Abstract：
INTRODUCTION:Genetic predisposition to familial hematological malignancies was previously described through several epidemiological analyses, but the genetic basis remains unclear. The tumor-suppressor ARLTS1 gene was previously described in sporadic hematological malignancies and familial cancer context. METHODS:In this study, we sequence the ARLTS1 gene in 100 patients belonging to 88 independent Tunisian and French families. RESULTS:After gene sequencing, we report 8 genetic variations, most of which were previously reported in several cancer forms. The most common variants were W149X and C148R and were previously associated to B-cell chronic lymphocytic leukemia and to high-risk of familial breast cancer. CONCLUSIONS:These results emphasize the fact that ARLTS1 gene mutations can be considered as a potential predisposing factor in familial hematological malignancies and other several cancer forms.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Hamadou WS,Besbes S,Mani R,Bourdon V,Ben Youssef Y,Achour B,Regaieg H,Eisinger F,Mari V,Gesta P,Dreyfus H,Bonadona V,Dugast C,Zattara H,Faivre L,Noguchi T,Khélif A,Sobol H,Soua Zdoi
10.1016/j.bulcan.2016.10.016subject
Has Abstractpub_date
2017-02-01 00:00:00pages
123-127issue
2eissn
0007-4551issn
1769-6917pii
S0007-4551(16)30283-1journal_volume
104pub_type
杂志文章abstract：:465 patients with broncho-pulmonary malignant tumors have been autopsied. Small cell carcinoma was diagnosed in 22.5 per cent of these patients. The histo-cytological variants of these tumors (lymphocytoid, polygonal, fusiform and polymorphic) had the same general characteristics (age, sex, survival) and a similar cli...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Endometrial cancer is a common cancer in older women and is often associated with comorbidities. Management of metastatic disease and/or relapse requires a multidisciplinary approach. Recent advances in the understanding of oncogenesis and molecular classification of endometrial cancers offer new therapeutic perspecti...
journal_title：Bulletin du cancer
pub_type： 杂志文章,实务指引
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更新日期：2020-10-01 00:00:00
abstract：:During the last decade, inhibitors of the vascular endothelial growth factor (VEGF) were developed for the treatment of cancer. Many anti-VEGF are available but the issue is still the same: to inhibit the effect of the VEGF on their receptors. There are two main classes, depending on the mechanism of action by blockin...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
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abstract：:Angiogenesis targeting with inhibitors of VEGF receptors is currently modifying in depth the treatment strategy of metastatic clear cell renal carcinoma. Although immunotherapy remains prescribed in selected patients with good prognosis, sunitinib and sorafenib are presently the most active agents in this malignancy. ...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:The 4 year results of a prospective clinical trial on the treatment of operable breast cancer, comparing the effects of preoperative radiotherapy followed by surgery with those of surgery followed or not by postoperative radiotherapy are presented for patient groups of approximately 100 each. At 4 years 85 per cent su...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1977-01-01 00:00:00
abstract：INTRODUCTION:Breast cancer of young women has medico-psychological issues, particularly in the perspective of "after cancer" period. The objective of the study was to analyze the changes in management, in a decade including the publication of Cancer Plans I and II. METHODS:This retrospective unicentric study involved ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2008.0795
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2016.03.009
更新日期：2016-07-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2011.1412
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2017.11.014
更新日期：2018-03-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2010.1087
更新日期：2010-04-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2017.03.009
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journal_title：Bulletin du cancer
pub_type： 杂志文章,meta分析
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更新日期：1997-06-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2017.10.024
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1976-07-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2004-02-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2008.0638
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journal_title：Bulletin du cancer
pub_type： 杂志文章
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
