes A,Kent D

    更新日期:2002-10-01 00:00:00

  • Changes in anterior segment morphology after laser peripheral iridotomy: an anterior segment optical coherence tomography study.

    abstract:PURPOSE:Novel anterior segment optical coherence tomography (ASOCT) parameters associated with angle closure include anterior chamber area (ACA), anterior chamber volume (ACV), anterior chamber width (ACW), lens vault (LV), iris thickness (IT), iris area (I-area), and iris curvature (I-curv). We aimed to investigate ch...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: How AC,Baskaran M,Kumar RS,He M,Foster PJ,Lavanya R,Wong HT,Chew PT,Friedman DS,Aung T

    更新日期:2012-07-01 00:00:00

  • Proton beam irradiation. An alternative to enucleation for intraocular melanomas.

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    pub_type: 杂志文章


    authors: Gragoudas ES,Goitein M,Verhey L,Munzenreider J,Suit HD,Koehler A

    更新日期:1980-06-01 00:00:00

  • An analysis and interpretation of refractive errors after penetrating keratoplasty.

    abstract::Despite advances in microsurgical techniques, astigmatism after penetrating keratoplasty is still a perplexing problem. In this paper, using retrospective studies, experiments, and observations, the factors that seem most significant in creating excessive postoperative astigmatism are delineated. The difficulty of cre...


    pub_type: 杂志文章


    authors: Perlman EM

    更新日期:1981-01-01 00:00:00

  • The ora serrata and the spiral of Tillaux. Anatomic relationship and clinical correlation.

    abstract::Conventional teaching states that the spiral of Tillaux marks the location of the ora serrata. On literature review, no source for this was found. This study explores this anatomic relationship. In 20 cadaver eyes, narrow-gauge needles were placed penetrating the center of each rectus muscle insertion, and distance to...


    pub_type: 杂志文章


    authors: White MH,Lambert HM,Kincaid MC,Dieckert JP,Lowd DK

    更新日期:1989-04-01 00:00:00

  • Optical coherence tomographic hyperreflective foci: a morphologic sign of lipid extravasation in diabetic macular edema.

    abstract:PURPOSE:To analyze hyperreflective foci typically seen in diabetic macular edema (DME) in optical coherence tomography (OCT). DESIGN:Prospective clinical trial. PARTICIPANTS:Twelve consecutive patients with treatment-naïve, clinically significant DME. METHODS:During a same-day examination, a standardized visual acui...


    pub_type: 临床试验,杂志文章


    authors: Bolz M,Schmidt-Erfurth U,Deak G,Mylonas G,Kriechbaum K,Scholda C,Diabetic Retinopathy Research Group Vienna.

    更新日期:2009-05-01 00:00:00

  • Rand-Stein analgesia protocol for cataract surgery.

    abstract:OBJECTIVE:To describe the safety and efficacy of an analgesia protocol that enables the surgeon to maintain control over an alert patient experiencing seemingly painless ambulatory cataract surgery, while eliminating the risks and side effects associated with general, local, topical, and intracameral anesthesia. DESIG...


    pub_type: 杂志文章


    authors: Rand WJ,Stein SC,Velazquez GE

    更新日期:2000-05-01 00:00:00

  • Development and validation of a predictive model for nonadherence with once-daily glaucoma medications.

    abstract:OBJECTIVE:To develop and validate a predictive model to estimate the probability of being nonadherent to topical glaucoma medications. DESIGN:Prospective cohort study. PARTICIPANTS:Patients being treated with once-daily prostaglandin eye drops. METHODS:A predictive model for nonadherence was developed from the Trava...


    pub_type: 杂志文章


    authors: Chang DS,Friedman DS,Frazier T,Plyler R,Boland MV

    更新日期:2013-07-01 00:00:00

  • Dipivefrin reduces blood flow in the ciliary body in humans.

    abstract:PURPOSE:Adrenergic substances are used widely for lowering intraocular pressure in the treatment of glaucoma. The hypothetic mechanisms for lowering the intraocular pressure by adrenergic drugs are decreased blood flow in the ciliary body and direct receptor-related reduction of aqueous humor production. The aim of thi...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Michelson G,Groh MJ

    更新日期:1994-04-01 00:00:00

  • Ophthalmic manifestations of Danon disease.

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    pub_type: 杂志文章


    authors: Prall FR,Drack A,Taylor M,Ku L,Olson JL,Gregory D,Mestroni L,Mandava N

    更新日期:2006-06-01 00:00:00

  • Prospective evaluation of radial keratotomy. Photokeratoscope corneal topography.

    abstract::Preoperative and postoperative corneascope photographs of 368 myopic patients undergoing radial keratotomy in the Prospective Evaluation of Radial Keratotomy (PERK) study were optically scanned and digitized. A high-resolution scanning system was developed in order to quantify the preoperative and postoperative cornea...


    pub_type: 杂志文章


    authors: Rowsey JJ,Balyeat HD,Monlux R,Holladay J,Waring GO 3rd,Lynn MJ

    更新日期:1988-03-01 00:00:00

  • Neodymium: YAG laser trabeculopuncture in open-angle glaucoma.

    abstract::Ten eyes of eight patients with open-angle glaucoma (OAG) had neodymium (Nd):YAG trabeculopuncture performed in an investigational protocol as an alternative to surgical intervention. In each, at four to six sites in the mid-trabecular meshwork, three to six superimposed applications were made (2 to 6 mJ). In four of ...


    pub_type: 杂志文章


    authors: Epstein DL,Melamed S,Puliafto CA,Steinert RF

    更新日期:1985-07-01 00:00:00

  • Epibulbar granular cell tumor. Report of a case and review of the literature.

    abstract:BACKGROUND:The granular cell tumor (GCT) is a common, usually benign, neoplasm of uncertain histogenesis that may affect any organ in the body. It occurs rarely in ophthalmic sites, where orbital location is most frequent. The purpose of this report is to describe a unique case of an epibulbar, subconjunctival GCT in a...


    pub_type: 杂志文章,评审


    authors: Charles NC,Fox DM,Glasberg SS,Sawicki J

    更新日期:1997-09-01 00:00:00

  • Clinical and electroretinographic findings of female carriers and affected males in a progressive X-linked cone-rod dystrophy (COD-1) pedigree.

    abstract:OBJECTIVE:To study the clinical and electroretinographic findings of affected males and female carriers in a family with X-linked cone-rod dystrophy (COD-1). DESIGN:Observational case series. PARTICIPANTS:Twenty-five members of a five-generation pedigree were examined. METHODS:A history of visual impairment includin...


    pub_type: 杂志文章


    authors: Brown J Jr,Kimura AE,Gorin MB

    更新日期:2000-06-01 00:00:00

  • Asymptomatic physiologic hyperdeviation in peripheral gaze.

    abstract::Asymptomatic hyperdeviation (HD) in peripheral gaze may be caused by muscle paresis, restrictive orbital diseases, cranial neuropathy, or skew deviation. The authors suspected that this finding was often physiologic and therefore examined 61 normal subjects with the Maddox rod. Forty-seven of 61 patients (77%) showed ...


    pub_type: 杂志文章


    authors: Slavin ML,Potash SD,Rubin SE

    更新日期:1988-06-01 00:00:00

  • Clinical and Genetic Characteristics of Japanese Patients with Age-Related Macular Degeneration and Pseudodrusen.

    abstract:PURPOSE:To investigate differences in clinical characteristics and genotype distribution in Japanese patients with age-related macular degeneration (AMD) and pseudodrusen using multimodal imaging. DESIGN:Retrospective, observational case series. PARTICIPANTS:A total of 101 patients (101 eyes) with AMD and pseudodruse...


    pub_type: 杂志文章


    authors: Elfandi S,Ooto S,Ueda-Arakawa N,Takahashi A,Yoshikawa M,Nakanishi H,Tamura H,Oishi A,Yamashiro K,Yoshimura N

    更新日期:2016-10-01 00:00:00

  • Anterior clear spaces in keratoconus.

    abstract::Anterior clear spaces were observed prospectively at slit-lamp examination in 26 of 69 consecutive eyes (38%) with keratoconus. Two corneal buttons with this finding were examined by light and electron microscopy and revealed breaks in Bowman's layer. Anterior clear spaces should be considered in the spectrum of clini...


    pub_type: 杂志文章


    authors: Shapiro MB,Rodrigues MM,Mandel MR,Krachmer JH

    更新日期:1986-10-01 00:00:00

  • Ocular findings in patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome.

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    pub_type: 杂志文章


    authors: Kaushik M,Pulido JS,Abreu R,Amselem L,Dispenzieri A

    更新日期:2011-04-01 00:00:00

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    pub_type: 杂志文章


    authors: Mandell AI,Stentz F,Kitabchi AE

    更新日期:1978-03-01 00:00:00

  • Retinal nerve fiber structure versus visual field function in patients with ischemic optic neuropathy. A test of a linear model.

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    pub_type: 杂志文章


    authors: Hood DC,Anderson S,Rouleau J,Wenick AS,Grover LK,Behrens MM,Odel JG,Lee AG,Kardon RH

    更新日期:2008-05-01 00:00:00

  • Complications associated with aphakic contact lenses.

    abstract::Complications associated with rigid contact lenses are more frequent in aphakia. The limited dexterity of older patients not only may prove an insurmountable barrier to the mastery of daily contact lens insertion and removal, but also may produce significant direct eye trauma, its seriousness determined by the integri...


    pub_type: 杂志文章


    authors: Ferris RL

    更新日期:1979-06-01 00:00:00

  • Recurrence of posterior uveal melanoma after 60Co episcleral plaque therapy.

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    pub_type: 杂志文章


    authors: Karlsson UL,Augsburger JJ,Shields JA,Markoe AM,Brady LW,Woodleigh R

    更新日期:1989-03-01 00:00:00

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    pub_type: 临床试验,杂志文章


    authors: Foster CS,Ahmed AR

    更新日期:1999-11-01 00:00:00