当前位置： SCI文献检索 > JOURNAL OF PERIODONTAL RESEARCH期刊下所有文献 > The effects of periodontal therapy on gingival crevicular fluid matrix metalloproteinase-8, interleukin-6 and prostaglandin E2 levels in patients with rheumatoid arthritis.

The effects of periodontal therapy on gingival crevicular fluid matrix metalloproteinase-8, interleukin-6 and prostaglandin E2 levels in patients with rheumatoid arthritis.

Abstract：

OBJECTIVE:The aim of this study was to evaluate the effects of non-surgical periodontal therapy on gingival crevicular fluid levels of matrix metalloproteinase-8 (MMP-8), interleukin-6 (IL-6) and prostaglandin E2 (PGE2 ) in patients with rheumatoid arthritis (RA) with periodontal disease. MATERIAL AND METHODS:Twenty-seven patients with gingivitis and periodontitis with RA, 26 patients with gingivitis and periodontitis that were systemically healthy and 13 periodontally and systemically healthy volunteers (control group) were included in this study. RA activity was assessed by disease activity score test. The clinical periodontal parameters, fasting venous blood and gingival crevicular fluid samples were obtained and gingival crevicular fluid MMP-8, IL-6 and PGE2 levels were evaluated at baseline and at 3 mo follow-up after non-surgical periodontal treatment. RESULTS:Gingival crevicular fluid MMP-8, PGE2 and IL-6 levels were higher in all groups than the control group. Following periodontal therapy, there were significant decreases in gingival crevicular fluid MMP-8, PGE2 and IL-6 levels from patients with RA with periodontitis (p < 0.05). Plaque index, gingival index and bleeding on probing were significantly correlated with IL-6 and PGE2 at baseline and at 3 mo follow-up after non-surgical periodontal treatment. CONCLUSION:Non-surgical periodontal therapy of patients with RA with periodontitis may provide beneficial effects on local inflammatory control via decreases in gingival crevicular fluid MMP-8, PGE2 and IL-6 levels.

journal_name

J Periodontal Res

journal_title

Journal of periodontal research

authors

Kurgan Ş,Fentoğlu Ö,Önder C,Serdar M,Eser F,Tatakis DN,Günhan M

doi

10.1111/jre.12337

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

586-95

issue

5

eissn

0022-3484

issn

1600-0765

journal_volume

51

pub_type

杂志文章

相关文献

JOURNAL OF PERIODONTAL RESEARCH文献大全
  • Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria.

    abstract：OBJECTIVES:Heat shock protein (HSP) can be utilized as a vaccine to cross-protect against multiple pathogenic species. The present study was performed to evaluate Porphyromonas gingivalis heat shock protein 60 (HSP60) as a vaccine candidate to inhibit multiple bacteria-induced alveolar bone loss. MATERIAL AND METHODS:...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2005.00832.x

    authors： Lee JY,Yi NN,Kim US,Choi JS,Kim SJ,Choi JI

    更新日期：2006-02-01 00:00:00

  • Nucleotide-binding oligomerization domain 1 regulates Porphyromonas gingivalis-induced vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 expression in endothelial cells through NF-κB pathway.

    abstract：BACKGROUND AND OBJECTIVE:Porphyromonas gingivalis has been shown to actively invade endothelial cells and induce vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) overexpression. Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular pattern recognition reporter, ...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12192

    authors： Wan M,Liu J,Ouyang X

    更新日期：2015-04-01 00:00:00

  • Characterization of hyperbranched core-multishell nanocarriers as an innovative drug delivery system for the application at the oral mucosa.

    abstract：BACKGROUND AND OBJECTIVES:In the oral cavity, the mucosal tissues may develop a number of different pathological conditions, such as inflammatory diseases (gingivitis, periodontitis) and autoimmune disorders (eg, oral lichen planus) that require therapy. The application of topical drugs is one common therapeutic approa...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12487

    authors： Jager J,Obst K,Lohan SB,Viktorov J,Staufenbiel S,Renz H,Unbehauen M,Haag R,Hedtrich S,Teutloff C,Meinke MC,Danker K,Dommisch H

    更新日期：2018-02-01 00:00:00

  • Effects of vascular endothelial cells on osteogenic differentiation of noncontact co-cultured periodontal ligament stem cells under hypoxia.

    abstract：BACKGROUND AND OBJECTIVE:During periodontitis or orthodontic tooth movement, the periodontal vasculature is severely impaired by chronic inflammation or excessive mechanical force. This leads to a hypoxic microenvironment of the periodontal cells and enhances the expression of various cytokines and growth factors that ...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2012.01503.x

    authors： Wu Y,Cao H,Yang Y,Zhou Y,Gu Y,Zhao X,Zhang Y,Zhao Z,Zhang L,Yin J

    更新日期：2013-02-01 00:00:00

  • Porphyromonas gingivalis displays a competitive advantage over Aggregatibacter actinomycetemcomitans in co-cultured biofilm.

    abstract：BACKGROUND AND OBJECTIVE:Biofilm formation occurs through the events of cooperative growth and competitive survival among multiple species. Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans are important periodontal pathogens. The aim of this study was to demonstrate competitive or cooperative interact...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12006

    authors： Takasaki K,Fujise O,Miura M,Hamachi T,Maeda K

    更新日期：2013-06-01 00:00:00

  • Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases.

    abstract：BACKGROUND AND OBJECTIVE:Autoimmune diseases, including atherosclerosis, diabetes mellitus and rheumatoid arthritis, can be triggered and aggravated by the pathogen-driven antigenic peptide from Porphyromonas gingivalis HSP60. P. gingivalis is the major pathogen of chronic periodontitis, which is a global epidemic prev...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2012.01501.x

    authors： Jeong E,Lee JY,Kim SJ,Choi J

    更新日期：2012-12-01 00:00:00

  • Phagocytosis of Porphyromonas gingivalis and Prevotella intermedia by human polymorphonuclear leukocytes in clots formed from human plasma or purified fibrinogen.

    abstract：:We have studied the polymorphonuclear leukocyte (PMN) phagocytosis of Porphyromonas gingivalis (Bacteroides gingivalis) and Prevotella intermedia (Bacteroides intermedius) in three-dimensional fibrin meshworks formed by either clotting human plasma or by clotting purified fibrinogen with human serum incorporated. PMN ...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.1992.tb01812.x

    authors： Hurst TJ,Wilton JM

    更新日期：1992-03-01 00:00:00

  • Basic fibroblast growth factor suppresses tropoelastin gene expression in cultured human periodontal fibroblasts.

    abstract：:Growth factors are known to play a major role in the regeneration of the periodontium. Basic fibroblast growth factor (bFGF) is a polypeptide growth factor considered to have a role in chemotaxis and mitogenesis of periodontal ligament (PDL) cells. The aim of this study was to assess the effect of bFGF on the transcri...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1034/j.1600-0765.2001.360201.x

    authors： Palmon A,Roos H,Reichenberg E,Grosskop A,Bar Kana I,Pitaru S,Redlich M

    更新日期：2001-04-01 00:00:00

  • Fibre guiding scaffolds for periodontal tissue engineering.

    abstract：:The periodontium is a highly hierarchically organized organ composed of gingiva, alveolar bone, periodontal ligament and cementum. Periodontitis leads to the destruction of hard and soft tissues ultimately leading to a loss of the teeth supporting apparatus. Current treatments are capable of limiting the disease progr...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章,评审

    doi：10.1111/jre.12729

    authors： Staples RJ,Ivanovski S,Vaquette C

    更新日期：2020-06-01 00:00:00

  • Cytokeratin profile of the junctional epithelium in partially erupted teeth.

    abstract：:This study uses cytokeratins (CK) as markers to investigate the phenotype of the junctional epithelium (JE) in partially erupted human teeth. The gingival samples, which were clinically healthy, were carefully dissected from the teeth. Cryostat sections were cut for histological staining, immunofluorescence microscopy...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.1994.tb01212.x

    authors： Feghali-Assaly M,Sawaf MH,Serres G,Forest N,Ouhayoun JP

    更新日期：1994-05-01 00:00:00

  • Human beta defensin-1 and -2 expression in the gingiva of patients with specific periodontal diseases.

    abstract：BACKGROUND AND OBJECTIVE:beta defensin antimicrobial peptides are important in epithelial innate immunity, and their differential expression is associated with periodontal diseases. The aims of this study were to determine the mRNA expression of human beta defensin-1 and -2 in the gingival tissue of patients with gingi...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2006.00964.x

    authors： Vardar-Sengul S,Demirci T,Sen BH,Erkizan V,Kurulgan E,Baylas H

    更新日期：2007-10-01 00:00:00

  • Activated KCNQ1 channel promotes fibrogenic response in hereditary gingival fibromatosis via clustering and activation of Ras.

    abstract：BACKGROUND AND OBJECTIVE:Activated potassium channels were found to be strongly correlated with gingival overgrowth (GO) phenotype as we reviewed syndromic hereditary gingival fibromatosis (HGF). Nevertheless, the functional roles of potassium channels in gingival fibrosis or gingival overgrowth remained uncovered. The...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12836

    authors： Gao Q,Yang C,Meng L,Wang Z,Chen D,Peng Y,Yang K,Bian Z

    更新日期：2020-12-31 00:00:00

  • Prepubertal periodontitis: a review of diagnostic criteria, pathogenesis, and differential diagnosis.

    abstract：:This paper reviews the literature on prepubertal periodontitis (PP) according to the definition and the classification of PP by Page. The generalized form of PP (G-PP) defined by Page was identified as the oral manifestation of a systemic disease called leukocyte adhesion deficiency (LAD) and thus the pathogenesis is ...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章,评审

    doi：10.1111/j.1600-0765.1990.tb01205.x

    authors： Watanabe K

    更新日期：1990-01-01 00:00:00

  • Significance of elevated gingival crevicular fluid tumor necrosis factor-alpha and interleukin-8 levels in chronic hemodialysis patients with periodontal disease.

    abstract：BACKGROUND AND OBJECTIVE:The prevalence of chronic renal disease in industrialized countries is increasing, and chronic renal disease and periodontitis can have significant, reciprocal effects. The aim of this study was to evaluate the associations between specific clinical parameters and the levels of tumor necrosis f...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2009.01252.x

    authors： Dağ A,Firat ET,Kadiroğlu AK,Kale E,Yilmaz ME

    更新日期：2010-08-01 00:00:00

  • Cystatin A in gingival crevicular fluid of periodontal patients.

    abstract：:Cystatins are physiological inhibitors of cysteine proteinases which are widely distributed in human tissues and fluids. In the present study we analysed both the cystatin activity and the different cystatin isoforms in gingival crevicular fluid and saliva samples of nine periodontitis patients. All crevicular fluid s...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.1997.tb00935.x

    authors： Blankenvoorde MF,Henskens YM,van der Weijden GA,van den Keijbus PA,Veerman EC,Nieuw Amerongen AV

    更新日期：1997-10-01 00:00:00

  • Irsogladine maleate counters the interleukin-1 beta-induced suppression in gap-junctional intercellular communication but does not affect the interleukin-1 beta-induced zonula occludens protein-1 levels in human gingival epithelial cells.

    abstract：BACKGROUND AND OBJECTIVE:Irsogladine maleate counters gap junctional intercellular communication reduction induced by interleukin-8 or Actinobacillus actinomycetemcomitans in cultured human gingival epithelial cells. Interleukin-1 beta is involved in periodontal disease. Little is known, however, about the effect of in...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2007.01000.x

    authors： Fujita T,Ashikaga A,Shiba H,Kajiya M,Kishimoto A,Hirata R,Tsunekuni N,Hirono C,Kawaguchi H,Shiba Y,Kurihara H

    更新日期：2008-02-01 00:00:00

  • Urokinase-plasminogen activator protects periodontal ligament fibroblast from oxidative induced-apoptosis and DNA damage.

    abstract：BACKGROUND AND OBJECTIVE:Urokinase-plasminogen activator (uPA) is a serine protease expressed at high basal level in normal gingival cervical fluid. Despite its known pathologic role in tissue proteolysis in periodontitis, little is known concerning uPA physiological function in oral tissue. Recent evidence in cancer c...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12576

    authors： Ahmad Akhoundi MS,Rokn A,Bagheri R,Momeni N,Hodjat M

    更新日期：2018-10-01 00:00:00

  • 25-Hydroxyvitamin D3 -enhanced PTPN2 positively regulates periodontal inflammation through the JAK/STAT pathway in human oral keratinocytes and a mouse model of type 2 diabetes mellitus.

    abstract：BACKGROUND AND OBJECTIVE:Periodontitis is an increasingly prevalent complication of diabetes mellitus (known as diabetes mellitus-associated periodontitis), and 25-hydroxyvitamin D3 (25VD3 ) was recently found to be a critical regulator of innate immunity in this disease, but the underlying mechanisms remain poorly und...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12535

    authors： Zhang P,Zhang W,Zhang D,Wang M,Aprecio R,Ji N,Mohamed O,Li Y,Ding Y,Wang Q

    更新日期：2018-06-01 00:00:00

  • Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease.

    abstract：BACKGROUND AND OBJECTIVE:Biological plausibility of an association between severe periodontitis and cardiovascular disease (CVD) has been proven. Genetic characteristics play an important role in both complex inflammatory diseases. Polymorphisms (single nucleotide polymorphisms [SNPs]) in the long noncoding RNA, antise...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12555

    authors： Schulz S,Seitter L,Werdan K,Hofmann B,Schaller HG,Schlitt A,Reichert S

    更新日期：2018-10-01 00:00:00

  • Inhibitory effects of green tea polyphenol (-)-epigallocatechin gallate on the expression of matrix metalloproteinase-9 and on the formation of osteoclasts.

    abstract：BACKGROUND:Alveolar bone resorption is a characteristic feature of periodontal diseases and involves the removal of both the mineral and organic constituents of the bone matrix, which is caused by either multinucleated osteoclast cells or matrix metalloproteinases (MMPs). The gram-negative bacterium, Porphyromonas ging...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2004.00743.x

    authors： Yun JH,Pang EK,Kim CS,Yoo YJ,Cho KS,Chai JK,Kim CK,Choi SH

    更新日期：2004-10-01 00:00:00

  • Clinical application of autologous fibroblast cell culture in gingival recession treatment.

    abstract：BACKGROUND AND OBJECTIVE:Gingival recession is defined as soft and hard tissue displacement resulting in root surface exposure. The optimal outcome of gingival recession treatment is complete, predictable and long-lasting root coverage with a significant level of tissue regeneration. Tissue engineering, which applies a...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/jre.12215

    authors： Milinkovic I,Aleksic Z,Jankovic S,Popovic O,Bajic M,Cakic S,Lekovic V

    更新日期：2015-06-01 00:00:00

  • Lipid peroxidation: a possible role in the induction and progression of chronic periodontitis.

    abstract：OBJECTIVES:Reactive oxygen species (ROS) are implicated in the destruction of the periodontium during inflammatory periodontal diseases. The imbalance in oxidant/antioxidant activity may be a key factor in the damaging effects of ROS. This study aimed to determine the lipid peroxidation levels in gingival crevicular fl...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2005.00818.x

    authors： Tsai CC,Chen HS,Chen SL,Ho YP,Ho KY,Wu YM,Hung CC

    更新日期：2005-10-01 00:00:00

  • Lipopolysaccharide-regulated production of bone sialoprotein and interleukin-8 in human periodontal ligament fibroblasts: the role of toll-like receptors 2 and 4 and the MAPK pathway.

    abstract：BACKGROUND AND OBJECTIVE:Lipopolysaccharide (LPS) on the cell wall of periodontal pathogens is a major mediator of the inflammatory response and can enhance alveolar bone resorption in periodontitis. Bone sialoprotein is an early marker of osteoblast differentiation. The proinflammatory cytokine, interleukin-8 (IL-8), ...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/jre.12193

    authors： Zhang Y,Li X

    更新日期：2015-04-01 00:00:00

  • Analysis of interleukin-1beta-modulated mRNA gene transcription in human gingival keratinocytes by epithelia-specific cDNA microarrays.

    abstract：BACKGROUND/OBJECTIVES:Proinflammatory cytokines such as interleukin-1beta are known to be synthesized in oral gingivitis and periodontitis and lead to the activation of the transcription factor nuclear factor-kappaB (NF-kappaB). Although numerous effects of interleukin-1beta on mesenchymal cells are known, e.g. up-regu...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2006.00884.x

    authors： Steinberg T,Dannewitz B,Tomakidi P,Hoheisel JD,Müssig E,Kohl A,Nees M

    更新日期：2006-10-01 00:00:00

  • Effect of cross-linked vs non-cross-linked collagen membranes on bone: A systematic review.

    abstract：:The aim of this study was to conduct a systematic review to compare the clinical outcomes of two different resorbable collagen membranes in terms of regenerated bone volume, postoperative complications and membrane degradation during bone regeneration procedures. Randomized controlled trials (RCT) or controlled trials...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章,评审

    doi：10.1111/jre.12470

    authors： Jiménez Garcia J,Berghezan S,Caramês JMM,Dard MM,Marques DNS

    更新日期：2017-12-01 00:00:00

  • Factors affecting human supragingival biofilm composition. I. Plaque mass.

    abstract：BACKGROUND AND OBJECTIVE:Little is known about the factors that affect the microbial composition of supragingival biofilms. This study was designed to examine the relationship between total DNA probe counts of supragingival biofilm samples, clinical parameters and supragingival biofilm composition. MATERIAL AND METHOD...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2008.01154.x

    authors： Haffajee AD,Teles RP,Patel MR,Song X,Veiga N,Socransky SS

    更新日期：2009-08-01 00:00:00

  • Effects of Polycan, a β-glucan, on experimental periodontitis and alveolar bone loss in Sprague-Dawley rats.

    abstract：BACKGROUND AND OBJECTIVE:Polycan is a promising candidate for the treatment of periodontal disease. This study was undertaken to examine whether Polycan, a type of β-glucan, has a protective effect on ligature-induced experimental periodontitis and related alveolar bone loss in Sprague-Dawley rats. MATERIAL AND METHOD...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2012.01502.x

    authors： Kim YS,Kang SJ,Kim JW,Cho HR,Moon SB,Kim KY,Lee HS,Han CH,Ku SK,Lee YJ

    更新日期：2012-12-01 00:00:00

  • From manual periodontal probing to digital 3-D imaging to endoscopic capillaroscopy: Recent advances in periodontal disease diagnosis.

    abstract：:Deepened periodontal pockets exert a significant pathological burden on the host and its immune system, particularly in a patient with generalized moderate to severe periodontitis. This burden is extensive and longitudinal, occurring over decades of disease development. Considerable diagnostic and prognostic successes...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章,评审

    doi：10.1111/jre.12585

    authors： Elashiry M,Meghil MM,Arce RM,Cutler CW

    更新日期：2019-02-01 00:00:00

  • Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients.

    abstract：BACKGROUND:Recent epidemiological studies have shown that individuals with periodontitis have a significantly increased risk of developing coronary heart disease. In addition to conventional risk factors, chronic infection and subsequent production of systemic inflammatory markers may be associated with this increased ...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2004.00772.x

    authors： Yamazaki K,Honda T,Oda T,Ueki-Maruyama K,Nakajima T,Yoshie H,Seymour GJ

    更新日期：2005-02-01 00:00:00

  • Naringenin inhibits human osteoclastogenesis and osteoclastic bone resorption.

    abstract：BACKGROUND AND OBJECTIVE:Naringenin, a naturally occurring flavonoid, possesses a wide range of pharmacological properties. The purpose of this study was to investigate the effect of naringenin on human osteoclastogenesis and osteoclastic bone resorption. MATERIAL AND METHODS:Naringenin was tested in a human osteoclas...

    journal_title：Journal of periodontal research

    pub_type： 杂志文章

    doi：10.1111/j.1600-0765.2008.01107.x

    authors： La VD,Tanabe S,Grenier D

    更新日期：2009-04-01 00:00:00