Abstract：
BACKGROUND AND OBJECTIVE:The purpose of this study was to determine any difference between Porphyromonas gingivalis isolates from periodontally healthy sites as compared to those from diseased sites with respect to the ability to invade host cells. MATERIAL AND METHODS:Subgingival plaque samples were obtained from periodontally healthy and diseased sites using paper points. P. gingivalis colonies were isolated and tested, using an antibiotic protection assay, for their ability to invade KB cells. P. gingivalis 381 and Escherichia coli MC1061 were used as controls. RESULTS:Mean values of 16.79 +/- 0.86 x 10(3) colony-forming units/mL and 26.14 +/- 2.11 x 10(3) colony-forming units/mL were observed in invasion assays for isolates from periodontally healthy and diseased sites, respectively. P. gingivalis present in diseased sites had significantly greater invasive abilities than strains isolated from healthy sites. No statistical difference was noted between male or female subjects concerning the degree of invasion; isolates from diseased sites from both genders had significantly greater invasion abilities than those from healthy sites. A significant correlation was found between the increased invasive capabilities of P. gingivalis isolates vs. an increased probing depth. CONCLUSION:The increased invasion noted with P. gingivalis isolates from diseased sites vs. healthy sites, and the increased invasive capabilities with increasing probing depth, indicate that P. gingivalis isolates have a varying ability to invade host cells in the periodontal pocket.
journal_name
J Periodontal Resjournal_title
Journal of periodontal researchauthors
Jandik KA,Bélanger M,Low SL,Dorn BR,Yang MC,Progulske-Fox Adoi
10.1111/j.1600-0765.2007.01064.xsubject
Has Abstractpub_date
2008-10-01 00:00:00pages
524-30issue
5eissn
0022-3484issn
1600-0765pii
JRE1064journal_volume
43pub_type
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journal_title：Journal of periodontal research
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doi：10.1111/j.1600-0765.1994.tb01087.x
更新日期：1994-01-01 00:00:00
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journal_title：Journal of periodontal research
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journal_title：Journal of periodontal research
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doi：10.1111/j.1600-0765.1992.tb01825.x
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journal_title：Journal of periodontal research
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journal_title：Journal of periodontal research
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journal_title：Journal of periodontal research
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journal_title：Journal of periodontal research
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journal_title：Journal of periodontal research
pub_type： 杂志文章
doi：10.1111/j.1600-0765.1994.tb01221.x
更新日期：1994-07-01 00:00:00
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doi：10.1111/j.1600-0765.2005.00863.x
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journal_title：Journal of periodontal research
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journal_title：Journal of periodontal research
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更新日期：2017-10-01 00:00:00
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doi：10.1111/j.1600-0765.1999.tb02265.x
更新日期：1999-10-01 00:00:00
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doi：10.1111/j.1600-0765.1992.tb02086.x
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pub_type： 杂志文章,评审
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更新日期：2017-12-01 00:00:00
abstract：:The titre and avidity of IgG antibodies to Porphyromonas gingivalis whole cells and a 47 kDa cell surface protein were determined in serum samples taken from 20 subjects with adult periodontitis and 20 controls, matched for age, gender, ethnic origin and oral hygiene status. Antibody titres were measured by ELISA and ...
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doi：10.1111/j.1600-0765.1997.tb01379.x
更新日期：1997-01-01 00:00:00
