Abstract：
:Mucositis, an acute inflammation of the digestive mucosa, is one of the main toxicities secondary to oncological treatments. Among its consequences, mucositis-related pain is an important complication due to its intensity and repercussion, especially on quality of life. Treatment of pain plays a central role in management of mucositis. It must be multimodal, combining local and general opioid or non-opioid treatments, adapted to pain intensity and based on international recommendations updated in 2014. A systemic analgesic treatment with morphine with a patient-controlled analgesia device is often necessary in severe mucositis. In case of insufficient analgesia, use of co-analgesics (paracetamol, ketamine, anticonvulsants, and antidepressants) can improve analgesic control and reduce morphine doses. Non-drug strategies (distraction, relaxation, hypnosis) and preventive measures must be a major concern. Among them, laser therapy using a low power athermal laser beam, is a promising therapeutic strategy whose effectiveness is based on its analgesic, anti-inflammatory, and healing properties. Despite many available studies, there is a limited number of clinically effective therapies. New therapeutic agents for the prevention and treatment of mucositis and its pain, based on the biological phenomena involved, must be further developed to improve the efficacy of analgesia.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Guerrini-Rousseau L,Marec-Berard P,Bolle S,Laurent Sdoi
10.1016/j.bulcan.2019.03.022subject
Has Abstractpub_date
2019-09-01 00:00:00pages
776-783issue
9eissn
0007-4551issn
1769-6917pii
S0007-4551(19)30198-5journal_volume
106pub_type
杂志文章,评审abstract：:Many efforts have been devoted to the development of gene therapy for primary liver tumors. This has been hampered by the absence of efficient gene transfer vectors for delivering genes into hepatoma cells in vivo. Also it remains to determine which type of gene has to be used to achieve complete tumor regression. Rec...
journal_title：Bulletin du cancer
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abstract：INTRODUCTION:The treatment of chronic myeloid leukemia (CML) has been revolutionized by the advent of tyrosine kinase inhibitors. The results of the IRIS trial demonstrated the efficacy and long-term safety profile of Imatinib. The objective of our work is to report the results at 15 years of treatment of CML in chroni...
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journal_title：Bulletin du cancer
pub_type： 共识发展会议,杂志文章,实务指引,评审
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journal_title：Bulletin du cancer
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journal_title：Bulletin du cancer
pub_type： 杂志文章
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
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journal_title：Bulletin du cancer
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journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章
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journal_title：Bulletin du cancer
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更新日期：1990-01-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
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journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1993-07-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/S0007-4551(16)30374-5
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
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journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
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pub_type： 杂志文章,实务指引
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journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
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