[Chemotherapeutic intensification in germ cell tumors].

Abstract:

:Chemotherapy has dramatically improved the prognosis of non-seminomatous germ cell tumors (NSGCT). However, some patients relapse and others are refractory to first line chemotherapy. We studied a salvage chemotherapeutic regimen with etoposide 75 gm/m2/day, and cisplatin 40 mg/m2/day, days 1-5 and Ifosfamide 3 g/m2/day, days 1 and 2 (VIhP regimen) in 32 patients. We observed 8 complete remissions with 4 long-term NED patients. Hematological, neurological and renal complications were frequent. In 16 other cases, a protocol using high dose chemotherapy, followed by autologous bone marrow rescue was studied. We observed 8 complete remissions with 4 long-term NED patients. These observations support a dose/effect relationship. A French randomized trial testing high dose chemotherapy, followed in some cases by an autologous marrow graft in poor risk advanced NSGCT, has recently been activated.

journal_name

Bull Cancer

journal_title

Bulletin du cancer

authors

Droz JP,Pico JL,Ghosn M,Ostronoff M,Azab M,Theodore C,Hayat M

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

349-54

issue

4

eissn

0007-4551

issn

1769-6917

journal_volume

77

pub_type

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