Abstract:
OBJECTIVE:The responsiveness of the sympathetic nervous system (SNS) and the hypothalamic--pituitary--adrenal (HPA) axis plays a major role in immune regulation and for the outcome of infections and inflammatory disorders. This study was designed to investigate whether chemical SNS denervation with the noradrenaline-selective neurotoxic drug 6-hydroxydopamine (6-OHDA), which destroys peripheral noradrenaline terminals, would influence immune responses to Gram-negative bacterial lipopolysaccharide (LPS) stimulation, and the progression of ligature-induced periodontal disease in Fischer 344 rats. MATERIAL AND METHODS:6-OHDA (40--60 microg/kg) or vehicle was injected intraperitoneally (i.p.) on days 1, 3 and 5, 10 days before application of the ligatures, and thereafter weekly in doses of 80 microg/kg. Periodontal disease was assessed when the ligatures had been in place for 49 days. At 24 and 2 h before decapitation, all rats received LPS (150 microg/kg i.p.) to induce a robust immune and HPA axis response. RESULTS:The 6-OHDA-treated rats showed significantly reduced bone loss as measured by digital X-rays (p< 0.01), and enhanced levels of the cytokines transforming growth factor-beta (p=0.05) and interleukin-6 (p=0.05), as well as the HPA axis derived hormone corticosterone (p=0.01), induced by LPS stimulation. CONCLUSIONS:6-OHDA-induced chemical sympathectomy inhibits ligature-induced periodontal disease in this model. This effect may be attributable to the well-documented ability of the SNS to regulate immune system function primarily via the adrenergic neurotransmitter noradrenaline released at sympathetic nerve terminals. The enhanced HPA axis activation may be a compensatory response that reduces the T helper (Th)2 to Th1 skewing effect of treatment with 6-OHDA.
journal_name
J Periodontal Resjournal_title
Journal of periodontal researchauthors
Breivik T,Gundersen Y,Opstad PK,Fonnum Fdoi
10.1111/j.1600-0765.2005.00803.xsubject
Has Abstractpub_date
2005-08-01 00:00:00pages
325-30issue
4eissn
0022-3484issn
1600-0765pii
JRE803journal_volume
40pub_type
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journal_title:Journal of periodontal research
pub_type: 杂志文章
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journal_title:Journal of periodontal research
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更新日期:1991-07-01 00:00:00
abstract::Human gingival tissues from periodontitis patients were found to contain from 126 fg/mg to 2161 fg/mg interleukin-1 beta as determined by a sensitive enzyme linked immunoassay. No IL-1 beta could be found in normal gingival tissue. This finding may have important consequences relevant to connective tissue destruction ...
journal_title:Journal of periodontal research
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journal_title:Journal of periodontal research
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更新日期:2020-06-01 00:00:00
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journal_title:Journal of periodontal research
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journal_title:Journal of periodontal research
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journal_title:Journal of periodontal research
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doi:10.1111/j.1600-0765.2006.00925.x
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abstract:BACKGROUND AND OBJECTIVE:Diabetes mellitus is believed to increase the risk and severity of periodontitis. However, less evidence is available on the converse effects of periodontitis on diabetes. The objective of the study was to investigate to what degree experimental periodontitis induced by Porphyromonas gingivalis...
journal_title:Journal of periodontal research
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更新日期:2020-12-01 00:00:00
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journal_title:Journal of periodontal research
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doi:10.1111/j.1600-0765.2007.01081.x
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更新日期:2020-12-12 00:00:00
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journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.1997.tb00542.x
更新日期:1997-04-01 00:00:00
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journal_title:Journal of periodontal research
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更新日期:2018-08-01 00:00:00
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journal_title:Journal of periodontal research
pub_type: 杂志文章,评审
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journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.2007.01063.x
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journal_title:Journal of periodontal research
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Journal of periodontal research
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doi:10.1111/j.1600-0765.2011.01376.x
更新日期:2011-10-01 00:00:00
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journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.1993.tb01065.x
更新日期:1993-05-01 00:00:00
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journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/jre.12087
更新日期:2014-02-01 00:00:00
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journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1034/j.1600-0765.2003.00693.x
更新日期:2003-10-01 00:00:00
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journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.2010.01277.x
更新日期:2010-10-01 00:00:00
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journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/j.1600-0765.2006.00953.x
更新日期:2007-08-01 00:00:00
abstract::Recently, nitric oxide (NO) has been shown to be vital in inflammatory processes. Nitric oxide synthase (NOS) exists in three different isoforms, two constitutively produced with physiological roles, and an inducible form, iNOS, which is involved in inflammation. This study examined the localisation of iNOS in biopsie...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1034/j.1600-0765.2000.035006369.x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effects of non-surgical periodontal therapy on gingival crevicular fluid levels of matrix metalloproteinase-8 (MMP-8), interleukin-6 (IL-6) and prostaglandin E2 (PGE2 ) in patients with rheumatoid arthritis (RA) with periodontal disease. MATERIAL AND METHODS:Twenty-s...
journal_title:Journal of periodontal research
pub_type: 杂志文章
doi:10.1111/jre.12337
更新日期:2016-10-01 00:00:00