[DNA mismatch repair and BRAF status in colorectal cancer: Interest for the therapeutic management?].

abstract：BACKGROUND:A high prevalence of renal insufficiency has been observed in cancer patients as well as a high incidence of de novo cancer in dialysis or renal transplant patients. MATERIAL AND METHODS:We aimed to determine the incidence of cancer in patients under dialysis and in kidney transplant recipients through a se...

journal_title：Bulletin du cancer

authors： Janus N,Launay-Vacher V,Ferrero JM,Thariat J

更新日期：2012-03-01 00:00:00

abstract：:Multidrug resistant (MDR) phenotype is characterized by a defect in drug accumulation caused by overexpression of a transmembrane glycoprotein, the P-glycoprotein (P-gp). MDR phenotype can be characterized either with monoclonal antibodies raised against P-gp or with functional tests, most often based on the incorpora...

journal_title：Bulletin du cancer

authors： Lizard G,Maynadié M,Roignot P,Lizard-Nacol S,Poupon MF

更新日期：1995-03-01 00:00:00

abstract：:Intraportal continuous infusion of 5-FU (600 mg/m2/24 h during 7 days) was administered in the immediate postoperative course of 6 consecutive patients with colorectal metastases resected for cure (one segmentectomy and 5 nonanatomical local resections). One month later, a systemic continuous infusion of 5-FU was deli...

journal_title：Bulletin du cancer

authors： Seitz JF,Aubert C,Giovannini M,Delpero JR,Houvenaeghel G,Guerinel G,Carcassonne Y

更新日期：1989-01-01 00:00:00

abstract：:Lung and head and neck cancers result from a multistep process involving activation of oncogenes and inactivation of tumor-suppressor genes. These two processes share common features and molecular players, while their corresponding clinical entities are both triggered by the tobacco carcinogens. In many cases, the mol...

journal_title：Bulletin du cancer

authors： Loriot Y,Mordant P,Fouret P,Deutsch E,Soria JC

更新日期：2009-01-01 00:00:00

abstract：:Localization of the sentinel lymph node (SLN) in digestive cancers was performed mainly for colorectal primaries and less frequently for oeso-gastric primaries. This technique is feasible in vivo or ex vivo, with a vital dye and/or with a radiolabeled marker. Technically, detection reliability is good, provided a few ...

journal_title：Bulletin du cancer

authors： Elias D,Lasser P,Duvillard P

更新日期：2002-06-01 00:00:00

abstract：:When a metastatic disease is localized and slowly evolving either spontaneously or after a general treatment, a local treatment may be proposed. For about 15 years, image-guided percutaneous ablation has been developed which allows to treat tumors with temperature modifications. These mini-invasive techniques may be r...

journal_title：Bulletin du cancer

authors： Palussière J,Buy X,Fonck M

更新日期：2013-04-01 00:00:00

abstract：:Cell signalling represents the network of cell communication pathways. Reception of a message by a cell results in the implementation of various direct and indirect actions, especially through the transcription of the genes required for carrying out the orders received. The signals exchanged by cells may concern proli...

journal_title：Bulletin du cancer

authors： Robert J

更新日期：2010-11-01 00:00:00

abstract：:Androgen deprivation in patients with metastatic prostate cancer produces palliation of symptoms, PSA decrease and tumoral regression in most patients. After a brief period of disease regression lasting 18 to 24 months nearly all pts will progress to androgen independence disease (HRPC) with progressive clinical deter...

journal_title：Bulletin du cancer

authors： Gravis G,Salem N,Bladou F,Viens P

更新日期：2007-07-01 00:00:00

abstract：:From 1941, estrogens are usually used in the treatment of prostatic carcinoma, wrongly in case of adjuvant hormonotherapy and exceedingly because of cardiovascular toxicity from over dosages. A recall of their mechanism of action and toxicity allows to argue about the palliative treatment and to look to their use for ...

journal_title：Bulletin du cancer

authors： Mauriac L,Richaud P,Mage P,Thomas L,Lamarche P

更新日期：1986-01-01 00:00:00

abstract：:The earlier a gastro-intestinal cancer is treated the better will be the prospects of cure for the patient. It is therefore important to study the early clinical stages of the pathway which leads to the diagnosis of gastro-intestinal cancer in order to make this pathway short and quick. This paper identifies the delay...

journal_title：Bulletin du cancer

authors： Mac Adam DB

更新日期：1980-01-01 00:00:00

abstract：:Since premedication of patients with an H1 antihistamine is recommended before the start of the intravenous infusion of temsirolimus, temsirolimus is to be used with caution in cases where there is a history of hypersensitivity to this class of antihistamines, or medical contra-indication for treatment with antihistam...

journal_title：Bulletin du cancer

authors： Massard C,Patard JJ,Hermine O,Ravaud A

更新日期：2011-01-01 00:00:00

abstract：:Chemotherapy has dramatically improved the prognosis of non-seminomatous germ cell tumors (NSGCT). However, some patients relapse and others are refractory to first line chemotherapy. We studied a salvage chemotherapeutic regimen with etoposide 75 gm/m2/day, and cisplatin 40 mg/m2/day, days 1-5 and Ifosfamide 3 g/m2/d...

journal_title：Bulletin du cancer

authors： Droz JP,Pico JL,Ghosn M,Ostronoff M,Azab M,Theodore C,Hayat M

更新日期：1990-01-01 00:00:00

abstract：:Local control and sphincter preservation are the two challenges of anal canal cancer treatment. These tumors are radio- and chemo-sensitive and treatment moved from surgical approach, with abdominoperineal resection, to definitive radiation therapy with or without concurrent chemotherapy. Randomised trials proved the ...

journal_title：Bulletin du cancer

authors： Ortholan C,François E,Gérard JP

更新日期：2005-12-01 00:00:00

abstract：:Forty-six tumors from patients with oropharyngeal carcinoma were analysed by flow cytometry after injection of bromodeoxyuridine (Budr) for the labelling index, the duration of S phase and the potential doubling time (Tpot). The results show large variations in Tpot (from 2.6 to 16.7 days) among these tumors from the ...

journal_title：Bulletin du cancer

authors： Bourhis J,Wilson GD,Janot F,Chavaudra N,Leridant AM,Wibault P,Girinsky T,Luboinski B,Eschwege F,Malaise EP

更新日期：1991-11-01 00:00:00

abstract：:Two operational subdivisions of hereditary colorectal cancer susceptibility are those with and those without premalignant adenomatous colonic polyp expression. In both of these subdivisions, reliable biomarkers of gene carriage would be of value in patient management as we have previously emphasized. Consideration mus...

journal_title：Bulletin du cancer

authors： Lynch HT,Schuelke GS,Lynch JF

更新日期：1984-01-01 00:00:00

abstract：:Infectious complications associated with granulocytopenia during the treatment of poor risk or relapsed germ cell tumors were studied in order to assess the frequency, morbidity and characteristics of these complications. Thirty-three cases were investigated at the Institut Gustave-Roussy; 63 episodes of granulocytope...

journal_title：Bulletin du cancer

authors： Ribrag V,Droz JP,Kattan J,Andremont A

更新日期：1992-01-01 00:00:00

abstract：:From July 1987 to July 1988, 35 patients with non small cell lung cancer, stage IV, were included in a phase II trial (GLOT NPC 87/01). The treatment was as follows: cisplatin 50 mg/m2 day 1, vindesin 3 mg/m2 day 1, mitomycin 6 mg/m2 day 2, and bleomycin 15 mg/day, day 1 + 2 by continuous infusion. The evaluation for ...

journal_title：Bulletin du cancer

authors： Souquet PJ,Fournel P,Jorda M,Laennec E,Piperno D,Trillet V,Rebattu P,Bernard JP

更新日期：1993-01-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) represents one of the most frequent epithelial tumours of the child in intermediate risk regions. In the Maghreb, it represents the first cancer of teenagers of 15-20 years old. The Epstein Barr virus (EBV) is the most important etiologic factor. Its role in the pathogeneses of NPC has b...

journal_title：Bulletin du cancer

authors： Toumi N,Frikha M,Siala W,Khabir A,Karray H,Boudawara T,Gargouri RM,Ghorbel M,Daoud J

更新日期：2010-04-01 00:00:00

abstract：:Brain metastases management is still controversial even though many trials are trying to define the respective roles of neurosurgery, whole-brain radiotherapy, single-dose stereotactic radiotherapy and fractionated stereotactic radiotherapy. In this article, we review data from trials that examine the role of radiosur...

journal_title：Bulletin du cancer

authors： Tanguy R,Métellus P,Mornex F,Mazeron JJ

更新日期：2013-01-01 00:00:00

abstract：:Superficial bladder tumor defined as pTa, pT1 and pTis stage is one of the most common cancer disease in the world. Intravesical BCGtherapy represents the best treatment when combined with transurethral resection to prevent tumor recurrence or progression and to lengthen the interval between recurrence. The toxicity i...

journal_title：Bulletin du cancer

authors： Prapotnich D

更新日期：1998-02-01 00:00:00

abstract：:Recent progress in the field of molecular biology has allowed us to identify at least two different molecular mechanisms implicated in colorectal carcinogenesis (CRC): chromosomal instability (CIN) and genetic instability. Even though the two molecular mechanisms differ, their signalling pathways, implicated in malign...

journal_title：Bulletin du cancer

authors： Laurent-Puig P,Agostini J,Maley K

更新日期：2010-11-01 00:00:00

abstract：:296 intraoral minor salivary gland tumors were observed among 702 salivary tumors. The study emphasizes a frequent palatine location, observed in more than 50 per cent of theses tumors. Pleiomorphic adenomas (or so called mixed tumors), are frequently encountered; but it is noteworthy that the proportion of muco-epide...

journal_title：Bulletin du cancer

authors： Brocheriou C,Crepy C,Guilbert F,Lartigau G,Payen J,Recoing J

更新日期：1980-01-01 00:00:00

abstract：:The most recent cancer mortality and morbidity data available for France are presented. In 1999, cancers are the first cause of death among men (87,000 deaths) and the second most common among women (57,000 deaths) after cardiovascular diseases. Lung cancer is the most common cause of cancer death (21,000) in the male...

journal_title：Bulletin du cancer

authors： Hill C,Doyon F

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Breast cancer of young women has medico-psychological issues, particularly in the perspective of "after cancer" period. The objective of the study was to analyze the changes in management, in a decade including the publication of Cancer Plans I and II. METHODS:This retrospective unicentric study involved ...

journal_title：Bulletin du cancer

authors： Soussoko M,Salleron J,Desandes E,Lesur A

更新日期：2019-12-01 00:00:00

abstract：:Malnutrition is frequently observed in oncology. The consequences on patient survival, chemotherapy toxicities and quality of life need to be identified and treated appropriately. A set of tools are available that enable clinicians to diagnose and detect malnutrition. Each tool must consider three items: the patient's...

journal_title：Bulletin du cancer

authors： Khan S,Alibay TA,Merad M,DiPalma M,Raynard B,Antoun S

更新日期：2016-09-01 00:00:00

abstract：:Whereas medicine is progressing in illness treatment that used to be incurable, physicians are still faced with treatment failure. Hippocrates used to say: "primum non nocere" [1]. When the patient cannot expect benefit from potentially aggressive care, current or possible treatments have to be challenged to leave jus...

journal_title：Bulletin du cancer

authors： Laude C,Deygas S

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:GemOx was defined as a D1-D2 schedule, based on preclinical data. In order to improve convenience for patients, we evaluated a simplified D1-D1 GemOx regimen (S-GemOx) in MPA. PATIENTS AND METHODS:Patients (pts) with MPA were 2:1 randomly assigned for first-line treatment to S-GemOx (gemcitabine 1,000 mg/m(2),...

journal_title：Bulletin du cancer

authors： Afchain P,Chibaudel B,Lledo G,Selle F,Bengrine-Lefevre L,Nguyen S,Paitel JF,Mineur L,Artru P,André T,Louvet C

更新日期：2009-05-01 00:00:00

abstract：:Indications and choice of antiepileptic drugs (AED), treatments for cerebral edema and prophylactic and curative treatments of thromboembolic complications of brain metastasis are discussed. ...

journal_title：Bulletin du cancer

authors： Le Rhun E,Taillandier L,Beauchene P,Bailon O,Dubois F

更新日期：2013-01-01 00:00:00

abstract：:Mucositis, an acute inflammation of the digestive mucosa, is one of the main toxicities secondary to oncological treatments. Among its consequences, mucositis-related pain is an important complication due to its intensity and repercussion, especially on quality of life. Treatment of pain plays a central role in manage...

journal_title：Bulletin du cancer

authors： Guerrini-Rousseau L,Marec-Berard P,Bolle S,Laurent S

更新日期：2019-09-01 00:00:00

abstract：:Sarcomas are a common type of tumor within the pediatric population. The utilization of proton therapy as a primary attribute the ability to spare adjacent healthy tissue, therefore, proton therapy has become a preferential indication in pediatrics compared to other photon irradiation modalities. Proton therapy is als...

journal_title：Bulletin du cancer

authors： Thariat J,Tessonnier T,Bonvalot S,Lerouge D,Mammar H,Bolle S,Claren A,Duffaud F,Alapetite C,Vogin G

更新日期：2018-09-01 00:00:00