[DNA mismatch repair and BRAF status in colorectal cancer: Interest for the therapeutic management?].

abstract：:Chemoprevention is the use of natural or synthetic compounds in order to reverse, suppress or prevent the carcinogenic process. Among the many pathways dysregulated during the carcinogenic process, cyclooxygenase-2 (Cox2) seems to be one of the most promising pathways to target in order to achieve chemopreventive and ...

journal_title：Bulletin du cancer

authors： Masmoudi A,Chevalier TL,Sabatier L,Soria JC

更新日期：2004-05-01 00:00:00

abstract：:Oncotype DX® has been validated as quantifying the likelihood of distant recurrence at 10 years and overall chemotherapy benefit in patients with estrogen-receptor-positive and HER-2-negative early breast cancer. In 2012, this genomic signature was routinely available for patients in Franche-Comté, France. Patients el...

journal_title：Bulletin du cancer

authors： Nerich V,Curtit E,Bazan F,Montcuquet P,Villanueva C,Chaigneau L,Cals L,Méneveau N,Dobi E,Altmotlak H,Algros MP,Choulot MJ,Nallet G,Limat S,Mansion S,Pivot X

更新日期：2014-07-01 00:00:00

abstract：:As compared to conventional axillary dissection, the sentinel node technique is accompanied by reduced morbidity and shorter hospital stay. Based on available data, the use of this technique does not seem to yield higher rates of axillary recurrence. A combination of both radioisotope detection and blue dye increases ...

journal_title：Bulletin du cancer

authors： Hindié E,Groheux D,Espie M,Bourstyn E,Toubert ME,Sarandi F,de Roquancourt A,Giacchetti S,Cuvier C,Cahen-Doidy L,Teyton P,Misset JL,Maylin C,Moretti JL

更新日期：2009-06-01 00:00:00

abstract：:Portal vein embolization consists of occluding a part of the portal venous system in order to achieve the hypertrophy of the non-embolized liver segments. This technique is used during the preoperative period of major liver resection when the future remnant liver (FRL) volume is insufficient, exposing to postoperative...

journal_title：Bulletin du cancer

authors： Piron L,Deshayes E,Escal L,Souche R,Herrero A,Pierredon-Foulongne MA,Assenat E,le Lam N,Quenet F,Guiu B

更新日期：2017-05-01 00:00:00

abstract：:This article briefly outlines three major biochemical problems in relation to the presence of chemical carcinogens in mammalian cells: (a) the enzymatic systems responsible for the chemical carcinogen metabolism; (b) the nature of the reactive metabolites and (c) the cellular target(s). References and examples are onl...

journal_title：Bulletin du cancer

authors： Gielen JE

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC). Due to its peculiar toxicities, improving patient's tolerance may need close follow-up. Nurses can play a crucial role, by driving a patient education program (EP). We aimed to prove that adding EP to usual care (UC) improves pa...

journal_title：Bulletin du cancer

authors： Brunot A,M'Sadek A,Le Roy F,Duval M,Le Sourd S,Ventroux E,Crouzet L,Guillygomarc'h A,Boucher E,Lelievre N,Laguerre B,Edeline J

更新日期：2016-11-01 00:00:00

abstract：:Newly synthesized dipyrido [4,3-b] [3,4-f] indole compounds have a structural similarity with the DNA intercalating agents ellipticines (pyrido-carbazoles). The procedure of synthesis of these compounds allows the addition of a lateral chain in position 1 of the nucleus. Comparison is made between different substituti...

journal_title：Bulletin du cancer

authors： Lidereau R,Chermann JC,Gruest J,Montagnier L,Ducrocq C,Rivalle C,Bisagni E

更新日期：1980-01-01 00:00:00

abstract：:Lung and head and neck cancers result from a multistep process involving activation of oncogenes and inactivation of tumor-suppressor genes. These two processes share common features and molecular players, while their corresponding clinical entities are both triggered by the tobacco carcinogens. In many cases, the mol...

journal_title：Bulletin du cancer

authors： Loriot Y,Mordant P,Fouret P,Deutsch E,Soria JC

更新日期：2009-01-01 00:00:00

abstract：:The study of mitotic transduction of the signal showed that overexpression of pAkt and reduction in pERK expression would be associated a biological relapse. For tumors T1-3 N0M0 at the high risk of local relapse after prostatectomy, an immediate radiotherapy compared with a differed radiotherapy (at the time of PSA r...

journal_title：Bulletin du cancer

authors： Oudard S,Medioni J,Scotté F,Banu E

更新日期：2005-10-01 00:00:00

abstract：:Screening methods for the detection of anticancer activity are of crucial importance in order to find solid tumor-specific agents. A review of past screening methods is followed by a description of present methodologies targetted toward the discovery of such agents. Finally, we discuss primary and secondary in vivo ev...

journal_title：Bulletin du cancer

authors： Bissery MC,Chabot GG

更新日期：1991-01-01 00:00:00

abstract：:By the genetic localization of the first melanoma susceptibility gene on chromosome 1p we thought that the puzzle on familial melanoma families would soon be solved. Now, almost fifteen years later we have learned that inherited melanoma is not a simple genetic disorder and that multiple genes, modifying genes and env...

journal_title：Bulletin du cancer

authors： Gruis NA,Van der Velden PA,Bergman W,Frants RR

更新日期：1998-07-01 00:00:00

abstract：:If doctor-patient communication is a frequent subject of research, couples communication where one partner has cancer is quite recent. Some studies deal with couples communication, but from an anecdotic perspective, without any operational measure. The aim of this paper is to study couples' communication frequency and...

journal_title：Bulletin du cancer

authors： Normand J,Lasry JC,Margolese RG,Perry JC,Fleiszer D

更新日期：2004-02-01 00:00:00

abstract：:Since the 1980's, women treated for breast cancer are reporting moderate cognitive impairments during and after chemotherapy. These cognitive impairments may be related to chemotherapy but also to hormone therapy, psychological distress, fatigue... This work is a critical review of the literature, which reports types ...

journal_title：Bulletin du cancer

authors： Vandenbossche S,Fery P,Razavi D

更新日期：2009-02-01 00:00:00

abstract：:Sarcomas are a common type of tumor within the pediatric population. The utilization of proton therapy as a primary attribute the ability to spare adjacent healthy tissue, therefore, proton therapy has become a preferential indication in pediatrics compared to other photon irradiation modalities. Proton therapy is als...

journal_title：Bulletin du cancer

authors： Thariat J,Tessonnier T,Bonvalot S,Lerouge D,Mammar H,Bolle S,Claren A,Duffaud F,Alapetite C,Vogin G

更新日期：2018-09-01 00:00:00

abstract：CAR-T THERAPY:CURRENT USE IN THE UNITED STATES IN 2018: Treatment with T-cells engineered with chimeric antigen receptors (CAR T-cell therapy) has been a field of intense research in the United States since the 1980s. The recent approval in August 2017 of Kymriah (tisagenlecleucel) opened the door to broader access to ...

journal_title：Bulletin du cancer

authors： Gauthier J

更新日期：2018-12-01 00:00:00

abstract：:In order to understand the kinetics of this experimental model, we studied the influence of age and sex on primary tumoral and pulmonary metastatic yields and on the growth kinetics parameters. Connective tissue tumors were induced by DMBA in male and female Swiss mice of various ages (pre and postpubertal, adult and ...

journal_title：Bulletin du cancer

authors： Vrignaud P,Denechaud M

更新日期：1985-01-01 00:00:00

abstract：:Colorectal liver metastasis is one of the best-known clinical models of multidisciplinary approach. Chemotherapy, targeted therapies, surgery and interventional radiology permitted to obtain up to 40 months of survival in palliative intent for liver metastases only and between 40 to 50% of overall survival in curative...

journal_title：Bulletin du cancer

authors： Evrard S

更新日期：2014-04-01 00:00:00

abstract：:Immunotherapy alone or in combination with chemotherapy is now an integral part of the treatment of metastatic NSCLC. This treatment is transforming the management of these cancers, with 20-30% of patients achieving long survival. However, disease progression under treatment is still the rule for the majority of patie...

journal_title：Bulletin du cancer

authors： Basse C,Swalduz A,Levra MG,Girard N,Remon J,Moro-Sibilot D

更新日期：2020-01-01 00:00:00

abstract：:Asbestos is known as mutagenic and carcinogenic for human and is responsible for many pulmonary diseases including asbestosis, bronchogenic carcinoma and malignant pleural mesothelioma. Occupational exposure to asbestos is involved in 70-80% of all malignant pleural mesothelioma. The later presents a growing challenge...

journal_title：Bulletin du cancer

authors： Mohr S,Keith G,Rihn B

更新日期：2005-11-01 00:00:00

abstract：:With the objective of improvement of quality in oncology, an assessment of chemotherapy practice in hospital pharmacies in public and private hospitals was carried out by the regional committee of oncology in Lorraine. The 36 hospitals reporting using chemotherapy, had varied practices. The results of this survey lead...

journal_title：Bulletin du cancer

authors： May I,Paulus C,Vigneron J,Watelet M,Veyrier B,Bichet F,Bideaux S,Bey P

更新日期：2001-04-01 00:00:00

abstract：:The retrospective evaluation of the dose after an irradiation accident is of paramount importance; it allows an adequate selection of patients and the most appropriate treatment can then be proposed. Classical physical dosimetry often lacks precision for dose assessment in such accidents. Cytogenetics, usually more re...

journal_title：Bulletin du cancer

authors： Hennequin C,Cosset JM,Cailleux PE,Girinsky T,Ganem G,Hubert D,Comoy E,Dutreix J

更新日期：1989-01-01 00:00:00

abstract：:Based upon the literature, we discuss epidemiological, histopathological, clinical and treatment aspects of postirradiation sarcomas. The risk of postirradiation sarcoma is very low and negligible in comparison with the beneficial effect of radiotherapy, and it should not be a major factor influencing treatment decisi...

journal_title：Bulletin du cancer

authors： Melhouf MM,Amrani N,Dubois JB

更新日期：1997-09-01 00:00:00

abstract：:Thyroid carcinoma on struma ovarii (TCSO) is a rare ovarian tumour, derivate from monodermic teratomas. It represents about 0.01% of overall ovarian tumours and 5 to 10% of struma ovarii. The diagnosis is histologic and retrospective after pelvic surgery; radiographic imaging being unspecific. Because of its rarity, t...

journal_title：Bulletin du cancer

authors： Lebreton C,Al Ghuzlan A,Floquet A,Kind M,Leboulleux S,Godbert Y

更新日期：2018-03-01 00:00:00

abstract：:Little is known about the late effects of damage to the gonads in children treated for cancer. This investigation requires a prolonged surveillance. Radiotherapy sterilizes the ovaries above a dose of about 500 rads in an adult. Therefore, to protect at least one ovary in partial irradiation of a child's abdomen in ma...

journal_title：Bulletin du cancer

authors： Flamant F,Schweisguth O

更新日期：1979-01-01 00:00:00

abstract：:Lung cancer is the first cause of death from cancer in males in France. This cancer is responsible for 19,000 deaths in males and 3,000 deaths in females. We studied the geographical and temporal variations in lung cancer mortality in France. The average increase in mortality clearly decreased in males, changing from ...

journal_title：Bulletin du cancer

authors： Rezvani A,Doyon F

更新日期：1996-11-01 00:00:00

abstract：INTRODUCTION:The treatment of chronic myeloid leukemia (CML) has been revolutionized by the advent of tyrosine kinase inhibitors. The results of the IRIS trial demonstrated the efficacy and long-term safety profile of Imatinib. The objective of our work is to report the results at 15 years of treatment of CML in chroni...

journal_title：Bulletin du cancer

authors： Dakkoune M,Qachouh M,Zoukal S,Hassoune S,Khoubila N,Cherkaoui S,Lamchahab M,Rachid M,Madani A,Quessar A

更新日期：2020-09-01 00:00:00

abstract：:An increasing number of clinicians is to day aware of the need to assess their diagnostic tools. Despite the fact that monetary value is only one of the components of the cost of a diagnostic test, economical problems are decisive stimuli for such an effort. Any diagnostic test involves a cost which is borne by the pa...

journal_title：Bulletin du cancer

authors： Alperovitch A

更新日期：1980-01-01 00:00:00

abstract：:BRCA is a tumor suppressor gene implicated in the major mechanisms of cellular stability in every type of cell. Its mutations are described in numerous cancers, mainly breast and ovarian in women. It was also found an increase of lifetime risk of pancreas, colon, prostate cancer or lymphoma in men carriers. We report ...

journal_title：Bulletin du cancer

authors： Girardstein-Boccara L,Mari V,Met-Domestici M,Burel-Vandenbos F,Berthet P,Paquis P,Frenay MP,Lebrun-Frenay C

更新日期：2014-09-01 00:00:00

abstract：:The results obtained in the treatment of 45 cases of soft tissue sarcomas are presented. All cases were reviewed and classified according to the modern criteria of malignancy. The treatment schedule comprised: (1) preoperative irradiation: 2 sessions of 6.50 Gy in 48 hours, target volume: whole limb segment; (2) surgi...

journal_title：Bulletin du cancer

authors： Abbatucci JS,Boulier N,Mandard AM,de Ranieri J,Tanguy A,Chasle J

更新日期：1981-01-01 00:00:00

abstract：SURGICAL DE-ESCALATION FOR INVASIVE BREAST CANCER TREATMENT:A surgical therapeutic de-escalation is going to continue but necessarily has to design in a progressive careful way and especially arranged with the other practitioners and therapeutic methods. These strategies concern as well the surgery of the breast as tha...

journal_title：Bulletin du cancer

authors： Houvenaeghel G,Cohen M,Bannier M,Jauffret C,Buttarelli M,Lambaudie E

更新日期：2016-06-01 00:00:00