Abstract：
:Targeted therapy against the EGF receptor was shown to be effective in a subgroup of patients with KRAS wild-type colorectal cancer. Therefore, cetuximab (Erbitux) or panitumumab (Vectibix) obtained the authorization by the EMEA restricted to patients with KRAS wild-type tumours. KRAS mutational testing has become part of the standard care in patients treated with EGFR targeting therapy. Testing for KRAS mutations is not standardized, there is a multitude of methods, some of which are commercially available CE marked techniques. Most frequently used assays are developed in this review. It is very difficult today to tell which test is the most reliable. Moreover tumour samples are very heterogeneous (fixation, biopsy, surgical specimen, neoadjuvant treatment) and one "best" method could depend upon the type of sample. A STIC program is on going in France (MOKAECM) to initiate a quality assurance (QA)-program for KRAS testing. All INCa labelled laboratories that develop somatic oncology genetic tests participate to this program. Methods will be tested on cell line DNAs at first, then DNAs from paraffin embedded tumours will be shared and typed by the various laboratories. Finally, an economical evaluation will be done to compare techniques at all levels. This is of importance since KRAS testing needs to be done in a wide numbers of laboratories with similar value. KRAS testing is the first predictive genetic test in a frequent solid tumour, the establishment of a QA-program can serve as a future example for the introduction of other markers based on tumour genetic alterations.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Blons H,Laurent-Puig Pdoi
10.1684/bdc.2009.0996subject
Has Abstractpub_date
2009-12-01 00:00:00pages
S47-56eissn
0007-4551issn
1769-6917pii
bdc.2009.0996journal_volume
96 Supplpub_type
杂志文章,评审abstract：:In man, the period of maximum risk for the embryo and foetus is between the second and tenth week after conception. The most frequent and most severe malformation is microcephaly which in extreme cases is accompanied by mental retardation. The results of studies in experimental animals and man agree that it is impossi...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:The results obtained in the treatment of 45 cases of soft tissue sarcomas are presented. All cases were reviewed and classified according to the modern criteria of malignancy. The treatment schedule comprised: (1) preoperative irradiation: 2 sessions of 6.50 Gy in 48 hours, target volume: whole limb segment; (2) surgi...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:The Li-Fraumeni syndrome is an autosomal dominant syndrome representing a genetic predisposition to a wide spectrum of tumours including sarcomas, breast carcinomas, brain tumors and adrenocortical carcinomas. In most of the cases, tumours will develop in children and young adults. Germline mutations of the tumor supp...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1997-07-01 00:00:00
abstract：:The relationships involved in host resistance to tumor development were studied. Animals were pretreated by local hyperthermia, local irradiation and combined local hyperthermia and x-irradiation. After treatment, the animals were inoculated with tumor cells 0--96 or 0--120 hours post treatment. (BALB/c X C57B1/6)F1 m...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Mucositis, an acute inflammation of the digestive mucosa, is one of the main toxicities secondary to oncological treatments. Among its consequences, mucositis-related pain is an important complication due to its intensity and repercussion, especially on quality of life. Treatment of pain plays a central role in manage...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2019.03.022
更新日期：2019-09-01 00:00:00
abstract：:In 2003, there was 147,000 deaths attributed to cancer in France, 88,000 in men and 59,000 in women. Cancer mortality rates have been decreasing since 1987 in the male population and since the late 60's in the female population, the decrease is larger for the male population. This decrease is observed for most sites o...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Pain is frequent in cancer patients. To date, there is a consequent therapeutic arsenal so to manage pain; the different treatment strategies are the subject of various recommendations. Patients with cancer also frequently suffer from renal insufficiency, and this comorbidity may disrupt or jeopardize the analgesic st...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2011.1488
更新日期：2012-03-01 00:00:00
abstract：:Propensity score, an indicator of the propensity to get one treatment among two (or more), is encountered in non randomized studies (prospective or retrospective). It is calculated after the research of predictive factors for treatment attribution, and corresponds to the probability to receive one of the treatments co...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
abstract：:The rising incidence of cancers affecting the kidney emphasizes the need to identify the molecular pathways involved in the initiation and progression of kidney tumors in order to counter this phenomenon. For many years, genes belonging to the PAX family have been the focus of intensive studies in the fields of organo...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2006-09-01 00:00:00
abstract：:The evidence that C cell hyperplasia is the precursor of medullary carcinoma in families where this tumour is inherited is very strong. It is suggested that the tumour is the result of at least two mutations, in the families with medullary carcinoma the first of these is genetically determined, and the second is an ac...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Genomic DNA displays a non canonical structure prone to be damaged and modified by genotoxic stresses, which are induced either by the endogenous metabolism or attacks from environment or therapeutic pressure. Several molecular pathways allow cells to repair such DNA lesions. Additional mechanisms have been selected t...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1202
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:A high prevalence of renal insufficiency has been observed in cancer patients as well as a high incidence of de novo cancer in dialysis or renal transplant patients. MATERIAL AND METHODS:We aimed to determine the incidence of cancer in patients under dialysis and in kidney transplant recipients through a se...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2012.1545
更新日期：2012-03-01 00:00:00
abstract：:Important progress have been recently achieved in the management of Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL). Prognostic factors are now better defined in HD thanks to new biologic and radiologic information which complete old and relevant clinical factors. These parameters are expected to improve decis...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
abstract：:When confluent human skin cultures are ultraviolet (UV)-irradiated before infection with Herpes Simplex type 1 virus (HSV), their capacity to support virus growth is impaired. When the time interval between UV-exposure and infection is increased up to 36 hours, different recoveries of HSV production capacity are obser...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Innovation in radiotherapy should meet multiple challenges, both technically, biologically, clinically and socially. Scientific, technological and biological advances have resulted in major changes in the implementation, indications, and therapeutic index of radiotherapy over the last century. Based on technical innov...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1016/j.bulcan.2018.12.006
更新日期：2019-01-01 00:00:00
abstract：:In a case of glioblastoma, the following karyotype was determined: 47, X, - Y, + der(1) t(1;9)(p21;p23), t(1;9)(p21;p23), + 3, + 7, der(9) t(Y;9)(q11;p21), - 13, t(13;16)(p13,p11), del(14)(q11q22). Classical satellite DNAs are mainly located in chromosomes 1, 9, 15, 16 and Y. Because, most of these chromosomes were im...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC). Due to its peculiar toxicities, improving patient's tolerance may need close follow-up. Nurses can play a crucial role, by driving a patient education program (EP). We aimed to prove that adding EP to usual care (UC) improves pa...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2016.09.017
更新日期：2016-11-01 00:00:00
abstract：:Bladder tumours are frequent with around 10,000 new cases each year in France. Less than 500 of these cases are not transitional cell carcinoma, the most frequent pathological aspect. The identification of these pathological patterns requires an initial biopsy through transurethral resection. Sarcomatoid, squamous and...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2010.1097
更新日期：2010-01-01 00:00:00
abstract：:The radiobiological properties of the hadrons (neutrons, protons, carbon ions) led to their therapeutic use in sarcomas, as a referent therapy or as an alternative to photon therapy. An extensive review of the literature has been conducted to assess the present indications and the perspectives for hadrontherapy. Compa...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1125
更新日期：2010-06-01 00:00:00
abstract：:Geriatric oncology represents a novel specialty which can be defined as specific older cancer patients management. It includes a validated geriatric procedure, the comprehensive geriatric assessment, which is the best way of approaching the complex interacting medical problems of frail older patients. Geriatric assess...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:In the French administrative "departement" of Côte-d'Or, between 1982 and 1990, the crude incidence rate and the age-adjusted world standardised incidence rate (ASR) for corpus uteri cancer were respectively 16.0 +/- 0.8 and 10.7 +/- 0.6 per 100,000 women per year. The incidence increased after 50 years of age, reachi...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1994-08-01 00:00:00
abstract：:Enzalutamide (MDV3100) is a non-steroidal antiandrogen of second generation that has shown efficacy in metastatic castration-resistant prostate cancer (mCRPC). The study AFFIRM demonstrated a statistically significant increase in overall survival among patients who have progressed following a docetaxel chemotherapy. B...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2013.1880
更新日期：2014-01-01 00:00:00
abstract：:Ewing tumours are characterised as tumours consisting of small, blue, round malignant cells that may exhibit varying degrees of neural differentiation. Most of them arise in bony sites, and they represent the second commonest primary osseous malignancy in and adolescence and young adults. During the past 30 years, che...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2010.1120
更新日期：2010-06-01 00:00:00
abstract：:Since premedication of patients with an H1 antihistamine is recommended before the start of the intravenous infusion of temsirolimus, temsirolimus is to be used with caution in cases where there is a history of hypersensitivity to this class of antihistamines, or medical contra-indication for treatment with antihistam...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2011.1447
更新日期：2011-01-01 00:00:00
abstract：:The aim of this review is to discuss the different communication skills training designed to physician interactions with cancer patients. The development of medicine and chronic cancer treatments indicates the need to improve communication skills that combine appropriate assessment, information and support. Literature...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2001-12-01 00:00:00
abstract：INTRODUCTION:Surgical treatment of malignant primitive tumors of bone needs a precise preoperative assessment of tumor local extension. Joint involvement (JI) represents the most important finding to determine, for the choice of surgical procedure (intra- or extra-articular resection). OBJECTIVE:To determine the value...
journal_title：Bulletin du cancer
pub_type： 杂志文章,多中心研究
doi：10.1016/j.bulcan.2016.09.018
更新日期：2016-11-01 00:00:00
abstract：:Between 1964 and 1978, 21 patients with locally extensive soft tissue sarcoma received intal-arterial regional chemotherapy (IAC), combined with radiotherapy. Some patients were also submitted to conservative surgery. Although there were three serious accidents, one of which was lethal, the tolerance was considered ac...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:If doctor-patient communication is a frequent subject of research, couples communication where one partner has cancer is quite recent. Some studies deal with couples communication, but from an anecdotic perspective, without any operational measure. The aim of this paper is to study couples' communication frequency and...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2004-02-01 00:00:00
abstract：:The objective of this study is to compare morbidity between 2 surgical procedures of axillary clearance: functional lymphadenectomy by classical dissection versus axillary dissection prepared by liposuction (Suzanne's procedure). Two hundred consecutive patients treated for breast cancer were included in a prospective...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1997-03-01 00:00:00
abstract：:Little is known about the late effects of damage to the gonads in children treated for cancer. This investigation requires a prolonged surveillance. Radiotherapy sterilizes the ovaries above a dose of about 500 rads in an adult. Therefore, to protect at least one ovary in partial irradiation of a child's abdomen in ma...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
