Abstract:
OBJECTIVE:To investigate systematically the natural history of visual outcome in nonarteritic anterior ischemic optic neuropathy (NAION). DESIGN:Cohort study. PARTICIPANTS:Three hundred forty consecutive untreated patients (386 eyes) with NAION, first seen in our clinic from 1973 to 2000. METHODS:At first visit, all patients gave a detailed ophthalmic and medical history and underwent a comprehensive ophthalmic evaluation. Visual evaluation was done by recording visual acuity, using the Snellen visual acuity chart, and visual fields with a Goldmann perimeter. The same ophthalmic evaluation was performed at each follow-up visit. MAIN OUTCOME MEASURES:Natural history of visual acuity and visual field outcome in NAION. RESULTS:Of the 386 eyes, 332 had 8 weeks or more of follow-up from the initial visit. At the initial visit, in eyes seen < or =2 weeks from onset of symptoms, 49% had visual acuity of > or =20/30 and 23% had < or =20/200; in these eyes, 38% had minimal to mild visual field defect and 43% marked to severe defect. In those who were first seen < or =2 weeks after onset with visual acuity < or =20/70, there was improvement in 41% at 6 months and in 42% at 1 year after the initial visit. Two years after the initial visit, there was deterioration in 9% of eyes with initial visual acuity of > or =20/60, and in 18% of those with initial visual acuity of < or =20/70. In those who were first seen < or =2 weeks of onset with moderate to severe visual field defect, there was improvement in 26% at 6 months and 27% at 1 year after the initial visit. Two years after the initial visit, 27% of eyes with initial minimal to mild field defects showed worsening, as did 19% of those with moderate to severe defects. CONCLUSIONS:About half of the eyes with NAION presented with almost normal visual acuity (20/15 to 20/30) at the initial visit. Thus, the presence of normal visual acuity does not rule out NAION. Visual acuity and visual fields showed improvement or further deterioration mainly up to 6 months, with no significant change after that.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Hayreh SS,Zimmerman MBdoi
10.1016/j.ophtha.2007.05.027subject
Has Abstractpub_date
2008-02-01 00:00:00pages
298-305.e2issue
2eissn
0161-6420issn
1549-4713pii
S0161-6420(07)00579-9journal_volume
115pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:OBJECTIVE:The purpose of the study is to examine the association between cardiovascular disease and its risk factors and the incidence of age-related maculopathy. PARTICIPANTS:A population of 3583 adults (range, 43-86 years of age at baseline) living in Beaver Dam, Wisconsin, was studied at baseline and 5 years later....
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30023-2
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:To compare the ice test with the rest test in subjects with myasthenic and nonmyasthenic ptosis. DESIGN:Randomized, noninterventional trial. PARTICIPANTS:(1) Ten subjects with ptosis from previously undiagnosed myasthenia gravis. (2) Fifteen subjects with nonmyasthenic ptosis. METHODS:Application of ice co...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(00)00458-9
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the surgical management and visual acuity outcomes in a large series of patients with dislocated intraocular lenses (IOLs). DESIGN:Retrospective consecutive noncomparative case series. PARTICIPANTS:All patients who underwent surgical management of dislocated IOLs by two vitreoretinal surgeons at...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(99)00017-2
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:To report the 3-month results of a randomized trial (Femtosecond Laser-Assisted Cataract Trial [FACT]) comparing femtosecond laser-assisted cataract surgery (FLACS) with standard phacoemulsification cataract surgery (PCS). DESIGN:Multicenter, randomized controlled trial funded by the UK National Institute of H...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2020.02.028
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To assess the structure of central optic disc pits (ODPs) using enhanced-depth imaging optical coherence tomography (EDI OCT) and to ascertain their clinical significance. DESIGN:Prospective, cross-sectional study. PARTICIPANTS:Patients with an ophthalmoscopically visible central ODP in either eye, irrespec...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.12.034
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To determine agreement between spectral-domain (SD) and time-domain (TD) optical coherence tomography (OCT) image assessments by certified readers in eyes treated for neovascular age-related macular degeneration (AMD). DESIGN:Cross-sectional study within the Comparison of AMD Treatments Trials (CATT). PARTI...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2014.04.020
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To describe the clinical and cytopathologic characteristics in patients with vitreous opacity of unknown cause or preceding inflammation, diagnosed cytopathologically as inflammation. DESIGN:Retrospective case series. PARTICIPANTS:Forty-three consecutive patients (61 eyes) who underwent vitrectomy for vitreou...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2011.10.020
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:To assess changes in retinal nonperfusion (RNP) in patients with retinal vein occlusion (RVO) treated with ranibizumab. DESIGN:Secondary outcome measure in randomized double-masked controlled clinical trial. PARTICIPANTS:Thirty-nine patients with central RVO (CRVO) and 42 with branch RVO (BRVO). METHODS:Subj...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2015.10.030
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:The purpose of this study is to examine the changes of blood-aqueous barrier function in cases of central or branch retinal vein occlusion. METHODS:In addition to fluorophotometry of the aqueous humor and posterior vitreous, the authors used a method that quantifies protein in the aqueous (aqueous flare) by me...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31875-5
更新日期:1992-06-01 00:00:00
abstract:PURPOSE:To assess whether sequential or simultaneous ptosis repair yields a better postoperative outcome in patients with documented preoperative Hering's dependency. DESIGN:Retrospective, case-control study. PARTICIPANTS AND CONTROLS:Of the 216 patients who underwent bilateral ptosis surgery, 109 patients with docum...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2011.07.008
更新日期:2012-02-01 00:00:00
abstract::Patients suffering a central retinal vein occlusion should be evaluated for conditions that promote and/or contribute to the formation of a thrombosis in the central retinal vein. These conditions include alterations of blood flow, altered viscosity of the blood, abnormalities of coagulation, and abnormalities of vess...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(83)34528-0
更新日期:1983-05-01 00:00:00
abstract::The authors examined 11 young adult, moderately myopic female patients who presented with visual loss secondary to a newly described disorder consisting of multiple small discrete lesions at the level of the retinal pigment epithelium and choriocapillaris. The condition appears to be inflammatory and occurs primarily ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33611-x
更新日期:1986-09-01 00:00:00
abstract::The clinical efficacy was investigated of fibronectin eyedrops on the nonhealing corneal epithelial defect after herpetic keratitis. Fibronectin eyedrops were prepared from the patient's own blood plasma by an affinity chromatography using gelatin-coupled agarose gel and by gel filtration technique. Twenty eyes with m...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)34050-2
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:Suprachoroidal hemorrhage may cause the expulsion of intraocular contents. Generally, cases of nonexpulsive suprachoroidal hemorrhage have a better outcome than their expulsive counterparts. Those cases with massive nonexpulsive suprachoroidal hemorrhage do better with treatment than without. Treatment modal...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31756-7
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:To determine whether an intravitreal injection of triamcinolone acetonide for persistent diabetic macular edema after adequate laser treatment improves visual acuity. DESIGN:Prospective, double-masked, placebo-controlled, randomized clinical trial. PARTICIPANTS AND CONTROLS:Sixty-nine eyes of 43 patients we...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ophtha.2004.05.025
更新日期:2004-11-01 00:00:00
abstract:PURPOSE:We sought to determine the most cost-effective treatment for patients with newly diagnosed neovascular macular degeneration: monthly or as-needed bevacizumab injections, or monthly or as-needed ranibizumab injections. DESIGN:Cost-effectiveness analysis. PARTICIPANTS:Hypothetical cohort of 80-year-old patients...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.10.037
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:To evaluate treatment of juxtapapillary choroidal melanoma with plaque radiotherapy and to investigate the role of supplemental transpupillary thermotherapy (TTT). DESIGN:Retrospective, comparative case series. PARTICIPANTS:We included 650 consecutive eyes with juxtapapillary choroidal melanoma within 1 mm of...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.06.007
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of intravitreal sirolimus in the management of noninfectious uveitis of the posterior segment (NIU-PS). DESIGN:Combined analysis of 2 phase 3, randomized, double-masked, multinational, 6-month studies. PARTICIPANTS:Adults with active NIU-PS (intermediate uveitis, posterior ...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2020.03.033
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:To determine the proportion of solid organ transplant recipients developing periocular nonmelanoma skin cancer and to describe the morbidity of these cancers in transplant recipients. DESIGN:Cohort study. PARTICIPANTS:Consecutive patients undergoing solid organ transplantation at the Cleveland Clinic between ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2015.09.030
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To evaluate the growth of geographic atrophy (GA) during anti-vascular endothelial growth factor (VEGF) therapy. DESIGN:Cohort within a clinical trial. PARTICIPANTS:Patients included in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). METHODS:Participants were randomly assigned to...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2014.11.007
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To report the first case of gaze-evoked amaurosis secondary to an intraocular foreign body and to highlight the characteristic clinical findings of patients with this symptom. DESIGN:Case report and review of the literature. METHODS:Case review, clinical history, electrophysiologic testing, and follow-up. ...
journal_title:Ophthalmology
pub_type: 杂志文章,评审
doi:10.1016/s0161-6420(00)00433-4
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the specific characteristics and management of internal orbital fractures in the pediatric population. DESIGN:Retrospective observational case series. PARTICIPANTS:Thirty-four pediatric patients between the ages of 1 and 18 years with internal orbital ("blowout") fractures. METHODS:Records of p...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00015-4
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVES:To assess the clinical value of retinal or choroidal biopsy in establishing a definitive diagnosis directing subsequent management and to assess the risk involved in such surgery. DESIGN:Retrospective noncomparative interventional case series. PARTICIPANTS:Thirteen patients with uveitis of suspected malign...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2002.10.002
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:Two similarly designed, phase-3 studies (VEGF Trap-Eye: Investigation of Efficacy and Safety in Wet AMD [VIEW 1, VIEW 2]) of neovascular age-related macular degeneration (AMD) compared monthly and every-2-month dosing of intravitreal aflibercept injection (VEGF Trap-Eye; Regeneron, Tarrytown, NY, and Bayer He...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2012.09.006
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:To determine the association between physical activity levels and the rate of visual field (VF) loss in glaucoma. DESIGN:Longitudinal, observational study. PARTICIPANTS:Older adults with suspect or manifest glaucoma. METHODS:Participants wore accelerometers for 1 week to define average steps per day, minutes...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2018.10.012
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:To report the clinical outcome and long-term follow-up of 10 patients with progressive ocular-cicatricial pemphigoid (OCP), nonresponsive to conventional therapy and treated with IV immunoglobulin (IVIg) therapy, reported earlier as a preliminary study. DESIGN:Noncomparative, prospective, interventional case...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2003.11.012
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:To define the range and life cycles of cuticular drusen phenotypes using multimodal imaging and to review the histologic characteristics of cuticular drusen. DESIGN:Retrospective, observational cohort study and experimental laboratory study. PARTICIPANTS:Two hundred forty eyes of 120 clinic patients with a cu...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2017.08.033
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To report a patient with agenesis of the right internal carotid artery associated with ipsilateral, congenital Homer's syndrome. DESIGN:Case report. METHODS:A 30-year-old woman, with a past history of migraine headaches, underwent neuro-ophthalmologic and neuroradiologic evaluation for transient visual obsc...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(99)00006-8
更新日期:2000-01-01 00:00:00
abstract::Sixty-two cases of corneal amyloidosis were studied. The median age of the 48 men and 14 women was 66 years. The patients had bilateral, diffuse corneal opacity extending to the limbus and severe visual impairment. The corneal condition was not familial. Advanced stages of trachoma were present in all individuals. Cli...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32765-5
更新日期:1989-08-01 00:00:00
abstract:OBJECTIVE:To estimate the rate of acute postoperative endophthalmitis after uncomplicated cataract surgery in patients treated before and after surgery with 1 of 2 different fourth-generation fluoroquinolone ophthalmic drops for surgical prophylaxis. DESIGN:Retrospective, multicenter, observational case series. PARTI...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2006.08.038
更新日期:2007-04-01 00:00:00