Abstract：
INTRODUCTION:Breast cancer of young women has medico-psychological issues, particularly in the perspective of "after cancer" period. The objective of the study was to analyze the changes in management, in a decade including the publication of Cancer Plans I and II. METHODS:This retrospective unicentric study involved two populations of women aged 40 and treated at the "Institut de cancérologie de Lorraine" in 2002-2004 (P1) and 2012-2014 (P2). Epidemiological-demographic, histological, diagnostic and therapeutic sequences were analyzed. RESULTS:216 patients were included. The mean age was 35.7 years (range 22-40), with no significant epidemiological difference, except for an increased rate of obesity in P2. Preoperative biopsies became almost systematic and the pre-therapeutic care plan rate increased over the decade from 3.8% to 8% (p < 0.001). The rate of breast-conserving treatment remained stable. The sentinel lymph node rate increased from 4.4% in P1 to 31.9% in P2 (p < 0.001), while the rate of lymph node dissection decreased (p < 0.001) between the two periods. Resort to breast nurses, psycho-oncologists, fertility experts and oncogenetic consultations has also increased. CONCLUSION:There is an improvement in the care and management of young women under 40 because of the first Cancer Plans. A study about the impact on the prognosis and a reflection to improve the experience of illness for these women are to lead.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Soussoko M,Salleron J,Desandes E,Lesur Adoi
10.1016/S0007-4551(20)30049-7subject
Has Abstractpub_date
2019-12-01 00:00:00pages
S60-S74issue
12S1eissn
0007-4551issn
1769-6917pii
S0007-4551(20)30049-7journal_volume
106pub_type
杂志文章abstract：:In 2003, there was 147,000 deaths attributed to cancer in France, 88,000 in men and 59,000 in women. Cancer mortality rates have been decreasing since 1987 in the male population and since the late 60's in the female population, the decrease is larger for the male population. This decrease is observed for most sites o...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Perioperative chemotherapy for gastric cancer is validated by two phase III studies. The impact of the preoperative neoadjuvant sequence is probably major in the benefit of this treatment. This chemotherapy increases the R0 resection without increasing either morbidity or mortality. Furthermore, it reduces local and s...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1287
更新日期：2011-01-01 00:00:00
abstract：:The epithelial-mesenchymal transition (EMT) is a morphogenetic program that converts epithelial into mesenchymal cells during the embryonic development. This mechanism is frequently reactivated during tumor progression and provides cells with motility and invasive capabilities favoring the metastatic dissemination fro...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2009.1025
更新日期：2010-01-01 00:00:00
abstract：:Surgery of locoregional failures is mainly represented by salvage surgery after radiotherapy. Due to progress of radiotherapy, especially modification of fractionation and association with chemotherapy, the problem of salvage surgery is nowadays emphasized. Despite the reduction of postoperative mortality and morbidit...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-01 00:00:00
abstract：IMMUNOTHERAPY IN GLIOBLASTOMAS:Targeting the immune system as a therapeutic strategy in solid tumors has shown great efficacy in various tumor types. However the role and success of this approach in glioblastomas remain to be determined. Recent studies demonstrated that central nervous system is no longer considered as...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/S0007-4551(18)30391-6
更新日期：2018-12-01 00:00:00
abstract：:To assess the effectiveness of a standardized form in altering family physicians knowledge regarding supportive care delivered to their patients. We conducted an uncontrolled before and after study involving 42 cancer patients who were provided with supportive care at hospital. During the intervention study period, a ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2011.1452
更新日期：2011-10-01 00:00:00
abstract：:Despite great improvements in the outcome of patients with lymphoma, some may still relapse or present with primary refractory disease. In these situations, allogeneic haematopoietic cell transplantation (allo-HCT) is a potentially curative option, in particular in the case of relapse after autologous stem cell transp...
journal_title：Bulletin du cancer
pub_type： 共识发展会议,杂志文章,实务指引,评审
doi：10.1016/j.bulcan.2017.08.008
更新日期：2017-12-01 00:00:00
abstract：:Treatment of soft-tissue sarcomas has to deal simultaneously with three goals: 1) to obtain the control of the primary tumor, 2) to preserve the function, and 3) to treat the micrometastatic disease. For local control, surgery remains the most efficient treatment, but the extent of the resection of macroscopically non...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:From July 1987 to July 1988, 35 patients with non small cell lung cancer, stage IV, were included in a phase II trial (GLOT NPC 87/01). The treatment was as follows: cisplatin 50 mg/m2 day 1, vindesin 3 mg/m2 day 1, mitomycin 6 mg/m2 day 2, and bleomycin 15 mg/day, day 1 + 2 by continuous infusion. The evaluation for ...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-01-01 00:00:00
abstract：:For two decades, the prognostic of adult patients with ALL was improved based on pediatric-inspired protocols. These approaches based on less myelosuppressive drugs have led to improved response rates, decreased relapse rates, with a benefit in survival observed in patients aged up to 50-60-years-old. Therapeutic inte...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2020.07.008
更新日期：2020-09-24 00:00:00
abstract：:Oncolor, the French regional cancer network of Lorraine, proposes clinical guidelines for the diagnosis, the treatment and the follow-up of cancers. In addition to paper documents, two computerized supports, a web site and the Kasimir software have been developed to make the use of these guidelines and their updating ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2003-04-01 00:00:00
abstract：FOCAL TREATMENT AND SYSTEMIC THERAPY IN METASTATIC KIDNEY CANCER:COMPLEMENTARY APPROACHES: To treat metastatic renal cell carcinoma, therapies used are with an oral intake, for the vast majority, and have many side effects that may compromise observance. Strategies of drug holiday have been studied and, in case of an i...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/S0007-4551(18)30376-X
更新日期：2018-12-01 00:00:00
abstract：:During the past two decades, the general acceptance of the surgical conservative treatments in tumors such as breast cancer, bone and soft tissue sarcoma, represents one of the significant steps achieved in the treatment of solid tumors. For low rectal cancer, abdominoperineal resection is considered the standard trea...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1996-03-01 00:00:00
abstract：:In recent studies, the economic criteria has begun to be integrated to the appraisal in cancerology. The question asked by the economist can be framed as follows: what incremental cost should the collectivity or the health insurance system consent, in order to improve the care of cancer patients? This involves first t...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:The considerable progress of molecular biology within the past twenty years has permitted a more and more detailed characterization of the molecular mechanisms regulating cell proliferation. The corollary to these discoveries has been the identification of different deregulations yielding to cell transformation and ca...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2001-04-01 00:00:00
abstract：:Paclitaxel is conventionally used in a wide range of oncology indications. Nab-paclitaxel is synthesized by a process of high pressure homogenization of paclitaxel in the presence of human albumin and it was originally developed to reduce the toxicity usually associated with cremophor in soluble paclitaxel and to incr...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2015.03.020
更新日期：2015-06-01 00:00:00
abstract：:The immune system plays a dual role against cancer: it prevents tumor cell outgrowth and also sculpts the immunogenicity of the tumor cells. Cancer cells are able to escape from the immune system by inhibiting T lymphocytes activation. New immunotherapies have been developped to target these T lymphocytes activation m...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2013.1771
更新日期：2013-06-01 00:00:00
abstract：:Improvements have been made recently in the treatment of cancer pain. First of all, this symptom is better recognized and evaluated in cancer patients. Then new therapeutic options have became available in France : tramadol, WHO level II analgesic, for intermediate to severe pain; gabapentine, a new anticonvulsivant d...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：:A better understanding of gliomas biology is now leading to a combined histo-molecular classification of these tumors. In anaplastic gliomas ongoing studies depend on 1p/19q codeletion status and in glioblastomas on MGMT methylation status. Advanced brain tumor imaging elicits a better identification of gliomas evolut...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2009.1019
更新日期：2010-01-01 00:00:00
abstract：:Basal-like carcinomas represent 10 to 15% of invasive breast carcinomas and have been identified from gene expression studies. Morphologically, these tumors are undifferentiated histopronostic grade 3 carcinomas, identified in clinical practice according to their immunophenotype "triple zero" (estrogen, progesterone a...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2010.1062
更新日期：2010-03-01 00:00:00
abstract：:Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in France. Recently, colorectal cancer subtyping consortium (CRCSC) identified 4 consensus molecular subtypes (CMS). CMS1 is enriched for CRC with deficient DNA mismatch repair system (dMMR) and tumors with mutated BRAF. Intriguingly, CMS1...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/S0007-4551(15)31220-0
更新日期：2015-06-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2016.11.018
更新日期：2017-02-01 00:00:00
abstract：:During their life, cells are exposed to a wide variety of extracellular stimuli and have to develop appropriate biological responses. Signal transduction from the plasma membrane, which is in contact with the extracellular environment, to the nucleus, where gene expression is achieved, thus represents a fundamental pr...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1998-06-01 00:00:00
abstract：:One of the most exciting areas in clinical oncology today is the translation of laboratory research in drug resistance into therapeutic tools to improve responses to antineoplastic drugs. Two areas of investigation are currently under study in both the laboratory and clinic: reversal of gluthathione-mediated resistanc...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章,评审
doi：
更新日期：1994-12-01 00:00:00
abstract：:Whereas it has been proposed almost one century ago, brachytherapy for prostate cancer has only recently emerged, especially thanks to endorectal echography, allowing to visualize seed implantation, to the development of seeds for permanent delivery and of micro-sources for high-dose rate delivery, and also to the dev...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2006-08-01 00:00:00
abstract：:Colorectal primary signet ring cell carcinoma (SRCC) is a rare entity accounting for nearly 1% of all colorectal carcinomas. It is an independent prognostic factor associated with less favorable outcome. This aggressiveness is mainly due to the intrinsic biology of these tumors. Here is an overview of the literature r...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2015.07.005
更新日期：2015-10-01 00:00:00
abstract：:A retrospective study of 337 cases of cervix cancers in women aged 35 years and under, treated between 1980-1990 at the Ibn Rochd Oncology Center in Casablanca, was analyzed in order to determine the main characteristics of this disease and the influence of age on prognosis. The incidence of these cases was stable thr...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1997-04-01 00:00:00
abstract：:A nonfusing variant M4 of the L6 line of rat myoblasts was isolated. This subline was tumorigenic when inoculated into suckling rats. Comparative studies of cells growth in vitro, serum requirement, cell adhesiveness and capacity to form colonies in soft agar confirmed that M4 cells had undergone neoplastic transforma...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The registry of digestive tumors of the department of Cote-d'Or recorded between 1976 and 1982, among 1543 colorectal cancers, 142 cases (9.2%) diagnosed with acute obstruction. Distribution of the tumors along the large bowel was as follows: rectal cancers were rarely obstructive (3.8%) whereas it was a more common f...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:We evaluated the efficacy and safety of a monotherapy by piperacillin and sulbactam potentially associated to vancomycin as an empiric antimicrobial therapy in febrile neutropenic patients treated with nephrotoxic chemotherapy for solid tumors. Twenty-three patients were treated during 32 episodes with piperacillin 4 ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
