Abstract:
OBJECTIVE:To determine the prevalence of age-related macular degeneration (AMD) and to identify its risk factors in an Oklahoma Indian population. DESIGN:Cross-sectional study design. PARTICIPANTS:Included 1019 Oklahoma Indians who participated in baseline and second examinations of the Strong Heart Study. METHODS:Retinal photographs of at least 1 eye were obtained and graded for AMD by the University of Wisconsin Ocular Epidemiology Reading Center. Retinal photographs of 986 participants were considered gradable and were included in the study. MAIN OUTCOME MEASURES:Age-related macular degeneration (early and late). RESULTS:The overall prevalence of AMD in the study was 35.2%, including a prevalence of 0.81% for late AMD. The prevalence of early AMD increased from 30.6% in those aged 48 to 59 years to 46.1% in those 70 to 82 years of age. When potential risk factors were analyzed individually (univariate analyses), men with hypertension had a significantly higher prevalence of AMD (P = 0.02) than those without hypertension. In women, high-density lipoprotein cholesterol and sun exposure were associated positively with the prevalence of AMD (P = 0.01), whereas a history of using multivitamins was associated with lower AMD prevalence (P = 0.005). When multiple risk factors were analyzed simultaneously using logistic regression, only age showed significant association with AMD in both men (P = 0.02) and women (P<0.0001) and was the only significant risk factor in men. In women, multivitamin use and total cholesterol had a significant inverse association with AMD, whereas sun exposure and high-density lipoprotein cholesterol had a positive association. When men and women were combined, age and high-density lipoprotein cholesterol had significant positive associations, whereas total cholesterol, multivitamin use, and current alcohol use showed a significant inverse association with AMD. CONCLUSIONS:This study was the first to report a detailed prevalence of AMD in Oklahoma Indians and its risk factors. The prevalence seemed to be relatively high compared with that in other ethnic groups. Some of the modifiable risk factors identified confirmed previous findings and can be used to design preventive programs to reduce the burden of AMD, although longitudinal data are still needed.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Butt AL,Lee ET,Klein R,Russell D,Ogola G,Warn A,Kingsley RM,Yeh Jdoi
10.1016/j.ophtha.2010.11.007subject
Has Abstractpub_date
2011-07-01 00:00:00pages
1380-5issue
7eissn
0161-6420issn
1549-4713pii
S0161-6420(10)01178-4journal_volume
118pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:OBJECTIVE:The purpose of the study is to evaluate whether a posterior capsulectomy combined with anterior vitrectomy is a necessity in pediatric cataract. DESIGN:The incidence of posterior capsule opacification, the need for additional surgical interventions, and the influence of a primary posterior capsulectomy after...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30045-1
更新日期:1997-12-01 00:00:00
abstract:PURPOSE:To present ophthalmic patient time-tradeoff vision utilities for quantifying vision-related quality-of-life when the fellow eye still has good vision. These utilities are important for performing reliable cost-utility analyses. DESIGN:Consecutive time-tradeoff vision utilities were obtained from ophthalmic pat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2017.12.033
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of a reading rehabilitation program (RRP) specifically designed for patients with impaired central vision from age-related macular degeneration (AMD) and the impact of the program on the quality of life (QoL) and to determine any predictable reading performance improvements between visi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.07.035
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Associations between glaucoma and survival have not been studied extensively, in part, because of the relatively low prevalence of this condition. This study examines associations between self-reported glaucoma and mortality in a nationally representative sample of U.S. adults. DESIGN:Annual cross-sectional ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00408-1
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:Geographic atrophy (GA) may cause significant compromise of visual function, even when there still is good visual acuity (VA), because of parafoveal scotomas and foveal function abnormalities antedating visible atrophy. This study evaluates the visual function abnormalities at baseline and the 2-year worsening ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30079-7
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVE:To evaluate prospectively the corneal refractive status before and after pterygium surgery and its relationship with preoperative pterygium size. DESIGN:Prospective, nonrandomized, comparative (self-controlled) trial. PARTICIPANTS:One hundred thirty-six eyes undergoing primary pterygium removal surgery. MA...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00219-0
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVE:West Nile virus (WNV) disease is a zoonotic infection with recent outbreaks in the United States. Recent reports have highlighted the intraocular findings associated with WNV disease. We describe the intraocular findings observed in two patients infected by the West Nile virus. DESIGN:Observational case repo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00720-6
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:To describe the initial experience and to evaluate the safety and feasibility of using the 25-gauge Transconjunctival Sutureless Vitrectomy System (TSV) for a variety of vitreoretinal procedures. DESIGN:Retrospective review of a consecutive interventional case series. PARTICIPANTS:Thirty-five eyes of 33 pat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(02)01119-3
更新日期:2002-10-01 00:00:00
abstract:PURPOSE:Novel anterior segment optical coherence tomography (ASOCT) parameters associated with angle closure include anterior chamber area (ACA), anterior chamber volume (ACV), anterior chamber width (ACW), lens vault (LV), iris thickness (IT), iris area (I-area), and iris curvature (I-curv). We aimed to investigate ch...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2012.01.019
更新日期:2012-07-01 00:00:00
abstract::Proton irradiation was used in the treatment of uveal melanomas in 36 eyes. The average follow-up period was 16 months. One patient developed metastatic disease and died. No eye has been enucleated and tumor regression has been observed in all 22 eyes with a follow-up of more than 12 months. This type of treatment off...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35212-3
更新日期:1980-06-01 00:00:00
abstract::Despite advances in microsurgical techniques, astigmatism after penetrating keratoplasty is still a perplexing problem. In this paper, using retrospective studies, experiments, and observations, the factors that seem most significant in creating excessive postoperative astigmatism are delineated. The difficulty of cre...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)35086-6
更新日期:1981-01-01 00:00:00
abstract::Conventional teaching states that the spiral of Tillaux marks the location of the ora serrata. On literature review, no source for this was found. This study explores this anatomic relationship. In 20 cadaver eyes, narrow-gauge needles were placed penetrating the center of each rectus muscle insertion, and distance to...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32866-1
更新日期:1989-04-01 00:00:00
abstract:PURPOSE:To analyze hyperreflective foci typically seen in diabetic macular edema (DME) in optical coherence tomography (OCT). DESIGN:Prospective clinical trial. PARTICIPANTS:Twelve consecutive patients with treatment-naïve, clinically significant DME. METHODS:During a same-day examination, a standardized visual acui...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2008.12.039
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To describe the safety and efficacy of an analgesia protocol that enables the surgeon to maintain control over an alert patient experiencing seemingly painless ambulatory cataract surgery, while eliminating the risks and side effects associated with general, local, topical, and intracameral anesthesia. DESIG...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00008-7
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:To develop and validate a predictive model to estimate the probability of being nonadherent to topical glaucoma medications. DESIGN:Prospective cohort study. PARTICIPANTS:Patients being treated with once-daily prostaglandin eye drops. METHODS:A predictive model for nonadherence was developed from the Trava...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.01.002
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:Adrenergic substances are used widely for lowering intraocular pressure in the treatment of glaucoma. The hypothetic mechanisms for lowering the intraocular pressure by adrenergic drugs are decreased blood flow in the ciliary body and direct receptor-related reduction of aqueous humor production. The aim of thi...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(94)31281-4
更新日期:1994-04-01 00:00:00
abstract:PURPOSE:To describe the ophthalmic findings in patients with Danon disease, an X-linked condition causing cardiomyopathy in males and females. DESIGN:Retrospective case series. PARTICIPANTS:Patients with genetically proven Danon disease. METHODS:Retrospective chart review of complete eye examinations including elect...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.02.030
更新日期:2006-06-01 00:00:00
abstract::Preoperative and postoperative corneascope photographs of 368 myopic patients undergoing radial keratotomy in the Prospective Evaluation of Radial Keratotomy (PERK) study were optically scanned and digitized. A high-resolution scanning system was developed in order to quantify the preoperative and postoperative cornea...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(88)33179-9
更新日期:1988-03-01 00:00:00
abstract::Ten eyes of eight patients with open-angle glaucoma (OAG) had neodymium (Nd):YAG trabeculopuncture performed in an investigational protocol as an alternative to surgical intervention. In each, at four to six sites in the mid-trabecular meshwork, three to six superimposed applications were made (2 to 6 mJ). In four of ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)33932-5
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND:The granular cell tumor (GCT) is a common, usually benign, neoplasm of uncertain histogenesis that may affect any organ in the body. It occurs rarely in ophthalmic sites, where orbital location is most frequent. The purpose of this report is to describe a unique case of an epibulbar, subconjunctival GCT in a...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0161-6420(97)30117-1
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:To study the clinical and electroretinographic findings of affected males and female carriers in a family with X-linked cone-rod dystrophy (COD-1). DESIGN:Observational case series. PARTICIPANTS:Twenty-five members of a five-generation pedigree were examined. METHODS:A history of visual impairment includin...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00086-5
更新日期:2000-06-01 00:00:00
abstract::Asymptomatic hyperdeviation (HD) in peripheral gaze may be caused by muscle paresis, restrictive orbital diseases, cranial neuropathy, or skew deviation. The authors suspected that this finding was often physiologic and therefore examined 61 normal subjects with the Maddox rod. Forty-seven of 61 patients (77%) showed ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(88)33108-8
更新日期:1988-06-01 00:00:00
abstract:PURPOSE:To investigate differences in clinical characteristics and genotype distribution in Japanese patients with age-related macular degeneration (AMD) and pseudodrusen using multimodal imaging. DESIGN:Retrospective, observational case series. PARTICIPANTS:A total of 101 patients (101 eyes) with AMD and pseudodruse...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.06.052
更新日期:2016-10-01 00:00:00
abstract::Anterior clear spaces were observed prospectively at slit-lamp examination in 26 of 69 consecutive eyes (38%) with keratoconus. Two corneal buttons with this finding were examined by light and electron microscopy and revealed breaks in Bowman's layer. Anterior clear spaces should be considered in the spectrum of clini...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33571-1
更新日期:1986-10-01 00:00:00
abstract:OBJECTIVE:Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare disorder. This study investigated the types of ocular signs and symptoms in patients with POEMS and any systemic factors that may be associated with development of such ocular findings. DESIGN:Cas...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.08.013
更新日期:2011-04-01 00:00:00
abstract::The dansyl chloride technique in conjunction with thin layer chromatography and autoradiography has shown that dipivalyl epinephrine is a pro-drug in the human eye. Dipivalyl epinephrine appears to be a more effective epinephrine compound, in that it penetrates the cornea approximately 17 times greater than epinephrin...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(78)35668-2
更新日期:1978-03-01 00:00:00
abstract:PURPOSE:To test a linear model relating the regional loss in retinal nerve fiber (RNFL) thickness to the corresponding regional loss in sensitivity with data from patients with previous anterior ischemic optic neuropathy (AION). DESIGN:Case-control study. PARTICIPANTS:Twenty-four individuals with AION and 20 with nor...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.06.001
更新日期:2008-05-01 00:00:00
abstract::Complications associated with rigid contact lenses are more frequent in aphakia. The limited dexterity of older patients not only may prove an insurmountable barrier to the mastery of daily contact lens insertion and removal, but also may produce significant direct eye trauma, its seriousness determined by the integri...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(79)35431-8
更新日期:1979-06-01 00:00:00
abstract::The authors analyzed the clinical and follow-up data on 277 selected patients with primary choroidal or ciliochoroidal melanoma who were treated with 60Co plaque radiotherapy between 1976 and 1982. Local recurrence of the irradiated melanoma developed in 39 (14%) patients during the follow-up interval. The 5-year tumo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32882-x
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:To report the effects of intravenous immunoglobulin treatment of ten patients with progressive ocular cicatricial pemphigoid who did not respond to conventional immunomodulatory regimens. DESIGN:Noncomparative, interventional case series. PARTICIPANTS:Ten patients with biopsy-proven progressive cicatricial ...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/S0161-6420(99)90496-7
更新日期:1999-11-01 00:00:00