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Vigabatrin-induced modification of Ki-67 expression in gingival epithelium: immunohistochemical study of a short series.

Abstract：

OBJECTIVE:To study the expression and role in vigabatrin (VGB)-induced gingival enlargement of Ki-67 antigen and p27KIP1, p21WAF1, and p53, proteins that activate or inhibit cell-cycle progression. MATERIALS AND METHODS:Six patients treated with VGB for partial epileptic seizures refractory to classic anticonvulsant treatment were studied. Gingival biopsies were taken from four of these patients for immunohistochemical studies; 10 control biopsies from individuals with healthy gingiva and 10 from patients with periodontal disease were also evaluated. RESULTS:Four of the six patients presented some degree of gingival enlargement (mild or moderate). Nuclear expression of Ki-67 was elevated (mean of 894 positive cells/mm2 in VGB-induced gingival enlargement vs. 391 cells/mm2 in controls with healthy gingiva and 425 cells/mm2 in controls with periodontal disease) (p < 0.01, analysis of variance: anova), and nuclear expression of cyclin-dependent kinase (cdk) inhibitors p27KIP1 and p21WAF1 was reduced. The patients with gingival enlargement presented inflammatory infiltrate in lamina propria, mainly composed of T lymphocytes (CD3+) and plasma cells (CD38+), which was even more intense than in the biopsies of patients with periodontal disease. CONCLUSION:The overexpression of antigen Ki-67 and slight underexpression of cdk-inhibitors p27KIP1 and p21WAF1 suggest that VGB induced an increase in cell proliferation and contributed, together with concomitant periodontal disease, to the gingival enlargement.

journal_name

J Periodontal Res

journal_title

Journal of periodontal research

authors

Mesa F,Aguilar M,Gonzalez-Moles MA,Guerrero A,Sanchez-Alvarez JC,Del Moral RG,O'Valle F

doi

10.1111/j.1600-0765.2004.00711.x

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

66-71

issue

1

eissn

0022-3484

issn

1600-0765

pii

711

journal_volume

39

pub_type

杂志文章

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