Abstract:
:The authors report their ultrastructural findings of 36 involved lymph-nodes in Hodgkin's disease (HD), before any treatment. More than 400 tumour cells were studied. An analytical study was carried out on the different aspects presented by the nuclei (uni or multi-lobated); the nucleoli (compact, reticulate or dispersed); and the cytoplasm (immunoblastic, complex, intermediate). No cellular structure evoking phagocytic activity with digestion, and consequently an eventual histiomonocytic origin, could be detected even on serial sections. The presence of lipid inclusions, sometimes of glycogen, as well as certain peculiar structures are described and discussed. The ultrastructural aspects could be easily correlated with the different types of tumour cell described in HD using light microscopy. The various kinds of cells which could could be detected in the same lymph node, may correspond to a real tumour cell lineage, consisting, firstly, of a cell of immunoblastic type with a mono- or bilobated nucleus, then an intermediate type with a bilobated or multisegmented nucleus, and finally a complex cell type with a multisegmented nucleus. The lacunar cells are characterised by a fragile hyaloplasm, without cellular organelles at their periphery, these being concentrated around the nucleus. This special organisation explains the aspects observed in light microscopy. However, no explanation could be offered to understand this particular aspect of the cytoplasm. The ultrastructural characteristics of the Reed-Sternberg cells and their variants did not allow a precise cellular origin to be proposed. The absence of phagolysosomes pleads against a histiocytic origin. However their similarity of the interdigitated reticular cells did not seem sufficient to propose this origin. The likeliness of the cytoplasm of cells with mono- or bilobated nuclei with that of immunoblasts, constitutes the most interesting morphological feature. This fact, associated with the appearance of immunoblasts similar to Reed-Sternberg cells of infectious mononucleosis, suggests a lymphoid origin. The study of the reactive cells around the tumor cells did not allow any consequences to be drawn. One could simply note that the Reed-Sternberg cells and their variants were surrounded by lymphocytes, forming a kind of crown. No etiological agent could be detected. These data are compared to those of other publications, and discussed. This ultrastructural study, therefore, does not offer the solution to most of the questions which still remain to be answered as to the origin of the Reed-Sternberg cells.(ABSTRACT TRUNCATED AT 400 WORDS)
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Diebold J,Reynes M,Marchal G,Tricottet V,Mrena Esubject
Has Abstractpub_date
1986-01-01 00:00:00pages
479-96issue
5eissn
0007-4551issn
1769-6917journal_volume
73pub_type
杂志文章abstract::Small cell lung carcinoma is the most frequent cancer in man. In France, the geographic distribution is not homogenous and the frequency is time-dependent. The main risk factors are smoking and some professional exposures. ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:Surgical treatment of malignant primitive tumors of bone needs a precise preoperative assessment of tumor local extension. Joint involvement (JI) represents the most important finding to determine, for the choice of surgical procedure (intra- or extra-articular resection). OBJECTIVE:To determine the value...
journal_title:Bulletin du cancer
pub_type: 杂志文章,多中心研究
doi:10.1016/j.bulcan.2016.09.018
更新日期:2016-11-01 00:00:00
abstract::In response to the evolution of the information-seeking behaviour of patients and concerns from health professionals regarding cancer patient information, the French National Federation of Comprehensive Cancer Centres (FNCLCC) introduced, in 1998, an information and education program dedicated to patients and relative...
journal_title:Bulletin du cancer
pub_type: 杂志文章,病人教育讲义
doi:
更新日期:2005-07-01 00:00:00
abstract::Targeted therapy against the EGF receptor was shown to be effective in a subgroup of patients with KRAS wild-type colorectal cancer. Therefore, cetuximab (Erbitux) or panitumumab (Vectibix) obtained the authorization by the EMEA restricted to patients with KRAS wild-type tumours. KRAS mutational testing has become par...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2009.0996
更新日期:2009-12-01 00:00:00
abstract::The evolution of anti-cancer chemotherapy has led to long duration treatments, which preferentially are given at home, with the participation of the general practitionner (G.P.). The indications and general supervision of these belong to the oncologist, so thus necessitates a coordinated effort between the many physic...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::In an attempt to harmonize clinical practices among French hematopoietic stem cell transplantation centers, the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) held its sixth annual workshop series in September 2015 in Lille. This event brought together practitioners from across the c...
journal_title:Bulletin du cancer
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1016/j.bulcan.2016.09.005
更新日期:2016-11-01 00:00:00
abstract::Portal vein embolization consists of occluding a part of the portal venous system in order to achieve the hypertrophy of the non-embolized liver segments. This technique is used during the preoperative period of major liver resection when the future remnant liver (FRL) volume is insufficient, exposing to postoperative...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/j.bulcan.2017.03.009
更新日期:2017-05-01 00:00:00
abstract::This paper reviewed the 2002 guidelines established by the National Federation of Cancer Centres. A group of experts nominated by the 3 French Societies involved in the treatment of cancer pain (AFSOS, SFAP, SFETD), established new guidelines ratios for morphine switching and/or changing of route of administration, in...
journal_title:Bulletin du cancer
pub_type: 杂志文章,实务指引,评审
doi:10.1016/j.bulcan.2018.06.011
更新日期:2018-11-01 00:00:00
abstract::Advances in medical imaging have greatly enhanced the speciality of radiation oncology by allowing more healthy tissue to be speared for better tumour coverage. Positron emission tomography (PET) with the glucose analogue [18F]-fluoro-2-deoxy-D-glucose (FDG) is a functional imaging method that has become widely used i...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract::Rapamycin (sirolimus) is a macrolide, related to cyclosporine with immunosuppressive properties and antiproliferative activity in various human tumor cells lines and tumor xenograft models. The cytosolic kinase mTOR which controls the initiation of the translation of messenger RNA is the main known target of rapamycin...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-10-01 00:00:00
abstract::We report a case of renal cell carcinoma presenting with bilateral adrenal masses diagnosed by ultrasonography four years after nephrectomy. The histopathological examination of the trucut biopsy specimens obtained percutaneously by ultrasound guidance revealed bilateral adrenal mestastases of renal cell carcinoma. ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract::Management of rectal cancers with synchronous metastasis is difficult. We evaluated in 23 patients a combination of pelvic radiotherapy at the dose of 45 Gy in 5 weeks and 25 fractions with chemotherapy by 5-fluorouracil (350 mg/m2/day) and folinic acid (20 mg/m2/day) for 5 days at the time of the first and the fifth ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::Important improvements in local control with increasing function-sparing treatment have been achieved in adult soft tissue sarcomas (STS). However, the global prognosis of these diseases remains poor and 40% of patients with STS currently die of metastases within 5 years. In fact, the impact of chemotherapy remains de...
journal_title:Bulletin du cancer
pub_type: 杂志文章,meta分析
doi:
更新日期:1997-06-01 00:00:00
abstract::Breast cancer remains a potentially lethal disease, which requires aggressive treatments and is associated with long-term consequences. Its prognosis is linked to both tumor biology and burden at diagnosis. Although treatments have allowed important improvements in prognosis over the past 20 years, breast cancer scree...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1016/j.bulcan.2016.06.005
更新日期:2016-09-01 00:00:00
abstract::Gangliosides are glycosphingolipids which contain neuraminic acid. Although they are present in the plasma membranes of all cells, gangliosides are expressed differently, both quantitatively and qualitatively, in certain types of cancer. Modifications in ganglioside composition may account for some of the abnormal int...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:1991-01-01 00:00:00
abstract::At the time of diagnosis, central nervous system (CNS) involvement is identified in less than 10% of adult acute lymphoblastic leukemia (ALL). Long-term disease-free survival can be achieved in these patients. CNS disease at presentation does not appear to be an independent poor prognostic factor. In CNS leukemia, inn...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2008.0645
更新日期:2008-07-01 00:00:00
abstract::Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) is now an entire part of treatment of peritoneal dissemination of colorectal malignancy, and it's possible to hope prolonged survival. This treatment is more and more codified. Four indications are recognized by some tree national evaluation committees: ...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2008.0553
更新日期:2008-01-01 00:00:00
abstract::There are very few active drugs in the treatment of metastatic gastric carcinoma. Among new drugs, docetaxel has shown one of the most important activity. With precise evaluation of objective response, this drug has demonstrated a 20% response rate in monotherapy. The favorable toxicity profile of this compound allowe...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-01 00:00:00
abstract:INTRODUCTION:The last years are marked by the emergence of new molecules for the treatment of metastatic cutaneous melanoma with a significant benefit on the survival. Besides, some techniques are in development for the loco-regional treatment of the metastatic sites, bringing new therapeutic perspectives. However, the...
journal_title:Bulletin du cancer
pub_type: 杂志文章,实务指引
doi:10.1684/bdc.2013.1868
更新日期:2014-01-01 00:00:00
abstract::Sentinel lymph node (SLN) biopsy is fast becoming the standard for testing lymph node involvement in many institutions. However questions remain as to stage underestimation. The aim of this study was to analyse this specific risk in a retrospective study. Between 1975 to 1999, 1,636 patients underwent a breast cancer ...
journal_title:Bulletin du cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::Oncolor, the French regional cancer network of Lorraine, proposes clinical guidelines for the diagnosis, the treatment and the follow-up of cancers. In addition to paper documents, two computerized supports, a web site and the Kasimir software have been developed to make the use of these guidelines and their updating ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:2003-04-01 00:00:00
abstract::CYP2D6 enzyme is implicated in the metabolism of drugs and nicotine. Genetic variability within CYP2D6, results in different CYP2D6 phenotypes. Inheritance of polymorphic CYP2D6 metabolizing enzyme is likely to be an important determinant of inter-individual variations in susceptibility to cancer. In this work, we hav...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2008.0583
更新日期:2008-02-01 00:00:00
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journal_title:Bulletin du cancer
pub_type: 信件
doi:
更新日期:1992-01-01 00:00:00
abstract::With over 70,000 patients treated worldwide, protontherapy has an evolution on their clinical applications and technological developments. The ballistic advantage of the Bragg peak gives the possibility of getting a high conformation of the dose distribution to the target volume. Protontherapy has accumulated a consid...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2010.1149
更新日期:2010-07-01 00:00:00
abstract::It is widely accepted that the development of carcinoma is not only due to somatic mutations in epithelial cells but also is influenced by the tumor microenvironment ie the stroma. The different stroma components produced growth factors, cytokines, the extra cellular matrix and also participated to the recruitment of ...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2008.0560
更新日期:2008-01-01 00:00:00
abstract::Targeted therapies, especially monoclonal antibodies, have reached an increasing importance in oncology. High-throughput techniques have allowed the identification of numerous transcripts, proteins, or non-protein antigens, which have generated the concept of immunome. This epitope library constitutes a huge reservoir...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract::We evaluated the efficacy and safety of a monotherapy by piperacillin and sulbactam potentially associated to vancomycin as an empiric antimicrobial therapy in febrile neutropenic patients treated with nephrotoxic chemotherapy for solid tumors. Twenty-three patients were treated during 32 episodes with piperacillin 4 ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND AND AIM:CABYR, a calcium-binding tyrosine phosphorylation regulated fibrous sheath protein, was initially reported to be testis-specific and subsequently shown to be present in brain tumors, pancreas cancer and lung cancer. This study aimed to investigate the expression and effects of the CABYR-c transcript ...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:10.1684/bdc.2011.1538
更新日期:2012-03-01 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice of hematologic malignancies. Acute graft versus host disease (GvHD) is common after HSCT and directly related to graft versus leukemia effect. Little progress has been done in the treatment of acute GvHD. The first line treatment is u...
journal_title:Bulletin du cancer
pub_type: 杂志文章,评审
doi:10.1684/bdc.2011.1410
更新日期:2011-08-01 00:00:00
abstract::The retrospective evaluation of the dose after an irradiation accident is of paramount importance; it allows an adequate selection of patients and the most appropriate treatment can then be proposed. Classical physical dosimetry often lacks precision for dose assessment in such accidents. Cytogenetics, usually more re...
journal_title:Bulletin du cancer
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00