[Advances in adults' gliomas biology, imaging and treatment].

Abstract:

:A better understanding of gliomas biology is now leading to a combined histo-molecular classification of these tumors. In anaplastic gliomas ongoing studies depend on 1p/19q codeletion status and in glioblastomas on MGMT methylation status. Advanced brain tumor imaging elicits a better identification of gliomas evolutive potential of. In low-grade gliomas, the importance of maximal resection and the role of chemotherapy are being increasingly recognized. In anaplastic gliomas, phase III studies have clarified the respective roles of chemotherapy and radiotherapy. In glioblastomas concomitant chemoradiotherapy is the standard. Most targeted therapies, namely anti-EGFR therapies have failed to demonstrate efficacy but anti-angiogenics are promising. The aim of this review is to discuss the main advances in adults' gliomas biology, imaging and treatment.

journal_name

Bull Cancer

journal_title

Bulletin du cancer

authors

Ducray F,Dutertre G,Ricard D,Gontier E,Idbaih A,Massard C

doi

10.1684/bdc.2009.1019

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

17-36

issue

1

eissn

0007-4551

issn

1769-6917

pii

S0007-4551(15)30895-X

journal_volume

97

pub_type

杂志文章,评审
  • [Clinical activity spectrum of irinotecan].

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    doi:

    authors: Cottu PH,Extra JM,Lerebours F,Espie M,Marty M

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  • Is the proportion of hypoxic cells in a solid tumour dependent on the host (mouse or rat)?

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    doi:

    authors: Guichard M,Chavaudra N,Malaise EP

    更新日期:1989-01-01 00:00:00

  • [Mechanisms of radiation-induced lymphopenia and therapeutic impact].

    abstract::Radiation induced lymphopenia is frequent and can be severe and durable. Although lymphocytes have long been known as highly radiosensitive cells, it is poorly characterized. Radiation-induced lymphopenia seems to affect lymphocyte subpopulations differently and seems to be influenced by radiation modalities. The dept...

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    doi:10.1016/j.bulcan.2020.04.009

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  • [Role of psychological factors in cancerogenesis and the development of cancerous disease].

    abstract::Psychoanalysts working in cancerology have to face three main difficulties concerning their methodology: the selection of representative populations, the identification of prospective factors and the choice and definition of the data they need to collect. Four examples are given hereafter: a prospective study on the p...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Raimbault E

    更新日期:1986-01-01 00:00:00

  • [Use of maintenance therapy and complete discontinuation for therapeutic management of non-resectable metastatic colorectal cancer].

    abstract::Management of unresectable metastatic colorectal cancer dramatically changed over the past 20 years. News standards of care combine cytotoxic drugs like fluoropyrimidines, irinotecan and oxaliplatin, with targeted therapies such as anti-EGFR monoclonal antibodies and anti-angiogenic agents. Survival benefit results fr...

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    doi:10.1684/bdc.2014.1984

    authors: Senellart H,Hiret S,Guerin-Meyer V,Bennouna J

    更新日期:2014-06-01 00:00:00

  • [Role of high-dose chemotherapy with hemopoietic stem-cell support in the treatment of adult patients with high-grade glioma].

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    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Linassier C,Destrieux C,Benboubker L,Alcaraz L,Bergemer-Fouquet AM,Jan M,Calais G,Colombat P

    更新日期:2001-09-01 00:00:00

  • [Surgery after chemotherapy: gastric cancer].

    abstract::Perioperative chemotherapy for gastric cancer is validated by two phase III studies. The impact of the preoperative neoadjuvant sequence is probably major in the benefit of this treatment. This chemotherapy increases the R0 resection without increasing either morbidity or mortality. Furthermore, it reduces local and s...

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    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2010.1287

    authors: Flamein R,Antomarchi O,Pezet D

    更新日期:2011-01-01 00:00:00

  • [Study of mdm2 gene amplification in primary breast tumors].

    abstract::mdm2 (mouse double minute) protein seems lead to p53 inactivation and therefore might potentially play a role in carcinogenesis. We have studied mdm2 gene amplification from 239 primary breast cancer tissues. mdm2 gene was amplified in 10% of cases (25/239). mdm2 amplification was associated with c-erbB2 amplification...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Fontana X,Ferrari P,Abbes M,Monticelli J,Namer M,Bussière F

    更新日期:1994-07-01 00:00:00

  • [Bellini tumours].

    abstract::In Europe, renal tumours are 7th in frequency of men cancers. They are rare tumours in 10 to 15% of cases. Collecting ducts carcinomas or Bellini tumours, described for the first time in 1949, are a distinct clinical and pathological entity. They represented 1% of epithelial cancers. Nephrectomy is the treatment of lo...

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    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2011.1462

    authors: Teghom C,Gachet J,Scotté F,Elaidi R,Oudard S

    更新日期:2011-10-01 00:00:00

  • [Specificities of carcinomas in adolescents and young adults].

    abstract::Carcinomas are rare tumors of the adolescent-young adult (AYA) with a different spectrum from those of adults. The most common sites outside of the thyroid is the nasopharynx, salivary gland, colon-rectum and ovaries. If nasopharyngeal carcinoma or salivary gland tumors are good prognosis, others are more reserved pro...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1016/j.bulcan.2016.11.013

    authors: Fresneau B,Dourthe ME,Jouin A,Laurence V,de Lambert G,Colas C,Coret M,Laprie A,Rebours C,Orbach D,Demoor-Goldschmidt C

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  • [The use of deodorants/antiperspirants does not constitute a risk factor for breast cancer].

    abstract::Based on the observation of a high incidence of breast cancer in the upper outer quadrant adjacent to the usual area of application of deodorants and/or antiperspirants, several scientific teams have advanced the hypothesis of a possible link between antiperspirants and breast cancer. The possibility of the involvemen...

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    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2008.0679

    authors: Namer M,Luporsi E,Gligorov J,Lokiec F,Spielmann M

    更新日期:2008-09-01 00:00:00

  • [What are the expectations of coordination and accompaniment of French patients with cancer towards their community pharmacist?]

    abstract:PURPOSES:Analyze the relationship and expectations of cancer patients towards the community pharmacist in a pharmaceutical care coordination project. METHODS:In November 2014, a questionnaire was distributed to ambulatory patients of a university hospital specialized in oncology. Thirteen questions explored the consum...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:10.1016/j.bulcan.2017.11.017

    authors: Hébert G,Minvielle E,Di Palma M,Lemare F

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  • [Proton therapy in soft tissue and bone sarcomas].

    abstract::Sarcomas are a common type of tumor within the pediatric population. The utilization of proton therapy as a primary attribute the ability to spare adjacent healthy tissue, therefore, proton therapy has become a preferential indication in pediatrics compared to other photon irradiation modalities. Proton therapy is als...

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    pub_type: 杂志文章,评审

    doi:10.1016/j.bulcan.2018.05.008

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  • [Hepatic transport of mitoxantrone in relation to multiple resistance].

    abstract::We have examined the effect of cyclosporin A on transport processes (uptake, efflux, binding) of mitoxantrone in isolated rat liver cells. Accumulation and binding of mitoxantrone was rapid with or without cyclosporin A. The initial uptake was linear over a wide concentration range (1 to 1000 microM). For the first 10...

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    pub_type: 杂志文章

    doi:

    authors: Coloma F,Lacarelle B,Poitou P,Filleul A,Covo J,Catalin J

    更新日期:1994-05-01 00:00:00

  • [Target antigens for therapeutic antibodies in oncology: many candidates, few successes].

    abstract::Targeted therapies, especially monoclonal antibodies, have reached an increasing importance in oncology. High-throughput techniques have allowed the identification of numerous transcripts, proteins, or non-protein antigens, which have generated the concept of immunome. This epitope library constitutes a huge reservoir...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Ceze N,Probst A,Lecomte T,Ohresser M,Paintaud G,Watier H

    更新日期:2007-01-01 00:00:00

  • [Rapamycin and CCI-779].

    abstract::Rapamycin (sirolimus) is a macrolide, related to cyclosporine with immunosuppressive properties and antiproliferative activity in various human tumor cells lines and tumor xenograft models. The cytosolic kinase mTOR which controls the initiation of the translation of messenger RNA is the main known target of rapamycin...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Alexandre J,Raymond E,Armand JP

    更新日期:1999-10-01 00:00:00

  • [Registry of cancers of the upper respiratory and digestive tract at the Northern and Pas-de-Calais departments from 1984 to 1986].

    abstract::Northern France is known to have the highest mortality rate for cancers of the upper aerodigestive tract (UADT); a UADT cancer registry was therefore set up in this region in January 1984. Three years of meticulous registration provided some significant information. The incidence of UADT cancer was alarming: 4538 UADT...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Adenis L,Lefebvre JL,Cambier L

    更新日期:1988-01-01 00:00:00

  • [Bleomycin is an antineoplastic agent capable of mimicking apoptosis].

    abstract::Bleomycin (BLM), a currently used anticancer drug, crosses the plasma membrane poorly. Electropermeabilization allows a defined number of BLM molecules to enter directly into the cell cytoplasm. Such a procedure has revealed that BLM is endowed with a very high intrinsic cytotoxicity. Here we show that when several mi...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Tounekti O,Belehradek J Jr,Mir LM

    更新日期:1994-12-01 00:00:00

  • [Angiogenesis and hematologic malignancy].

    abstract::Angiogenesis plays an important role in the progression of tumors. This relationship has been described in several hematologic malignancies. Vascular endothelial growth factor and basic fibroblast growth factor are predictors of poor prognosis in leukemia and non Hodgkin's lymphoma. Bone marrow microvessels were found...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Zini JM,Tobelem G

    更新日期:2007-07-01 00:00:00

  • [Nasopharyngeal epitheliomas: experience of the Regional Cancer Control Center in Lille (79 cases 1970-1982)].

    abstract::From 1970 to 1982, 79 cases of nasopharyngeal carcinomas were treated at the Regional Cancer Center of Lille (France). At the term of the study, it appears that patients of Central Europe origin have a rather high risk of NPC (17% of cases, that ethnic population representing about 8% of all superior aerodigestive tra...

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    pub_type: 杂志文章

    doi:

    authors: Lefebvre JL,Madelain M,Adenis L,Demaille MC,Delobelle A,Demaille A

    更新日期:1983-01-01 00:00:00

  • [Testicular germ cell tumors].

    abstract::Testicle germ cells tumors are the most common young men neoplasm. The incidence is maximal in Scandinavian countries. Cryptorchidism is a predisposing factor. Diagnosis is clinic, first treatment is radical orchidectomy by inguinal incision, after study of tumor markers. Histology shows seminoma or non seminomatous t...

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    doi:

    authors: Dourthe LM,Ouachet M,Fizazi K,Droz JP

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  • [Acute lymphoblastic leukemia and pregnancy. Apropos of a case].

    abstract::The authors report on a case of a woman with acute lymphoblastic leukemia treated with cortisone therapy during pregnancy. No problems were encountered during the gestational period or at parturition; and no maternal or neonatal complications were observed. ...

    journal_title:Bulletin du cancer

    pub_type: 信件

    doi:

    authors: Hamdoun L,Zeineb NB,Ferchiou M,Zhioua F,Meriah S

    更新日期:1992-01-01 00:00:00

  • [Coordinated organization of symptoms management and support in all the stages of cancer disease: putting in place pluridisciplinary structures of supportive oncological care].

    abstract::The organization of the management of pain and other symptoms all along the cancer disease, of psychological support and palliative care is a complex question that does not correspond to any perfectly established model, both in France and abroad. Different structures are implied in there care and coexist with an insuf...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Krakowski I,Chardot C,Bey P,Guillemin F,Philip T

    更新日期:2001-03-01 00:00:00

  • [Immunotherapy of metastatic non-small cell lung cancer from first line to resistance and its management].

    abstract::Immunotherapy alone or in combination with chemotherapy is now an integral part of the treatment of metastatic NSCLC. This treatment is transforming the management of these cancers, with 20-30% of patients achieving long survival. However, disease progression under treatment is still the rule for the majority of patie...

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    doi:10.1016/j.bulcan.2020.04.018

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  • Urging medical students to publish: Advantages, disadvantages and new challenges.

    abstract::As soon as they get accepted into medical school, students find themselves facing numerous expectations: coping with tremendous study burden, competing with others for the best rank, completing internships and participating in the race for publishing are only to name a few. This big juggle makes it hard for the medica...

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    pub_type: 社论

    doi:10.1016/j.bulcan.2018.04.005

    authors: Rached G,Hobeika C,Karam E,Kourié HR,Kattan J

    更新日期:2018-06-01 00:00:00

  • [Biology of small-cell bronchogenic carcinoma: recent advances].

    abstract::In the last ten years considerable progress has been made in small-cell lung carcinoma (SCLC) biology, along with the technical progress made in molecular biology. This progress now allows us to propose a model for the genesis and the development of this type of tumor. Tobacco, the principal causal factor plays a dual...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Levy R,Andrieu JM,Even P

    更新日期:1992-01-01 00:00:00

  • Detailed overview on rare malignant ovarian tumors.

    abstract::The group of rare malignant ovarian tumors includes the group of germ cell tumors, sex cords stromal ovarian tumors, small cell carcinoma, malignant Brenner tumors, rare epithelial tumors such as mucinous carcinoma, clear cell carcinoma, or low-grade serous carcinoma, as well as ovarian carcinosarcoma. Together they c...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1016/j.bulcan.2020.01.011

    authors: Aust S,Eberst L,Tredan O,Rousset-Jablonski C,Treilleux I,Méeus P,Chopin N,Beurrier F,Charreton A,Véronique D,Hallouz A,Coulon A,Ricoeur A,Mastier C,Bouhamama A,Racadot S,Devouassoux-Shisheboran M,Haddad V,Ray-Coquard

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  • [Role of interleukin 6 in hepatocellular carcinoma].

    abstract::Interleukin 6 (IL-6) is a pleiotropic cytokine which possesses a broad spectrum of action in diverse pathological conditions. It is mainly produced and metabolised in the liver where it carries out one of its best known actions in the mediation of the acute phase response. We studied its behaviour in hepatocellular ca...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Malaguarnera M,Di Fazio I,Laurino A,Romeo MA,Giugno I,Trovato BA

    更新日期:1996-05-01 00:00:00

  • [The problems raised by the irradiation of pregnant women. Effects of ionizing radiations on the embryon and foetus (author's transl)].

    abstract::In man, the period of maximum risk for the embryo and foetus is between the second and tenth week after conception. The most frequent and most severe malformation is microcephaly which in extreme cases is accompanied by mental retardation. The results of studies in experimental animals and man agree that it is impossi...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Tubiana M

    更新日期:1979-01-01 00:00:00

  • [The contribution of PET to radiation treatment planning].

    abstract::Advances in medical imaging have greatly enhanced the speciality of radiation oncology by allowing more healthy tissue to be speared for better tumour coverage. Positron emission tomography (PET) with the glucose analogue [18F]-fluoro-2-deoxy-D-glucose (FDG) is a functional imaging method that has become widely used i...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Belkacémi Y,Lartigau E,Kerrou K,Carpentier P,Taïeb S,Giraud P

    更新日期:2007-01-01 00:00:00