Sulfated glucuronic acid-containing glycoconjugates are temporally and spatially regulated antigens in the developing mammalian nervous system.

abstract：:The mouse protamine mRNAs, Prm-1 and Prm-2, are translationally repressed for several days during male germ cell differentiation. The translational delay of mouse Prm-1 mRNA has previously been shown to be dependent upon cis-acting elements that reside in the last 62 nucleotides of the Prm-1 3' untranslated region (3'...

journal_title：Developmental biology

authors： Fajardo MA,Haugen HS,Clegg CH,Braun RE

更新日期：1997-11-01 00:00:00

abstract：:Epithelial sheet movement is an essential morphogenetic process during mouse embryonic eyelid closure in which Mitogen-Activated Protein 3 Kinase 1 (MAP3K1) and c-Jun play a critical role. Here we show that MAP3K1 associates with the cytoskeleton, activates Jun N-terminal kinase (JNK) and actin polymerization, and pro...

journal_title：Developmental biology

authors： Meng Q,Mongan M,Wang J,Tang X,Zhang J,Kao W,Xia Y

更新日期：2014-11-01 00:00:00

abstract：:Wnt signaling is essential to many events during organogenesis, including the development of the mammalian lung. The Wnt family member Wnt4 has been shown to be required for the development of kidney, gonads, thymus, mammary and pituitary glands. Here, we show that Wnt4 is critical for proper morphogenesis and growth ...

journal_title：Developmental biology

authors： Caprioli A,Villasenor A,Wylie LA,Braitsch C,Marty-Santos L,Barry D,Karner CM,Fu S,Meadows SM,Carroll TJ,Cleaver O

更新日期：2015-10-15 00:00:00

abstract：:The mammalian kidney collecting ducts are critical for water, electrolyte and acid-base homeostasis and develop as a branched network of tubular structures composed of principal cells intermingled with intercalated cells. The intermingled nature of the different collecting duct cell types has made it challenging to id...

journal_title：Developmental biology

authors： Grassmeyer J,Mukherjee M,deRiso J,Hettinger C,Bailey M,Sinha S,Visvader JE,Zhao H,Fogarty E,Surendran K

更新日期：2017-04-01 00:00:00

abstract：:5' HoxD genes are required for the correct formation of limb skeletal elements. Hoxd13, the most 5'-located HoxD gene, is important for patterning the most distal limb region, and its mutation causes human limb malformation syndromes. The mechanisms underlying the control of developmental processes by Hoxd13, and by H...

journal_title：Developmental biology

authors： Salsi V,Vigano MA,Cocchiarella F,Mantovani R,Zappavigna V

更新日期：2008-05-15 00:00:00

abstract：:The lateral line system displays highly divergent patterns in adult teleost fish. The mechanisms underlying this variability are poorly understood. Here, we demonstrate that the lateral line mechanoreceptor, the neuromast, gives rise to a series of accessory neuromasts by a serial budding process during postembryonic ...

journal_title：Developmental biology

authors： Wada H,Ghysen A,Satou C,Higashijima S,Kawakami K,Hamaguchi S,Sakaizumi M

更新日期：2010-04-15 00:00:00

abstract：:The dysgenetic lens (dyl) mouse mutant has mutations in Foxe3, which inactivate DNA binding by the encoded forkhead transcription factor. Here we confirm, by targeted inactivation, that Foxe3 mutations are responsible for the dyl phenotype, which include loss of lens epithelium; a small, cataractic lens; and failure o...

journal_title：Developmental biology

authors： Blixt A,Landgren H,Johansson BR,Carlsson P

更新日期：2007-02-01 00:00:00

abstract：:The term "transdifferentiation" has been used to describe the apparent phenotypic conversion of chick embryo neural retina Müller glial cells into lens-like cells in vitro. This phenotypic conversion is characterized by expression of such lens-specific proteins as delta crystallin and has been viewed as an example of ...

journal_title：Developmental biology

authors： Linser PJ,Irvin CK

更新日期：1987-06-01 00:00:00

abstract：:In many animals, the first cue for development is transcripts and/or proteins that are provided maternally and are localized at specific regions of fertilized eggs and early embryos. The ascidian is known to exhibit a mosaic mode of development, which is largely dependent on localized maternal factors. In early Ciona ...

journal_title：Developmental biology

authors： Yamada L

更新日期：2006-08-15 00:00:00

abstract：:The inner ear, the sensory organ responsible for hearing and balance, contains specialized sensory and non-sensory epithelia arranged in a highly complex three-dimensional structure. To achieve this complexity, a tight coordination between morphogenesis and cell fate specification is essential during otic development....

journal_title：Developmental biology

authors： Vázquez-Echeverría C,Dominguez-Frutos E,Charnay P,Schimmang T,Pujades C

更新日期：2008-10-01 00:00:00

abstract：:The engrailed gene is well known from its role in segmentation and central nervous system development in a variety of species. In molluscs, however, engrailed is involved in shell formation. So far, it seemed that engrailed had been co-opted uniquely for this particular process in molluscs. Here, we show that, in the ...

journal_title：Developmental biology

authors： Nederbragt AJ,van Loon AE,Dictus WJ

更新日期：2002-06-15 00:00:00

abstract：:A series of chimeras was generated by injecting single normal, parthenogenetic, or androgenetic blastomeres carrying transgenic markers under the zona pellucida of nontransgenic eight-cell embryos. These chimeras were cultured to the blastocyst stage and sectioned, and the transgenic component was detected by in situ ...

journal_title：Developmental biology

authors： Thomson JA,Solter D

更新日期：1989-02-01 00:00:00

abstract：:Nicastrin is a recently identified member of high-molecular weight complexes containing presenilin. The Caenorhabditis elegans homolog of nicastrin, aph-2, was shown to be required for GLP-1/Notch signaling in the early embryo. In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant animals also di...

journal_title：Developmental biology

authors： Levitan D,Yu G,St George Hyslop P,Goutte C

更新日期：2001-12-15 00:00:00

abstract：:Spinal cord regenerative ability is lost with development, but the mechanisms underlying this loss are still poorly understood. In chick embryos, effective regeneration does not occur after E13, when spinal cord injury induces extensive apoptotic response and tissue damage. As initial experiments showed that treatment...

journal_title：Developmental biology

authors： Lange S,Gögel S,Leung KY,Vernay B,Nicholas AP,Causey CP,Thompson PR,Greene ND,Ferretti P

更新日期：2011-07-15 00:00:00

abstract：:Caenorhabditis elegans PEB-1 is a novel DNA-binding protein expressed in most pharyngeal cell types and outside the pharynx in the hypodermis, hindgut, and vulva. Previous RNAi analyses indicated that PEB-1 is required for normal morphology of these tissues and growth; however, the peb-1 null phenotype was unknown. He...

journal_title：Developmental biology

authors： Fernandez AP,Gibbons J,Okkema PG

更新日期：2004-12-15 00:00:00

abstract：:The axonal functions that act in the formation of the neuronal network have been shown to occur in close interdependence with the tissue that surrounds the growing axons. However, little is known about the molecular building blocks underlying axonal functions, although more than 400 axonal proteins have been identifie...

journal_title：Developmental biology

authors： Sonderegger P,Lemkin PF,Lipkin LE,Nelson PG

更新日期：1986-11-01 00:00:00

abstract：:Cell adhesion molecules (CAMs) perform numerous functions during neural development. An individual CAM can play different roles during each stage of neuronal differentiation; however, little is known about how such functional switching is accomplished. Here we show that Drosophila N-cadherin (CadN) is required at mult...

journal_title：Developmental biology

authors： Kurusu M,Katsuki T,Zinn K,Suzuki E

更新日期：2012-06-15 00:00:00

abstract：:Activation of progenitor cells is crucial to promote tissue repair following injury in adult animals. In the context of successful limb regeneration following amputation, progenitor cells residing within the stump must re-enter the cell cycle to promote regrowth of the missing limb. We demonstrate that in axolotls, am...

journal_title：Developmental biology

authors： Johnson K,Bateman J,DiTommaso T,Wong AY,Whited JL

更新日期：2018-01-15 00:00:00

abstract：:The proper removal of superfluous neurons through apoptosis and subsequent phagocytosis is essential for normal development of the central nervous system (CNS). During Drosophila embryogenesis, a large number of apoptotic neurons are efficiently engulfed and degraded by phagocytic glia. Here we demonstrate that glial ...

journal_title：Developmental biology

authors： Shklyar B,Sellman Y,Shklover J,Mishnaevski K,Levy-Adam F,Kurant E

更新日期：2014-09-15 00:00:00

abstract：:To determine whether low oxygen is a stimulus for endothelial cell differentiation and vascular development in the kidney, we examined the effect of low oxygen on rat metanephric organ culture, a model known to recapitulate nephrogenesis in the absence of vessels. After 6 days in culture in standard (20% O2) or low ox...

journal_title：Developmental biology

authors： Tufro-McReddie A,Norwood VF,Aylor KW,Botkin SJ,Carey RM,Gomez RA

更新日期：1997-03-15 00:00:00

abstract：:The mesoderm of the sea urchin embryo conventionally is divided into two populations of cells; the primary mesenchyme cells (PMCs), which produce the larval skeleton, and the secondary mesenchyme cells (SMCs), which differentiate into a variety of cell types but do not participate in skeletogenesis. In this study we e...

journal_title：Developmental biology

authors： Ettensohn CA,McClay DR

更新日期：1988-02-01 00:00:00

abstract：:The adrenal cortex has a complex vasculature that is essential for growth, tissue maintenance, and access of secreted steroids to the bloodstream. However, the interaction between vasculature and adrenal cortex during early organogenesis remains largely unclear. In this study, we focused on the zebrafish counterpart o...

journal_title：Developmental biology

authors： Liu YW,Guo L

更新日期：2006-09-01 00:00:00

abstract：:The mature heart valves and septa are derived from the cardiac cushions which initially form as local outgrowths of mesenchymal cells within the outflow tract and atrioventricular regions. Endocardial cells respond to signals from the overlying myocardium and undergo an epithelial-to-mesenchymal transformation to inva...

journal_title：Developmental biology

authors： Kim RY,Robertson EJ,Solloway MJ

更新日期：2001-07-15 00:00:00

abstract：:How organisms control organ size is not fully understood. We found that Syd/JIP3 is required for proper wing size in Drosophila. JIP3 mutations are associated with organ size defects in mammals. The underlying mechanisms are not well understood. We discovered that Syd/JIP3 inhibition results in a downregulation of the...

journal_title：Developmental biology

authors： Ahmad V,Vadla GP,Chabu CY

更新日期：2021-01-01 00:00:00

abstract：:Midline defects account for approximately 5% of congenital abnormalities observed at birth. However, the molecular mechanisms underlying the formation of the ventral body wall are not well understood. Recent studies linked mutations in Porcupine-an O-acetyl transferase mediating Wnt ligand acylation-with defects in th...

journal_title：Developmental biology

authors： Snowball J,Ambalavanan M,Cornett B,Lang R,Whitsett J,Sinner D

更新日期：2015-05-15 00:00:00

abstract：:The unc-52 gene of Claenorhabditis elegans encodes a homologue of the basement membrane heparan sulfate proteoglycan perlecan. Viable alleles reduce the abundance of UNC-52 in late larval stages and increase the frequency of distal tip cell (DTC) migration defects caused by mutations disrupting the UNC-6/netrin guidan...

journal_title：Developmental biology

authors： Merz DC,Alves G,Kawano T,Zheng H,Culotti JG

更新日期：2003-04-01 00:00:00

abstract：:A newly defined genetic locus designated lethal (1) optic ganglion reduced (l(1)ogre: 1-18.8, 6E1/2-6E4/5) is characterized. Four alleles have been isolated, one organismal viable and three organismal lethals. Histological analyses of these mutants at the light microscopic level have detected defects only in the devel...

journal_title：Developmental biology

authors： Lipshitz HD,Kankel DR

更新日期：1985-03-01 00:00:00

abstract：:In this report we describe the development of a sensitive assay for gene expression in zebrafish embryos using beta-lactamase as a reporter gene. We show that injection of a green fluorescent substrate for beta-lactamase allows the detection of reporter gene expression in live embryos. The beta-lactamase enzyme cataly...

journal_title：Developmental biology

authors： Raz E,Zlokarnik G,Tsien RY,Driever W

更新日期：1998-11-15 00:00:00

abstract：:Calcium influx is known to be prerequisite for membrane fusion of myoblasts. However, little is known about the channels that are responsible for the entry of calcium into the cells. Here we show that K(Ca) channels and stretch-activated channels are involved in the calcium influx. Upon analysis of single-channel reco...

journal_title：Developmental biology

authors： Shin KS,Park JY,Ha DB,Chung CH,Kang MS

更新日期：1996-04-10 00:00:00

abstract：:The vertebrate pituitary gland is a key endocrine control organ that contains six distinct hormone secreting cell types. In this study, we analyzed the role of direct cell-to-cell Delta-Notch signaling in zebrafish anterior pituitary cell type specification. We demonstrate that initial formation of the anterior pituit...

journal_title：Developmental biology

authors： Dutta S,Dietrich JE,Westerfield M,Varga ZM

更新日期：2008-07-15 00:00:00