[DNA mismatch repair and BRAF status in colorectal cancer: Interest for the therapeutic management?].

Abstract:

:Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in France. Recently, colorectal cancer subtyping consortium (CRCSC) identified 4 consensus molecular subtypes (CMS). CMS1 is enriched for CRC with deficient DNA mismatch repair system (dMMR) and tumors with mutated BRAF. Intriguingly, CMS1 is characterized by better relapse-free survival but worse survival after relapse, compared with the other subtypes. In this review, we provide a comprehensive overview of prognostic and predictive impacts of MMR and BRAF status. We highlight immune checkpoints inhibitors as potentially future therapeutics for CRC with deficient MMR. We also focus on the management of BRAF mutant metastatic CRC, with a particular interest on targeted therapies.

journal_name

Bull Cancer

journal_title

Bulletin du cancer

authors

Cohen R,Cervera P,Svrcek M,Dumont C,Garcia ML,Chibaudel B,de Gramont A,Pocard M,Duval A,Fléjou JF,André T

doi

10.1016/S0007-4551(15)31220-0

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

S72-81

issue

6 Suppl 1

eissn

0007-4551

issn

1769-6917

pii

S0007-4551(15)31220-0

journal_volume

102

pub_type

杂志文章,评审
  • [Experimental program personalized care in patients with head and neck cancer].

    abstract:OBJECTIVE:Describe the implementation and preliminary results of the “Experimental Program Personalized care” in patients with Head and Neck cancer. MATERIALS AND METHODS:After being selected a graduate nurse status, called coordination, participated in the development of forms of detection needs and concerns of patie...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:10.1684/bdc.2014.2040

    authors: Hans S,Scotte F,Hoffman C,Pelicier N,Ménard M,Badoual C,Oudard S,Housset M,Brasnu D

    更新日期:2014-10-01 00:00:00

  • [Neoadjuvant approach for non-metastatic rectal cancer combining radiotherapy and chemotherapy. Biotargeted drugs].

    abstract::Neoadjuvant chemoradiotherapy is considered at the present time as the standard treatment of most T3-4 rectal cancer. In France a combination of radiotherapy (45 Gy/5 weeks) with concurrent capecitabine (1,600 mg/m2) is the most popular protocol. Randomized trials try to optimize this approach using new cytotoxic drug...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2009.0838

    authors: Gérard JP,Francois E,Deustch E,Rostom Y,Douar N,Benezery K,Milano G

    更新日期:2009-03-01 00:00:00

  • [Oxaliplatin in combination with 5-fluoro-uracil and folinic acid as treatment of metastatic colorectal cancer].

    abstract::Unusual aspect of the development of oxaliplatin was that substantial evidence of its activity was gathered when used in combination with protracted infusion of 5FU combined with leucovorin, preceeding the formal demonstration of its single activity in this disease. Phase II trials in previously treated patients by 5F...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: André T,Louvet C,Maindrault-Goebel F,Gramont AD

    更新日期:2001-08-01 00:00:00

  • [Acute lymphoblastic leukemia and pregnancy. Apropos of a case].

    abstract::The authors report on a case of a woman with acute lymphoblastic leukemia treated with cortisone therapy during pregnancy. No problems were encountered during the gestational period or at parturition; and no maternal or neonatal complications were observed. ...

    journal_title:Bulletin du cancer

    pub_type: 信件

    doi:

    authors: Hamdoun L,Zeineb NB,Ferchiou M,Zhioua F,Meriah S

    更新日期:1992-01-01 00:00:00

  • [Adult acute lymphoblastic leukemia with central nervous system involvement: an overview].

    abstract::At the time of diagnosis, central nervous system (CNS) involvement is identified in less than 10% of adult acute lymphoblastic leukemia (ALL). Long-term disease-free survival can be achieved in these patients. CNS disease at presentation does not appear to be an independent poor prognostic factor. In CNS leukemia, inn...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2008.0645

    authors: Thomas X,Pavan L,Le QH

    更新日期:2008-07-01 00:00:00

  • [Characterization of chromosomal rearrangements by in situ hybridization in glioblastoma].

    abstract::In a case of glioblastoma, the following karyotype was determined: 47, X, - Y, + der(1) t(1;9)(p21;p23), t(1;9)(p21;p23), + 3, + 7, der(9) t(Y;9)(q11;p21), - 13, t(13;16)(p13,p11), del(14)(q11q22). Classical satellite DNAs are mainly located in chromosomes 1, 9, 15, 16 and Y. Because, most of these chromosomes were im...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Bourgeois CA,Kokalj-Vokac N,Dutrillaux AM,Poisson M,Delattre JY,Vega F,Malfoy B,Dutrillaux B

    更新日期:1994-05-01 00:00:00

  • [Primary cerebral non-Hodgkin lymphoma in non-immunocompromised subjects].

    abstract::Cerebral non Hodgkin's lymphomas (NHL) of immunocompetent patients are rare disease (1% of all NHL), but their incidence has been steadily increasing in the last 20 years. Most cerebral NHL are diffuse large cell NHL with a B phenotype. These tumors are most often localized in the central nervous system, the eye or me...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,meta分析

    doi:

    authors: Blay JY

    更新日期:1997-10-01 00:00:00

  • [Following communications made at American Society of Clinical Oncology 2010, what will change our practice? The point of view of the editorial board of Bulletin du Cancer].

    abstract::The congress of Asco made the object of numerous summaries of congress made in the heat of the moment and the Bulletin du Cancer decided to ask to his editorial board, a digested summary, at distance of the congress, to try to sum up the data of the congress which are going to change practice. Of the considerable numb...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:10.1684/bdc.2010.1221

    authors: André T,Wislez M,Goncalves A,de La Motte Rouge T,Blay JY,Massard C,Bay JO,comité de rédaction du Bulletin du Cancer.

    更新日期:2010-12-01 00:00:00

  • Primary signet ring cell carcinoma of the colon and rectum.

    abstract::Colorectal primary signet ring cell carcinoma (SRCC) is a rare entity accounting for nearly 1% of all colorectal carcinomas. It is an independent prognostic factor associated with less favorable outcome. This aggressiveness is mainly due to the intrinsic biology of these tumors. Here is an overview of the literature r...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1016/j.bulcan.2015.07.005

    authors: Arifi S,Elmesbahi O,Amarti Riffi A

    更新日期:2015-10-01 00:00:00

  • [Sensitivity and specificity of meta-iodobenzylguanidine (mIBG) scintigraphy in the evaluation of neuroblastoma: analysis of 115 cases].

    abstract::Seventy children (3.7 +/- 3.3 y) with definitely confirmed diagnosis of neuroblastoma had 115 whole body scans carried out 24 h after injection of 3.7 MBq/kg of I-123 mIBG (83 scans) or 0.7 MBq/kg of I-131 mIBG (17 scans) or 0.9 to 4.5 GBq of I-131 mIBG (15 post-therapeutic scans). The scans were interpreted as positi...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Lumbroso J,Guermazi F,Hartmann O,Coornaert S,Rabarison Y,Lemerle J,Parmentier C

    更新日期:1988-01-01 00:00:00

  • [Metastatic stomach cancer: Clinical trials in Asia and in Occident].

    abstract::Although cytotoxic chemotherapy is the main therapeutic option to treat gastric cancer in the metastatic setting, molecular targeted agents have recently been introduced in an effort to improve survival outcomes which in average do not exceed 1 year. Trastuzumab and ramucirumab, antibodies directed against HER2 and VE...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1016/j.bulcan.2018.07.012

    authors: Bui QL,Grazziotin-Soares D,Hasiniatsy RE,Trinh HS,Richard S,Lotz JP,Gligorov J,Khalil A

    更新日期:2018-10-01 00:00:00

  • [BCG therapy of superficial tumors of the bladder].

    abstract::Superficial bladder tumor defined as pTa, pT1 and pTis stage is one of the most common cancer disease in the world. Intravesical BCGtherapy represents the best treatment when combined with transurethral resection to prevent tumor recurrence or progression and to lengthen the interval between recurrence. The toxicity i...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Prapotnich D

    更新日期:1998-02-01 00:00:00

  • Bilateral adrenal metastases of renal cell carcinoma: a case report.

    abstract::We report a case of renal cell carcinoma presenting with bilateral adrenal masses diagnosed by ultrasonography four years after nephrectomy. The histopathological examination of the trucut biopsy specimens obtained percutaneously by ultrasound guidance revealed bilateral adrenal mestastases of renal cell carcinoma. ...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Sahin A,Ozen H,Ozmen M,Remzi D

    更新日期:1994-02-01 00:00:00

  • The role of CYP2D6*4 variant in bladder cancer susceptibility in Tunisian patients.

    abstract::CYP2D6 enzyme is implicated in the metabolism of drugs and nicotine. Genetic variability within CYP2D6, results in different CYP2D6 phenotypes. Inheritance of polymorphic CYP2D6 metabolizing enzyme is likely to be an important determinant of inter-individual variations in susceptibility to cancer. In this work, we hav...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:10.1684/bdc.2008.0583

    authors: Ouerhani S,Marrakchi R,Bouhaha R,Ben Slama MR,Sfaxi M,Ayed M,Chebil M,El Gaaied AB

    更新日期:2008-02-01 00:00:00

  • [End of chemotherapy decision for metastatic breast cancer patients.].

    abstract::If chemotherapy beyond the third line often gives sum clinical benefits, it is sometimes prescribed only to avoid telling bad news to patients. Palliative chemotherapy can lead to symptom reduction and greater health related quality-of-live, but longer survival is unlikely. Physician's questioning about chemotherapy c...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:10.1684/bdc.2009.0895

    authors: Bouleuc C,Chvetzoff G

    更新日期:2009-09-01 00:00:00

  • [Primary cerebral tumors in children. II: Topography and treatment].

    abstract::In part I of this article, we reviewed the general aspects of childhood brain tumors. In part II, we present the most common neoplasms and their treatment. The quality of the surgical resection appears to be of first importance in the prognosis. Progress in radiotherapy and chemotherapy have contributed to the improve...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Carrie C,Bouffet E,Brunat-Mentigny M,Philip T,Lacroze M

    更新日期:1989-01-01 00:00:00

  • [Measurement of the kinetics of cell proliferation of cancer of the oropharynx in vivo by the incorporation of bromodeoxyuridine and flow cytometry].

    abstract::Forty-six tumors from patients with oropharyngeal carcinoma were analysed by flow cytometry after injection of bromodeoxyuridine (Budr) for the labelling index, the duration of S phase and the potential doubling time (Tpot). The results show large variations in Tpot (from 2.6 to 16.7 days) among these tumors from the ...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Bourhis J,Wilson GD,Janot F,Chavaudra N,Leridant AM,Wibault P,Girinsky T,Luboinski B,Eschwege F,Malaise EP

    更新日期:1991-11-01 00:00:00

  • [Breast tissue: estrogen receptors. Immunohistochemical and biochemical analysis of normal and hyperplastic tissue and carcinoma in situ. Apropos of 86 cases].

    abstract::Estrogen receptors (ER) were investigated using immunohistochemical techniques in 54 cases and biochemical techniques in 38 cases on a series of biopsy specimens of normal, hyperplasic and malignant mammary tissue (intraductal carcinoma). Immunohistochemical data were submitted to quantitative and semi-quantitative an...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Jacquemier J,Gandilhon PH,Charpin C,Pourreau-Schneider N,Hassoun J,Martin PM

    更新日期:1987-01-01 00:00:00

  • [New insight into MyoD regulation: involvement in rhabdomyosarcoma pathway?].

    abstract::The transcription factor MyoD, member of the myogenic regulators family, induces differentiation in precursor cells by its ability to arrest cell proliferation and to activate muscle specific genes. MyoD plays a key role in the antagonism between proliferation and differentiation. The withdrawal from the cell cycle an...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Tintignac LA,Leibovitch MP,Leibovitch SA

    更新日期:2001-06-01 00:00:00

  • [Major therapeutic advances in the treatment of metastatic melanoma].

    abstract::The treatment of metastatic melanoma is presently in complete revolution. Two molecules have recently been authorized for this indication. These treatments have a very different mechanism of action compared to previous chemotherapies. Vemurafenib is a targeted therapy, which blocks BRAF selectively. This molecule indu...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2012.1594

    authors: Mateus C,Robert C

    更新日期:2012-06-01 00:00:00

  • [Safety of selective inhibitors of inducible cyclooxygenase-2 taken for a long period].

    abstract::The serious digestive side effects of the selective inhibitors the inducible cyclooxygenase-2 are reduced by 60% as compared to the nonselective non-steroidal anti-inflammatory drugs. The main risk factors associated with gastro-intestinal ulcers caused by the latter were found also with the selective inhibitors taken...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Lamarque D

    更新日期:2004-05-01 00:00:00

  • An ethics dilemma: when parents and doctors disagree on the best treatment for the child.

    abstract::The increasing complexity of present day medicine--with highly effective and yet risky treatments, individual and collective expectations, and evolving ideological and cultural landmarks--often gives rise to difficult ethical problems. Specific meetings are valuable for understanding such problems, acquiring the relev...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Oppenheim D,Brugières L,Corradini N,Vivant F,Hartmann O

    更新日期:2004-09-01 00:00:00

  • [Obstacles and reticences in the screening of cancer of the cervix by the general practitioner].

    abstract::To have a better understanding of the poor participation rate among general practitioners (GPs) in cervical cancer screening, we have conducted a survey in the department of Bas-Rhin on a small sample of GPs. This helped to explain how they perceived this technical act, the problems or barriers related to it: rate, fu...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Weil O,Schaffer P

    更新日期:1994-04-01 00:00:00

  • [Impact of radiotherapy on female fertility].

    abstract::Radiation therapy may have deleterious effects on female fertility. It can cause ovarian dysfunction, uterine damages or disrupt the hypothalamic-pituitary axis. These effects occur at varying dose levels usually relatively low compared to the prescribed doses. Other co-factors influence the effects of radiation thera...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1016/j.bulcan.2015.03.015

    authors: Mazeron R,Maroun P,Cao K,Mbagui R,Slocker-Escarpa A,Chargari C,Haie-Meder C

    更新日期:2015-05-01 00:00:00

  • [Pre-therapeutic and evolutive characteristics of patients suffering from chronic myeloid leukemia, in Abidjan, Ivory Coast].

    abstract:INTRODUCTION:The diagnosis of chronic myeloid leukemia is based on the presence of translocation t(9,22). Additional cytogenetic abnormalities may exist at diagnosis and have prognostic value. The authors evaluated the relationship between these additional chromosomal abnormalities, clinical presentation, and therapeut...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:10.1016/j.bulcan.2019.03.013

    authors: Silué DA,Kouakou B,Nanho CD,Kamara I,Djoko S,Sowhe T,Meité N,Ayemou R,Emeuraude N,Tolo A,Koffi G,Sanogo I

    更新日期:2019-06-01 00:00:00

  • [Use of the functional imaging modalities in radiation therapy treatment planning in patients with glioblastoma].

    abstract::Glioblastoma multiforme still remains, at present, the most frequent and deadly primary malignant glioma in adult. Despite safer and larger neurosurgical resections, patients almost always relapse very close or inside the tumor bed. Since more than 20 years, radiation therapy (RT) continue delivering the same dose of ...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Dhermain F,Ducreux D,Bidault F,Bruna A,Parker F,Roujeau T,Beaudre A,Armand JP,Haie-Meder C

    更新日期:2005-04-01 00:00:00

  • [Leiomyosarcoma of the larynx. Review of the literature apropos of a case].

    abstract::Leiomyosarcoma of the larynx is extremely rare, only 21 cases were reported in the literature. The authors report a personal case in a 26 years old patient treated by a total laryngectomy and analyse all cases of the literature. It comes in relative young man (42 years old) in regard to the others ORL localisations. T...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Samlali R,Acharki A,Sahraoui S,Tihyfa M,Benider A,Kahlain A

    更新日期:1996-10-01 00:00:00

  • [Gemcitabine and pemetrexed in genito-urinary tumors treatment].

    abstract::Among genito-urinary tumors, gemcitabine is indicated only for the treatment of locally advanced and metastatic urothelial cancer. The combination of gemcitabine and cisplatin is a new standard in this disease. Gemcitabine shows activity in refractory germ cell tumors. In salvage treatment its role is ongoing evaluati...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Fléchon A

    更新日期:2007-01-01 00:00:00

  • [Demonstration of fetal-type thymidine kinase in cancer of the breast].

    abstract::Seventy five human breast cancers were examined in order to search for the presence of thymidine kinase of the fetal-type (TK-F). The presence of TK-F was evidenced in all tumors. Its activity varied from one to another tumor, but it was evident that the increased TK activity observed in mammary cancers could exclusiv...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Javre JL,Hannouche N,Samperez S,Jouan P

    更新日期:1986-01-01 00:00:00

  • [The frequency of cancer in France in 2006, mortality trends since 1950, incidence trends since 1980 and analysis of the discrepancies between these trends].

    abstract::In 2006, a total number of 149,000 cancer deaths were observed in France, 88,500 in the male population and 60,500 in the female population. In 2005, the number of new diagnoses of cancer is estimated to be 319,000, 183,000 among men and 136,000 among women. Age-standardised mortality rates are decreasing for most fre...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:10.1684/bdc.2008.0795

    authors: Guérin S,Doyon F,Hill C

    更新日期:2009-01-01 00:00:00