Delayed hypersensitivity in Graves' disease and exophthalmos: identification of thyroglobulin in normal human orbital muscle.

abstract：:The present study was conducted to examine the effect of LH on phospholipid metabolism in corpora luteal tissue. Collagenase-dispersed cells obtained from bovine corpora lutea of early pregnancy were incubated with 32PO4 in the presence or absence of LH and examined for their ability to incorporate this label into pho...

journal_title：Endocrinology

authors： Davis JS,Farese RV,Marsh JM

更新日期：1981-08-01 00:00:00

abstract：:Cell proliferation, terminal differentiation, and angiogenesis occur during cycles of follicular and luteal development. In other paradigms, mac25, a potent tumor inhibitor is strongly induced in senescent epithelial cells, whereas CTGF stimulates angiogenesis and wound healing. Using in situ hybridization and immunoh...

journal_title：Endocrinology

authors： Wandji SA,Gadsby JE,Barber JA,Hammond JM

更新日期：2000-07-01 00:00:00

abstract：:It is well established that endotoxemia disrupts reproductive capability, and several proinflammatory cytokines, especially IL-1 beta, IL-6, and TNF-alpha in the brain, have been implicated in this endocrine aberration. However, no previous study has directly compared the effects of the three major proinflammatory cyt...

journal_title：Endocrinology

authors： Watanobe H,Hayakawa Y

更新日期：2003-11-01 00:00:00

abstract：:Many New World primate species have elevated circulating free plasma cortisol concentrations, target tissue resistance to cortisol, and no evidence of sodium retention. A representative New World primate, the squirrel monkey (Saimiri sciureus), has plasma cortisol concentrations above those necessary to cause complete...

journal_title：Endocrinology

authors： Chrousos GP,Loriaux DL,Brandon D,Shull J,Renquist D,Hogan W,Tomita M,Lipsett MB

更新日期：1984-07-01 00:00:00

abstract：:The follicular phase rise in circulating estradiol causes a suppression of GnRH pulse amplitude and an increase in pulse frequency before stimulation of the preovulatory GnRH surge in the ewe. Studies in which samples were collected at 10-min intervals were found unsuitable to determine whether GnRH secretion is exclu...

journal_title：Endocrinology

authors： Evans NP,Dahl GE,Mauger D,Karsch FJ

更新日期：1995-04-01 00:00:00

abstract：:Acylation-stimulating protein (ASP) is a potent lipogenic protein produced by adipocytes. In vitro studies have shown that ASP increases triglyceride synthesis and glucose transport in both murine and human adipocytes. Our initial study indicated that complement C3-deficient (-/-) mice (and, therefore, ASP deficient) ...

journal_title：Endocrinology

authors： Murray I,Havel PJ,Sniderman AD,Cianflone K

更新日期：2000-03-01 00:00:00

abstract：:Mediators of lymphocyte infiltration in inflammatory thyroid disease have yet to be identified. Here we examine the ability of IL-1beta to enhance the production of chemoattractants by human thyrocytes. Primary cultures, when treated with the cytokine, release T lymphocyte chemotactic activity. The effect of IL-1beta ...

journal_title：Endocrinology

authors： Gianoukakis AG,Martino LJ,Horst N,Cruikshank WW,Smith TJ

更新日期：2003-07-01 00:00:00

abstract：:Heat shock protein (HSP) synthesis increases in cells with a broad range of stress conditions. We recently showed that induction of HSP-70 is associated with inhibition of hormone-sensitive steroidogenesis, but not hormone-sensitive cAMP accumulation, in rat luteal cells by a mechanism associated with interruption of ...

journal_title：Endocrinology

authors： Khanna A,Aten RF,Behrman HR

更新日期：1995-04-01 00:00:00

abstract：:Sex difference in the number of neurons projecting axons from the lateral septum (LS) to the midbrain central gray (MCG) that are concerned with the lordosis-inhibiting system was investigated by injection of Fluoro-Gold (FG), a retrograde tracer, into the rostral MCG on the right side in male and female rats. Immunoh...

journal_title：Endocrinology

authors： Tsukahara S,Yamanouchi K

更新日期：2002-01-01 00:00:00

abstract：:Split hand/foot malformation (SHFM) is syndromic ectrodactyly often associated with mental retardation and/or craniofacial defects. Several clinical reports previously described urogenital dysplasia such as micropenis, hypospadias, and small testis in SHFM patients. Genetic lesions in the Dlx5 and Dlx6 (Dlx5/6) locus ...

journal_title：Endocrinology

authors： Nishida H,Miyagawa S,Vieux-Rochas M,Morini M,Ogino Y,Suzuki K,Nakagata N,Choi HS,Levi G,Yamada G

更新日期：2008-05-01 00:00:00

abstract：:Female Chinese hamsters (n = 10) were immunized with Chinese hamster ovary (CHO) cells that expressed the human TSH receptor (TSHR) to generate a model of Graves' disease. TSHR-autoantibodies (TSHR-Ab) were determined by CHO-TSHR. Two hamsters with stimulating TSHR-Ab showed thyrocyte hypertrophy associated with a foc...

journal_title：Endocrinology

authors： Ando T,Imaizumi M,Graves P,Unger P,Davies TF

更新日期：2003-02-01 00:00:00

abstract：:Vasoactive intestinal polypeptide (VIP) was measured by RIA in the hypophysial portal blood of rats after total hypophysectomy. The mean (+/- SE) VIP concentrations were 1332 +/- 171 pg/ml (range, 300-3868 pg/ml) under urethane anesthesia and 1735 +/- 707 pg/ml under pentobarbital anesthesia. The concentrations of VIP...

journal_title：Endocrinology

authors： Shimatsu A,Kato Y,Matsushita N,Katakami H,Yanaihara N,Imura H

更新日期：1981-02-01 00:00:00

abstract：:During luteinization of bovine granulosa cells in vitro in the presence of insulin, or insulin plus forskolin, there is a massive upregulation not only of progesterone production, but also of the gene for the peptide hormone oxytocin, with secretion of the peptide into the medium. By using the progesterone receptor an...

journal_title：Endocrinology

authors： Lioutas C,Einspanier A,Kascheike B,Walther N,Ivell R

更新日期：1997-11-01 00:00:00

abstract：:There are now robust data supporting the Developmental Origins of Health and Disease (DOHaD) paradigm. This includes human and animal data focusing on nutrition or environmental chemicals during development. However, the term DOHaD has not been generally accepted as the official term to be used when one is concerned w...

journal_title：Endocrinology

authors： Heindel JJ,Balbus J,Birnbaum L,Brune-Drisse MN,Grandjean P,Gray K,Landrigan PJ,Sly PD,Suk W,Cory Slechta D,Thompson C,Hanson M

更新日期：2015-10-01 00:00:00

abstract：:We previously showed that peroxisome proliferator-activated receptor delta (PPARdelta) is crucial for embryo implantation as a receptor for cyclooxygenase-2-derived prostacyclin in mice. PPARs belong to the nuclear receptor superfamily. They form heterodimer with a retinoid X receptor, recruit transcriptional cofactor...

journal_title：Endocrinology

authors： Lim HJ,Moon I,Han K

更新日期：2004-06-01 00:00:00

abstract：:Glutamate (Glu) is the most prevalent excitatory neurotransmitter in the brain and has been implicated in the regulation of GnRH secretion in several mammalian species, including the monkey. To investigate the neuroanatomical basis for Glu-GnRH interactions, we performed an immunocytochemical study at both the light a...

journal_title：Endocrinology

authors： Goldsmith PC,Thind KK,Perera AD,Plant TM

更新日期：1994-02-01 00:00:00

abstract：:Adult rats which have received monosodium-L-glutamate (MSG, 4 mg/g BW) on alternate days for the first 10 days of life manifest central nervous system lesions largely restricted to the retina and the arcuate nucleus of the hypothalamus in which nearly 90% of the perikarya are destroyed, leaving axons in passage intact...

journal_title：Endocrinology

authors： Greeley GH Jr,Nicholson GF,Nemeroff CB,Youngblood WW,Kizer JS

更新日期：1978-07-01 00:00:00

abstract：:Analogs of the seco-steroid hormone, 1,25-dihydroxyvitamin D3 [1,25-(OH)-2D3] can preferentially stimulate genomic or nongenomic signaling pathways in osteoblasts. In this study, we used 1,25-(OH)2D3 analogs and voltage-sensitive Ca2+ channel (VSCC) ligands, including dihydropyridines (Bay K 8644 and nitrendipine), in...

journal_title：Endocrinology

authors： Khoury R,Ridall AL,Norman AW,Farach-Carson MC

更新日期：1994-12-01 00:00:00

abstract：:Recent work has implicated stimulatory kisspeptin neurons in the arcuate nucleus (ARC) as important for seasonal changes in reproductive function in sheep, but earlier studies support a role for inhibitory A15 dopaminergic (DA) neurons in the suppression of GnRH (and LH) pulse frequency in the nonbreeding (anestrous) ...

journal_title：Endocrinology

authors： Goodman RL,Maltby MJ,Millar RP,Hileman SM,Nestor CC,Whited B,Tseng AS,Coolen LM,Lehman MN

更新日期：2012-12-01 00:00:00

abstract：:To determine in neonates the effects of protein restriction on growth, serum IGF-I, and IGF-I gene expression, we adapted a technique for rearing neonatal rats (days 6-18 of life) artificially by continuous infusion of milk through a gastrostomy. The artificially reared (AR) animals were given isocaloric diets contain...

journal_title：Endocrinology

authors： Moats-Staats BM,Brady JL Jr,Underwood LE,D'Ercole AJ

更新日期：1989-11-01 00:00:00

abstract：:RNA blot hybridization analysis with cloned rat CRF precursor (prepro-CRF) cDNA as a probe showed that prepro-CRF mRNA existed in rat hypothalamic and extrahypothalamic brain tissue, whereas it was undetectable in the pituitary and adrenal. To study the effect of glucocorticoid on the level of prepro-CRF mRNA in the h...

journal_title：Endocrinology

authors： Jingami H,Matsukura S,Numa S,Imura H

更新日期：1985-10-01 00:00:00

abstract：:Activin A is a member of the transforming growth factor-beta family of growth factors and a potent regulator of cellular activity. A number of binding proteins for activin A have been identified, including alpha 2-macroglobulin (alpha 2M). Alpha 2M has several conformational states that are known to have different gro...

journal_title：Endocrinology

authors： Niemuller CA,Randall KJ,Webb DJ,Gonias SL,LaMarre J

更新日期：1995-12-01 00:00:00

abstract：:We have shown that nonlactogenic rat (r) GH is far more potent than rPRL in inducing rat mammary development. To determine the relative roles of GH and PRL in mammary development and their mechanisms of action, we have compared the abilities of a group of native and mutant GHs, PRLs, and placental lactogens (PLs) to i...

journal_title：Endocrinology

authors： Feldman M,Ruan W,Cunningham BC,Wells JA,Kleinberg DL

更新日期：1993-10-01 00:00:00

abstract：:In rat uterus and prostate, 7 alpha, 17 alpha-dimethyl-19-nortestosterone (DMNT) binds to the androgen receptor specifically and with high affinity. However, this steroid does not bind to glucocorticoid receptors, since it does not displace binding of [3H]triamcinolone acetonide in calf thymus cytosol. In calf uterine...

journal_title：Endocrinology

authors： Traish AM,Müller RE,Wotiz HH

更新日期：1986-04-01 00:00:00

abstract：:Many human breast tumors are driven by high intratumor concentrations of 17beta-estradiol that appear to be locally synthesized. The role of aromatase is well established, but the possible contribution of the steroid sulfatase (STS), which liberates estrogens from their biologically inactive sulfates, has been inadequ...

journal_title：Endocrinology

authors： James MR,Skaar TC,Lee RY,MacPherson A,Zwiebel JA,Ahluwalia BS,Ampy F,Clarke R

更新日期：2001-04-01 00:00:00

abstract：:A method to prepare suspension cultures of highly viable pinealocytes is described. Pineal glands of neonatal or adult rats can be used; the best yield is obtained from neonatal glands. Morphological examination of the cells indicates that they have a normal, healthy appearance and retain some structures typical of ne...

journal_title：Endocrinology

authors： Buda M,Klein DC

更新日期：1978-10-01 00:00:00

abstract：:A new hydrolase activity has been identified by its capability of cleaving t-boc-Ala-Ala-Pro-Ala-AMC, the released 7-amino-4-methylcoumarin (AMC) being quantified fluorometrically. The activity in the 28,000 X g supernatant fraction of homogenates of weanling mouse uterus was about one fifth that of the adult mouse. T...

journal_title：Endocrinology

authors： Katz J,Finlay TH,Tom C,Levitz M

更新日期：1980-12-01 00:00:00

abstract：:GnRH peptides in the hypothalami of marsupials (tammar wallaby, short-nosed bandicoot, and eastern quoll) and a monotreme (echidna) were investigated by reverse phase HPLC and RIA with region-specific antisera. In the wallaby hypothalamic extract, a single form of GnRH was present, which eluted in the same position as...

journal_title：Endocrinology

authors： King JA,Mehl AE,Tyndale-Biscoe CH,Hinds L,Millar RP

更新日期：1989-11-01 00:00:00

abstract：:We have investigated the effects of hCG and estradiol on the time course of the inhibition of C17-20-lyase and the depletion of the estradiol cytosol receptor in testicular tissue of male rats. In hCG-treated animals the first significant decrease in C17-20-lyase activity was observed 16 h after injection of the hormo...

journal_title：Endocrinology

authors： Brinkmann A,Leemborg I,Rommerts F,van der Molen H

更新日期：1982-05-01 00:00:00

abstract：:The intraislet insulin hypothesis has been proposed to explain absent glucagon responses to hypoglycemia. Recently we directly confirmed this hypothesis by restoring glucagon secretion via provision of a pancreatic artery insulin infusion, which was switched off at the time of hypoglycemia in Wistar rats made diabetic...

journal_title：Endocrinology

authors： Zhou H,Zhang T,Oseid E,Harmon J,Tonooka N,Robertson RP

更新日期：2007-06-01 00:00:00