Abstract：
:In a case of glioblastoma, the following karyotype was determined: 47, X, - Y, + der(1) t(1;9)(p21;p23), t(1;9)(p21;p23), + 3, + 7, der(9) t(Y;9)(q11;p21), - 13, t(13;16)(p13,p11), del(14)(q11q22). Classical satellite DNAs are mainly located in chromosomes 1, 9, 15, 16 and Y. Because, most of these chromosomes were implicated in the rearrangements, a detailed cytogenetic study was undertaken. This study included in situ hybridization of the satellite and alphoid DNAs of chromosomes 1, 9, 16 and Y combined with various chromosome banding methods (DA-DAPI, quinacrine mustard and R-banding). The data obtained, demonstrated that the breakpoints were always located outside the areas containing the satellite and alphoid DNAs. The situation observed here differs from that reported in breast cancers for which a high proportion of the breakpoints occur within these areas. These findings suggest that in glioblastoma, chromosome rearrangements result from different mechanisms than those implicated in breast cancers. Thus, in cancers, chromosomal instabilities may result from several mechanisms.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Bourgeois CA,Kokalj-Vokac N,Dutrillaux AM,Poisson M,Delattre JY,Vega F,Malfoy B,Dutrillaux Bsubject
Has Abstractpub_date
1994-05-01 00:00:00pages
360-5issue
5eissn
0007-4551issn
1769-6917journal_volume
81pub_type
杂志文章abstract：:Angiogenesis inhibition is a major antitumor strategy that has emerged during the last decade. Oral tyrosine kinase inhibitors (TKI) targeting the VEGF receptor, including sunitinib, sorafenib, axitinib, regorafenib, pazopanib, and vandetanib reduce tumor growth and metastasis. These agents are approved for the treatm...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2015.10.020
更新日期：2016-03-01 00:00:00
abstract：:The publication of the new WHO classification of head and neck tumours in 2017 brought major modifications. Especially, a new chapter is dedicated to the oropharynx, focusing on the description of squamous cell carcinoma induced by the virus Human Papilloma Virus (HPV), and new entities of tumors are described in nasa...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2018.04.004
更新日期：2018-06-01 00:00:00
abstract：:Induction of hyperthermia by ultrasound is facilitated by the characteristics of sound absorption in tissue: at frequency of 500 kHz the penetration distance in muscle is about 12.5 cm. Energy deposition patterns can be shaped by focussing or by the use of multiple transducers. An initial clinical study has demonstrat...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:From January 1, 1983 to December 31, 1990 two hundred and six patients with an invasive, non metastatic endometrial carcinoma were first treated at Institut Curie. Initial tumoral staging (TNM) was as follows: stage Ia: 48%, stage Ib: 31%, stage II: 15% and stage III-IV: 6%. Total hysterectomy or colpohysterectomy was...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：INTRODUCTION:Genetic predisposition to familial hematological malignancies was previously described through several epidemiological analyses, but the genetic basis remains unclear. The tumor-suppressor ARLTS1 gene was previously described in sporadic hematological malignancies and familial cancer context. METHODS:In t...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2016.10.016
更新日期：2017-02-01 00:00:00
abstract：:The evidence that genetic factors are of some importance in the etiology of cancer originates has been determined by genetic epidemiology, molecular biology, cytogenetics. Genetic counselling is one of the possible strategies for controlling cancer through genetics. Genetic counselling in this field more often concern...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Surgery of locoregional failures is mainly represented by salvage surgery after radiotherapy. Due to progress of radiotherapy, especially modification of fractionation and association with chemotherapy, the problem of salvage surgery is nowadays emphasized. Despite the reduction of postoperative mortality and morbidit...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-01 00:00:00
abstract：:CAR T-cells are autologous or allogeneic human lymphocytes that are genetically engineered to express a chimeric antigen receptor targeting an antigen expressed on tumor cells such as CD19. CAR T-cells represent a new class of medicinal products, and belong to the broad category of Advanced Therapy Medicinal Products ...
journal_title：Bulletin du cancer
pub_type： 共识发展会议,杂志文章,实务指引
doi：10.1016/j.bulcan.2017.10.017
更新日期：2017-12-01 00:00:00
abstract：:This review will describe the current knowledge in the pathophysiology, diagnosis, prognosis and treatment of pulmonary MALT (Mucosa Associated Lymphoid Tissue) lymphoma. Pulmonary MALT lymphomas are low-grade B cell lymphoma and are the most frequent lymphomas arising from the lung. Tumour cells arise from mucosa ass...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2014.1885
更新日期：2014-02-01 00:00:00
abstract：UNLABELLED:This CORCAN study is concerned with the way patients hospitalised for peritoneal carcinosis perceive surgical treatment and hyperthermic intraperitoneal chemotherapy (HIPEC). OBJECTIVES:(1) To identify and analyse, using concepts of social representation and accounts of the illness, characteristics of the w...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2015.10.015
更新日期：2016-02-01 00:00:00
abstract：:Treatment of metastatic renal cell carcinoma with interleukin 2 (IL2) remains controversial despite the authorization from the French government for IL2 with the West schedule in this disease. We report herein the study of the Institute Gustave-Roussy of 73 patients, who received from 1989 to 1991 a new schedule of hi...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：:Twenty-five adult patients, 15 men and 10 women, with a median age of 49, and presenting with metastatic or locally advanced soft tissue sarcomas, have been treated with chemotherapy protocol combining cisplatinum, 100 mg/m2, vindesine, 4 mg/m2, and either adriamycin, 50 mg/m2 (APEL) (16 patients), or epirubicin, 100 ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Targeted therapy against the EGF receptor was shown to be effective in a subgroup of patients with KRAS wild-type colorectal cancer. Therefore, cetuximab (Erbitux) or panitumumab (Vectibix) obtained the authorization by the EMEA restricted to patients with KRAS wild-type tumours. KRAS mutational testing has become par...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2009.0996
更新日期：2009-12-01 00:00:00
abstract：:The association between cancer and dependence was estimated using a cross-sectional study among persons 75 years of age or-older in Tarn county (area with a cancer registry recognized by the National Committee of Registries). A representative random sample stratified on age, sex, and size of district, was drawn using ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1997-02-01 00:00:00
abstract：:As soon as they get accepted into medical school, students find themselves facing numerous expectations: coping with tremendous study burden, competing with others for the best rank, completing internships and participating in the race for publishing are only to name a few. This big juggle makes it hard for the medica...
journal_title：Bulletin du cancer
pub_type： 社论
doi：10.1016/j.bulcan.2018.04.005
更新日期：2018-06-01 00:00:00
abstract：INTRODUCTION:Surgical treatment of malignant primitive tumors of bone needs a precise preoperative assessment of tumor local extension. Joint involvement (JI) represents the most important finding to determine, for the choice of surgical procedure (intra- or extra-articular resection). OBJECTIVE:To determine the value...
journal_title：Bulletin du cancer
pub_type： 杂志文章,多中心研究
doi：10.1016/j.bulcan.2016.09.018
更新日期：2016-11-01 00:00:00
abstract：INTRODUCTION:The treatment of chronic myeloid leukemia (CML) has been revolutionized by the advent of tyrosine kinase inhibitors. The results of the IRIS trial demonstrated the efficacy and long-term safety profile of Imatinib. The objective of our work is to report the results at 15 years of treatment of CML in chroni...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2020.05.013
更新日期：2020-09-01 00:00:00
abstract：:The evolution of anti-cancer chemotherapy has led to long duration treatments, which preferentially are given at home, with the participation of the general practitionner (G.P.). The indications and general supervision of these belong to the oncologist, so thus necessitates a coordinated effort between the many physic...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Over the last decade, the development of new therapeutic options has made more patients benefit from antitumoral strategies including several lines of chemotherapy, the aim of which is a long-term control of the disease progression. In such a context of "chronic" management, the choice of tumor response as a single pa...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2008.0738
更新日期：2008-11-01 00:00:00
abstract：:Cell signalling represents the network of cell communication pathways. Reception of a message by a cell results in the implementation of various direct and indirect actions, especially through the transcription of the genes required for carrying out the orders received. The signals exchanged by cells may concern proli...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1199
更新日期：2010-11-01 00:00:00
abstract：:The endothelins (ET1, ET2, ET3) are a family of peptides that exert vasoactive and mitogenic effects. ETs bind to at least two subtypes of receptors: the ETA subtype is ET1 selective whereas the ETB subtype binds ET1, ET2 and ET3. By RT-PCR, we detected ETA receptor mRNA and ETB receptor mRNA in leiomyoma and in homol...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:The results obtained in the treatment of 45 cases of soft tissue sarcomas are presented. All cases were reviewed and classified according to the modern criteria of malignancy. The treatment schedule comprised: (1) preoperative irradiation: 2 sessions of 6.50 Gy in 48 hours, target volume: whole limb segment; (2) surgi...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Death still occurs in Hodgkin's disease (HD) patients with advanced stages, but also in early stages. Therefore, the identification of the population of HD patients who would best benefit from an intensification of treatment is a prerequisite in all stages. The best known prognostic factors are bulky mediastinum, B sy...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1995-08-01 00:00:00
abstract：:Pain is frequent in the course of cancer and can have negative consequences on patients quality of life. The great majority of patients can be helped by simple treatments. The prescription of morphine (M) must be preceded by some explanations. In order to verify the reality of these explanations, a study was done in a...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-04-01 00:00:00
abstract：:Docetaxel (Taxotère) has been developed in breast cancer during the last decade. First its activity in monotherapy was proven in metastatic setting after failure of anthracycline therapy. Then the association with anthracycline demonstrated substantial activity leading to its development in early stages of breast canc...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2004-05-01 00:00:00
abstract：:In 2006, a total number of 149,000 cancer deaths were observed in France, 88,500 in the male population and 60,500 in the female population. In 2005, the number of new diagnoses of cancer is estimated to be 319,000, 183,000 among men and 136,000 among women. Age-standardised mortality rates are decreasing for most fre...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2008.0795
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:We analyzed renal cell carcinoma (RCC) brain metastasis (BM) risk factors and compared BM occurrence in metastatic RCC (mRCC) treated with or without anti-angiogenic agents (AA). METHODS:Data from all consecutive metastatic RCC patients (patients) treated in a french cancer center between 1995 and 2008 were...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2012.1672
更新日期：2012-12-01 00:00:00
abstract：:Oral cavity and pharyngeal cancers account for 75% of head and neck cancers and are the fourth most spread cancer in men. Their incidence has decreased since 1980 in men (incidence from 2011 gives 13,930 for lip, oral cavity, pharyngeal and laryngeal carcinomas) but has increased in women, linked to the more recent sm...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2014.1962
更新日期：2014-05-01 00:00:00
abstract：:At the time of diagnosis, central nervous system (CNS) involvement is identified in less than 10% of adult acute lymphoblastic leukemia (ALL). Long-term disease-free survival can be achieved in these patients. CNS disease at presentation does not appear to be an independent poor prognostic factor. In CNS leukemia, inn...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2008.0645
更新日期：2008-07-01 00:00:00
abstract：:The physician-patient relationship has three main stakes : creating a high-quality inter-personal relationship, exchanging information and decision-making. The achievement of these stakes implies that the physician and the patient are able to reach specific communicational objectives. The aim of this paper is to revie...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2006-04-01 00:00:00
