Abstract：
:Targeted therapies, especially monoclonal antibodies, have reached an increasing importance in oncology. High-throughput techniques have allowed the identification of numerous transcripts, proteins, or non-protein antigens, which have generated the concept of immunome. This epitope library constitutes a huge reservoir of candidate antigens susceptible to become some say the target of an antibody for passive immunotherapy. However, the conception and development of a therapeutic antibody represent a very important investment, both in terms of human power and finance, such that there is a requirement for an early identification of the best candidates among the potential target antigens. Among multiple criteria, the function of the antigen is crucial when it has been identified. A receptor antigen can be targeted by an agonistic or an antagonistic antibody, according to what is sought. When the antigen function is unknown, a therapeutic antibody can be useful, for instance through induction of apoptosis or through accrual of immuno-competent cells, via its Fc portion (complement-dependent cytotoxicity or antibody-dependent cytotoxicity). Other antibody features, unrelated to its function, can also be exploited, such as its internalisation or its translocation in membrane lipid rafts. The expression of the target antigen may also be crucial, in terms of localisation and levels, as is its tumour specificity, which can influence the efficacy and toxicity of the targeting antibody. The multiplicity of the factors to be taken into account and the complexity of the mechanism of action of therapeutic antibodies renders the choice of a target antigen a hazardous bet. Very often, this is only when the clinical efficacy of a targeting antibody is demonstrated that the antigen can be considered as a good target.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Ceze N,Probst A,Lecomte T,Ohresser M,Paintaud G,Watier Hsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
F129-36issue
7 Suppleissn
0007-4551issn
1769-6917journal_volume
94pub_type
杂志文章,评审abstract：:With 2 436 deaths in 1979, ovarian cancer is relatively infrequent in France comprising but 5 per cent of female mortality from malignant disease. However, the rate of increase in mortality is considerable, 70 per cent between 1955 and 1979 or 2,9 per cent per year, greater than that for female bladder and breast canc...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:The first study evaluating directly by the referring physician the clinical impact of [18F]-FDG-PET on modification of patient's management was performed only recently in California by means of a questionnaire. We have used the same methodology to evaluate this clinical impact during the opening year of our PET centre...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:According to the point 7.6 and 7.7 of the Cancer Plan 2014, all cancer patients should have access to supportive care. Indeed, the supportive care consultation in oncology is an important tool for the symptom management of cancer patients at all times of treatment. This consultation can be mono-disciplinary or multi-d...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2015.04.019
更新日期：2015-09-01 00:00:00
abstract：:We have treated in 1990 and 1991, 84 arteriovenous malformations (AVMs) by radiosurgery. Irradiation was realized by 5 to 7 arcs with 15 MV X rays circular minibeams of a GE-CGR Saturne 43 Linac diameter, at 100 cm 6 to 20 mm; the Betti arm chair and the Talairach frame. The prescribed peripheral dose containing the n...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1995-12-01 00:00:00
abstract：:In recent years, Internet has become an indispensable tool for all types of information. Its importance has increased in medicine and particularly in human malignancies. The data issued by the Internet are many and varied sources ranging from official websites to patient's blogs. HIV infection is an infection highly p...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2010.1160
更新日期：2010-10-01 00:00:00
abstract：:If chemotherapy beyond the third line often gives sum clinical benefits, it is sometimes prescribed only to avoid telling bad news to patients. Palliative chemotherapy can lead to symptom reduction and greater health related quality-of-live, but longer survival is unlikely. Physician's questioning about chemotherapy c...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2009.0895
更新日期：2009-09-01 00:00:00
abstract：:Antineoplastic drug induced nausea and vomiting are common adverse events in cancer care of paediatric patients ; therefore, prevention and management of these adverse events is a major concern for healthcare professionals. There are common features between paediatric and adult patients in terms of the emetogenic leve...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2020.03.015
更新日期：2020-01-01 00:00:00
abstract：:Cancer patients are often moved inside the hospital to different examination clinics, such as radiology, CT scan, MRI... and to treatment clinics, such as radiotherapy. These transports induce important pain phenomena, not really recognized by professional teams. As these kinds of pains are expected and can be prevent...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2008.0638
更新日期：2008-05-01 00:00:00
abstract：:Melanoma of the female genital tract is a rare location (less than 2% of melanomas all sites combined). These cancers have a very poor prognosis, due to the delay in diagnosis. Vulvar location is about 1% of melanomas then the vaginal location, uterine and ovarian. There is no consensus to date regarding their care, d...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2013.1881
更新日期：2014-01-01 00:00:00
abstract：:Cardiac neoplasms are a rare occurrence in clinical practice. The various frequencies of primary and secondary malignant tumors vary from report to report, approximately 1% in most autopsy series and 4% in cancer patient's autopsies. Cardiac malignancies account for less 1% of cardiac surgery and about for 0.1% of car...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-01 00:00:00
abstract：:In a dozen years of development, irinotecan (CPT11) became one of major therapeutics in the taking care of the metastatic colorectal cancer (CCRM). First used in monotherapy every three weeks, irinotecan has been later developed in association with 5FU and folinic acid according to two modalities of administration (bo...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2006-05-01 00:00:00
abstract：:Patients wish to be fully informed about their health, but some information and its disclosure may pose special challenges depending on the severity of the illness. This prospective observational study investigates the content of information about the disease and treatment, as well as the process by which information ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2011.1530
更新日期：2012-02-01 00:00:00
abstract：:To show the nature and magnitude of EKG anomalies subsequent to 5-fluorouracil (5FU) administration and determine whether the onset is dependent on a pre-existing cardiovascular pathological condition. 1,350 patients were treated by 5FU between 1995 and 2000. EKG were recorded in all patients before each administratio...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:Describe the implementation and preliminary results of the “Experimental Program Personalized care” in patients with Head and Neck cancer. MATERIALS AND METHODS:After being selected a graduate nurse status, called coordination, participated in the development of forms of detection needs and concerns of patie...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2014.2040
更新日期：2014-10-01 00:00:00
abstract：:In a case of glioblastoma, the following karyotype was determined: 47, X, - Y, + der(1) t(1;9)(p21;p23), t(1;9)(p21;p23), + 3, + 7, der(9) t(Y;9)(q11;p21), - 13, t(13;16)(p13,p11), del(14)(q11q22). Classical satellite DNAs are mainly located in chromosomes 1, 9, 15, 16 and Y. Because, most of these chromosomes were im...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:Cerebral non Hodgkin's lymphomas (NHL) of immunocompetent patients are rare disease (1% of all NHL), but their incidence has been steadily increasing in the last 20 years. Most cerebral NHL are diffuse large cell NHL with a B phenotype. These tumors are most often localized in the central nervous system, the eye or me...
journal_title：Bulletin du cancer
pub_type： 杂志文章,meta分析
doi：
更新日期：1997-10-01 00:00:00
abstract：UNLABELLED:The legislative process of the surrogate appears to be unclear to health professionals and to patients and next of kin. To better adapt this process to the clinical practice our objective was here to document how the persons designated as surrogate perceived their role and how they described the difficulties...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2016.03.003
更新日期：2016-07-01 00:00:00
abstract：CONTEXT:Survival of children, adolescents and young adults treated for cancer increased with improved treatments. But there is still an increased risk of second primary cancer (SPC) in the long term compared to the population of the same age, especially related to treatments. A reflection on the follow-up of this popul...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2015.03.017
更新日期：2015-07-01 00:00:00
abstract：:We report a case of renal cell carcinoma presenting with bilateral adrenal masses diagnosed by ultrasonography four years after nephrectomy. The histopathological examination of the trucut biopsy specimens obtained percutaneously by ultrasound guidance revealed bilateral adrenal mestastases of renal cell carcinoma. ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1994-02-01 00:00:00
abstract：:Primary chemotherapy is the use of anticancer drugs as the first treatment in patients with localized tumor presentations for which there is an alternative but less than satisfactory treatment. Its most important feature is the preservation of the primary tumor mass as a biologic marker of response, and in this sense ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1988-01-01 00:00:00
abstract：:Twenty-five adult patients, 15 men and 10 women, with a median age of 49, and presenting with metastatic or locally advanced soft tissue sarcomas, have been treated with chemotherapy protocol combining cisplatinum, 100 mg/m2, vindesine, 4 mg/m2, and either adriamycin, 50 mg/m2 (APEL) (16 patients), or epirubicin, 100 ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:All the retrospective and prospective studies concerning IORT in tumors of the digestive tract tend to substantiate a significant improvement in local control without a significant increase in survival. Improvements in the results of IORT can be expected in the near future, and may occur on several fronts: - Technolog...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2001-02-01 00:00:00
abstract：:Fifty-one patients with non-Hodgkin's lymphoma refractory or relapsing after CHOP-like regimen, underwent a salvage chemotherapy by VPH: etoposide 100 mg/m2/d, D1 to D3, cisplatin 20 mg/m2/d, D1 to D5, ifosfamide 1 g/m2/d D1 to D5, mesna 1.2 g/m2/d D1 to D5, every 4 weeks. Among 46 evaluable patients for efficacy, 21 ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:Cancerogenesis is believed to be a multistep process composed of different alterations that drive the transformation of normal human cells into highly malignant derivatives. These changes include self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, the evasion of programmed cell death, a lim...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2008.0600
更新日期：2008-03-01 00:00:00
abstract：:Acute and chronic renal failures are very common after allogeneic HSCT. These complications have a real impact on mortality and morbidity of transplant recipients. Within the framework of the ninth workshops of practice harmonization of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-...
journal_title：Bulletin du cancer
pub_type： 共识发展会议,杂志文章,实务指引
doi：10.1016/j.bulcan.2019.05.002
更新日期：2020-01-01 00:00:00
abstract：:Seventy children (3.7 +/- 3.3 y) with definitely confirmed diagnosis of neuroblastoma had 115 whole body scans carried out 24 h after injection of 3.7 MBq/kg of I-123 mIBG (83 scans) or 0.7 MBq/kg of I-131 mIBG (17 scans) or 0.9 to 4.5 GBq of I-131 mIBG (15 post-therapeutic scans). The scans were interpreted as positi...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Surgery of locoregional failures is mainly represented by salvage surgery after radiotherapy. Due to progress of radiotherapy, especially modification of fractionation and association with chemotherapy, the problem of salvage surgery is nowadays emphasized. Despite the reduction of postoperative mortality and morbidit...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-01 00:00:00
abstract：:Ataxia telangiectasia (AT) is a hereditary disease transmitted in a recessive mode and characterized by chromosomal instability and radiosensitivity. AT patients have a 100-fold higher risk of cancer than the general population. Although AT is a rare disease of which the frequency has been estimated to be 1/40,000, th...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：AIM:Harvesting of the "sentinel lymph node" (SLN) as identified by lymphoscintigraphy (LSG) is becoming increasingly important in the staging of patients with malignant melanoma. The purpose of the current study was to determine whether the appearance time of the LSG had a prognostic value in predicting metastasis diss...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：BACKGROUND:Depression is an important symptom for many palliative care patients but is rarely identified. It's known to reduce quality of life and impact on palliation of physical symptom. These physical symptoms can be improved by an adequate treatment of depression. Many depressed cancer patients are not treated due ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2011.1310
更新日期：2011-02-01 00:00:00
