Immunothérapie des glioblastomes.

Abstract:

IMMUNOTHERAPY IN GLIOBLASTOMAS:Targeting the immune system as a therapeutic strategy in solid tumors has shown great efficacy in various tumor types. However the role and success of this approach in glioblastomas remain to be determined. Recent studies demonstrated that central nervous system is no longer considered as an immunoprivileged sanctuary with impressive immune response without blood brain barrier's disruption. Improving our understanding of immune privilege in the central nervous system could lead to better treatment strategies in gliobastomas. This review focuses on describing the immune system in the central nervous system and immuno-therapeutic strategies under development in glioblastomas.

journal_name

Bull Cancer

journal_title

Bulletin du cancer

authors

Baldini C,Romano PM,Varga A,Champiat S,Dumont S,Dhermain F,Louvel G,Marabelle A,Postel-Vinay S,Angevin E,Gazzah A,Ribrag V,Bahleda R,Michot JM,Hollebecque A,Soria JC,Massard C

doi

10.1016/S0007-4551(18)30391-6

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

S59-S67

eissn

0007-4551

issn

1769-6917

pii

S0007-4551(18)30391-6

journal_volume

105 Suppl 1

pub_type

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